LOCUS       NM_153629               4521 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 4
            (Hspa4), mRNA.
ACCESSION   NM_153629
VERSION     NM_153629.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4521)
  AUTHORS   Tu,Z., Jin,P., Wang,Q., Feng,Y., Chu,X., Fu,L., Hou,S. and Li,W.
  TITLE     Dynamically changed HSP70 after reperfusion following cerebral
            infarction in human and rats: correlation with p38 MAPK
  JOURNAL   Neuroreport 35 (7), 439-446 (2024)
   PUBMED   38597327
  REMARK    GeneRIF: Dynamically changed HSP70 after reperfusion following
            cerebral infarction in human and rats: correlation with p38 MAPK.
REFERENCE   2  (bases 1 to 4521)
  AUTHORS   Lee,C.H., Su,T.C., Lee,M.S., Hsu,C.S., Yang,R.C. and Kao,J.K.
  TITLE     Heat shock protein 70 protects the lungs from hyperoxic injury in a
            neonatal rat model of bronchopulmonary dysplasia
  JOURNAL   PLoS One 18 (5), e0285944 (2023)
   PUBMED   37200358
  REMARK    GeneRIF: Heat shock protein 70 protects the lungs from hyperoxic
            injury in a neonatal rat model of bronchopulmonary dysplasia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4521)
  AUTHORS   Qu,B., Zhao,Q., Ma,Q., Yang,T., Li,X., Chen,Y., Yang,J. and
            Zhang,Y.
  TITLE     Overexpression of miR-144-3p alleviates polycystic ovaries syndrome
            through targeting expression of HSP-70
  JOURNAL   Gene Ther 29 (5), 217-226 (2022)
   PUBMED   32917949
  REMARK    GeneRIF: Overexpression of miR-144-3p alleviates polycystic ovaries
            syndrome through targeting expression of HSP-70.
REFERENCE   4  (bases 1 to 4521)
  AUTHORS   Belity,T., Horowitz,M., Hoffman,J.R., Epstein,Y., Bruchim,Y.,
            Todder,D. and Cohen,H.
  TITLE     Heat-Stress Preconditioning Attenuates Behavioral Responses to
            Psychological Stress: The Role of HSP-70 in Modulating Stress
            Responses
  JOURNAL   Int J Mol Sci 23 (8), 4129 (2022)
   PUBMED   35456946
  REMARK    GeneRIF: Heat-Stress Preconditioning Attenuates Behavioral
            Responses to Psychological Stress: The Role of HSP-70 in Modulating
            Stress Responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4521)
  AUTHORS   Porto,R.R., Dutra,F.D., Crestani,A.P., Holsinger,R.M.D.,
            Quillfeldt,J.A., Homem de Bittencourt,P.I. Jr. and de Oliveira
            Alvares,L.
  TITLE     HSP70 Facilitates Memory Consolidation of Fear Conditioning through
            MAPK Pathway in the Hippocampus
  JOURNAL   Neuroscience 375, 108-118 (2018)
   PUBMED   29374537
  REMARK    GeneRIF: Male rats were trained in contextual fear conditioning
            task and HSP70 content was analyzed by western blot in the
            hippocampus at different time points. We observed rapid and
            transient elevations in HSP70 60min following training. Double
            immunofluorescence with GFAP and HSP72 revealed that astrocytes
            were not the site for HSP72 induction by CFC training.
REFERENCE   6  (bases 1 to 4521)
  AUTHORS   Luo,D.L., Zhou,J.H., Liu,B.H., Huang,X.K., Chen,J.P., Qiu,J.,
            Xiong,R.P. and Wang,Z.G.
  TITLE     [Study on the relationship of heat shock protein 70 with secondary
            liver damage in early stage after severe multiple injury]
  JOURNAL   Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15 (4), 204-206 (2003)
   PUBMED   12857439
  REMARK    GeneRIF: Excessive expression of HSP70 may cause injury to liver
            after severe multiple injury.
REFERENCE   7  (bases 1 to 4521)
  AUTHORS   Weiss,Y.G., Maloyan,A., Tazelaar,J., Raj,N. and Deutschman,C.S.
