LOCUS       NM_001012197            2803 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heat shock protein 90 beta family member 1
            (Hsp90b1), mRNA.
ACCESSION   NM_001012197 XM_343192
VERSION     NM_001012197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Liu,K., Qu,Y., Li,B., Zeng,N., Yao,G., Wu,X., Xu,H., Yan,C. and
            Wu,L.
  TITLE     GRP94 in cerebrospinal fluid may contribute to a potential
            biomarker of depression: Based on proteomics
  JOURNAL   J Psychiatr Res 169, 328-340 (2024)
   PUBMED   38081093
  REMARK    GeneRIF: GRP94 in cerebrospinal fluid may contribute to a potential
            biomarker of depression: Based on proteomics.
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Wang,S., Duan,J., Liao,J., Wang,Y., Xiao,X., Li,L., Liu,Y., Gu,H.,
            Yang,P., Fu,D., Du,J., Li,X. and Shao,M.
  TITLE     LncRNA H19 inhibits ER stress induced apoptosis and improves
            diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis
  JOURNAL   Aging (Albany NY) 14 (16), 6809-6828 (2022)
   PUBMED   36044268
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Ghiasi,S.M., Dahlby,T., Hede Andersen,C., Haataja,L., Petersen,S.,
            Omar-Hmeadi,M., Yang,M., Pihl,C., Bresson,S.E., Khilji,M.S.,
            Klindt,K., Cheta,O., Perone,M.J., Tyrberg,B., Prats,C., Barg,S.,
            Tengholm,A., Arvan,P., Mandrup-Poulsen,T. and Marzec,M.T.
  TITLE     Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is
            Essential for Proinsulin Handling
  JOURNAL   Diabetes 68 (4), 747-760 (2019)
   PUBMED   30670477
  REMARK    GeneRIF: We found that GRP94 coimmunoprecipitated with proinsulin
            and that inhibition of GRP94 function and/or expression reduced
            glucose-dependent insulin secretion, shortened proinsulin
            half-life, and lowered intracellular proinsulin and insulin levels.
REFERENCE   4  (bases 1 to 2803)
  AUTHORS   Zhang,Y., Miao,L., Zhang,H., Wu,G., Zhang,Z. and Lv,J.
  TITLE     Chlorogenic acid against palmitic acid in endoplasmic reticulum
            stress-mediated apoptosis resulting in protective effect of primary
            rat hepatocytes
  JOURNAL   Lipids Health Dis 17 (1), 270 (2018)
   PUBMED   30486828
  REMARK    GeneRIF: We demonstrated that incubation of hepatocytes for 16 h
            with palmitic acid elevated cell death. Moreover, Western blot
            analyses demonstrated increased levels of the endoplasmic reticulum
            stress markers - glucose regulated protein 78 (GRP78), C/EBP
            homologous protein (CHOP), and glucose regulated protein 94
            (GRP94).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2803)
  AUTHORS   Li,J., Akil,O., Rouse,S.L., McLaughlin,C.W., Matthews,I.R.,
            Lustig,L.R., Chan,D.K. and Sherr,E.H.
  TITLE     Deletion of Tmtc4 activates the unfolded protein response and
            causes postnatal hearing loss
  JOURNAL   J Clin Invest 128 (11), 5150-5162 (2018)
   PUBMED   30188326
REFERENCE   6  (bases 1 to 2803)
  AUTHORS   Shin,H.J., Kim,S.S., Cho,Y.H., Lee,S.G. and Rho,H.M.
  TITLE     Host cell proteins binding to the encapsidation signal epsilon in
            hepatitis B virus RNA
  JOURNAL   Arch Virol 147 (3), 471-491 (2002)
   PUBMED   11958450
REFERENCE   7  (bases 1 to 2803)
  AUTHORS   Reddy,R.K., Lu,J. and Lee,A.S.
  TITLE     The endoplasmic reticulum chaperone glycoprotein GRP94 with
            Ca(2+)-binding and antiapoptotic properties is a novel proteolytic
            target of calpain during etoposide-induced apoptosis
  JOURNAL   J Biol Chem 274 (40), 28476-28483 (1999)
   PUBMED   10497210
REFERENCE   8  (bases 1 to 2803)
  AUTHORS   Bogan,J.S. and Lodish,H.F.
