LOCUS       NM_013083               2580 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 5
            (Hspa5), mRNA.
ACCESSION   NM_013083
VERSION     NM_013083.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Mou,L., Sun,D., Qu,J., Tan,X., Wang,S., Zeng,Q. and Liu,C.
  TITLE     GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP
            facilitates iodoacetic acid-mediated testosterone decline
  JOURNAL   J Hazard Mater 476, 135101 (2024)
   PUBMED   39002476
  REMARK    GeneRIF: GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP
            facilitates iodoacetic acid-mediated testosterone decline.
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Yan,Z., Liu,Y., Yang,B., Zhao,W., Wang,Y., Wang,D., Li,J., Jiao,X.
            and Cao,J.
  TITLE     Endoplasmic reticulum stress caused by traumatic injury promotes
            cardiomyocyte apoptosis through acetylation modification of GRP78
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (1), 96-105 (2024)
   PUBMED   38105649
  REMARK    GeneRIF: Endoplasmic reticulum stress caused by traumatic injury
            promotes cardiomyocyte apoptosis through acetylation modification
            of GRP78.
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Han,J., Jia,D., Yao,H., Xu,C., Huan,Z., Jin,H. and Ge,X.
  TITLE     GRP78 improves the therapeutic effect of mesenchymal stem cells on
            hemorrhagic shock-induced liver injury: Involvement of the NF-small
            ka, CyrillicB and HO-1/Nrf-2 pathways
  JOURNAL   FASEB J 38 (1), e23334 (2024)
   PUBMED   38050647
  REMARK    GeneRIF: GRP78 improves the therapeutic effect of mesenchymal stem
            cells on hemorrhagic shock-induced liver injury: Involvement of the
            NF-small ka, CyrillicB and HO-1/Nrf-2 pathways.
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Ishteyaque,S., Yadav,K.S., Verma,S., Washimkar,K.R. and Mugale,M.N.
  TITLE     CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis
            and promotes progression of hepatocellular carcinoma
  JOURNAL   Arch Biochem Biophys 745, 109701 (2023)
   PUBMED   37499993
  REMARK    GeneRIF: CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit
            apoptosis and promotes progression of hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Wang,S., Duan,J., Liao,J., Wang,Y., Xiao,X., Li,L., Liu,Y., Gu,H.,
            Yang,P., Fu,D., Du,J., Li,X. and Shao,M.
  TITLE     LncRNA H19 inhibits ER stress induced apoptosis and improves
            diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis
  JOURNAL   Aging (Albany NY) 14 (16), 6809-6828 (2022)
   PUBMED   36044268
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Kuznetsov,G., Chen,L.B. and Nigam,S.K.
  TITLE     Several endoplasmic reticulum stress proteins, including ERp72,
            interact with thyroglobulin during its maturation
  JOURNAL   J Biol Chem 269 (37), 22990-22995 (1994)
   PUBMED   7916014
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Viville,S., Neefjes,J., Lotteau,V., Dierich,A., Lemeur,M.,
            Ploegh,H., Benoist,C. and Mathis,D.
  TITLE     Mice lacking the MHC class II-associated invariant chain
  JOURNAL   Cell 72 (4), 635-648 (1993)
   PUBMED   7679955
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Pedersen,R.C. and Brownie,A.C.
  TITLE     Steroidogenesis-activator polypeptide isolated from a rat Leydig
            cell tumor
  JOURNAL   Science 236 (4798), 188-190 (1987)
   PUBMED   3563495
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Chang,S.C., Wooden,S.K., Nakaki,T., Kim,Y.K., Lin,A.Y., Kung,L.,
            Attenello,J.W. and Lee,A.S.
  TITLE     Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its
            regulatory sequences and the effect of protein glycosylation on its
            expression
  JOURNAL   Proc Natl Acad Sci U S A 84 (3), 680-684 (1987)
   PUBMED   3468506
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Munro,S. and Pelham,H.R.
  TITLE     An Hsp70-like protein in the ER: identity with the 78 kd
            glucose-regulated protein and immunoglobulin heavy chain binding
            protein
  JOURNAL   Cell 46 (2), 291-300 (1986)
   PUBMED   3087629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB578015.1, BC062017.1, M14050.1 and CB327067.1.
