LOCUS       NM_001395016            3085 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus heat shock protein family A (Hsp70) member 12B
            (Hspa12b), transcript variant 1, mRNA.
ACCESSION   NM_001395016 XM_006235027
VERSION     NM_001395016.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3085)
  AUTHORS   Selvaraju,V., Suresh,S.C., Thirunavukkarasu,M., Mannu,J.,
            Foye,J.L.C., Mathur,P.P., Palesty,J.A., Sanchez,J.A., McFadden,D.W.
            and Maulik,N.
  TITLE     Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein
            A12B to Prevent Ventricular Dysfunction Following Acute Myocardial
            Infarction in Diabetic Rats
  JOURNAL   J Cardiovasc Transl Res 10 (2), 209-220 (2017)
   PUBMED   28281242
  REMARK    GeneRIF: HSPA12B overexpression interacts with AKAP12 and
            downregulate TXNIP in diabetic rats following acute myocardial
            infarction.
REFERENCE   2  (bases 1 to 3085)
  AUTHORS   Shi,J., Yang,D., Cong,X., Li,Y., Yang,X. and Liu,Y.
  TITLE     Expression of HSPA12B in acute cardiac allograft rejection in rats
  JOURNAL   Pathol Res Pract 211 (1), 20-26 (2015)
   PUBMED   25433995
  REMARK    GeneRIF: HSPA12B might play crucial roles in heart pathophysiology
            after transplantation
REFERENCE   3  (bases 1 to 3085)
  AUTHORS   Kang,L., Zhang,G., Yan,Y., Ke,K., Wu,X., Gao,Y., Li,J., Zhu,L.,
            Wu,Q. and Zhou,Z.
  TITLE     The role of HSPA12B in regulating neuronal apoptosis
  JOURNAL   Neurochem Res 38 (2), 311-320 (2013)
   PUBMED   23292195
  REMARK    GeneRIF: The expression of HSPA12B may be required for protecting
            neurons from ischemic insults.
REFERENCE   4  (bases 1 to 3085)
  AUTHORS   Cui,Z., Wang,P., Sun,L., Liu,H., Yang,J., Li,X., Kang,L., Huang,Y.,
            Shen,A. and Cheng,C.
  TITLE     Lipopolysaccharide-evoked HSPA12B expression by activation of MAPK
            cascade in microglial cells of the spinal cord
  JOURNAL   J Neurol Sci 294 (1-2), 29-37 (2010)
   PUBMED   20488464
  REMARK    GeneRIF: results suggested HSPA12B may be important for host
            defense in microglia-mediated immune response; understanding the
            cell signal pathway may provide a novel strategy against
            inflammatory and immune reaction in neuroinflammtion in CNS
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On May 26, 2021 this sequence version replaced XM_006235027.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.15455.1,
                                           SRR26643289.10918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000003.1  138799396-138799501
            107-226             JAXUCZ010000003.1  138804303-138804422
            227-286             JAXUCZ010000003.1  138805854-138805913
            287-384             JAXUCZ010000003.1  138807621-138807718
            385-509             JAXUCZ010000003.1  138808814-138808938
            510-696             JAXUCZ010000003.1  138810137-138810323
            697-801             JAXUCZ010000003.1  138810639-138810743
            802-918             JAXUCZ010000003.1  138811043-138811159
            919-1093            JAXUCZ010000003.1  138812581-138812755
            1094-1180           JAXUCZ010000003.1  138813449-138813535
            1181-1285           JAXUCZ010000003.1  138814228-138814332