  TITLE     Two compartments for insulin-stimulated exocytosis in 3T3-L1
            adipocytes defined by endogenous ACRP30 and GLUT4
  JOURNAL   J Cell Biol 146 (3), 609-620 (1999)
   PUBMED   10444069
REFERENCE   9  (bases 1 to 2803)
  AUTHORS   Hoshino,T., Wang,J., Devetten,M.P., Iwata,N., Kajigaya,S.,
            Wise,R.J., Liu,J.M. and Youssoufian,H.
  TITLE     Molecular chaperone GRP94 binds to the Fanconi anemia group C
            protein and regulates its intracellular expression
  JOURNAL   Blood 91 (11), 4379-4386 (1998)
   PUBMED   9596688
REFERENCE   10 (bases 1 to 2803)
  AUTHORS   De Vouge,M.W., Yamazaki,A., Bennett,S.A., Chen,J.H., Shwed,P.S.,
            Couture,C. and Birnboim,H.C.
  TITLE     Immunoselection of GRP94/endoplasmin from a KNRK cell-specific
            lambda gt11 library using antibodies directed against a putative
            heparanase amino-terminal peptide
  JOURNAL   Int J Cancer 56 (2), 286-294 (1994)
   PUBMED   8314313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081917.1, EV771986.1 and BP471985.1.
            
            On Oct 29, 2008 this sequence version replaced NM_001012197.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2014              BC081917.1         1-2014
            2015-2452           EV771986.1         290-727
            2453-2711           BC081917.1         2844-3102
            2712-2801           BC081917.1         3104-3193
            2802-2803           BP471985.1         1-2                 c
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2803
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /note="heat shock protein 90 beta family member 1"
                     /db_xref="GeneID:362862"
                     /db_xref="RGD:1310482"
     exon            1..173
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2539
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /note="endoplasmin; tumor rejection antigen gp96; GRP-94;
                     94 kDa glucose-regulated protein; heat shock protein 90
                     kDa beta member 1; heat shock protein 90, beta, member 1;
                     heat shock protein 90kDa beta (Grp94), member 1"
                     /codon_start=1
                     /product="endoplasmin precursor"
                     /protein_id="NP_001012197.2"
                     /db_xref="GeneID:362862"
                     /db_xref="RGD:1310482"
                     /translation="MRVLWVLGLCCVLLTFGFVRADDEVDVDGTVEEDLGKSREGSRT
                     DDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLR
                     ELISNASDALDKIRLISLTDENALAGNEELTVKIKCDREKNLLHVTDTGVGMTREELV
                     KNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNND
                     TQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVRKYSQFIN
                     FPIYVWSSKTETVEEPLEEDETAQEEKEEADDEAAVEEEEEEKKPKTKKVEKTVWDWE
                     LMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTS
                     APRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
                     LQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAK
                     LLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVI
                     YLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREATEKEFEPLLNWMKD
                     KALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQK
                     KTFEINPRHPLIRDMLRRVKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIE
                     RMLRLSLNIDPEAQVEEEPEEEPEDTTEDTTDDSEQDEEETDAGAEEEEEEQETEKEP
                     TEKDEL"
     exon            174..276
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..418
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..535
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..867
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..979
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1099
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1216
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1354
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1432
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1498
