LOCUS       NM_001106177            1514 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus heat shock transcription factor 4 (Hsf4), mRNA.
ACCESSION   NM_001106177 XM_001075468 XM_214668
VERSION     NM_001106177.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Ho,E.A. and Piquette-Miller,M.
  TITLE     KLF6 and HSF4 transcriptionally regulate multidrug resistance
            transporters during inflammation
  JOURNAL   Biochem Biophys Res Commun 353 (3), 679-685 (2007)
   PUBMED   17196161
  REMARK    GeneRIF: KLF6 and HSF4 are stimuli-specific regulatory elements
            which may be important in the control of the rat mdr1b and mrp3
            genes during health and disease.
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Talamas,E., Jackson,L., Koeberl,M., Jackson,T., McElwee,J.L.,
            Hawes,N.L., Chang,B., Jablonski,M.M. and Sidjanin,D.J.
  TITLE     Early transposable element insertion in intron 9 of the Hsf4 gene
            results in autosomal recessive cataracts in lop11 and ldis1 mice
  JOURNAL   Genomics 88 (1), 44-51 (2006)
   PUBMED   16595169
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Hu,Y. and Mivechi,N.F.
  TITLE     Association and regulation of heat shock transcription factor 4b
            with both extracellular signal-regulated kinase mitogen-activated
            protein kinase and dual-specificity tyrosine phosphatase DUSP26
  JOURNAL   Mol Cell Biol 26 (8), 3282-3294 (2006)
   PUBMED   16581800
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Min,J.N., Zhang,Y., Moskophidis,D. and Mivechi,N.F.
  TITLE     Unique contribution of heat shock transcription factor 4 in ocular
            lens development and fiber cell differentiation
  JOURNAL   Genesis 40 (4), 205-217 (2004)
   PUBMED   15593327
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Fujimoto,M., Izu,H., Seki,K., Fukuda,K., Nishida,T., Yamada,S.,
            Kato,K., Yonemura,S., Inouye,S. and Nakai,A.
  TITLE     HSF4 is required for normal cell growth and differentiation during
            mouse lens development
  JOURNAL   EMBO J 23 (21), 4297-4306 (2004)
   PUBMED   15483628
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Somasundaram,T. and Bhat,S.P.
  TITLE     Developmentally dictated expression of heat shock factors:
            exclusive expression of HSF4 in the postnatal lens and its specific
            interaction with alphaB-crystallin heat shock promoter
  JOURNAL   J Biol Chem 279 (43), 44497-44503 (2004)
   PUBMED   15308659
  REMARK    GeneRIF: HSF4 binds to alphaB-crystallin, Hsp70, and Hsp82
            promoters and has a role in interacting with the canonical heat
            shock element of the alphaB-crystallin gene [HSF4]
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Jablonski,M.M., Lu,L., Wang,X., Chesler,E.J., Carps,E., Qi,S.,
            Gu,J. and Williams,R.W.
  TITLE     The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near
            cadherin 1
  JOURNAL   Mol Vis 10, 577-587 (2004)
   PUBMED   15343150
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Bu,L., Jin,Y., Shi,Y., Chu,R., Ban,A., Eiberg,H., Andres,L.,
            Jiang,H., Zheng,G., Qian,M., Cui,B., Xia,Y., Liu,J., Hu,L.,
            Zhao,G., Hayden,M.R. and Kong,X.
