LOCUS       NM_175761               2795 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus heat shock protein 90 alpha family class A member
            1 (Hsp90aa1), mRNA.
ACCESSION   NM_175761
VERSION     NM_175761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Deng,Z.H., Chen,Y.X., Xue-Gao, Yang,J.Y., Wei,X.Y., Zhang,G.X. and
            Qian,J.X.
  TITLE     Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary
            hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway
  JOURNAL   Biochem Pharmacol 226, 116382 (2024)
   PUBMED   38909785
  REMARK    GeneRIF: Mesenchymal stem cell-derived exosomes ameliorate hypoxic
            pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
REFERENCE   2  (bases 1 to 2795)
  AUTHORS   Wang,Q., Kong,X., Guo,W., Liu,L., Tian,Y., Tao,X., Lin,N. and Su,X.
  TITLE     HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by
            Activating TRAF6/NFATc1 Signaling
  JOURNAL   Inflammation 47 (1), 363-375 (2024)
   PUBMED   37902841
  REMARK    GeneRIF: HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis
            by Activating TRAF6/NFATc1 Signaling.
REFERENCE   3  (bases 1 to 2795)
  AUTHORS   Marunouchi,T., Iguchi,A., Shindo,A., Shimbo,N., Yano,E. and
            Tanonaka,K.
  TITLE     Involvement of Hsp90 in NLRP3 inflammasome activation in the
            failing heart following myocardial infarction in rats
  JOURNAL   Biochem Pharmacol 212, 115547 (2023)
   PUBMED   37054848
  REMARK    GeneRIF: Involvement of Hsp90 in NLRP3 inflammasome activation in
            the failing heart following myocardial infarction in rats.
REFERENCE   4  (bases 1 to 2795)
  AUTHORS   Lopez-Martin,E., Jorge-Barreiro,F.J., Relova-Quintero,J.L.,
            Salas-Sanchez,A.A. and Ares-Pena,F.J.
  TITLE     Exposure to 2.45 GHz radiofrequency modulates calcitonin-dependent
            activity and HSP-90 protein in parafollicular cells of rat thyroid
            gland
  JOURNAL   Tissue Cell 68, 101478 (2021)
   PUBMED   33373917
  REMARK    GeneRIF: Exposure to 2.45 GHz radiofrequency modulates
            calcitonin-dependent activity and HSP-90 protein in parafollicular
            cells of rat thyroid gland.
REFERENCE   5  (bases 1 to 2795)
  AUTHORS   Alsarhan,A., Amawi,K.F., Al-Mazari,I.S., Hurirah,H.A. and
            Alkhatib,A.J.
  TITLE     The Compound Expression of HSP90 and INOS in the Testis of Diabetic
            Rats as Cellular and Pathologic Adverse Effects of Diabetes
  JOURNAL   Anal Cell Pathol (Amst) 2020, 3906583 (2020)
   PUBMED   32676275
  REMARK    GeneRIF: The Compound Expression of HSP90 and INOS in the Testis of
            Diabetic Rats as Cellular and Pathologic Adverse Effects of
            Diabetes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2795)
  AUTHORS   Young,J.C., Obermann,W.M. and Hartl,F.U.
  TITLE     Specific binding of tetratricopeptide repeat proteins to the
            C-terminal 12-kDa domain of hsp90
  JOURNAL   J Biol Chem 273 (29), 18007-18010 (1998)
   PUBMED   9660753
REFERENCE   7  (bases 1 to 2795)
  AUTHORS   Takahashi,K., Kubo,T., Goomer,R.S., Amiel,D., Kobayashi,K.,
            Imanishi,J., Teshima,R. and Hirasawa,Y.
  TITLE     Analysis of heat shock proteins and cytokines expressed during
            early stages of osteoarthritis in a mouse model
  JOURNAL   Osteoarthritis Cartilage 5 (5), 321-329 (1997)
   PUBMED   9497939
REFERENCE   8  (bases 1 to 2795)
  AUTHORS   Rallu,M., Loones,M., Lallemand,Y., Morimoto,R., Morange,M. and
            Mezger,V.
