LOCUS       NM_001329896            2455 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 1B
            (Hspa1b), mRNA.
ACCESSION   NM_001329896 NM_212504 XM_215309
VERSION     NM_001329896.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2455)
  AUTHORS   Krzemien-Ojak,L., Goral,A., Joachimiak,E., Filipek,A. and
            Fabczak,H.
  TITLE     Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein
            Hsp90
  JOURNAL   J Cell Biochem 118 (2), 420-429 (2017)
   PUBMED   27496612
REFERENCE   2  (bases 1 to 2455)
  AUTHORS   Jian,J., Tian,Q.Y., Hettinghouse,A., Zhao,S., Liu,H., Wei,J.,
            Grunig,G., Zhang,W., Setchell,K.D.R., Sun,Y., Overkleeft,H.S.,
            Chan,G.L. and Liu,C.J.
  TITLE     Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is
            Therapeutic Against Gaucher Disease
  JOURNAL   EBioMedicine 13, 212-224 (2016)
   PUBMED   27789271
REFERENCE   3  (bases 1 to 2455)
  AUTHORS   Seo,J.H., Park,J.H., Lee,E.J., Vo,T.T., Choi,H., Kim,J.Y.,
            Jang,J.K., Wee,H.J., Lee,H.S., Jang,S.H., Park,Z.Y., Jeong,J.,
            Lee,K.J., Seok,S.H., Park,J.Y., Lee,B.J., Lee,M.N., Oh,G.T. and
            Kim,K.W.
  TITLE     ARD1-mediated Hsp70 acetylation balances stress-induced protein
            refolding and degradation
  JOURNAL   Nat Commun 7, 12882 (2016)
   PUBMED   27708256
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2455)
  AUTHORS   Fang,C.T., Kuo,H.H., Pan,T.S., Yu,F.C. and Yih,L.H.
  TITLE     HSP70 regulates the function of mitotic centrosomes
  JOURNAL   Cell Mol Life Sci 73 (20), 3949-3960 (2016)
   PUBMED   27137183
REFERENCE   5  (bases 1 to 2455)
  AUTHORS   Sharma,H.S., Muresanu,D.F., Lafuente,J.V., Sjoquist,P.O.,
            Patnaik,R. and Sharma,A.
  TITLE     Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein
            Expressions in Spinal Cord Injury: Neuroprotective Effects of the
            Proteasome Inhibitor Carfilzomib and the Antioxidant Compound
            H-290/51
  JOURNAL   Mol Neurobiol 52 (2), 882-898 (2015)
   PUBMED   26126513
  REMARK    GeneRIF: Rats subjected to spinal cord injury after nanoparticle
            treatment showed an exacerbation of HSP72 immunoreactivities in the
            cord, vs normal rats following trauma. HSP expression plays a key
            role in neuronal injury in SCI, not reported earlier.
REFERENCE   6  (bases 1 to 2455)
  AUTHORS   Lisowska,K., Scieglinska,D. and Krawczyk,Z.
  TITLE     Construction of cDNA library from liver RNA of heat shocked rats
            and DNA sequence analysis of the clone containing the 3'-end
            untranslated region (3'UTR) of the heat inducible gene hsp70.2
  JOURNAL   Acta Biochim Pol 43 (2), 313-317 (1996)
   PUBMED   8862176
REFERENCE   7  (bases 1 to 2455)
  AUTHORS   Lisowska,K., Krawczyk,Z., Widlak,W., Wolniczek,P. and Wisniewski,J.
  TITLE     Cloning, nucleotide sequence and expression of rat heat inducible
            hsp70 gene
  JOURNAL   Biochim Biophys Acta 1219 (1), 64-72 (1994)
   PUBMED   8086479
REFERENCE   8  (bases 1 to 2455)
  AUTHORS   Mestril,R., Chi,S.H., Sayen,M.R. and Dillmann,W.H.
