LOCUS       NM_021863               2501 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 2
            (Hspa2), transcript variant 1, mRNA.
ACCESSION   NM_021863
VERSION     NM_021863.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Afiyani,A.A., Deemeh,M.R., Tavalaee,M., Razi,M., Bahadorani,M.,
            Shokrollahi,B. and Nasr-Esfahani,M.H.
  TITLE     Evaluation of heat-shock protein A2 (HSPA2) in male rats before and
            after varicocele induction
  JOURNAL   Mol Reprod Dev 81 (8), 766-776 (2014)
   PUBMED   25043441
  REMARK    GeneRIF: HSPA2 abundance increased whereas ubiquitin expression
            reduced in the affected testis of a rat varicocele model.
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Liu,M., Shi,X., Bi,Y., Qi,L., Guo,X., Wang,L., Zhou,Z. and Sha,J.
  TITLE     SHCBP1L, a conserved protein in mammals, is predominantly expressed
            in male germ cells and maintains spindle stability during meiosis
            in testis
  JOURNAL   Mol Hum Reprod 20 (6), 463-475 (2014)
   PUBMED   24557841
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Jakobsson,M.E., Moen,A., Bousset,L., Egge-Jacobsen,W.,
            Kernstock,S., Melki,R. and Falnes,P.O.
  TITLE     Identification and characterization of a novel human
            methyltransferase modulating Hsp70 protein function through lysine
            methylation
  JOURNAL   J Biol Chem 288 (39), 27752-27763 (2013)
   PUBMED   23921388
REFERENCE   4  (bases 1 to 2501)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   5  (bases 1 to 2501)
  AUTHORS   Gehrig,S.M., van der Poel,C., Sayer,T.A., Schertzer,J.D.,
            Henstridge,D.C., Church,J.E., Lamon,S., Russell,A.P., Davies,K.E.,
            Febbraio,M.A. and Lynch,G.S.
  TITLE     Hsp72 preserves muscle function and slows progression of severe
            muscular dystrophy
  JOURNAL   Nature 484 (7394), 394-398 (2012)
   PUBMED   22495301
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2501)
  AUTHORS   Dix,D.J., Allen,J.W., Collins,B.W., Poorman-Allen,P., Mori,C.,
            Blizard,D.R., Brown,P.R., Goulding,E.H., Strong,B.D. and Eddy,E.M.
  TITLE     HSP70-2 is required for desynapsis of synaptonemal complexes during
            meiotic prophase in juvenile and adult mouse spermatocytes
  JOURNAL   Development 124 (22), 4595-4603 (1997)
   PUBMED   9409676
REFERENCE   7  (bases 1 to 2501)
  AUTHORS   Mamelak,D. and Lingwood,C.
  TITLE     Expression and sulfogalactolipid binding specificity of the
            recombinant testis-specific cognate heat shock protein 70
  JOURNAL   Glycoconj J 14 (6), 715-722 (1997)
   PUBMED   9337084
REFERENCE   8  (bases 1 to 2501)
  AUTHORS   Zhu,D., Dix,D.J. and Eddy,E.M.
  TITLE     HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse
            spermatocytes
  JOURNAL   Development 124 (15), 3007-3014 (1997)
   PUBMED   9247342
  REMARK    Erratum:[Development 1997 Sep;134(17):3218]
REFERENCE   9  (bases 1 to 2501)
  AUTHORS   Dix,D.J., Allen,J.W., Collins,B.W., Mori,C., Nakamura,N.,
            Poorman-Allen,P., Goulding,E.H. and Eddy,E.M.
  TITLE     Targeted gene disruption of Hsp70-2 results in failed meiosis, germ
            cell apoptosis, and male infertility
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3264-3268 (1996)
   PUBMED   8622925
REFERENCE   10 (bases 1 to 2501)
  AUTHORS   Wisniewski,J., Kordula,T. and Krawczyk,Z.
  TITLE     Isolation and nucleotide sequence analysis of the rat
            testis-specific major heat-shock protein (HSP70)-related gene
  JOURNAL   Biochim Biophys Acta 1048 (1), 93-99 (1990)
   PUBMED   1688714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X15705.2.