  TITLE     Function and regulation of heat shock factor 2 during mouse
            embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2392-2397 (1997)
   PUBMED   9122205
REFERENCE   9  (bases 1 to 2795)
  AUTHORS   Chen,M.S., Silverstein,A.M., Pratt,W.B. and Chinkers,M.
  TITLE     The tetratricopeptide repeat domain of protein phosphatase 5
            mediates binding to glucocorticoid receptor heterocomplexes and
            acts as a dominant negative mutant
  JOURNAL   J Biol Chem 271 (50), 32315-32320 (1996)
   PUBMED   8943293
REFERENCE   10 (bases 1 to 2795)
  AUTHORS   Minami,Y., Kimura,Y., Kawasaki,H., Suzuki,K. and Yahara,I.
  TITLE     The carboxy-terminal region of mammalian HSP90 is required for its
            dimerization and function in vivo
  JOURNAL   Mol Cell Biol 14 (2), 1459-1464 (1994)
   PUBMED   8289821
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ428213.1.
            
            On Mar 12, 2003 this sequence version replaced NM_175761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ428213.1, BC072489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2795
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /note="heat shock protein 90 alpha family class A member
                     1"
                     /db_xref="GeneID:299331"
                     /db_xref="RGD:631409"
     exon            1..58
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2260
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /EC_number="3.6.4.10"
                     /function="chaperone"
                     /note="HSP 86; heat shock 86 kDa; heat shock protein 1,
                     alpha; heat shock protein 86; heat shock protein 90, alpha
                     (cytosolic), class A member 1; heat shock protein 90kDa
                     alpha family class A member 1"
                     /codon_start=1
                     /product="heat shock protein HSP 90-alpha"
                     /protein_id="NP_786937.1"
                     /db_xref="GeneID:299331"
                     /db_xref="RGD:631409"
                     /translation="MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIF
                     LRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKAD
                     LINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQY
                     AWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPI
                     TLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKK
                     KKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEG
                     QLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDS
                     EDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGI
                     HEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAF
                     VERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKK
                     TKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNS
                     TMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP
                     QTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPLEGDDDTSRMEEVD"
     exon            59..220
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            221..587
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            588..721
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            722..1042
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1208
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1399
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1547
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1816
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2150
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2785