  TITLE     Mutant DNA-binding domain of HSF4 is associated with autosomal
            dominant lamellar and Marner cataract
  JOURNAL   Nat Genet 31 (3), 276-278 (2002)
   PUBMED   12089525
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001075468.1, XM_214668.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760475,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1514
                     /gene="Hsf4"
                     /note="heat shock transcription factor 4"
                     /db_xref="GeneID:291960"
                     /db_xref="RGD:1310808"
     exon            1..190
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1338
                     /gene="Hsf4"
                     /codon_start=1
                     /product="heat shock factor protein 4"
                     /protein_id="NP_001099647.1"
                     /db_xref="GeneID:291960"
                     /db_xref="RGD:1310808"
                     /translation="MGAGRRPRHRPPHPLEPDGFRKVVSIEQGGLLRPERDHVEFQHP
                     SFVRGCEQLLERVRRKVPALRGDDTRWRPEDLGRLLGEVQALRGVQESTEARLQELRQ
                     QNEILWREVVTLRQSHSQQHRVIGKLIQCLFGPLQTGPSSTGAKRKLSLMLDEGSACS
                     ASAKFNACPVSGALLQDPYFIQSPSTCSPSQRPPWASALTGPEGLSSLTSQKTAHLLK
                     DTGFLPPVLAGAPPPLPVAVVQAILEGKGSFSPEGPRSIQQPEPRGPREVPDRGTLGL
                     DRGNRSPESLLPPVLLRPPPETVEPMDALGPSLHGREWTLMDLDMELSLMQPLAPERA
                     EAELTVKDLTSSGVGKDHTLGTPLMLDVQADLEGAALSVPGALTLYNATESNASYLDP
                     GASPSSP"
     exon            191..318
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            319..443
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..519
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            520..584
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            585..687
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            688..826
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..950
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1047
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1113
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1183
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1514
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactttcacg gctttgacaa gcccgcagcg gccgggctgg aacgctgagc ccggccgaga
       61 ctgcgccatg caggaagcgc cagctgcgct gcccacggag ccaggcccca gcccggtacc
      121 tgccttcctc ggcaagctat gggcgctggt aggcgaccca ggcaccgacc acctcatccg
      181 ctggagcccg atggttttcg gaaggtggtg agcatcgagc aaggtggcct gctaagacca
      241 gagcgtgacc acgttgagtt tcagcatccg agcttcgtgc gaggctgtga gcagctactg
      301 gagcgcgtgc gccgcaaggt acctgcgctg cgaggtgatg acactcgatg gcgtcctgaa
      361 gacctgggcc gactgctggg agaggtgcaa gctttgaggg gagtgcagga gagcacggag
      421 gcacggctgc aggaactcag gcagcagaac gagatcttgt ggcgagaggt ggtgacgctg
      481 cggcagagcc acagtcagca gcaccgggtc atcggcaagc taatccagtg cctgtttggg
      541 ccacttcaga cagggcccag cagtacagga gccaagagaa agctgtccct aatgctagat
      601 gaggggagtg catgttcagc atctgccaaa ttcaatgcct gccctgtgtc tggtgctctg
      661 ctccaggacc cctactttat ccagtcgcct tctacttgca gcccctccca gagaccaccg
      721 tgggcctcag ccctcacagg gccagagggc ctatcatctc tgacatccca gaagactgcc
      781 catctcctga aggacacagg ctttctccct ccagtgctgg caggagcacc cccaccgctg
      841 cccgtggctg tggtgcaggc catcctggaa gggaaaggga gcttcagccc tgaggggccc
      901 aggagcatac aacagcctga accaaggggc cccagggagg tacctgacag gggaactctg
      961 ggcctggatc gcggtaaccg gagcccagag agtctgctgc cccccgtgct gcttcggcct
     1021 ccccctgaaa ctgtggagcc catggatgcg ctgggtccta gcctgcatgg acgagaatgg
     1081 accttgatgg atctggacat ggagttgtct ctgatgcagc ctttggctcc agagagggct
     1141 gaagctgagc tgacagtcaa ggacttgact tcttcaggtg tagggaaaga ccacacgctg
     1201 ggaaccccac tcatgctaga tgttcaggcg gatttggagg gtgcagcact atcggtgcct
     1261 ggggctttaa ccctgtacaa tgccaccgag agcaatgctt cctacttgga tcctggagcc
     1321 agtccctcct ctccctgaga tctgcacccc tctgaaaaag cctggctaag gagccagcac
     1381 gcaacagcac acccctttag gcttcctggc gcccccgccc ccgccctggg aggtgagcga
     1441 agccctccta tatgtgacag cctctctcca ctaccccagt gaaccctgca acataaactg
     1501 cattccctac tctg
//
