LOCUS       NM_001004082            2338 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heat shock protein 90 alpha family class B member
            1 (Hsp90ab1), mRNA.
ACCESSION   NM_001004082 XM_217339
VERSION     NM_001004082.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2338)
  AUTHORS   Liang,T., Hu,X., Zeng,L., Zhou,Z., Zhang,J., Xu,Z., Zeng,J. and
            Xu,P.
  TITLE     HSP90beta regulates EAAT2 expression and participates in
            ischemia-reperfusion injury in rats
  JOURNAL   Mol Med Rep 29 (1) (2024)
   PUBMED   37975223
  REMARK    GeneRIF: HSP90beta regulates EAAT2 expression and participates in
            ischemia-reperfusion injury in rats.
REFERENCE   2  (bases 1 to 2338)
  AUTHORS   Oroz,J., Chang,B.J., Wysoczanski,P., Lee,C.T., Perez-Lara,A.,
            Chakraborty,P., Hofele,R.V., Baker,J.D., Blair,L.J., Biernat,J.,
            Urlaub,H., Mandelkow,E., Dickey,C.A. and Zweckstetter,M.
  TITLE     Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau
            complex
  JOURNAL   Nat Commun 9 (1), 4532 (2018)
   PUBMED   30382094
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2338)
  AUTHORS   Krzemien-Ojak,L., Goral,A., Joachimiak,E., Filipek,A. and
            Fabczak,H.
  TITLE     Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein
            Hsp90
  JOURNAL   J Cell Biochem 118 (2), 420-429 (2017)
   PUBMED   27496612
REFERENCE   4  (bases 1 to 2338)
  AUTHORS   Okabe,T., Chavan,R., Fonseca Costa,S.S., Brenna,A., Ripperger,J.A.
            and Albrecht,U.
  TITLE     REV-ERBalpha influences the stability and nuclear localization of
            the glucocorticoid receptor
  JOURNAL   J Cell Sci 129 (21), 4143-4154 (2016)
   PUBMED   27686098
REFERENCE   5  (bases 1 to 2338)
  AUTHORS   Haslbeck,V., Eckl,J.M., Drazic,A., Rutz,D.A., Lorenz,O.R.,
            Zimmermann,K., Kriehuber,T., Lindemann,C., Madl,T. and Richter,K.
  TITLE     The activity of protein phosphatase 5 towards native clients is
            modulated by the middle- and C-terminal domains of Hsp90
  JOURNAL   Sci Rep 5, 17058 (2015)
   PUBMED   26593036
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2338)
  AUTHORS   Rallu,M., Loones,M., Lallemand,Y., Morimoto,R., Morange,M. and
            Mezger,V.
  TITLE     Function and regulation of heat shock factor 2 during mouse
            embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2392-2397 (1997)
   PUBMED   9122205
REFERENCE   7  (bases 1 to 2338)
  AUTHORS   Sepehrnia,B., Paz,I.B., Dasgupta,G. and Momand,J.
  TITLE     Heat shock protein 84 forms a complex with mutant p53 protein
            predominantly within a cytoplasmic compartment of the cell
  JOURNAL   J Biol Chem 271 (25), 15084-15090 (1996)
   PUBMED   8663025
REFERENCE   8  (bases 1 to 2338)
  AUTHORS   Nemoto,T., Ohara-Nemoto,Y., Ota,M., Takagi,T. and Yokoyama,K.
  TITLE     Mechanism of dimer formation of the 90-kDa heat-shock protein
  JOURNAL   Eur J Biochem 233 (1), 1-8 (1995)
   PUBMED   7588731
REFERENCE   9  (bases 1 to 2338)
  AUTHORS   McGuire,J.A., Poellinger,L., Wikstrom,A.C. and Gustafsson,J.A.
  TITLE     Cloning and regulation by glucocorticoid receptor ligands of a rat
            hsp90
  JOURNAL   J Steroid Biochem Mol Biol 42 (8), 813-822 (1992)
   PUBMED   1525042
REFERENCE   10 (bases 1 to 2338)
  AUTHORS   Denis,M.
  TITLE     Two-step purification and N-terminal amino acid sequence analysis
            of the rat Mr 90,000 heat shock protein
  JOURNAL   Anal Biochem 173 (2), 405-411 (1988)
   PUBMED   3189818
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY695392.1.
