LOCUS       NM_024351               2130 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 8
            (Hspa8), mRNA.
ACCESSION   NM_024351 XM_001053026
VERSION     NM_024351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2130)
  AUTHORS   Xu,S., Liu,S., Yang,J., Li,R., Mao,M., Feng,S. and Wang,X.
  TITLE     miR-3120/Hsc70 participates in forced swim stress-induced
            mechanical hyperalgesia in rats in an inflammatory state
  JOURNAL   Mol Med Rep 29 (1) (2024)
   PUBMED   37947174
  REMARK    GeneRIF: miR-3120/Hsc70 participates in forced swim stress-induced
            mechanical hyperalgesia in rats in an inflammatory state.
REFERENCE   2  (bases 1 to 2130)
  AUTHORS   Mi,J., Yang,Y., Yao,H., Huan,Z., Xu,C., Ren,Z., Li,W., Tang,Y.,
            Fu,R. and Ge,X.
  TITLE     Inhibition of heat shock protein family A member 8 attenuates
            spinal cord ischemia-reperfusion injury via astrocyte
            NF-kappaB/NLRP3 inflammasome pathway : HSPA8 inhibition protects
            spinal ischemia-reperfusion injury
  JOURNAL   J Neuroinflammation 18 (1), 170 (2021)
   PUBMED   34362408
  REMARK    GeneRIF: Inhibition of heat shock protein family A member 8
            attenuates spinal cord ischemia-reperfusion injury via astrocyte
            NF-kappaB/NLRP3 inflammasome pathway : HSPA8 inhibition protects
            spinal ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2130)
  AUTHORS   Dong,F. and Zhang,J.
  TITLE     Carboxyl terminus of Hsc70-interacting protein (CHIP) promotes
            pulmonary artery smooth muscle cell (PASMC) proliferation via
            enhancement of intracellular Ca2+ concentration ([Ca2+]i)
  JOURNAL   Exp Lung Res 46 (9), 332-340 (2020)
   PUBMED   32873086
  REMARK    GeneRIF: Carboxyl terminus of Hsc70-interacting protein (CHIP)
            promotes pulmonary artery smooth muscle cell (PASMC) proliferation
            via enhancement of intracellular Ca(2+) concentration ([Ca(2+)]i).
REFERENCE   4  (bases 1 to 2130)
  AUTHORS   Sahni,S., Krisp,C., Molloy,M.P., Nahm,C., Maloney,S., Gillson,J.,
            Gill,A.J., Samra,J. and Mittal,A.
  TITLE     PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer
            progression
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129682 (2020)
   PUBMED   32663515
REFERENCE   5  (bases 1 to 2130)
  AUTHORS   Ikezaki,M., Nishioka,N., Nishikawa,T., Higashimoto,N. and Ihara,Y.
  TITLE     Hsc70 is required for E-cadherin expression in epithelial-like
            NRK-52E cells
  JOURNAL   Biochem Biophys Res Commun 527 (2), 481-488 (2020)
   PUBMED   32336545
  REMARK    GeneRIF: Hsc70 is required for E-cadherin expression in
            epithelial-like NRK-52E cells.
REFERENCE   6  (bases 1 to 2130)
  AUTHORS   Morita,K., Wakui,H., Komatsuda,A., Ohtani,H., Miura,A.B., Itoh,H.
            and Tashima,Y.
  TITLE     Induction of heat-shock proteins HSP73 and HSP90 in rat kidneys
            after ischemia
  JOURNAL   Ren Fail 17 (4), 405-419 (1995)
   PUBMED   7569112
REFERENCE   7  (bases 1 to 2130)
  AUTHORS   Lee,Y.C. and Lai,Y.K.
  TITLE     Integrity of intermediate filaments is associated with the
            development of acquired thermotolerance in 9L rat brain tumor cells
  JOURNAL   J Cell Biochem 57 (1), 150-162 (1995)
   PUBMED   7721954
REFERENCE   8  (bases 1 to 2130)
  AUTHORS   Green,L.A. and Liem,R.K.
  TITLE     Beta-internexin is a microtubule-associated protein identical to
            the 70-kDa heat-shock cognate protein and the clathrin uncoating
            ATPase
  JOURNAL   J Biol Chem 264 (26), 15210-15215 (1989)
   PUBMED   2527848
REFERENCE   9  (bases 1 to 2130)
  AUTHORS   Sorger,P.K. and Pelham,H.R.
  TITLE     Cloning and expression of a gene encoding hsc73, the major
            hsp70-like protein in unstressed rat cells
  JOURNAL   EMBO J 6 (4), 993-998 (1987)
   PUBMED   3595567
REFERENCE   10 (bases 1 to 2130)
  AUTHORS   O'Malley,K., Mauron,A., Barchas,J.D. and Kedes,L.