  TITLE     Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates
            experimental acute respiratory distress syndrome
  JOURNAL   J Clin Invest 110 (6), 801-806 (2002)
   PUBMED   12235111
REFERENCE   8  (bases 1 to 4521)
  AUTHORS   Thomas,G., Souil,E., Richard,M.J., Saunier,B., Polla,B.S. and
            Bachelet,M.
  TITLE     Hyperthermia assists survival of astrocytes from oxidative-mediated
            necrotic cell death
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 48 (2), 191-198 (2002)
   PUBMED   11990455
  REMARK    GeneRIF: As Hsp70 may transfer from glial to neuronal cells, its
            synthesis by astrocytes may represent an important survival
            mechanism by which astrocytes protect neurons against
            oxidative-mediated cell death
REFERENCE   9  (bases 1 to 4521)
  AUTHORS   Harano,T., Nose,S., Uezu,R., Shimizu,N. and Fujiki,Y.
  TITLE     Hsp70 regulates the interaction between the peroxisome targeting
            signal type 1 (PTS1)-receptor Pex5p and PTS1
  JOURNAL   Biochem J 357 (Pt 1), 157-165 (2001)
   PUBMED   11415446
REFERENCE   10 (bases 1 to 4521)
  AUTHORS   Yagita,Y., Kitagawa,K., Taguchi,A., Ohtsuki,T., Kuwabara,K.,
            Mabuchi,T., Matsumoto,M., Yanagihara,T. and Hori,M.
  TITLE     Molecular cloning of a novel member of the HSP110 family of genes,
            ischemia-responsive protein 94 kDa (irp94), expressed in rat brain
            after transient forebrain ischemia
  JOURNAL   J Neurochem 72 (4), 1544-1551 (1999)
   PUBMED   10098860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF077354.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF077354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4521
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /note="heat shock protein family A (Hsp70) member 4"
                     /db_xref="GeneID:266759"
                     /db_xref="RGD:628878"
     exon            1..332
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2748
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /note="expressed in rat brain after transient forebrain
                     ischemia; ischemia responsive 94 kDa protein; heat shock
                     protein 4; heat shock protein family A member 4"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 4"
                     /protein_id="NP_705893.1"
                     /db_xref="GeneID:266759"
                     /db_xref="RGD:628878"
                     /translation="MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPK
                     NRSVGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIK
                     VTYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPSFYTDAERRSVMDAT
                     QIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRG
                     KLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKVRALLRLSQECEKLKKL
                     MSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSILDQSKLKKED
                     IYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVREF
                     SITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSPQ
                     DLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEE
                     PMETDQNAKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQ
                     AKKAKVKTSTVDLPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEY
                     VYEMRDKLSGEYEKFVSEDDRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLG
                     QPIKTRFQESEERPKLFEELGKQIQQYMKVISSFKNKEDQYEHLDAADMTKVEKSTNE
