LOCUS       NM_024393               2415 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus heat shock transcription factor 1 (Hsf1), mRNA.
ACCESSION   NM_024393 XM_001061027 XM_001075095
VERSION     NM_024393.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2415)
  AUTHORS   He,Y.F., Hu,X.M., Khan,M.A., Yu,B.Y., Sheng,Y.C., Xiao,X.Z.,
            Wan,X.X., Tan,S.P. and Xiong,K.
  TITLE     HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis
            in a Sepsis Model
  JOURNAL   Mediators Inflamm 2023, 2252255 (2023)
   PUBMED   36741074
  REMARK    GeneRIF: HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced
            Pyroptosis in a Sepsis Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2415)
  AUTHORS   Li,L., Li,Y., He,B., Li,H., Ji,H., Wang,Y., Zhu,Z., Hu,Y., Zhou,Y.,
            Yang,T., Sun,C., Yuan,Y. and Wang,Y.
  TITLE     HSF1 is involved in suppressing A1 phenotype conversion of
            astrocytes following spinal cord injury in rats
  JOURNAL   J Neuroinflammation 18 (1), 205 (2021)
   PUBMED   34530848
  REMARK    GeneRIF: HSF1 is involved in suppressing A1 phenotype conversion of
            astrocytes following spinal cord injury in rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2415)
  AUTHORS   Martin,T.G., Tawfik,S., Moravec,C.S., Pak,T.R. and Kirk,J.A.
  TITLE     BAG3 expression and sarcomere localization in the human heart are
            linked to HSF-1 and are differentially affected by sex and disease
  JOURNAL   Am J Physiol Heart Circ Physiol 320 (6), H2339-H2350 (2021)
   PUBMED   33989081
  REMARK    GeneRIF: BAG3 expression and sarcomere localization in the human
            heart are linked to HSF-1 and are differentially affected by sex
            and disease.
REFERENCE   4  (bases 1 to 2415)
  AUTHORS   Mun,G.I., Choi,E., Lee,Y. and Lee,Y.S.
  TITLE     Decreased expression of FBXW7 by ERK1/2 activation in
            drug-resistant cancer cells confers transcriptional activation of
            MDR1 by suppression of ubiquitin degradation of HSF1
  JOURNAL   Cell Death Dis 11 (5), 395 (2020)
   PUBMED   32457290
  REMARK    GeneRIF: Decreased expression of FBXW7 by ERK1/2 activation in
            drug-resistant cancer cells confers transcriptional activation of
            MDR1 by suppression of ubiquitin degradation of HSF1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2415)
  AUTHORS   Bhatti,M., Dinn,S., Miskiewicz,E.I. and MacPhee,D.J.
  TITLE     Expression of heat shock factor 1, heat shock protein 90 and
            associated signaling proteins in pregnant rat myometrium:
            Implications for myometrial proliferation
  JOURNAL   Reprod Biol 19 (4), 374-385 (2019)
   PUBMED   31522994
  REMARK    GeneRIF: localized to both the cytoplasm and nuclei of myometrial
            cells in both muscle layers throughout gestation
REFERENCE   6  (bases 1 to 2415)
  AUTHORS   Cahill,C.M., Waterman,W.R., Xie,Y., Auron,P.E. and Calderwood,S.K.
  TITLE     Transcriptional repression of the prointerleukin 1beta gene by heat
            shock factor 1
  JOURNAL   J Biol Chem 271 (40), 24874-24879 (1996)
   PUBMED   8926278
REFERENCE   7  (bases 1 to 2415)
  AUTHORS   Baler,R., Zou,J. and Voellmy,R.
  TITLE     Evidence for a role of Hsp70 in the regulation of the heat shock
            response in mammalian cells
  JOURNAL   Cell Stress Chaperones 1 (1), 33-39 (1996)
   PUBMED   9222587
REFERENCE   8  (bases 1 to 2415)
  AUTHORS   Green,M., Schuetz,T.J., Sullivan,E.K. and Kingston,R.E.
  TITLE     A heat shock-responsive domain of human HSF1 that regulates
            transcription activation domain function
  JOURNAL   Mol Cell Biol 15 (6), 3354-3362 (1995)
   PUBMED   7760831
REFERENCE   9  (bases 1 to 2415)
  AUTHORS   Zuo,J., Baler,R., Dahl,G. and Voellmy,R.
  TITLE     Activation of the DNA-binding ability of human heat shock
            transcription factor 1 may involve the transition from an
            intramolecular to an intermolecular triple-stranded coiled-coil
            structure
  JOURNAL   Mol Cell Biol 14 (11), 7557-7568 (1994)
   PUBMED   7935471
REFERENCE   10 (bases 1 to 2415)
  AUTHORS   Baler,R., Dahl,G. and Voellmy,R.