  TITLE     Constitutively expressed rat mRNA encoding a 70-kilodalton
            heat-shock-like protein
  JOURNAL   Mol Cell Biol 5 (12), 3476-3483 (1985)
   PUBMED   3939319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061547.1 and BC098914.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001053026.1, NM_024351.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098914.1, M11942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1741              BC061547.1         8-1748
            1742-2130           BC098914.1         1694-2082
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2130
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /note="heat shock protein family A (Hsp70) member 8"
                     /db_xref="GeneID:24468"
                     /db_xref="RGD:621725"
     exon            1..75
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     exon            76..285
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2021
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /EC_number="3.6.4.10"
                     /note="heat shock 70kD protein 8; Heat shock cognate
                     protein 70; heat shock protein A8; heat shock protein 8;
                     heat shock 70kDa protein 8"
                     /codon_start=1
                     /product="heat shock cognate 71 kDa protein"
                     /protein_id="NP_077327.1"
                     /db_xref="GeneID:24468"
                     /db_xref="RGD:621725"
                     /translation="MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF
                     TDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPK
                     VQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKD
                     AGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFE
                     VKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSS
                     STQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDI
                     VLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLL
                     LLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMT
                     KDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKG
                     RLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDED
                     KQKILDKCNEIISWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGG
                     FPGGGAPPSGGASSGPTIEEVD"
     exon            286..491
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     exon            492..644
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1200
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1403
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1602
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1835
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2103
                     /gene="Hspa8"
                     /gene_synonym="Hsc70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcattgaac gcggagccag ctctcggggg tctctgtgtg gtctcgtcat cagcacagct
       61 gggcctacac gcaagcaacc atgtctaagg gacctgcagt tggcattgat cttggcacca
      121 cctactcctg tgtgggtgtc ttccagcatg gaaaggtgga aataattgcc aatgaccagg
      181 gtaaccgcac cacgccgagc tatgttgctt tcaccgacac agaacgatta attggggatg
      241 cggccaagaa tcaggttgca atgaacccca ccaacacagt ttttgatgcc aaacgtctga
      301 tcggacgtag gttcgatgat gctgttgttc agtctgacat gaagcactgg cccttcatgg
      361 tggtgaacga tgcaggcagg cccaaggtcc aagtcgaata caaaggggag acaaaaagtt
      421 tctatcctga ggaagtgtct tcaatggttc tgacaaaaat gaaggaaatt gcagaagctt
      481 accttggaaa gactgttacc aatgccgtgg tcaccgtgcc agcttacttc aatgactctc
      541 agcgacaggc aacaaaagat gctggaacta ttgctggcct caacgtactt cgaattatca
      601 atgagccaac tgctgctgct attgcctatg gcttagataa gaaggtcggg gctgaaagga
      661 atgtgctcat ttttgacttg ggaggtggca cttttgatgt gtcaatcctc actatcgagg
      721 atggaatttt tgaagtcaaa tcaacagctg gagacaccca cttgggcgga gaagactttg
      781 acaaccgaat ggtcaaccat ttcattgctg agtttaagcg aaagcacaag aaggacatca
      841 gtgagaacaa gagagctgtc aggcgtctcc gcactgcctg tgagcgggcc aagcgcaccc
      901 tctcctccag cacccaggcc agtattgaga ttgattctct ctatgaggga attgacttct
      961 acacctccat tacccgtgct cgatttgagg agttgaatgc tgacctgttc cgtggcacac
     1021 tggaccctgt agagaaggcc cttcgagatg ccaaactaga caagtcacag atccatgata
     1081 ttgtcctggt gggtggttct accagaatcc ccaagatcca gaaacttctg caagacttct
     1141 tcaatggaaa agagctgaat aagagcatta accccgatga agctgttgcc tatggtgcag
     1201 ctgtccaggc agccattcta tctggagaca agtctgagaa tgttcaggat ttgctgctct
     1261 tggatgtcac tcctctttcc cttgggattg aaactgctgg tggagtcatg actgtcctca
     1321 tcaagcgcaa taccaccatt cccaccaagc agacccagac tttcaccacc tactctgaca
     1381 accagccagg tgtactcatc caggtgtatg aaggtgaaag ggccatgacc aaggacaaca
     1441 acctgcttgg gaagtttgag ctcacaggca tacctccagc accccgtggg gttcctcaga
     1501 ttgaggttac ttttgacatt gatgccaatg gcatcctcaa tgtttctgct gtagataaga
     1561 gcacaggaaa ggagaacaag atcaccatca ccaatgacaa gggccgcttg agtaaggagg
     1621 atattgagcg catggtccaa gaagctgaga agtacaaagc tgaggatgag aagcagagag
     1681 ataaggtttc ctctaagaac tcgctggagt cttatgcttt caacatgaaa gcaactgttg
     1741 aggatgagaa acttcaaggc aagatcaatg atgaagacaa acagaagatt cttgacaagt
     1801 gcaacgaaat catcagctgg ctggataaga accagactgc ggagaaggaa gaatttgagc
     1861 atcagcagaa agaactggag aaggtctgca accctatcat caccaagctg taccagagtg
     1921 ctggtggcat gcctggagga atgcctggtg gcttccctgg tggaggagct cctccatctg
     1981 gtggtgcttc ttcaggcccc accattgaag aggtcgatta agtcaaagta gagggtatag
     2041 cattgttcca cagggaccca aaacaagtaa catggaataa taaaactatt taaattggca
     2101 ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