            
            On Mar 25, 2010 this sequence version replaced NM_013083.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062017.1, CF111168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                CB578015.1         1-40
            41-2249             BC062017.1         1-2209
            2250-2507           M14050.1           2126-2383
            2508-2580           CB327067.1         1-73                c
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2580
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /note="heat shock protein family A (Hsp70) member 5"
                     /db_xref="GeneID:25617"
                     /db_xref="RGD:2843"
     exon            1..80
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     exon            81..303
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2146
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /EC_number="3.6.4.10"
                     /note="78 kDa glucose-regulated protein; heat shock 70 kDa
                     protein 5; steroidogenesis-activator polypeptide;
                     immunoglobulin heavy chain-binding protein; GRP-78; heat
                     shock 70kDa protein 5 (glucose-regulated protein); heat
                     shock 70kD protein 5; heat shock protein 5; HSP70 family
                     protein 5; binding-immunoglobulin protein; heat shock
                     protein 70 family protein 5; endoplasmic reticulum
                     chaperone BiP; heat shock protein family A member 5"
                     /codon_start=1
                     /product="endoplasmic reticulum chaperone BiP precursor"
                     /protein_id="NP_037215.1"
                     /db_xref="GeneID:25617"
                     /db_xref="RGD:2843"
                     /translation="MKFTVVAAALLLLCAVRAEEEDKKEDVGTVVGIDLGTTYSCVGV
                     FKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRT
                     WNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY
                     LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEK
                     NILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGK
                     DVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDL
                     FRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDE
                     AVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQI
                     FSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGI
                     LRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELE
                     SYAYSLKNQIGDKEKLGGKLSPEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELE
                     EIVQPIISKLYGSGGPPPTGEEDTSEKDEL"
     exon            304..535
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     exon            536..673
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     exon            674..786
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1177
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1415
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1583
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..2563
                     /gene="Hspa5"
                     /gene_synonym="BIP; GRP 78; GRP78"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgagtcg gcgaccggcg cgctcgatac tggctgtgac tacactgact tggacacttg
       61 gccttttgcg ggtttgagag atcagaaccg tcgtcgcgtt tcggggctac agcctgttgc
      121 tggactctgt gagacacctg accgaccgct gagcgactga ctggtccaca gcgccggcaa
      181 gatgaagttc actgtggtgg cggcggcgct gctgctgctg tgtgcggtgc gggcggagga
      241 ggaggacaag aaggaggatg taggcacggt ggttggcatc gacttgggga ccacctattc
      301 ctgcgtcggt gtattcaaga acggccgcgt ggagatcata gccaacgatc agggcaaccg
      361 catcacaccg tcgtatgtgg ccttcactcc tgaaggggag cgtctgattg gcgatgcggc
      421 caagaaccaa ctcacgtcca acccggagaa caccgtcttc gacgccaagc gcctcatcgg
      481 acgcacttgg aatgaccctt ccgtgcagca ggacatcaag ttcttgccat tcaaggtggt
      541 tgaaaagaaa actaaaccat atattcaagt tgatatcgga ggtgggcaaa ccaagacatt
      601 tgccccagaa gaaatttctg ctatggttct cactaaaatg aaggaaactg ccgaggcgta
      661 tttgggaaag aaggtcaccc atgcagttgt gactgtacca gcttacttca atgatgcaca
      721 gcggcaagca accaaggatg ctggcactat tgctggactg aatgtcatga ggatcatcaa
      781 tgagccaaca gcagctgcta ttgcatatgg cctggataag agagagggag agaagaacat
      841 cctcgtgttt gacctgggtg gtggaacctt cgatgtgtct cttctcacca ttgacaatgg
      901 tgtctttgaa gtggtggcca ctaatggaga cactcatctg ggtggggaag actttgatca
      961 gcgggtcatg gagcacttca tcaagctgta caaaaagaag actgggaaag atgtcagaaa
     1021 ggacaacaga gctgtgcaga aactccggcg tgaggtagaa aaggccaaga gagccctgtc
     1081 ttctcagcat caagcgagga ttgaaattga gtccttcttc gaaggagaag acttctcaga
     1141 gacccttact cgggccaaat ttgaagagct gaacatggac ctgttccgct ctaccatgaa
     1201 acctgtccag aaagtgttgg aagactctga tctgaagaaa tctgatattg atgagattgt
     1261 tctggttggc ggatctactc gaattccaaa gattcagcag ttggtgaaag agttcttcaa
     1321 tggcaaggag ccgtcccgtg gcatcaaccc agatgaggct gtagcatatg gtgccgctgt
     1381 ccaggctggt gtcctctctg gtgatcaaga tacaggtgac ctggttctgc ttgatgtgtg
     1441 tcctcttaca cttggtattg aaactgtggg aggtgtcatg acaaaactga ttccgaggaa
     1501 cactgtggtg cccaccaaga agtctcagat cttctccaca gcttctgata atcagcccac
     1561 cgtaacaatc aaggtctacg aaggtgaacg acccctgaca aaagacaatc accttctggg
     1621 tacatttgat ctgactggaa tccctcctgc tccccgtggg gtaccccaga ttgaagtcac
     1681 ctttgagata gatgtgaatg gtattcttcg agtgacagct gaagacaaag ggacaggaaa
     1741 caaaaacaaa atcaccatca ccaatgacca aaaccgcctg acccctgaag aaattgaaag
     1801 gatggtcaat gacgccgaga agtttgctga ggaagacaaa aagctcaaag agcgcattga
     1861 cacgaggaat gaattggaaa gctatgctta ctctcttaag aaccagatcg gagataaaga
     1921 gaagctggga ggtaagctgt ctcctgaaga taaagagacc atggagaaag ctgtagagga
     1981 aaagatcgaa tggctggaaa gccaccagga tgcagacatt gaagacttta aagctaaaaa
     2041 gaaggaacta gaagaaattg ttcagccaat tatcagcaaa ctctatggaa gtggaggccc
     2101 tcccccaact ggtgaagagg atacatcaga aaaagatgag ttgtaggtgc actgatctgc
     2161 tagagctgta atattgtaaa tactggactc aggaactttc gttgggagaa aattgagaga
     2221 acttaagtct cgaatgtaat tggaatcttc acctcagagt ggagttgaaa atgctatagc
     2281 ccaagtggct gtttactgct tttcattagc agttgctcac gtgtcttggg gtcagggaga
     2341 ggaggaattg gctattttaa aattggggaa aagctgggtc agggtgtgtg ttcaccttgg
     2401 atatgttcta tttaacggtt gggtcatgca catctggtgt aggaactttt ttctaccata
     2461 agtgacacca ataaatgttt gttatttaca ctggtctagt ttttgtgaaa agcttgtaat
     2521 tatatccatc ttttatttta gataactaaa atttaagact ggaaaaaaaa aaaaaaaaaa
//