            1286-1544           JAXUCZ010000003.1  138814430-138814688
            1545-1648           JAXUCZ010000003.1  138815195-138815298
            1649-3085           JAXUCZ010000003.1  138815960-138817396
FEATURES             Location/Qualifiers
     source          1..3085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3085
                     /gene="Hspa12b"
                     /note="heat shock protein family A (Hsp70) member 12B"
                     /db_xref="GeneID:311427"
                     /db_xref="RGD:1312004"
     exon            1..106
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            107..226
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            227..286
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2301
                     /gene="Hspa12b"
                     /note="heat shock protein 70kDa 12B; heat shock protein
                     12B"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 12B"
                     /protein_id="NP_001381945.1"
                     /db_xref="GeneID:311427"
                     /db_xref="RGD:1312004"
                     /translation="MLTVPEMGLQGLYISSSPERSPVPSPPGSPRTQESCGIAPLTPS
                     QSPKPEVRAPQRASFSVVVAIDFGTTSSGYAFSFATDPEAIHMMRKWEGGDPGVAHQK
                     TPTCLLLTPEGIFHSFGYTARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLE
                     AVNGKKMLALEVFAHALRFFKEHALQELREQSECMLEKDAVRWVLTVPAIWKQPAKQF
                     MREAAYLAGLVSREDAEKLLIALEPEAASVYCRKLRLHQLMDLSSRTAGGGRLGERRS
                     IDSSFRHAREQLRRSRHSRTFLVESGVGELWSEMQEGDRYMVADCGGGTVDLTVHQLE
                     QPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIAKFKRQRPAAWVDLTIAFE
                     ARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNFVKWSSQGMLRMSC
                     EAMNELFQPTVSGIIQHIEMLLAKPEVQGVKLLFLVGGFAESAVLQHAVQEALGNRGL
                     RVVVPHDVGLTILKGAVLFGQAPGVVRVRRSPLTYGVGVLNRFVPGHHPPEKLLVRDG
                     RRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITDPGV
                     RKCGALSLELEPEGSPENTGTSPSRREIRAAMQFGDTEIKVTAVDVSTNRSVRAAIDF
                     LSN"
     exon            287..384
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            385..509
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            510..696
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            697..801
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            802..918
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1093
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1180
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1285
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1544
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1648
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..3085
                     /gene="Hspa12b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagacgg gcctggcgca cgtcgagggc cacagtaggc tctgctgcgg tgctctgagc
       61 tagcagccaa gcgacgagat cccgaggagc tgtccgagga gcggagtgct agcctgcagc
      121 cttggttctg aagaccgctc cctttgcact gtgcgtgccc gtccaccaca agttgccagt
      181 ggaagccgat agaatcacct cagcgcagat tccaggctgt tctgtggtac agagactgca
      241 aggatgttga ctgtcccaga aatgggcctt caagggctgt atatcagctc tagtccagaa
      301 aggtccccgg tgcccagccc tcccggctcc ccaaggaccc aggaaagctg tggcattgct
      361 cccctcacgc cttcacagtc tccaaagcca gaggtccgag ctccacagcg ggcttccttc