                     AMEWMNSKLNLQNKQSLTADPVVKTKEIEAKIKELTNICSPIISKPKPKVEPPKEEPK
                     HAEQNGPVDGQGDNPGTQAAEHGADTAVPSDGDKKLPEMDID"
     exon            333..390
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            391..531
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            532..654
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            655..754
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            755..888
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1133
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1210
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1362
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1469
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1603
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1785
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1875
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2028
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2154
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2262
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2382
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2544
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..4520
                     /gene="Hspa4"
                     /gene_synonym="Hsp110; Hsp70; irp94"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgcctct tctgcggccg tggagccgga gccggcctga gcggtagagg cccgtctttt
       61 tcaaggaccc aagcatcctc gtggacggtc gtccggcttc gcccgcccag ccgcggtgct
      121 ccatcagccc acgcggcgcg ccctctccac gcgccaaccc cgtcgggttc cgtgtgcagt
      181 gtcggcggcc ggccctgggc ccgagcccga gcagtagccg gcgccatgtc ggtggtgggc
      241 atagacctgg gctttcagag ctgctatgtc gctgtggccc gcgccggcgg cattgagacg
      301 atcgctaatg agtatagcga ccgctgcacg ccggcttgtg tttctttcgg tcctaagaat
      361 cgttcagttg gagcagcagc aaagagccag gtaatttcca atgccaagaa cacagttcaa
      421 gggtttaaaa gatttcatgg gcgtgcattc tcagatccat ttgtggaagc agaaaaatct
      481 aaccttgcat atgatattgt acagttgccc actggattaa cgggcataaa ggttacatat
      541 atggaagaag agaggaattt taccactgaa caagtgactg ccatgctctt gtcaaaactg
      601 aaggagacag cagaaagtgt tcttaagaag cctgttgtag actgtgttgt ttcggttcct
      661 agtttctaca ctgatgcaga acgacggtca gtgatggatg ccacacagat tgctggtctc
      721 aattgcttgc ggttaatgaa tgaaacaact gcagttgctc ttgcttatgg aatctataaa
      781 caagaccttc ctgccttaga agaaaaacca agaaatgtag tttttgtaga tatgggacat
      841 tctgcctatc aagtttctgt atgtgcattt aatagaggaa aactgaaagt tttggccaca
      901 gcttttgata caacattggg aggcagaaaa tttgatgagg tgttggtaaa tcacttctgt
      961 gaagaatttg gaaagaaata caagctagac ataaaatcta aagttcgtgc tttattgcga
     1021 ctctctcaag agtgtgagaa actcaagaaa ttaatgagtg cgaatgcttc agacctccct
     1081 ttgagtattg aatgctttat gaacgatatt gatgtatcgg gaaccatgaa tagaggcaaa
     1141 tttttggaga tgtgtgatga tctcttagca agagtggagc cgccacttcg tagcatcttg
     1201 gaccaatcca agttaaagaa agaagatatt tatgcagtgg agatagttgg tggagccaca
     1261 cggatccctg ccgtgaaaga gaagatcagc aagttctttg gtaaagaact cagcacaaca
     1321 ttaaatgcgg atgaagcagt cactcgaggc tgtgctctgc agtgtgcaat cttatcacct
     1381 gctttcaaag tcagagaatt ttctatcact gatgtggtac catatccaat atctttgagg
     1441 tggaattctc cagctgaaga ggggtcaagt gactgtgaag tcttccccaa aaaccatgct
     1501 gctcctttct ccaaagtcct caccttttat agaaaggaac cgttcactct ggaggcctac
     1561 tatagttctc ctcaggattt gccctatcca gatcctgcta tagctcagtt ttcagttcag
     1621 aaagtcactc cacagtctga tggctccagc tcaaaagtga aagtcaaggt ccgggtaaat
     1681 gtgcatggca ttttcagtgt gtccagtgcg gccttagtag aggtgcacaa gtccgaggag
