LOCUS       NM_031971               4045 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 1A
            (Hspa1a), mRNA.
ACCESSION   NM_031971
VERSION     NM_031971.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4045)
  AUTHORS   He,X., Guo,X., Deng,B., Kang,J., Liu,W., Zhang,G., Wang,Y., Yang,Y.
            and Kang,X.
  TITLE     HSPA1A ameliorated spinal cord injury in rats by inhibiting
            apoptosis to exert neuroprotective effects
  JOURNAL   Exp Neurol 361, 114301 (2023)
   PUBMED   36538982
  REMARK    GeneRIF: HSPA1A ameliorated spinal cord injury in rats by
            inhibiting apoptosis to exert neuroprotective effects.
            Erratum:[Exp Neurol. 2023 Jul;365:114419. doi:
            10.1016/j.expneurol.2023.114419.. PMID: 37127509]
REFERENCE   2  (bases 1 to 4045)
  AUTHORS   Simonova,V.V., Guzeev,M.A., Ekimova,I.V. and Pastukhov,Y.F.
  TITLE     Chaperone Hsp70 (HSPA1) Is Involved in the Molecular Mechanisms of
            Sleep Cycle Integration
  JOURNAL   Int J Mol Sci 23 (8), 4464 (2022)
   PUBMED   35457282
  REMARK    GeneRIF: Chaperone Hsp70 (HSPA1) Is Involved in the Molecular
            Mechanisms of Sleep Cycle Integration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4045)
  AUTHORS   Mikeladze,M.A., Dutysheva,E.A., Kartsev,V.G., Margulis,B.A.,
            Guzhova,I.V. and Lazarev,V.F.
  TITLE     Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6
            Glioblastoma Cells to Hypoxic Stress
  JOURNAL   Int J Mol Sci 22 (4), 1520 (2021)
   PUBMED   33546324
  REMARK    GeneRIF: Disruption of the Complex between GAPDH and Hsp70
            Sensitizes C6 Glioblastoma Cells to Hypoxic Stress.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4045)
  AUTHORS   Russell,M.F., Bailey,G.C., Miskiewicz,E.I. and MacPhee,D.J.
  TITLE     Inducible heat shock protein A1A (HSPA1A) is markedly expressed in
            rat myometrium by labour and secreted via myometrial cell-derived
            extracellular vesicles
  JOURNAL   Reprod Fertil Dev 33 (4), 279-290 (2021)
   PUBMED   33573715
  REMARK    GeneRIF: Inducible heat shock protein A1A (HSPA1A) is markedly
            expressed in rat myometrium by labour and secreted via myometrial
            cell-derived extracellular vesicles.
REFERENCE   5  (bases 1 to 4045)
  AUTHORS   Pan,Z., Wu,Q., Xie,Z., Wu,Q., Tan,X. and Wang,X.
  TITLE     Upregulation of HSP72 attenuates tendon adhesion by regulating
            fibroblast proliferation and collagen production via blockade of
            the STAT3 signaling pathway
  JOURNAL   Cell Signal 71, 109606 (2020)
   PUBMED   32199935
  REMARK    GeneRIF: Upregulation of HSP72 attenuates tendon adhesion by
            regulating fibroblast proliferation and collagen production via
            blockade of the STAT3 signaling pathway.
REFERENCE   6  (bases 1 to 4045)
  AUTHORS   Lisowska,K., Scieglinska,D. and Krawczyk,Z.
  TITLE     Construction of cDNA library from liver RNA of heat shocked rats
            and DNA sequence analysis of the clone containing the 3'-end
            untranslated region (3'UTR) of the heat inducible gene hsp70.2
  JOURNAL   Acta Biochim Pol 43 (2), 313-317 (1996)
   PUBMED   8862176
REFERENCE   7  (bases 1 to 4045)
  AUTHORS   Lisowska,K., Krawczyk,Z., Widlak,W., Wolniczek,P. and Wisniewski,J.
  TITLE     Cloning, nucleotide sequence and expression of rat heat inducible
            hsp70 gene
  JOURNAL   Biochim Biophys Acta 1219 (1), 64-72 (1994)
   PUBMED   8086479
REFERENCE   8  (bases 1 to 4045)
  AUTHORS   Mestril,R., Chi,S.H., Sayen,M.R. and Dillmann,W.H.
  TITLE     Isolation of a novel inducible rat heat-shock protein (HSP70) gene
            and its expression during ischaemia/hypoxia and heat shock
  JOURNAL   Biochem J 298 Pt 3 (Pt 3), 561-569 (1994)
   PUBMED   8141767
REFERENCE   9  (bases 1 to 4045)
  AUTHORS   Walter,L., Rauh,F. and Gunther,E.
  TITLE     Comparative analysis of the three major histocompatibility
            complex-linked heat shock protein 70 (Hsp70) genes of the rat
  JOURNAL   Immunogenetics 40 (5), 325-330 (1994)
   PUBMED   7927536
REFERENCE   10 (bases 1 to 4045)
  AUTHORS   Longo,F.M., Wang,S., Narasimhan,P., Zhang,J.S., Chen,J., Massa,S.M.
            and Sharp,F.R.