                     /gene="Hsp90aa1"
                     /gene_synonym="Hsp86; Hsp90; Hspca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgcttca gtgtcccggt gcggttagtc acgtttcgtg cgtgctcatt ctgccaagat
       61 gcctgaggaa acccagaccc aagaccaacc aatggaggaa gaggaggtcg aaacctttgc
      121 ctttcaggca gaaattgccc agttaatgtc cttgatcatc aacactttct actcgaacaa
      181 agagatcttt ctgagggagc tcatttccaa ctcctcagac gctctggata agatcagata
      241 cgagagcttg accgacccta gtaaactgga ctcggggaag gagctgcaca ttaatctcat
      301 tcccaacaag caagaccgaa ccctcactat tgtggatact ggcattggaa tgaccaaggc
      361 tgacttgatc aataaccttg gcactattgc caagtcaggc accaaagcct tcatggaggc
      421 tttgcaggct ggtgcagata tctctatgat tggccagttt ggtgttggtt tttactctgc
      481 gtatttggtt gctgagaaag tgactgtcat caccaagcat aatgatgacg agcagtacgc
      541 ctgggagtcc tcagctggag gatccttcac tgtgaggaca gacacaggtg aaccaatggg
      601 tcgtggaaca aaggttatct tgcatctaaa agaagaccaa actgagtatt tggaggaaag
      661 gagaataaaa gaaattgtga agaaacattc tcagtttatt ggctacccca ttactctctt
      721 tgtggagaag gaacgtgaca aggaagtcag tgatgatgag gctgaagaaa aggaagagaa
      781 agaggaagag aaagaaaaag aagaaaagga gtctgatgac aagcctgaaa tagaagatgt
      841 tggttctgat gaagaagaag aagagaagaa ggatggtgac aagaagaaaa agaagaagat
      901 aaaggaaaag tacattgatc aagaagaact caacaaaaca aagccgatct ggaccagaaa
      961 tcctgatgac attacgaatg aagaatacgg agagttctac aagagcttaa ccaacgactg
     1021 ggaagaacat ttggcagtaa agcatttttc tgttgaagga caattagaat tccgggctct
     1081 tctttttgtc ccaagacgcg ctccttttga tctatttgaa aacagaaaga aaaagaacaa
     1141 catcaagttg tatgttcgca gagtttttat catggataac tgtgaggagt taatccccga
     1201 gtatctgaat ttcatcagag gggtggtgga ttctgaggat ctccctctaa atatttcccg
     1261 tgaaatgctg caacaaagca aaattctgaa agttatcagg aagaatttgg tcaagaaatg
     1321 cctagaacta tttactgaac tggctgaaga taaagagaac tacaaaaagt tttatgagca
     1381 gttctcaaaa aatataaagc ttggaattca tgaagactct caaaatcgga agaagctttc
     1441 agagctgttg agatactaca catctgcttc tggggatgag atggtttctc tgaaggacta
     1501 ctgcaccaga atgaaggaaa accagaagca catctatttt atcacaggtg agaccaagga
     1561 ccaggttgct aactcagcct ttgtggaacg tctccgaaag catggcttag aagtaatcta
     1621 tatgattgag cccattgatg agtattgtgt gcaacagctg aaggaatttg agggcaagac
     1681 cttggtgtca gttaccaaag aaggactgga acttccagaa gatgaagagg aaaagaagaa
     1741 acaggaagag aaaaagacaa aatttgagaa cctctgcaaa attatgaagg atattttaga
     1801 gaaaaaggtt gaaaaggtgg ttgtgtcaaa ccgattggtg acatccccat gctgtattgt
     1861 cacaagcaca tatggctgga cagcaaacat ggagagaatc atgaaagctc aagccctcag
     1921 agacaactca acaatgggtt acatggcagc aaagaaacac ctggagataa accctgatca
     1981 ctccattatt gaaaccttaa ggcaaaaggc agaggctgac aagaatgaca agtctgtgaa
     2041 agatctggtc atcttgctgt acgaaacagc actcctgtct tccggcttca gtctggaaga
     2101 tccccagacc catgctaaca ggatctacag gatgatcaag cttggtctag gtattgatga
     2161 ggatgatcct actgtggatg ataccagtgc tgctgtaact gaagaaatgc cacccctgga
     2221 aggagatgat gacacatcac gcatggaaga agtagactag gcttcaccag aactatgtgt
     2281 ttgatgctta ccttcattcc ttctgataat atattttcca tgatttttgt ttatttttgt
     2341 taacatttaa aacatctgtg tggcatgaaa actaggggaa ggtaaaaatt tctacatgtg
     2401 atactgtgat actataggtt tgactcaaga ggttgataga acgtttgttg taagacgtaa
     2461 tgtaacctac tgttactgtt aactatgtgg tctgaagtgt ttagctgttg agctggattc
     2521 ctttagtaga ccaaattaag atgacttaag tttcatctta aatttttttc attccctgta
     2581 gttaattctg catgtactag tcttagaagt aaacacaagc taaaacaact tgacaggaat
     2641 tccccaagtg gcttgttttc caaagtactg agaacaaaac cctaagttcc cctaggtctt
     2701 gtaactcagc aaggcttgtg aatgtgaaaa taacagtgcc caatcacatt ctgctttaaa
     2761 aaggtaaata cagatgagat aaaaaaaaaa aaaaa
//
