LOCUS       NM_001100658            2834 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 9
            (Hspa9), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001100658 XM_001062585 XM_214583
VERSION     NM_001100658.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2834)
  AUTHORS   Zhang,C., Liu,B., Sheng,J., Wang,J., Zhu,W., Xie,C., Zhou,X.,
            Zhang,Y., Meng,Q. and Li,Y.
  TITLE     Potential targets for the treatment of MI: GRP75-mediated Ca2+
            transfer in MAM
  JOURNAL   Eur J Pharmacol 971, 176530 (2024)
   PUBMED   38527700
  REMARK    GeneRIF: Potential targets for the treatment of MI: GRP75-mediated
            Ca[2+] transfer in MAM.
REFERENCE   2  (bases 1 to 2834)
  AUTHORS   Ferre,C.A., Thouard,A., Betourne,A., Le Dorze,A.L., Belenguer,P.,
            Miquel,M.C., Peyrin,J.M., Gonzalez-Dunia,D. and Szelechowski,M.
  TITLE     HSPA9/Mortalin mediates axo-protection and modulates mitochondrial
            dynamics in neurons
  JOURNAL   Sci Rep 11 (1), 17705 (2021)
   PUBMED   34489498
  REMARK    GeneRIF: HSPA9/Mortalin mediates axo-protection and modulates
            mitochondrial dynamics in neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2834)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2834)
  AUTHORS   Lv,L.J., Li,J., Qiao,H.B., Nie,B.J., Lu,P., Xue,F. and Zhang,Z.M.
  TITLE     Overexpression of GRP75 inhibits inflammation in a rat model of
            intracerebral hemorrhage
  JOURNAL   Mol Med Rep 15 (3), 1368-1372 (2017)
   PUBMED   28098881
  REMARK    GeneRIF: GRP75 expression is significantly decreased in brain
            tissues following ICH, and that overexpression of GRP75 inhibits
            inflammation and neuronal apoptosis in a rat model of ICH.
REFERENCE   5  (bases 1 to 2834)
  AUTHORS   Shan,Y. and Cortopassi,G.
  TITLE     Mitochondrial Hspa9/Mortalin regulates erythroid differentiation
            via iron-sulfur cluster assembly
  JOURNAL   Mitochondrion 26, 94-103 (2016)
   PUBMED   26702583
REFERENCE   6  (bases 1 to 2834)
  AUTHORS   Massa,S.M., Longo,F.M., Zuo,J., Wang,S., Chen,J. and Sharp,F.R.
  TITLE     Cloning of rat grp75, an hsp70-family member, and its expression in
            normal and ischemic brain
  JOURNAL   J Neurosci Res 40 (6), 807-819 (1995)
   PUBMED   7629893
REFERENCE   7  (bases 1 to 2834)
  AUTHORS   Yang,T., Kozopas,K.M. and Craig,R.W.
  TITLE     The intracellular distribution and pattern of expression of Mcl-1
            overlap with, but are not identical to, those of Bcl-2
  JOURNAL   J Cell Biol 128 (6), 1173-1184 (1995)
   PUBMED   7896880
REFERENCE   8  (bases 1 to 2834)
  AUTHORS   Webster,T.J., Naylor,D.J., Hartman,D.J., Hoj,P.B. and
            Hoogenraad,N.J.
  TITLE     cDNA cloning and efficient mitochondrial import of pre-mtHSP70 from
            rat liver
  JOURNAL   DNA Cell Biol 13 (12), 1213-1220 (1994)
   PUBMED   7811387
REFERENCE   9  (bases 1 to 2834)
  AUTHORS   Bruschi,S.A., West,K.A., Crabb,J.W., Gupta,R.S. and Stevens,J.L.
  TITLE     Mitochondrial HSP60 (P1 protein) and a HSP70-like protein
            (mortalin) are major targets for modification during
            S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity
  JOURNAL   J Biol Chem 268 (31), 23157-23161 (1993)
   PUBMED   7901206
REFERENCE   10 (bases 1 to 2834)
  AUTHORS   Akamizu,T., Saji,M. and Kohn,L.D.