            
            On Jun 10, 2007 this sequence version replaced NM_001004082.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY695392.1, BC082009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..2338
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /note="heat shock protein 90 alpha family class B member
                     1"
                     /db_xref="GeneID:301252"
                     /db_xref="RGD:1303075"
     exon            1..45
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2220
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /note="HSP 84; HSP84; heat shock 84 kDa; heat shock
                     protein 90kDa alpha (cytosolic), class B member 1; heat
                     shock 90kDa protein 1, beta; heat shock protein 90 alpha
                     (cytosolic), class B member 1; heat shock protein 90kDa
                     alpha family class B member 1"
                     /codon_start=1
                     /product="heat shock protein HSP 90-beta"
                     /protein_id="NP_001004082.3"
                     /db_xref="GeneID:301252"
                     /db_xref="RGD:1303075"
                     /translation="MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELI
                     SNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNL
                     GTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS
                     AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLE
                     KEREKEISDDEAEEEKGEKEEEDKEDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKY
                     IDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF
                     IPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISR
                     EMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR
                     LSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGF
                     EVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKL
                     MKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKK
                     HLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
                     MIKLGLGIDEDEVTAEEPSAAVPDEIPPLEGDEDASRMEEVD"
     exon            46..192
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            193..399
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            400..559
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            560..1002
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1168
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1359
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1507
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1776
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2110
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2338
                     /gene="Hsp90ab1"
                     /gene_synonym="HSP90-BETA; HSP90B; HSPC2; Hspcb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggcccac cctgctctgt actactactc ggctttctcg tcaagatgcc tgaggaagtg
       61 caccatggag aggaagaggt ggagaccttc gcctttcagg cagaaattgc ccagctgatg
      121 tccctcatca tcaacacttt ctactcaaac aaagagattt tcctccggga gttgatctct
      181 aatgcttctg atgccctgga caagattcgg tatgagagcc tgactgaccc ttccaagttg
      241 gacagcggga aagagctgaa gattgacatc atccccaacc ctcaggaacg cacgctgact
      301 ttggtggaca caggcattgg catgaccaag gctgacctca taaataactt gggaaccatt
      361 gctaagtctg gtacaaaggc gttcatggag gctctccagg ctggtgcaga catctccatg
      421 attgggcagt ttggtgtcgg cttctactct gcctacctgg tggcagagaa agtggttgtg
      481 atcacgaagc acaacgatga tgagcagtat gcctgggagt cttctgctgg tggatccttc
      541 actgtccgtg cagaccacgg tgagcccatt ggccggggta ccaaagtgat ccttcacctc
      601 aaagaagacc agacagagta cttagaggag aggagggtca aggaggtggt gaagaaacac
      661 tcacagttca taggctaccc catcaccctc tatctggaga aggaacgcga gaaggagatc
      721 agtgatgatg aggcagagga agagaaaggg gagaaggagg aggaagataa ggaggatgag
      781 gagaagccta agattgagga tgtgggatct gatgaggagg atgacagcgg caaagataag
      841 aaaaagaaaa caaagaagat caaggagaag tacattgacc aggaagagct gaataagacg
      901 aagcccatct ggaccagaaa tcctgatgac atcactcaag aggaatatgg tgaattctac
      961 aagagcctca ccaatgactg ggaagaccac ttggcagtca agcacttctc tgtagaaggg
     1021 cagttggaat tcagggcatt gctcttcatt ccccggcgag ctccctttga cctctttgag
     1081 aacaagaaga agaagaacaa catcaaattg tatgtccgtc gtgtgttcat catggacagc
     1141 tgtgatgagc tgatacctga gtacctcaac ttcatccgtg gtgtggttga ttccgaggac
     1201 ctgcctctga acatctcccg agaaatgctc cagcagagca agatcctgaa agtcatccgc
     1261 aaaaacattg tgaagaagtg ccttgagctc ttctctgagt tggctgaaga caaagagaac
     1321 tacaagaaat tttatgaggc attctctaag aatttaaagc ttggaatcca tgaggattcc
     1381 actaaccgtc gccgcctctc tgagctcctt cgctaccata cctctcagtc tggagatgag
     1441 atgacttccc tgtcagagta tgtgtctcgc atgaaggaga cacagaagtc catctactat
     1501 atcactggtg agagcaaaga gcaggtggcc aactctgcct tcgtggagcg tgtgcggaaa
     1561 cggggctttg aggtggtata catgactgag cccattgatg agtactgcgt acagcagctc
     1621 aaggagttcg atggcaagag cctggtctcc gtgaccaagg agggcctgga gctaccagag
     1681 gatgaggaag agaagaaaaa aatggaggag agcaaggcaa agtttgagaa tctctgcaag
     1741 ctcatgaagg agatcttgga caagaaggtt gaaaaagtga ctatctccaa taggcttgtg
     1801 tcttccccct gctgcattgt gaccagcacc tacggctgga cagccaacat ggaacggatt
     1861 atgaaggccc aggcactgcg ggacaactcg acaatgggct acatgatggc caagaaacac
     1921 ctagagatca accctgacca ccccattgtg gagactctgc ggcagaaggc tgaggcagac
     1981 aaaaacgaca aagctgtcaa agacctggtg gtgctgctgt ttgagactgc tctgctctcc
     2041 tctggcttct cacttgagga cccccaaacc cactccaacc gcatctaccg catgattaaa
     2101 ctaggcctgg gcattgatga agatgaggtc actgcagaag agcccagtgc tgctgttccc
     2161 gatgagatcc ccccactgga gggtgatgag gatgcctctc gcatggaaga agtggattaa
     2221 aggctcctgg gaagcccccg ccctctgtat agtatccctg tggctccccc aacagccttg
     2281 actggccctg acccacctgg ctctctgctc atgtctacaa gaatctcttc tatcctgt
//
