LOCUS       NM_001271328            2176 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus hematopoietic SH2 domain containing (Hsh2d),
            mRNA.
ACCESSION   NM_001271328 XM_002728380 XM_003752875
VERSION     NM_001271328.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Herrin,B.R., Groeger,A.L. and Justement,L.B.
  TITLE     The adaptor protein HSH2 attenuates apoptosis in response to
            ligation of the B cell antigen receptor complex on the B lymphoma
            cell line, WEHI-231
  JOURNAL   J Biol Chem 280 (5), 3507-3515 (2005)
   PUBMED   15569688
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Greene,T.A., Powell,P., Nzerem,C., Shapiro,M.J. and Shapiro,V.S.
  TITLE     Cloning and characterization of ALX, an adaptor downstream of CD28
  JOURNAL   J Biol Chem 278 (46), 45128-45134 (2003)
   PUBMED   12960172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Sep 16, 2012 this sequence version replaced
            XM_002728380.2, XM_003752875.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2387905.1,
                                           SRR26643284.18425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000016.1  17681963-17682013   c
            52-198              JAXUCZ010000016.1  17677944-17678090   c
            199-288             JAXUCZ010000016.1  17673956-17674045   c
            289-454             JAXUCZ010000016.1  17672957-17673122   c
            455-577             JAXUCZ010000016.1  17672372-17672494   c
            578-2176            JAXUCZ010000016.1  17669345-17670943   c
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2176
                     /gene="Hsh2d"
                     /note="hematopoietic SH2 domain containing"
                     /db_xref="GeneID:100360518"
                     /db_xref="RGD:2321939"
     exon            1..51
                     /gene="Hsh2d"
                     /inference="alignment:Splign:2.1.0"
     exon            52..198
                     /gene="Hsh2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1081
                     /gene="Hsh2d"
                     /codon_start=1
                     /product="hematopoietic SH2 domain-containing protein"
                     /protein_id="NP_001258257.1"
                     /db_xref="GeneID:100360518"
                     /db_xref="RGD:2321939"
                     /translation="MAEAGRLPPPLPPRLDWFVHTQADLLAQSGIPEWFHGTISREAA
                     ENLLESQPPGTFLIRVSHSHVGYTLSYKAETCCRHFMVKLSEDGTFVFAGDHVTHASL
                     DALVTFHQQNPIRPYGELLTRACGQKDPASVDYEDLFLYWNALVQDNGRQLLRMEVQR
                     PSSGSPEEASEGKPSTTTKGESALASCSTKVLFEESGQKLWKNLRSLPQTSRKVKQRL
                     TSNLSAMNLLGNARRVAQQHHSPVTRAFSWDSASHSEDPCAVTTSLQNPTQPEALRDR
                     EATFRDSKRASWREALSGVKAWHGKVIRGLSAPEPANSPEAQGWLPEEYLPPPPFAPG
                     Y"
     exon            199..288
                     /gene="Hsh2d"
                     /inference="alignment:Splign:2.1.0"
     exon            289..454
                     /gene="Hsh2d"
                     /inference="alignment:Splign:2.1.0"
     exon            455..577
                     /gene="Hsh2d"
                     /inference="alignment:Splign:2.1.0"
     exon            578..2176
                     /gene="Hsh2d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccagtgg cagctcaaga acccttcgga acacagctca gcctgtccaa ggtgaccacc
       61 ttccctggat gccatggcag aggctgggag gctccctcca ccactacccc ctcggctgga
      121 ctggtttgtg cacacccagg cggacctgct ggcccaatcc gggatccccg agtggttcca
      181 tggcaccatt tcccgagagg ctgctgagaa cctgttggag tcccaacccc cggggacctt
      241 tcttatccga gtcagccaca gccatgtggg ctacaccctt tcctacaaag ccgaaacctg
      301 ctgccgtcac ttcatggtga agctttcaga agatgggact ttcgtcttcg ctggggacca
      361 cgtgacccac gcctctctgg acgccctggt caccttccac caacaaaacc ctattcggcc
      421 atacggggag ctgctgaccc gggcctgcgg gcagaaggat ccagcaagtg tggactacga
      481 agatctcttc ctatactgga atgcgctggt tcaggataat ggaaggcaac ttctgagaat
      541 ggaagttcaa aggccttctt ccggctcacc tgaagaggct tctgaaggga agccatccac
      601 aacaactaaa ggagaatccg cattggcttc ctgctccaca aaagtccttt tcgaggagtc
      661 tggacagaaa ctgtggaaga acctgaggtc cctacctcag accagccgga aggtgaaaca
      721 gcggctcact tcaaacctgt cggccatgaa cctgctgggg aatgccaggc gcgtggcaca
      781 gcaacatcat agccctgtga ctcgagcgtt cagctgggac agtgcaagcc actccgagga
      841 cccctgtgca gtcactacct ctctccaaaa ccccacacag cccgaggccc tgagagacag
      901 agaagccacc ttcagggact ccaagcgtgc cagctggagg gaggcactct caggggtcaa
      961 agcctggcat ggaaaggtga taaggggcct gtcagccccg gagcctgcca actcgccaga
     1021 agcccagggc tggttgcctg aggaatatct cccaccacca ccttttgccc ctgggtactg
     1081 acaggacctt ctgagtcttg ggtattcatc tccttacagc cagagaactg tactgaagag
     1141 gttagggggc tgaaccctgc aggcaccagc tgagggagcc taaataatgg aattactgct
     1201 accactttag ggacccggtg aggtggccca gtgcatagga aggtaaaaga actttcagcc
     1261 acgcccaaca cctgagttct atccccagga ctcccacggg gagagctgtg gaccaacttc
     1321 tggaggacgt cctcagactt ctacatacgt gtgttagcac acactcgtaa gccgatgtaa
     1381 ctttaaaaga tggcagcaga gacgtggcag gttcaacagg tgccaggcct gtgccgtgtg
     1441 tcatctctca gtatcgttgg gatgcatgtc tcatgttcag ccacattcaa atacaaatgt
     1501 ttttccaggg gttggggatt tagctcagtg gtagagcgct tgcctagcaa atgcaaggtt
     1561 ctgtcctcag ctccagggat gacatttttt ttttctgaaa gctttatgtc ttctgagggt
     1621 tggggagata actcagtgag taaagggctg agaggacctg agttcaattc ccccaagccc
     1681 acaaagatgc tgcagtagcg tgtgtgtgtg tgtcctcaga gcagctacaa ggagacggga
     1741 ggtggctgct gccttacaga gaccttgctt ccacaaggtg gaggacagac atgcgggcaa
     1801 tccaacatgt tcccgcccac actcacacac taggacacgc agaggaggag ggggagagag
     1861 aggggatgca aagcaattgc atctgtggcc aggggtgtgg gggcagcatt tgggcagcaa
     1921 agacaagagg tgtcaggagc ccaaagccag cctcggctta cctggagttt gagattagcc
     1981 tgggctacat gaaagcttga ctgagagaag aaaaactgtg agacaggcat agtggtacac
     2041 accagtaatc ccagcactcc agaggcagag gcgggaagag ctctgtgagt ttgaggccag
     2101 cttggtctcc gtagtgagtt tcagggctac acagggagac ctcatctaaa taaaaagtga
     2161 aatgcatctg tactga
//