            
            On Apr 20, 2006 this sequence version replaced NM_021863.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2501
                     /gene="Hspa2"
                     /gene_synonym="Hspt70; Hst70"
                     /note="heat shock protein family A (Hsp70) member 2"
                     /db_xref="GeneID:60460"
                     /db_xref="RGD:620664"
     exon            1..2501
                     /gene="Hspa2"
                     /gene_synonym="Hspt70; Hst70"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2018
                     /gene="Hspa2"
                     /gene_synonym="Hspt70; Hst70"
                     /note="heat shock protein family A member 2; HST; heat
                     shock protein 70.2; heat shock protein 2; heat shock
                     protein alpha 2; heat shock 70kDa protein 2;
                     testis-specific heat shock protein-related gene hst70"
                     /codon_start=1
                     /product="heat shock-related 70 kDa protein 2"
                     /protein_id="NP_068635.1"
                     /db_xref="GeneID:60460"
                     /db_xref="RGD:620664"
                     /translation="MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVA
                     FTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKP
                     KVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAYLGGKVQSAVITVPAYFNDSQRQATK
                     DAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDG
                     IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRT
                     LSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQI
                     QEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQ
                     DLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGER
                     AMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITN
                     DKGRLSKDDIDRMVQEADGYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKIS
                     EQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGGSS
                     GGPTIEEVD"
     polyA_site      2501
                     /gene="Hspa2"
                     /gene_synonym="Hspt70; Hst70"
                     /note="polyA addition site"
ORIGIN      
        1 cgggagacgc tagtcgcgct cgtggagagc agtgcgaagc gaccgttggc tcgggtcccg
       61 gcttgcctct cctgactctt tcgtcctaac gttgctttgc ctgtttttca gtcaggatgt
      121 ccgcccgcgg cccggctatc ggcatcgacc tgggcaccac ttactcgtgc gtgggggtct
      181 tccaacatgg caaggtggag atcatcgcca acgaccaggg taaccggacc acccccagct
      241 acgtggcctt caccgacacc gagcgcctta tcggcgacgc cgccaagaac caagtggcca
      301 tgaaccccac aaacaccatc ttcgacgcca agcggctgat cggacggaag ttcgaagacg
      361 ccacggtgca gtcggatatg aagcactggc cgttcagagt ggtgagcgaa ggtgggaagc
      421 ccaaagtgca ggtggaatat aaaggggaga tgaagacctt cttccctgag gagatttctt
      481 ccatggtcct cactaagatg aaggagatcg ccgaagccta cctggggggc aaggtgcaga
      541 gcgcagtcat cactgttcct gcctatttca acgactcgca gcgccaggcc accaaggatg
      601 cgggcaccat caccggtctc aatgtattgc gtatcatcaa cgaacccaca gcagcggcca
      661 tcgcttatgg cctggataag aagggctgcg cgggcggcga gaagaacgtg ctcatctttg
      721 acctgggcgg gggcaccttc gatgtgtcca tcctcaccat cgaggatggc atcttcgagg
      781 tcaagtccac ggccggcgac acccacctgg gtggcgaaga cttcgacaac cgtatggtca
      841 gccacctggc ggaggagttc aagcgcaaac acaagaagga cattgggccc aacaagcgcg
      901 ctgtgcgccg gctgcgcacc gcctgcgagc gcgctaagcg caccctgagc tcgtccacgc
      961 aggccagcat cgagatcgac tcgctgtacg agggcgtgga tttctacacg tccatcaccc
     1021 gcgcccgctt cgaggagctc aacgccgatc tctttcgagg gactctggag ccggtggaaa
     1081 aggcgctgcg cgatgccaag ctagacaagg gccagatcca ggagatagtg ctggtgggcg
     1141 gctctacccg catccctaag atccagaagc tcctgcagga tttcttcaac ggcaaggagc
     1201 tgaacaagag catcaatccc gacgaggcgg tggcctacgg cgccgctgtg caggcggcta
     1261 tcctcattgg cgacaagtct gagaacgtgc aggatctgct gttactcgac gtgactccct
     1321 tgtcgcttgg cattgaaaca gctggcggtg tcatgacccc actcataaag agaaacacca
     1381 ccatccctac caagcagacg cagaccttca ctacctactc agacaaccag agcagcgtgc
     1441 tggtgcaagt gtacgagggc gaacgggcca tgaccaagga caataacctc ttgggcaagt
     1501 tcgacctaac tgggatccct ccagcacccc gcggcgtccc ccagatcgag gtcacctttg
     1561 acatcgatgc caacggcatt cttaacgtca ctgctgcaga caagagcacc ggcaaagaaa
     1621 ataaaatcac catcaccaac gacaagggtc gtctgagcaa agacgacatt gaccggatgg
     1681 tgcaggaggc agacgggtac aaatcggaag atgaagctaa tcgcgatcgc gtggcagcca
     1741 aaaacgcggt tgagtcctat acctacaaca tcaagcagac ggtggaagac gagaaactga
     1801 ggggcaagat tagcgagcag gacaaaaaca agattctcga caagtgtcag gaggtgatca
     1861 actggcttga ccgaaaccag atggcagaga aagatgagta cgaacacaag cagaaagagc
     1921 ttgagagagt gtgcaacccc atcatcagca aactttacca aggcggtcca ggcggcggcg
     1981 gctcctctgg aggacccacc attgaggaag tggactaggc ttgcgctgga gtccgcgtaa
     2041 acctcttttc ctttctttct tttcttttct ttttcttttt ctcccttttg ttttggtttc
     2101 tttgaaatgt ccttgtgcca agtaagatct gttgttggaa gtctttagcc tggtgcatac
     2161 atatgaaagg aaaggtgcaa caacttagtt tagttataaa aagttagttc taaagtttga
     2221 tttgggggaa aaatgaggtt tctctttaat gcatttagag cgattgctga tttgagcttt
     2281 tgttgttgtt gttaagctta agtatgtacg tggagatttg cttgaaatga gaaacctgat
     2341 gtttgcacac ctgtcctatg gaagcttggt tacactaaga tacagagaag cttgaattat
     2401 ttttatgtac tatgagatga aagtaaacac tgcggtaata aagacaggta tattctgtaa
     2461 acacataaat gcacattcaa agtaaagctg aaattgatct c
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