     1741 agcgaggagc caatggagac tgatcagaat gcaaaggaag aagagaagat gcaggtggac
     1801 caggaagaac cacatactga agagcaacag ccacagacac cagcagaaaa caaggcggag
     1861 tctgaggaga tggagacctc tcaagctgga tcaaaagata aaaagatgga ccaaccacct
     1921 caagcaaaga aggcaaaagt gaagaccagc accgtggacc tgcccattga gagccagctg
     1981 ctgtggcagc tggaccggga aatgctcggc ctgtacacag agaatgaggg taagatgatc
     2041 atgcaggata aactggagaa ggaacggaat gacgccaaaa atgcggtgga agagtatgtg
     2101 tatgagatga gagacaaact tagtggtgaa tatgagaagt ttgtgagtga agatgatcgt
     2161 aataatttta ctttgaaatt agaggataca gaaaactggc tgtatgaaga tggagaagat
     2221 caaccaaagc aagtttatgt agacaaattg gctgagttaa gaactttagg tcaacctatt
     2281 aagacacggt tccaggaatc tgaagaaaga ccaaaattat ttgaagaatt agggaagcaa
     2341 atccaacagt atatgaaagt gatcagctct ttcaaaaaca aggaggacca gtatgaacac
     2401 ttggatgctg ctgacatgac aaaggtagag aaaagcacca atgaggcgat ggagtggatg
     2461 aatagtaagc tgaacctgca gaacaaacag agcctgacgg cggatccagt tgtcaagaca
     2521 aaagagattg aagctaaaat taaggagctg acaaatattt gcagtcctat aatttcaaag
     2581 cccaaaccca aagtggaacc ccctaaggag gaaccaaaac atgctgagca gaatggacca
     2641 gtggatggcc aaggagacaa cccaggcacc caagctgctg agcacggtgc agacacagct
     2701 gtgccttctg atggtgacaa gaagcttcct gagatggaca ttgattgatt ccaacacttg
     2761 tttatattaa aacagactat tataaagctt taagttgtca actttgttct gaatatcaac
     2821 tagagcaagc aaatactgga gatttcttag tcagttttta ggggatctcg gggtggggta
     2881 tataggtaat atacagagca ttttgacttc taaatagtta gatccagaga tgaagtgcac
     2941 tgttctctct tcattatgat cctgtttaag agcccagcta gtctttctga gctcttgcct
     3001 ccctccttgt tttaatcatg cttctacaag gtgaagtgtg tttggggaaa ctgagctcta
     3061 acaaaagctg tgagagccac taggcaggct tttcctcaaa catgacagaa gttcaaatta
     3121 tgcttggaaa ggctgagtgg agatcaccac cagcattctc tgcctgtggg gctgtgggac
     3181 tgtggggctg gtgcttcctc catttctgag ggtctgagaa tggcccagca tgcattaaca
     3241 caggagagcg cagagcgcag cagggcctgc tctcattgcc ctctattccc agccctgtct
     3301 tcctcttccg tccgcaagca gtataaatgc catgtgccct ctgcacttag agtgagcctt
     3361 agcgtatcaa ggggctttga cgtggctccc cgtacttcct gaaagtattc actgacactg
     3421 aagcgtcaga gtctagtgta accttaaggt aggttgtaaa taacagttgg ctgtaggcat
     3481 ggtaagtctg agcagcccat ccttagtgtg gtgggaaggt ctgtaccctg acctgctcca
     3541 cggtagatgg tgtatgtaaa ttagaggttt cgatggaaca ggatgagagc tcaaggttct
     3601 ttgtttggta ttatttgtgt taatgtgtct tgaatctgcc aatctgtatg ttaaaacagc
     3661 tgacagattg taaagctatt gccctggaca agtctgaaat tagtgtaaaa gaaaacctca
     3721 tcgttaactg cagccgctgt cagggtacca tatattcctg gaacaagtct atggggaaga
     3781 gatgttctgc agacaaaggg acggatgcct atggtagagg tcagagttgg ttacctgcct
     3841 tagttacaag tgttacgttc tgggtctttg taatcactga tctctgtaac agagcctctg
     3901 tttattcttg cttgttggaa ataagcttaa accatgcata gttagaatta ctatgcttct
     3961 gtctacacag gaagtgctgt agctctcaag tgctctagag gccattggtt ggagaggaag
     4021 gaatgcatgc ttatgttatg taagcaactg gactcccgct cagtacaggc ctggagctcc
     4081 aggccgagtg catactctgc tgctttgagt gctgcaggag tgcccactgg cctggctgtg
     4141 aggctgatag ctttttcaag tgcaggctgc aggattaagc caactcttat gcaactgact
     4201 gtccttaatg atgatctcat aaacatttgt gtgtgggggt gggagggttt gggtgtcggg
     4261 atggggaatg aatttgaagt ctaaagttaa agctagaaat cagatgatca gcttctgctc
     4321 tgtctatata gacgattgga tttatgtgga ggcaggccag atggcaactg atgacttgtg
     4381 tgcaaacaag catttatcca ggttgcaata tccaaattgg tttgttaaaa actctaggtc
     4441 acattcttac actaagaaaa acagtaaaca tgagacaaag tttaggaaaa actaataaaa
     4501 gaaacctgtc ttaacttgaa a
//