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1768
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2014
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2151
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2230
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2386
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2512
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2803
                     /gene="Hsp90b1"
                     /gene_synonym="Grp94; Tra1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctgcgcg cggtttagtg ggcggaccgc gctgctggag gtgtgaggac ctgagactcc
       61 gggttggggg ggtggaggcg gctcctgcga ccgaaaagga cttgcgactc tccggccacg
      121 caccatgagg gtcctgtggg tgctgggcct ctgctgcgtc ctgctgacct tcgggtttgt
      181 gagagctgac gatgaagtcg atgtggatgg cacggtagaa gaggacctgg gtaaaagtag
      241 agaaggctca cggacagacg atgaagttgt gcagagagag gaagaagcta ttcagttgga
      301 tggtttaaat gcatcacaaa taagggaact tagagaaaaa tcggaaaagt tcgccttcca
      361 agctgaagtt aacaggatga tgaaacttat catcaattct ttgtataaaa ataaagagat
      421 tttcctgaga gaactgattt caaatgcttc tgatgcttta gacaagataa ggctcatctc
      481 actaactgat gaaaatgcac ttgctggaaa tgaggagttg acggtcaaga ttaagtgtga
      541 cagagagaaa aacctgctgc atgtcacaga cacgggtgta ggaatgacca gagaggagct
      601 ggttaaaaac ctgggcacca tagccaaatc tggaaccagc gagtttctaa acaaaatgac
      661 agaagcacaa gaagacggtc agtcaacttc cgaactgatc ggccagtttg gtgtcggttt
      721 ttattctgcc ttccttgtag cagataaggt cattgtcacg tcgaaacaca acaatgatac
      781 ccagcacatc tgggaatccg actctaatga attctctgtg attgctgacc caagaggaaa
      841 cacactaggt cgtggaacaa cgattactct tgtcttaaaa gaagaagcat ctgattacct
      901 tgaattggat acaattaaaa atctcgtcag aaagtattct cagttcatca actttcccat
      961 ctatgtgtgg agtagcaaga ctgagactgt ggaggagccc ttggaagaag acgaaacagc
     1021 acaagaagag aaggaggaag ctgatgatga agccgcagta gaagaggagg aggaagagaa
     1081 gaagccaaag acgaagaaag ttgaaaagac tgtgtgggac tgggaactta tgaatgacat
     1141 caaaccaata tggcagaggc cgtccaaaga agtagaagaa gacgagtaca aagctttcta
     1201 caagtcgttt tcaaaggaaa gtgatgaccc catggcttat atccacttta ctgcagaagg
     1261 ggaagtcacc ttcaagtcaa ttttgtttgt gcctacatct gcgcctcgag gtctgtttga
     1321 cgagtatgga tctaagaaga gcgattatat taagctctat gtgcgccgag tgttcatcac
     1381 agacgacttc catgacatga tgcccaagta cctgaatttt gtcaaaggtg ttgtggattc
     1441 cgatgatctc cccctcaatg tttcccgtga gactcttcag caacataaat tgctcaaggt
     1501 gattaggaag aagcttgtcc gcaaaactct ggacatgatc aagaagatcg ctgatgagaa
     1561 atataatgac actttctgga aagaatttgg caccaatatc aagcttggtg tgattgaaga
     1621 tcactcaaat cgaacacggc ttgctaaact tcttaggttc cagtcttctc accattcaac
     1681 tgacattact agtttagacc agtatgtgga aagaatgaag gaaaaacagg acaaaatcta
     1741 cttcatggct gggtcaagca gaaaagaggc tgaatcttct ccgtttgttg agaggcttct
     1801 gaagaagggc tatgaagtta tttacctcac agagcccgtg gatgaatact gcattcaggc
     1861 tcttcctgag tttgatggga aacggttcca gaatgttgcc aaagaaggag tgaagtttga
     1921 tgagagtgag aaaagtaaag aaagtcggga agcaacagag aaggagtttg agcctctgct
     1981 caactggatg aaagataagg ccctcaagga caagatcgaa aaggctgtgg tgtcccagcg
     2041 cctcacagag tctccctgtg cccttgtggc cagccagtat ggatggtctg gaaacatgga
     2101 gaggatcatg aaggcacaag cataccagac gggcaaggac atctctacaa attactatgc
     2161 cagtcagaag aaaacgtttg aaattaatcc tagacaccca ctgatcaggg acatgctgcg
     2221 gagggttaag gaagatgaag atgacaagac tgtcatggat cttgctgtag ttttgtttga
     2281 aacggcaact cttcggtcag gataccttct acccgacacc aaggcatatg gagacaggat
     2341 agaaaggatg ctccgcctca gcttaaacat tgaccctgaa gcacaggtag aggaagagcc
     2401 agaggaggag cctgaagaca ccacagaaga caccacagat gactccgagc aggatgaaga
     2461 agagacagac gcaggggcag aagaagaaga agaagaacag gaaacagaaa aggaacctac
     2521 agagaaggat gaattgtaat tatactctca ctatgaatcc tgtgtggaga gggaatgtga
     2581 cattttaaag ttatttcttt tgaaagactt gttttggatg ctcccccaag cctccctctc
     2641 ccctgcactg taaaatgttg ggattatggg tcacaggaag aagtggtttt tttagttgaa
     2701 tttttttttt taacattcct cctgaatgta aatttgtact atttaactga ctattggtgt
     2761 aaaatcttgt catgtgtata aaaataaaaa aagatcccaa ata
//
