LOCUS       NM_001106428            4183 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 4 like
            (Hspa4l), mRNA.
ACCESSION   NM_001106428 XM_001063049 XM_215549
VERSION     NM_001106428.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4183)
  AUTHORS   Hageman,J., van Waarde,M.A., Zylicz,A., Walerych,D. and
            Kampinga,H.H.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   2  (bases 1 to 4183)
  AUTHORS   Matsumori,M., Itoh,H., Toyoshima,I., Komatsuda,A., Sawada,K.,
            Fukuda,J., Tanaka,T., Okubo,A., Kinouchi,H., Mizoi,K., Hama,T.,
            Suzuki,A., Hamada,F., Otaka,M., Shoji,Y. and Takada,G.
  TITLE     Characterization of the 105-kDa molecular chaperone.
            Identification, biochemical properties, and localization
  JOURNAL   Eur J Biochem 269 (22), 5632-5641 (2002)
   PUBMED   12423363
  REMARK    GeneRIF: characterization of the biochemical properties of the
            testis and brain-specific 105-kDa protein [105-kDa molecular
            chaperone (APG-1/OSP94)]
REFERENCE   3  (bases 1 to 4183)
  AUTHORS   Kumagai,J., Fukuda,J., Kodama,H., Murata,M., Kawamura,K., Itoh,H.
            and Tanaka,T.
  TITLE     Germ cell-specific heat shock protein 105 binds to p53 in a
            temperature-sensitive manner in rat testis
  JOURNAL   Eur J Biochem 267 (10), 3073-3078 (2000)
   PUBMED   10806408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC168157.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001106428.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..4183
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /note="heat shock protein family A (Hsp70) member 4 like"
                     /db_xref="GeneID:294993"
                     /db_xref="RGD:1306528"
     exon            1..516
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            517..690
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     CDS             584..3100
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /note="heat shock 70-related protein APG-1; heat shock
                     70kDa protein 4-like; heat shock protein 4-like; osmotic
                     stress protein 94"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 4L"
                     /protein_id="NP_001099898.2"
                     /db_xref="GeneID:294993"
                     /db_xref="RGD:1306528"
                     /translation="MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSR
                     TRAIGNAAKSQIVTNVRNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVK
                     VRYLEEERPFAIEQVTGMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAA
                     QVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKPRNVVFIDMGHSAYQVSVCAFNKG
                     KLKVLATTFDPYLGGRNFDEALVDYFCDEFKAKYKINVKENSRALLRLYQECEKLKKL
                     MSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVMDQANLQRED
                     INSIEIVGGATRIPAVKEQVTRFFLKDISTTLNADEAVARGCALQCAILSPAFKVREF
                     SITDLVPYSVTLSWKTSFEEGTGECEVFSKNHPAPFSKVITFHKKEPFELEAFYTNLH
                     EVPYPDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHN
                     DAPMETEASKNEGKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAPPSDKQD
                     RINQTIKKGKIKSIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAV
                     EEYVYDFRDKLGTVYEKFITPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDKLQELK
                     KYGQPIQMKYVEHEERPKALNDLGKKIQLVLKVIEAHRNKDERYDHLDPAEMEKVEKY
                     ISDSMNWLNSKMNAQNKLSLTQDPVVKVSEIVTKSKELDNFCNPIVYKPKPKVEAPED
                     KTKASSEHNGPMDGQNGAESSPDPPKGGSQHTDSGEMEVD"
     exon            691..748
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            749..889
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1012
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1112
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1246
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1491
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1568
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1720
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1827
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1961
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2158
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2257
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2395
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2521
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2629
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2749
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2911
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..4154
                     /gene="Hspa4l"
                     /gene_synonym="APG-1; OSP94"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgaagcaa tagtgtcatc ccaggtgact tggtatagtt cctgaaatgt attttgtatt
       61 cattatagca acagcgggag ctattgccac acttgctgct gctgccctga ccgcagtgtt
      121 aatagtgaaa cgtctgagta acttaaaaag gggcacaaat acggactatg agagtactga
