LOCUS       NM_212546               2632 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 1 like
            (Hspa1l), mRNA.
ACCESSION   NM_212546
VERSION     NM_212546.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Maggioli,E., Boiocchi,C., Zorzetto,M., Mannarino,S., Bossi,G. and
            Cuccia,M.
  TITLE     HLA class III genes involvement in Kawasaki disease: a case-control
            study in Caucasian population
  JOURNAL   Int J Immunogenet 41 (1), 44-53 (2014)
   PUBMED   23870089
REFERENCE   2  (bases 1 to 2632)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 2632)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 2632)
  AUTHORS   Chien,C.Y., Chang,N.C., Tai,S.Y., Wang,L.F., Wu,M.T. and Ho,K.Y.
  TITLE     Heat shock protein 70 gene polymorphisms in sudden sensorineural
            hearing loss
  JOURNAL   Audiol Neurootol 17 (6), 381-385 (2012)
   PUBMED   22922572
REFERENCE   5  (bases 1 to 2632)
  AUTHORS   Dun,M.D., Smith,N.D., Baker,M.A., Lin,M., Aitken,R.J. and Nixon,B.
  TITLE     The chaperonin containing TCP1 complex (CCT/TRiC) is involved in
            mediating sperm-oocyte interaction
  JOURNAL   J Biol Chem 286 (42), 36875-36887 (2011)
   PUBMED   21880732
REFERENCE   6  (bases 1 to 2632)
  AUTHORS   Han,C., Chen,T., Li,N., Yang,M., Wan,T. and Cao,X.
  TITLE     HDJC9, a novel human type C DnaJ/HSP40 member interacts with and
            cochaperones HSP70 through the J domain
  JOURNAL   Biochem Biophys Res Commun 353 (2), 280-285 (2007)
   PUBMED   17182002
REFERENCE   7  (bases 1 to 2632)
  AUTHORS   Yang,M., Tan,H., Yang,Q., Wang,F., Yao,H., Wei,Q., Tanguay,R.M. and
            Wu,T.
  TITLE     Association of hsp70 polymorphisms with risk of noise-induced
            hearing loss in Chinese automobile workers
  JOURNAL   Cell Stress Chaperones 11 (3), 233-239 (2006)
   PUBMED   17009596
REFERENCE   8  (bases 1 to 2632)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   9  (bases 1 to 2632)
  AUTHORS   Martin,A.M., Nolan,D., Gaudieri,S., Almeida,C.A., Nolan,R.,
            James,I., Carvalho,F., Phillips,E., Christiansen,F.T.,
            Purcell,A.W., McCluskey,J. and Mallal,S.
  TITLE     Predisposition to abacavir hypersensitivity conferred by HLA-B*5701
            and a haplotypic Hsp70-Hom variant
  JOURNAL   Proc Natl Acad Sci U S A 101 (12), 4180-4185 (2004)
   PUBMED   15024131
REFERENCE   10 (bases 1 to 2632)
  AUTHORS   Walter,L., Rauh,F. and Gunther,E.
  TITLE     Comparative analysis of the three major histocompatibility
            complex-linked heat shock protein 70 (Hsp70) genes of the rat
  JOURNAL   Immunogenetics 40 (5), 325-330 (1994)
   PUBMED   7927536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883045.1.
            
            On Oct 21, 2009 this sequence version replaced NM_212546.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108297.1, CK600407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132300, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               BX883045.1         165103-165250
            149-2632            BX883045.1         169345-171828
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2632
                     /gene="Hspa1l"
                     /gene_synonym="Hsp70-3"
                     /note="heat shock protein family A (Hsp70) member 1 like"
                     /db_xref="GeneID:24963"
                     /db_xref="RGD:1595925"
     exon            1..148
                     /gene="Hspa1l"
                     /gene_synonym="Hsp70-3"
                     /inference="alignment:Splign:2.1.0"
     exon            149..2632
                     /gene="Hspa1l"
                     /gene_synonym="Hsp70-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2087
                     /gene="Hspa1l"
                     /gene_synonym="Hsp70-3"
                     /note="heat shock 70 kDa protein 1L; HSP70.3; heat shock
                     70 kDa protein 3; Heat shock protein 70-1l; heat shock
                     protein 70; heat shock protein 1-like"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1-like"
                     /protein_id="NP_997711.1"
                     /db_xref="GeneID:24963"
                     /db_xref="RGD:1595925"