  TITLE     A microsequencing approach to identify proteins which appear to
            interact with thyrotropin in rat FRTL-5 thyroid cells
  JOURNAL   Biochem Biophys Res Commun 170 (1), 351-358 (1990)
   PUBMED   2372296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Oct 27, 2012 this sequence version replaced NM_001100658.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.49727.1,
                                           SRR22582416.746500.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000018.1  26828215-26828398   c
            185-243             JAXUCZ010000018.1  26826746-26826804   c
            244-331             JAXUCZ010000018.1  26826445-26826532   c
            332-513             JAXUCZ010000018.1  26825202-26825383   c
            514-638             JAXUCZ010000018.1  26823526-26823650   c
            639-712             JAXUCZ010000018.1  26822562-26822635   c
            713-819             JAXUCZ010000018.1  26822363-26822469   c
            820-982             JAXUCZ010000018.1  26821035-26821197   c
            983-1075            JAXUCZ010000018.1  26820531-26820623   c
            1076-1285           JAXUCZ010000018.1  26816119-26816328   c
            1286-1513           JAXUCZ010000018.1  26814793-26815020   c
            1514-1618           JAXUCZ010000018.1  26813849-26813953   c
            1619-1736           JAXUCZ010000018.1  26813208-26813325   c
            1737-1831           JAXUCZ010000018.1  26812042-26812136   c
            1832-1924           JAXUCZ010000018.1  26811583-26811675   c
            1925-2065           JAXUCZ010000018.1  26811232-26811372   c
            2066-2834           JAXUCZ010000018.1  26810235-26811003   c
FEATURES             Location/Qualifiers
     source          1..2834
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2834
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /note="heat shock protein family A (Hsp70) member 9"
                     /db_xref="GeneID:291671"
                     /db_xref="RGD:1311806"
     exon            1..184
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2143
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /note="GRP 75; mtHSP70; mortalin; peptide-binding protein
                     74; heat shock 70 kDa protein 9; 75 kDa glucose-regulated
                     protein; heat shock 70kDa protein 9A; heat shock protein,
                     A; catecholamine regulated protein 40; heat shock protein
                     9; heat shock protein family A member 9; stress-70
                     protein, mitochondrial-like"
                     /codon_start=1
                     /product="stress-70 protein, mitochondrial"
                     /protein_id="NP_001094128.2"
                     /db_xref="GeneID:291671"
                     /db_xref="RGD:1311806"
                     /translation="MISASRAAAARLVGTTASRSPAAARHQDGWNGLSHEAFRFVSRR
                     DYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTPDGERLVG
                     MPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVEAHGKL
                     YSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLR
                     VINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGE
                     DFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTM
                     DASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRM
                     PKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETL
                     GGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGI
                     PPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAE
                     KYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLAR
                     KDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSSTGEQKEDQKEEKQ"
     exon            185..243
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            244..331
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            332..513
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            514..638
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            639..712
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            713..819
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            820..982