      181 acatgtggat aaaaattacg tgtctagttc cagggtggaa caggaagcac acaaaaactt
      241 ggacgagaca gaacacaagg aattgaatga gaaggatcag cagatacatg aagaaccaga
      301 taagggtcag catatacatg aagaattgaa caagaagggt cagcatataa atgaagaact
      361 aggtaagaag ggccagcaga tacacgaaga actaggtaaa agccaggaga tacatgaaga
      421 actggaccct aaggaacggg ggacaaaggg gctggataag gaagagccga gttcgcgctg
      481 ggatgtgcat gggaaggagc gggaccgcca gacttcgagt cgcagcgccc gcagtgggga
      541 cccgcagcgg gacgctgtcc cccgacccgg agcggtaggc gggatgtcgg tggtgggcat
      601 tgacctcggc ttcctcaact gctacatcgc tgtggcgagg agcggcggca tcgagaccat
      661 cgccaacgag tacagcgaca ggtgcacgcc ggcctgtata tctttgggat ctagaactcg
      721 agccattgga aatgcagcta agagccagat agtcacaaat gtaagaaata caattcatgg
      781 cttcaaaaag cttcatggac gatcatttga tgatcccatt gtacaaacgg agagaatcag
      841 gcttccctat gaactgcaga agatgcctaa tggaagtgca ggagttaagg tgcggtacct
      901 ggaagaagag cggccctttg caattgagca agtcactggg atgttgctgg ctaagcttaa
      961 agagacctca gaaaatgccc tgaagaagcc agtggctgac tgtgtgatct cgatcccgag
     1021 ctttttcacc gatgcagaga gaagatctgt gatggccgca gcccaggttg caggcctaaa
     1081 ctgtctgagg ctgatgaatg aaaccactgc agttgcgctg gcatatggaa tttataagca
     1141 agatcttccc tcattagatg agaagccaag gaatgttgtg tttatcgaca tggggcattc
     1201 tgcctatcag gtctctgttt gtgcttttaa caaaggaaaa cttaaagtgt tggctactac
     1261 ctttgaccca tatttgggtg gaaggaactt tgatgaggct ttagtagact acttctgtga
     1321 tgaattcaag gccaaatata agataaatgt caaagagaac tctcgggcct tgttgcggct
     1381 gtatcaggaa tgtgaaaaac taaagaagct gatgagtgca aatgcgtcag atcttcccct
     1441 aaacatcgag tgtttcatga atgaccttga tgtttctagt aagatgaaca gggctcaatt
     1501 tgaacagttg tgtgcttccc tgttggccag ggttgaacca cctttaaaag cagtaatgga
     1561 tcaagctaac ttacaacgtg aagacataaa cagcatagaa atcgtaggag gagccactcg
     1621 gattcctgca gtcaaggagc aggtcactag gttcttcctg aaagacatca gtaccaccct
     1681 aaatgctgat gaagccgtcg cccgaggatg tgcactgcag tgtgcgattc tctcaccagc
     1741 atttaaagtg cgtgaatttt ccataacaga ccttgttccc tactcagtca cattaagttg
     1801 gaagacttct tttgaagaag ggactgggga atgtgaagtc ttctctaaga accacccggc
     1861 tccattctca aaagtcataa ctttccacaa gaaggaacca tttgaactag aagcatttta
     1921 tactaatttg catgaagtgc cttatcctga tccaagaatt ggaaacttca ctattcagaa
     1981 tgttttccca cagtctgatg gtgacagttc taaagtaaag gttaaagttc gtattaacat
     2041 ccatggaatc ttcagtgtgg ccagtgcatc agtaattgag aagcagaatc tggaaggtga
     2101 tcataacgat gcccccatgg aaacagaagc ttctaagaat gaaggcaaag aggatgtgga
     2161 caaaatgcag gttgaccaag aagaaggagg tcatcagaaa tgtcatgctg aacatacccc
     2221 agaagaagag attgaccaca ctggggccaa ggcaaaggca cctccttcag acaagcaaga
     2281 tcgcataaat caaactatta aaaaagggaa aatcaagagt attgatctac ctatccagag
     2341 tagcctgtac agacaactga ctcaagatct tctcaatagc tacattgaaa atgaggggaa
     2401 gatgataatg caggataaat tagagaaaga aagaaatgat gctaaaaatg ctgttgaaga
     2461 atacgtctat gatttcagag acaaattggg cactgtctac gaaaagttca tcactccaga
     2521 agacatgaat aagctgtctg caatgttaga agacacagaa aattggcttt atgaagaagg
     2581 agaggaccaa cctaaacaag tttatgtgga taagcttcag gagctaaaga aatatggcca
     2641 gcccattcaa atgaagtacg tggagcatga agagagacca aaagctttaa atgacttggg
     2701 gaaaaagatc cagcttgtcc tgaaagtgat agaagcacac agaaacaagg atgaaagata
     2761 tgaccatctg gatcctgctg aaatggaaaa agttgaaaag tacatcagtg actccatgaa
     2821 ctggctaaac agtaagatga acgcgcagaa taaattaagt cttactcaag atcccgtggt
     2881 aaaggtgtca gaaatagtta caaagtcaaa ggaactggat aatttctgta accccatcgt
     2941 ttataagccc aaaccaaaag tagaagctcc cgaagataaa acaaaagcta gtagtgagca
     3001 caatggaccg atggatggac agaatggtgc agagagcagc ccagacccac ccaaaggagg
     3061 ctcccagcac accgactctg gagagatgga agtggactag gcgccatgta attcagcagg
     3121 ggttaaccac agggtccgtc catccttatg cctggtacac acaacatatg ttcagttgtt
     3181 cctaactact ttgtcatttg ttttttggag tagtttcgaa aagtgtctat attgagtgca
     3241 tattgatgtc cattgctgct gtgaagcttt agctgaatat agacgtacaa atcagtttga
     3301 gctctcctta catactttgt gtcagtatgc aggactgcta tgtactcggc aaccacccac
     3361 tgtagccaca gcttctactt gcatagccct cagcttctgt gtgcaggaac aggatactgc
     3421 attgctcttt tgttgcagag gcagggttaa ctgcattatt gttgtgaaaa caatctgaag
     3481 ataatgtggt ttagagccac cagcactgac ccttttctag ttccctaatg ctatcactta
     3541 aatattaaaa caaacgggag gttctgacat cctagaacat ctcactgatg cgccataagg
     3601 aatccagtct tgtcatcaca taaatgatca aaatgacact cagagggaca gtgtggtttg
     3661 agttggaata acaccagcat ttgctgcttt tgttagtagc atggatttgt gtttcctcct
     3721 cgagtaactc ttcatttgaa actgttgatc tacttgtcca aaagaccagc tgctgtccac
     3781 acttgtccac actaatgcta aagcactgtt gacctgctca ggtgtgcatc tgtgatgctg
     3841 acagccttgg ttcagtttat agttgtgttg gttttcttaa ttgctttttg ttaataatac
     3901 cttaatctgg ggtagggaga cgttgcacaa tgccttgcat tatatatacc tatcactgat
     3961 ttaatgttcc aatgtagata gacactatta aataagcagt aattccttga aaggagtacc
     4021 tgtaccaagt cttaggaaat aatgcttgta ataaactgtg ttacatcagt aggtaaaata
     4081 cataatgtta catagtgtaa tatgatataa tgtgattaaa ttatagttcc tgctgttaaa
     4141 ttgccttttg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