  TITLE     cDNA cloning and expression of stress-inducible rat hsp70 in normal
            and injured rat brain
  JOURNAL   J Neurosci Res 36 (3), 325-335 (1993)
   PUBMED   8271311
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883045.1.
            
            On Sep 29, 2009 this sequence version replaced NM_031971.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4045
                     /gene="Hspa1a"
                     /gene_synonym="Hsp70-1; HSP70-2; HSP70.1; HSP70.2; HSP72;
                     Hspa1"
                     /note="heat shock protein family A (Hsp70) member 1A"
                     /db_xref="GeneID:24472"
                     /db_xref="RGD:2840"
     exon            1..4045
                     /gene="Hspa1a"
                     /gene_synonym="Hsp70-1; HSP70-2; HSP70.1; HSP70.2; HSP72;
                     Hspa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1248..3173
                     /gene="Hspa1a"
                     /gene_synonym="Hsp70-1; HSP70-2; HSP70.1; HSP70.2; HSP72;
                     Hspa1"
                     /note="heat shock 70 kDa protein 1A/1B; heat shock protein
                     70-1; HSP70.1/2; heat shock 70 kDa protein 1/2;
                     HSP70-1/HSP70-2; HSP70.1/HSP70.2; Heat shock 70 kDa
                     protein 1; heat shock 70kD protein 1A; heat shock 70 kDa
                     protein 1B; heat shock 70 kDa protein 2"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1A"
                     /protein_id="NP_114177.2"
                     /db_xref="GeneID:24472"
                     /db_xref="RGD:2840"
                     /translation="MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF
                     TDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPK
                     VQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKD
                     AGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFE
                     VKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSS
                     STQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDL
                     VLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLL
                     LLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMT
                     RDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKG
                     RLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEAD
                     KKKVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGA
                     QAPKGGSGSGPTIEEVD"
ORIGIN      
        1 ccaggcatcc ttctctgagt ttctatcttt ctctcgattg taactcctct cttcgaccat
       61 caataccata ttcaaaaagg tcttgtctgc ctccgatttc agctcagact aatttcagcc
      121 actaatgtcc ctcaagagcc caaccccatt ttttcttggt tgccaacacc caaatccaga
      181 attaaaactg gggttcctgt gtggagagcc aagaggagac ctaaggatgg tggcttccac
      241 tagaccacgt ctgtaaatca atcaaaccta agaaaattct tggcccatta aataagaacc
      301 aactggaatt ccaggctcac ctggaatctc tacgccttcg atccagtttg gaaaatttga
      361 agtcgctgag cccctacgag tggggagctc caggaacatc caaactgagc aactggggtt
      421 ccccccaccc cccaccccgc ccctcccggc aactttgagc ctcttctggg acagatcctc
      481 tgattcctaa ataagtccat gaggtcagag ttagcactgc cattgtaacg cggctggagg
      541 ggggtcacgt caccggacac gcccccaggc acctcccttg ggtctcccaa ggctaggaag
      601 gggaagttat aacccttaac tcgagcccca taatcagaac tgtgcgagtc tgcgaacccc
      661 cacaaatcac aaccaactgt ccacaacacg gagctagcag tgacctttcc tgtccattcc
      721 actcaggcct cagtaatgcg tcgccatagc aacagtgtca acagcagcac cagcaggtcc
      781 cgccaccctc ccccacagga atccgtcctt tccagctaac cccagatctg tctggagagt
      841 tctgaacagg ggcggaaccc tcaactccta ttactcaaag gaggcgggga agctccaccc
      901 gacgcgaaac tgctggaaga ttcctggccc caaggcctcc tcccgctcgc tgattggccc
      961 atgggagggt gggcggggcc ggaggaggct ccttaaaggc gcagggcggc gcgcaggaca