  TITLE     Isolation of a novel inducible rat heat-shock protein (HSP70) gene
            and its expression during ischaemia/hypoxia and heat shock
  JOURNAL   Biochem J 298 Pt 3 (Pt 3), 561-569 (1994)
   PUBMED   8141767
REFERENCE   9  (bases 1 to 2455)
  AUTHORS   Walter,L., Rauh,F. and Gunther,E.
  TITLE     Comparative analysis of the three major histocompatibility
            complex-linked heat shock protein 70 (Hsp70) genes of the rat
  JOURNAL   Immunogenetics 40 (5), 325-330 (1994)
   PUBMED   7927536
REFERENCE   10 (bases 1 to 2455)
  AUTHORS   Longo,F.M., Wang,S., Narasimhan,P., Zhang,J.S., Chen,J., Massa,S.M.
            and Sharp,F.R.
  TITLE     cDNA cloning and expression of stress-inducible rat hsp70 in normal
            and injured rat brain
  JOURNAL   J Neurosci Res 36 (3), 325-335 (1993)
   PUBMED   8271311
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L16764.1.
            
            [WARNING] On Apr 11, 2024 this sequence was replaced by
            NM_001329896.2.
            
            On Mar 12, 2021 this sequence version replaced NM_212504.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: L16764.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2455
                     /gene="Hspa1b"
                     /gene_synonym="HSP70; HSP70-1; Hsp70-2; HSP70.1; HSP70.2;
                     Hsp72; Hspa2"
                     /note="heat shock protein family A (Hsp70) member 1B"
                     /db_xref="GeneID:108348108"
                     /db_xref="RGD:1593284"
     exon            1..2455
                     /gene="Hspa1b"
                     /gene_synonym="HSP70; HSP70-1; Hsp70-2; HSP70.1; HSP70.2;
                     Hsp72; Hspa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2103
                     /gene="Hspa1b"
                     /gene_synonym="HSP70; HSP70-1; Hsp70-2; HSP70.1; HSP70.2;
                     Hsp72; Hspa2"
                     /note="heat shock protein 70; Heat shock 70 kDa protein 2;
                     heat shock protein 1B; heat shock 70kD protein 1B; heat
                     shock 70 kDa protein 1A/1B"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1B"
                     /protein_id="NP_001316825.1"
                     /db_xref="GeneID:108348108"
                     /db_xref="RGD:1593284"
                     /translation="MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF
                     TDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPK
                     VQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKD
                     AGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFE
                     VKATAGDTDLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSS
                     STQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDL
                     VLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLL
                     LLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMT
                     RDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKG
                     RLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEAD
                     KKKVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGA
                     QAPKGGSGSGPTIEEVD"
     polyA_site      2455