      421 tctgtggttg tggccatcga ctttgggacc acatccagtg gctatgcctt cagttttgct
      481 actgaccctg aggccattca catgatgagg aaatgggagg gaggggaccc aggcgtggcc
      541 caccagaaga cccccacttg cctgctgctg accccagaag gcatcttcca cagttttggc
      601 tacactgccc gtgactacta ccacgaccta gaccctgagg aggctcggga ctggctctac
      661 tttgagaagt ttaagatgaa gatccacagt gccactgatc ttaccttgaa gacccagcta
      721 gaggcagtaa acggaaagaa gatgctggcc ctggaggtgt ttgcccatgc cctccgcttc
      781 ttcaaggaac atgcccttca ggagctaagg gagcagagcg agtgcatgct tgagaaggat
      841 gctgtgcgct gggtgctgac agtgcctgcc atctggaaac agccagctaa acagttcatg
      901 agagaggctg cctacctggc tggcctggtg tctcgagaag atgcagaaaa actactcatt
      961 gccctggagc ctgaggctgc ctcggtctac tgtcggaaac ttcgtctgca ccagctcatg
     1021 gacctgagta gccggactgc aggtggtggg cgcctgggtg agcggcggtc cattgactcc
     1081 agcttccgac atgcccgaga gcagctgcgg aggtctcgcc acagccgaac attcctggtg
     1141 gagtccggtg tgggagaact gtggtcagag atgcaagaag gagaccgcta catggtggca
     1201 gactgtgggg gtggcactgt ggacctgacg gtacaccaac tggagcagcc tcatggaacc
     1261 ctcaaggagc tgtacaaggc ttctggcggc ccttatggtg cagtaggggt ggacctggcc
     1321 tttgagcagc tgctctgccg catatttggg gaggacttca tcgccaagtt caaaaggcaa
     1381 cggccagctg cttgggtgga tctaaccatt gccttcgagg cccgcaaacg caccgcaggc
     1441 ccgcaccgtg cgggggcgct caacatttcg cttcccttct ctttcattga cttctaccgc
     1501 aagcaacgag gccacaatgt ggagacggcc ctgcgcagga gcagtgtgaa cttcgtgaag
     1561 tggtcttcac aggggatgct ccggatgtcc tgtgaagcta tgaatgagct gtttcagccc
     1621 acagtcagcg ggatcatcca acacatagag atgctgttgg ctaagcctga ggtgcagggt
     1681 gtgaagctgc tattcctggt gggcggcttt gcggagtcag cggtgctgca gcacgcggtg
     1741 caggaagctc taggcaatcg tggcctgcgg gtggtggtcc cgcacgatgt gggcctcacc
     1801 atcctcaagg gagcagtgct cttcggccag gcacctggtg tggtgcgggt gcgccgctcc
     1861 ccgctcactt acggtgtggg cgtgctcaat cgttttgtgc ctggccacca cccaccagag
     1921 aaattgctgg ttcgggatgg gcgccgctgg tgcactgatg tctttgagcg ctttgtcgca
     1981 gcagagcagt cggtggccct aggagaggag gtgcggcgca gctactgtcc cgcgcgcccc
     2041 ggccagcggc gtgtgctcat caatctgtac tgctgcgctg cggaggacgc gcgcttcatc
     2101 actgaccctg gtgtacgcaa gtgtggtgcg ctcagcctgg agcttgagcc tgaaggcagc
     2161 ccagaaaaca cgggcacgtc ccccagccgc cgtgagatcc gtgctgccat gcagtttgga
     2221 gatactgaga ttaaggtcac tgctgtggat gtcagcacca atcgctcagt gcgggcagcc
     2281 atcgactttc tttccaactg agggtgcacc cttcggtggg gacacaagaa catggtagtt
     2341 ttcacaacag agtctctttc tcgtggtaag gacacatgga gactcgcttt acggctgtgc
     2401 cttgatctgc tgactggagc actaaaatcc ccttacccca agaggcgagg tggtataaag
     2461 agactcctaa gaagtttgct tagagggtga gcctggcttg gtaagtgtgt gactgtgaag
     2521 agactgcaat agaggattaa acactggcct gaacttgagg ttaggcgaag ctgctgagga
     2581 gccacaggag gtacagaacc agggtagaag gttagagttc atcaactgtt gagttcaagc
     2641 cacaggaagc ccacgagagc aatctcatgc aggggggagt ggggaggggt gtgttcggcc
     2701 catgctagag ggactggtgt gacagcacct tcctggctgt gtgactgtta attgcagcac
     2761 cgtggctgac aggtgaggag cctgtattgc cacagtgaaa agcagtttgg aggagatgtg
     2821 gacacagcac tctcaaagga cccacagaaa agccataaat gacccattca cccccaaccc
     2881 agccacagaa ggacagagtt tactgtggcc agggctaggg ggacgttcca gctctgccac
     2941 atagcagaat agtagggcat taggaaatca gataatcagt ttctccaggt gtgaagtgtc
     3001 aggcatttcc tgccaaccat gtgtagggta gcttttccgc ccaagaactc accctaagct
     3061 gaaaataaag tgtgaggtca agaaa
//