     1021 ccagattcct cctcttaatc tgacagaatc agtttctggt tccactcgca gagaagcaga
     1081 gaagcggagc aagcggcgcg ttccagaacc tcgggcaaga ccagcctctc ccagagcatc
     1141 cccaccgcga agcgcaacct tctccagagc atcccccagc ggagcgcacc cttccccaga
     1201 gcatccccgc cgccaagcgc aaccttccag aagcagagag cggcgacatg gccaagaaaa
     1261 cagcgatcgg catcgacctg ggcaccacct actcgtgcgt gggcgtgttc cagcacggca
     1321 aggtggagat catcgccaac gaccagggca accgcacgac ccccagctac gtggccttca
     1381 ccgacaccga gcggctcatc ggggacgccg ccaagaacca ggtggcgctg aacccgcaga
     1441 acaccgtgtt cgacgcgaag cggctgatcg gccgcaagtt cggcgacccg gtggtgcagt
     1501 cggacatgaa gcactggccc ttccaggtgg tgaacgacgg cgacaagccc aaggtgcagg
     1561 tgaactacaa gggcgagaac cggtcgttct acccggagga gatctcgtcc atggtgctga
     1621 ccaagatgaa ggagatcgcc gaggcgtacc tgggccaccc ggtgaccaac gcggtgatca
     1681 ccgtgcccgc ctacttcaac gactcgcagc ggcaggccac caaggacgcg ggcgtgatcg
     1741 cgggtctgaa cgtgctgcgg atcatcaacg agcccacggc ggccgccatc gcctacgggc
     1801 tggaccggac cggcaagggc gagcgcaacg tgctcatctt cgacctgggg ggcggcacgt
     1861 tcgacgtgtc catcctgacg atcgacgacg gcatcttcga ggtgaaggcc acggcgggcg
     1921 acacgcacct gggcggggag gacttcgaca accggctggt gagccacttc gtggaggagt
     1981 tcaagaggaa gcacaagaag gacatcagcc agaacaagcg cgcggtgcgg cgactgcgca
     2041 cggcgtgcga gagggccaag aggacgctgt cgtccagcac ccaggccagc ctggagatcg
     2101 actctctgtt cgagggcatc gacttctaca cgtccatcac gcgggcgcgg ttcgaggagc
     2161 tgtgctcgga cctgttccgc ggcacgctgg agcccgtgga gaaggccctg cgcgacgcca
     2221 agctggacaa ggcgcagatc cacgacctgg tgctggtggg cggctcgacg cgcatcccca
     2281 aggtgcagaa gctgctgcag gacttcttca acgggcgcga cctgaacaag agcatcaatc
     2341 cggacgaggc ggtggcctac ggggcggcgg tgcaggcggc catcctgatg ggggacaagt
     2401 cggagaacgt gcaggacctg ctgctgctgg acgtggcgcc gctgtcgctg ggtctggaga
     2461 ccgcgggcgg cgtgatgacg gcgctcatca agcgcaactc caccatcccc accaagcaga
     2521 cgcagacctt caccacctac tcggacaacc agcccggggt gctgatccag gtgtacgagg
     2581 gcgagagggc catgacgcgc gacaacaacc tgctggggcg cttcgagttg agcggcatcc
     2641 cgccggctcc caggggcgtg ccccagatcg aggtgacctt cgacatcgac gccaacggca
     2701 tcctgaacgt cacggccact gacaagagca ccggcaaggc caacaagatc accatcacca
     2761 acgacaaggg ccgcctgagc aaggaggaga tcgagcgcat ggtgcaggag gccgagcgct
     2821 acaaggcgga ggacgaggtg cagcgcgaga gggtggctgc caagaatgcg ctcgagtcct
     2881 atgccttcaa catgaagagc gccgtggagg acgagggtct caagggcaag atcagcgagg
     2941 ctgacaagaa gaaggtgctg gacaagtgcc aggaggtcat ctcctggctg gactctaaca
     3001 cgctggctga gaaagaggag ttcgtgcaca agcgggagga gctggagcgg gtgtgcaacc
     3061 cgatcatcag cgggctgtat cagggtgcgg gtgctcccgg ggctgggggc ttcggggccc
     3121 aggcgcccaa gggaggctct gggtcggggc ccaccatcga ggaggtggat tagaggctct
     3181 ttctggcgct ccaggtgtga tctaggagac agatgggtgg ccttgaggac tttgggttat
     3241 tgtcgtttag gacattaact ccttcgttcg gtctgcaatc aagtcctagg tttaagcaaa
     3301 ctgccttcca tttactctgt ggaatttcac gtgtgctttg cattcccagt aaattagtac
     3361 tgggagtgtg tctttgcaat agatataatt tcctgccttc aagtcagcac tgcccccccc
     3421 cccgaagtta tttcttttgc aggacagtca gagctatatt gatatagcaa gaggtgtgtt
     3481 acaaaaacac caggacactg ttgagttcct ttgtgtttgg actctcccct gggcgacagt
     3541 gttgaggcac tgttaagtca ggagctcagg ggccaccggt ggatcactga aagctgagac
     3601 tctgttgctt ctcccgtttg acactctgtt gctttccttg catggtggct cacctaaggc
     3661 tgagactctt gttctccttc cctgtataat cttgcctggc cgttgcactt gttccccagt
     3721 gtgtgaactc ggagatgagt ttacaccacc actgttagtt cacgtttttt gtttttacat
     3781 aaccatcctg aactcaggtc aatttttact ggctatttga aaataaactt caaaagaact
     3841 tgccaggtct tgtgtctgtt gtcttttgag gtcaggaatt gctgtgtatg tcttacagat
     3901 tggactacgc ttgactgaca ttttatggta agatggggtg gggagcaccc agggactttg
     3961 cattgggatc tgcttgtgtg agaaaaatga aagcagtcag agcaaataac aaccagtccg
     4021 gggctgaggt ctagtacagt gcaga
//