                     /translation="MAANKGMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYV
                     AFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGK
                     PKVLVSYKGEKKAFYPEEISSMVLTKMKETAEAFLGHSVTNAVITVPAYFNDSQRQAT
                     KDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLIFDLGGGTFDVSILTIDDGI
                     FEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTL
                     SSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKAKIH
                     DIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQD
                     LLLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERA
                     MTRDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITND
                     KGRLSKEEIERMVQEAERYKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISE
                     SDKKKILDKCSEVLSWLEANQLAEKEEFDHKRKELENMCNPIITKLYQSGCTGPTCAP
                     GYTPGRAATGPTIEEVD"
ORIGIN      
        1 cagaagaggc tcaaagttgc cgggaggggc ggggtggggg gtggggggaa ccccagttgc
       61 tcagtttgga tgttcctgga gctccccact cgtaggggct cagcgacttc aaattttcca
      121 aactggatcg aaggcgtaga gattccaggc ctcggaaaac catggctgct aataaaggaa
      181 tggccatagg catcgacctg ggcaccacct actcgtgcgt gggcgtgttc cagcacggca
      241 aggtggagat catcgccaac gaccagggca accgcacgac cccaagctac gtggccttca
      301 ccgacaccga gcggctcatc ggggacgccg ccaagaacca ggtggccatg aatccccaga
      361 acactgtttt tgacgccaaa cgtctaattg gcaggaagtt taatgatccc gtcgtgcagt
      421 cggatatgaa gctgtggcca tttcaagtga tcaatgaagc gggcaagcct aaggtgctgg
      481 tgtcctacaa aggagagaag aaagccttct acccggagga gatctcgtcc atggtgctga
      541 ccaagatgaa ggagactgca gaggcttttt tgggccacag tgtcaccaac gctgtgatca
      601 ccgtgccagc ctatttcaat gactcccaga gacaggccac taaagatgca ggggtcatcg
      661 caggactcaa cgtgctgcga atcatcaatg agcccacagc ggcggccatc gcctacggct
      721 tggataaagg aagtcacgga gagcggcacg tgctcatctt cgacctgggg ggcggcacgt
      781 tcgacgtgtc catcctgacg atcgacgacg gcatcttcga ggtgaaggcc acggcgggcg
      841 acacgcacct gggcggggag gacttcgaca accggctggt gagccacttc gtggaggagt
      901 tcaagaggaa gcacaagaag gacatcagcc agaacaagcg cgcggtgcgg cgtctgcgca
      961 cggcgtgcga gagggccaag aggacgctgt cgtccagcac ccaggccaac ctggagatcg
     1021 actctctgta cgagggcatc gacttctaca cgtccatcac gcgggcgcgg ttcgaggagc
     1081 tgtgtgcaga cctatttaga ggcacgcttg agcccgtgga gaagtctctc cgggacgcca
     1141 agatggacaa ggctaaaatc catgacattg ttctagtagg gggctctacc cgcatcccaa
     1201 aggtgcaaaa gctgcttcaa gactacttta atggacggga tctcaacaag agtatcaatc
     1261 ccgatgaggc ggtggcgtac ggagctgcag tccaggcagc tattttaatg ggcgacaaat
     1321 ctgaaaaagt acaggatttg cttttgttgg acgtagctcc cctgtctcta ggattggaga
     1381 cagccggggg tgtgatgact gttctgatca agcgcaactc caccatcccc accaagcaga
     1441 cgcagatctt caccacctac tcggacaacc agcccggggt gctgatccag gtgtacgagg
     1501 gcgagagggc catgacgcgc gacaacaacc tcctggggcg ctttgacctg actggaatac
     1561 cccctgcacc taggggtgtg ccccagatcg aggtgacctt cgacatcgac gccaacggga
     1621 ttctcaacgt cacagccatg gacaagagca ccggcaaggc caacaagatc accatcacca
     1681 acgacaaggg ccgcttgagc aaggaggaga tcgagcgcat ggtgcaagag gccgagcggt
     1741 acaaggccga ggacgagggc cagagggaga agatcgctgc caaaaatgcc ttagaatcgt
     1801 atgcctttaa catgaagagc gctgtaggcg atgagggtct gaaggacaag atcagcgagt
     1861 ctgataaaaa gaaaatactg gataaatgca gtgaggtcct ttcctggctg gaggccaacc
     1921 agctggcgga gaaagaagag ttcgatcata aaagaaaaga gctggaaaac atgtgcaacc
     1981 ctatcatcac aaagctgtac cagagcggct gcacagggcc cacctgcgcg ccagggtata
     2041 cacccggcag ggctgccaca ggccccacca ttgaggaagt agattagcct ttcccagaaa
     2101 ggcagggtgc tagggtgcct ctaggcgaca tttattcacc tcccaacatc actgtgattc
     2161 ttgaactgac tggacttgag cctaagtcac catcctttgg gatctgatgc agaacccacg
     2221 gactccgcct ttccacgccc ccaccctctg atctatgatc ctgaactgga tctttagcac
     2281 aaccaggccc ctctttgagc ctcgtgaaga atttggatgt ctgttattta tcatccacac
     2341 cccgcctttc acctccctgt gtggatggtt atttgtctct cagtaaattt gttcccaaag
     2401 gaaacgtctg tcacttttcg atttgtttag tcgagggcct tactgtatat gtctagctga
     2461 cctgacgctt accgcattgg ccaatttggt ccttaacttg cagcaatcct cctgtctctg
     2521 ccacctgaat ttcgagatta cggacctgca ccatcatgcc caacttgtga tttttttttt
     2581 ttgggaggca gggtttcttg aagcctaggt tagcctagaa cattctatac ac
//