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1075
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1285
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1513
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1618
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1736
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1831
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1924
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2065
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2834
                     /gene="Hspa9"
                     /gene_synonym="Crp40; GRP-75; Hspa9a; PBP74"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccacgtggt tggagggttc cagaagcgta gccaccgccg tgcacgcagc tccgggtctg
       61 tggggtgttt gttcttgccc tcgtagccct ctgtccagcc gccatgataa gcgccagcag
      121 agccgcggcc gcgcgtctcg tgggcaccac agcgtcccgg agtcccgccg ccgcccgtca
      181 ccaggatggc tggaatggcc ttagtcatga ggcttttaga tttgtttcaa gaagggatta
      241 tgcgtcagaa gcaatcaagg gtgcagttgt tggaattgat ttgggtacta ctaactcctg
      301 tgtggctgtt atggagggca aacaagccaa ggtcctggag aacgccgaag gtgccagaac
      361 taccccttct gtggttgcct ttacaccaga tggggagcga cttgttggta tgccagcaaa
      421 acgacaagct gtcaccaacc caaacaatac tttctatgct acaaagcgtc ttattggacg
      481 acgatatgat gaccctgaag tacagaaaga cactaagaat gttcccttta aaattgtccg
      541 tgcctccaat ggtgatgcct gggtggaggc tcatggaaaa ctctattctc cgagtcagat
      601 tggagcgttt gtgttgatga agatgaaaga gactgcagaa aattacttgg gccatacagc
      661 aaaaaatgct gtgatcacag tccctgctta tttcaatgac tcacagcgac aggccactaa
      721 ggatgctggc cagatatctg ggctaaatgt gctccgagtg atcaacgagc ctacagctgc
      781 agctctggct tacggtctgg acaaatccga agacaaagtc attgctgtat atgatttagg
      841 tggaggaacc tttgacattt ctatcctgga aattcagaaa ggagtgtttg aggtgaaatc
      901 caccaatggg gacactttct taggaggtga agactttgac caagctttgt tacggcacat
      961 tgtcaaggag ttcaagaggg agacaggggt tgatttgacc aaagacaaca tggcacttca
     1021 gagggttcgg gaagctgctg agaaggctaa atgtgagctc tcctcatctg tacagactga
     1081 catcaacttg ccatacctta caatggatgc ttctggacca aagcatttga atatgaagtt
     1141 gactcgagct cagtttgaag gcattgtcac agatctaatc aagagaacta ttgctccgtg
     1201 tcagaaagct atgcaggatg cagaagtcag caagagtgac ataggagaag tgatcctggt
     1261 tggtggcatg acgaggatgc ccaaggttca gcagactgtg caagatcttt ttggcagagc
     1321 cccaagtaaa gctgttaatc ctgatgaggc tgtagccatt ggagctgcca ttcaaggagg
     1381 tgtgttggct ggtgatgtta cagatgtgct actcttggat gtcactcccc tctctctagg
     1441 tattgagaca cttggaggtg tctttaccaa gcttattaat aggaacacca ctattccaac
     1501 caaaaagagc caggtatttt ctactgctgc tgatggacaa actcaagtag agattaaagt
     1561 gtgtcagggg gaaagagaga tggccggaga caacaaactt ctaggacagt tcactttgat
     1621 tggaattccc ccagcccctc gtggagtgcc tcagattgaa gttacatttg acattgatgc
     1681 caatgggatt gtgcacgttt ctgccaaaga taaagggaca ggacgtgagc aacagattgt
     1741 aatccagtct tctggtggat taagcaaaga tgatattgaa aacatggtta aaaatgcaga
     1801 gaagtacgct gaagaagacc ggaggaagaa ggaacgtgtt gaagcagtta atatggctga
     1861 aggaattatt catgacacag aaaccaagat ggaagaattc aaggaccagt tgcctgctga
     1921 cgagtgcaac aagctaaagg aagagatttc caaaatgaga gaactccttg ctcgaaagga
     1981 cagtgaaaca ggagaaaaca ttaggcaggc ggcatcttcc cttcagcagg catcattgaa
     2041 actctttgaa atggcatata aaaagatggc atctgaacgg gaaggttctg gaagttctag
     2101 cactggggaa cagaaggaag atcagaagga agagaaacag taatagtggc agtgcattgt
     2161 ggagccagga cgacatacta tgaagcttgg gagtaaagga acttcctgag cagaaaaggg
     2221 gcaaacttca gtctttttac tgtatttttg cagtattcta tatataattt ccttaatata
     2281 taaatccagt gacaatagct ataactcatt taatggtaat aaagtcagca atagcaggtt
     2341 cacacttcta taactagcct gctgttttca gctgcacgta aaggggtggg atggggctgc
     2401 gtaccaatca ttattaggta aatctggttt gtgctgaagt agctatgttt tcaagatgga
     2461 agcccatttc acatgcagta gaggtaatct gtcatggacc ttgaattgag gtcatatgca
     2521 gatgcttgtt gaccaagagc actgctataa atgacctgtg tgtacatttg ctccttcaac
     2581 tgatgccttg caagactaag ctctctgtgt catggtctat aggtacagaa gttaggtcaa
     2641 tggataacag ctgtgttagc catagcttaa agtgatctat caagaattat acaagcctct
     2701 catgggccta aggcatactt ctccagctac cctcttgggt ggccaatgtc tgacatctat
     2761 attcttgatg attgttcctt tttcatccat tctggatttt tttttttttt aataaaattc
     2821 tgaaagcctc ttga
//