                     /gene="Hspa1b"
                     /gene_synonym="HSP70; HSP70-1; Hsp70-2; HSP70.1; HSP70.2;
                     Hsp72; Hspa2"
ORIGIN      
        1 agagaagcag agaagcagag caagcggcgc gttcccgaac ctcgggcaag accagcctct
       61 cccagagcat ccccaccgcg aacgcaccct tctccagagc ataccccagc ggaggccacc
      121 cttccccaga gcatccccgc cgccaagcgc aaccttccag aagcagaccg cagcgacatg
      181 gccaagaaaa cagcgatcgg catcgacctg ggcaccacct actcgtgcgt gggcgtgttc
      241 cagcacggca aggtggagat catcgccaac gaccagggca accgcacgac ccccagctac
      301 gtggccttca ccgacaccga gcggctcatc ggggacgccg ccaagaacca ggtggcgctg
      361 aacccgcaga acaccgtgtt cgacgcgaag cggctgatcg gccgcaagtt cggcgacccg
      421 gtggtgcagt cggacatgaa gcactggccc ttccaggtgg tgaacgacgg cgacaagccc
      481 aaggtgcagg tgaactacaa gggcgagaac cggtcgttct acccggagga gatctcgtcc
      541 atggtgctga ccaagatgaa ggagatcgcc gaggcgtacc tgggccaccc ggtgaccaac
      601 gcggtgatca ccgtgcccgc ctacttcaac gactcgcagc ggcaggccac caaggacgcg
      661 ggcgtgatcg cgggtctgaa cgtgctgcgg atcatcaacg agcccacggc ggccgccatc
      721 gcctatgggc tggaccggac cggcaagggc gagcgcaacg tgctcatctt cgacctgggg
      781 ggcggcacgt tcgacgtgtc catcctgacg atcgacgacg gcatcttcga ggtgaaggcc
      841 acggcgggcg acaccgacct gggcggggag gacttcgaca accggctggt gagccacttc
      901 gtggaggagt tcaagaggaa gcacaagaag gacatcagcc agaacaagcg cgcggtgcgg
      961 cgcctgcgca cggcgtgcga gagggccaag aggacgctgt cgtccagcac ccaggccagc
     1021 ctggagatcg actctctgtt cgagggcatc gacttctaca cgtccatcac gcgggcgcgg
     1081 ttcgaggagc tgtgctcgga cctgttccgc ggcacgctgg agcccgtgga gaaggccctg
     1141 cgcgacgcca agctggacaa ggcgcagatc cacgacctgg tgctggtggg cggctcgacg
     1201 cgcatcccca aggtgcagaa gctgctgcag gacttcttca acgggcgcga cctgaacaag
     1261 agcatcaatc cggacgaggc ggtggcctac ggggcggcgg tgcaggcggc catcctgatg
     1321 ggggacaagt cggagaacgt gcaggacctg ctgctgctgg acgtggcgcc gctgtcgctg
     1381 ggtctggaga ccgcgggcgg cgtgatgacg gcgctcatca agcgcaactc caccatcccc
     1441 accaagcaga cgcagacctt caccacctac tcggacaacc agcccggggt gctgatccag
     1501 gtgtacgagg gcgagagggc catgacgcgc gacaacaacc tgctggggcg cttcgagttg
     1561 agcggcatcc cgccggctcc caggggcgtg ccccagatcg aggtgacctt cgacatcgac
     1621 gccaacggca tcctgaacgt cacggccacg gacaagagca ccggcaaggc caacaagatc
     1681 accatcacca acgacaaggg ccgcctgagc aaggaggaga tcgagcgcat ggtgcaggag
     1741 gccgagcgct acaaggcgga ggacgaggtg cagcgcgaga gggtggctgc caagaatgcg
     1801 ctcgagtcct acgccttcaa tatgaagagc gccgtggagg acgagggtct caagggcaag
     1861 atcagcgagg ctgacaagaa gaaggtgctg gacaagtgcc aggaggtcat ctcctggctg
     1921 gactctaaca cgctggctga gaaagaggag ttcgtgcaca agcgggagga gctggagcgg
     1981 gtgtgcaacc cgatcatcag cgggctgtat cagggtgcgg gtgctcccgg ggctgggggc
     2041 ttcggggccc aggcgcccaa gggaggctct gggtcggggc ccaccatcga ggaggtggat
     2101 tagaggcttt tctggctctc agggtgttgg ctagagacag actcttgatg gctgctggtg
     2161 cacgattctt atcaagttac tccttctctc cggagttcag tttaaagtta cagcctttta
     2221 tacggtaatt gatttgagtt tgttacattt tgtatgctcg tgggtttttt atatattcaa
     2281 attaaggttg catgttcttt gcgtttaatc taagtagctg tgtaaaaatg gtgtttcctt
     2341 cctgcgaaca cctcagcact gccaccctgt gtacagtttt ttccttgcat ccctacaaac
     2401 tgagaaaaaa agttatcttt tgtaacttaa acattcaaaa taaaatgtta caagt
//