  TITLE     Activation of human heat shock genes is accompanied by
            oligomerization, modification, and rapid translocation of heat
            shock transcription factor HSF1
  JOURNAL   Mol Cell Biol 13 (4), 2486-2496 (1993)
   PUBMED   8455624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_001061027.1, XM_001075095.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.29643.1,
                                           SRR26643298.40607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000007.1  110076710-110077024
            316-424             JAXUCZ010000007.1  110098466-110098574
            425-561             JAXUCZ010000007.1  110098947-110099083
            562-686             JAXUCZ010000007.1  110099289-110099413
            687-762             JAXUCZ010000007.1  110100043-110100118
            763-824             JAXUCZ010000007.1  110100192-110100253
            825-921             JAXUCZ010000007.1  110100376-110100472
            922-1058            JAXUCZ010000007.1  110100578-110100714
            1059-1328           JAXUCZ010000007.1  110100848-110101117
            1329-1434           JAXUCZ010000007.1  110102353-110102458
            1435-1500           JAXUCZ010000007.1  110102536-110102601
            1501-1570           JAXUCZ010000007.1  110102672-110102741
            1571-2415           JAXUCZ010000007.1  110102821-110103665
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2415
                     /gene="Hsf1"
                     /note="heat shock transcription factor 1"
                     /db_xref="GeneID:79245"
                     /db_xref="RGD:620913"
     exon            1..315
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1776
                     /gene="Hsf1"
                     /codon_start=1
                     /product="heat shock factor protein 1"
                     /protein_id="NP_077369.1"
                     /db_xref="GeneID:79245"
                     /db_xref="RGD:620913"
                     /translation="MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSF
                     HVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHP
                     CFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLA
                     MKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSSS
                     AHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSP
                     LASPGRSIDERPLSSSTLVRVKEEPPSPPHSPRVLEASPGRPASMDTPLSPTAFIDSI
                     LRESEPTPAASNTAPMDTTGAQAPAPPAPSTPEKCLSVACLDKNELSDHLDAMDSNLD
                     NLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEA
                     ENSNADSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTI
                     SLLTGTEPHKAKDPTVS"
     exon            316..424
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..561
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..686
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..762
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..824
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..921
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1058
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1328
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1434
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1500
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1570
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..2415
                     /gene="Hsf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcctgcgc acaggaggta caggtctggc cctagcgaga gcgcgccggt cgcaagatgg
       61 ctgcggccat gcgaggcctt gctgtgtgtg cgcagcgggc ggcggagcgg cccggacatc
      121 aggggcagcg acgacactag ctcagccttc agccactctt ctagaacgcc accccagcct
      181 ctgcctgctt cttcggagat ggatctggct gtgggccccg gtgcagcggg gcccagcaac
      241 gtcccggcct tcctaaccaa gctgtggacc ctcgtgagcg acccggacac agacgcgctc
      301 atctgctgga gcccgagtgg gaacagcttc cacgtgtttg accagggcca gtttgccaag
      361 gaggtgctgc ccaagtactt caagcacaac aacatggcca gctttgtgcg gcagctcaac
      421 atgtatggct tccgaaaagt agtccacatt gagcagggtg gcctggtcaa gcctgagagg
      481 gatgacaccg agttccagca tccatgtttc ctgcgtggcc aggaacagct ccttgagaat
      541 atcaagagga aagtgaccag cgtgtccacc ctgaagagtg aggacataaa aatacgccag
      601 gacagtgtca ccaggctgtt gacagatgtg cagctgatga aggggaaaca ggagtgtatg
      661 gactccaagc tcctggccat gaagcacgag aacgaggccc tgtggcggga ggtggccagc
      721 cttcggcaga agcatgccca gcagcaaaaa gttgtcaaca agctcatcca attcctgatc
      781 tcactggtgc agtcgaaccg gatcctgggg gtgaagagaa agatccctct gatgttgagt
      841 gacagcagct cagcacactc tgtgcccaag tatggtcgac agtactccct ggagcatgtc
      901 catggtcccg gcccatactc agctccatct ccagcctaca gcagctctag cctttactcc
      961 tctgatgctg tcaccagctc tgggcccata atctccgata tcactgagct ggctcccacc
     1021 agccctttgg cctccccagg caggagcata gatgagaggc ctctgtccag cagcaccctg
     1081 gtccgtgtca aggaagagcc ccccagccca cctcatagcc ctcgggtact ggaggcaagc
     1141 cctgggcgcc cagcctccat ggatacccct ttgtccccaa ctgccttcat tgactccatc
     1201 cttcgagaga gcgaacctac ccctgctgcc tcaaacacag cccctatgga cacaaccgga
     1261 gcccaagccc ctgcaccccc agccccctcc acccctgaga agtgcctcag cgtagcctgc
     1321 ctagacaaga acgagctaag tgatcacctg gatgccatgg actccaacct ggacaacctg
     1381 cagaccatgc tgacaagcca cggcttcagt gtggacacca gtgccctgct ggacctgttc
     1441 agcccctcgg tgaccatgcc cgacatgagc ctgcctgacc tggacagcag cctggccagc
     1501 attcaggaac ttctatctcc ccaagagcct cccaggccta ttgaggcaga gaatagtaac
     1561 gccgactcag gaaagcagct ggtgcactac acggctcagc ctctgttcct gctggaccct
     1621 gatgctgtgg acacagggag cagtgaactg cctgtgctct ttgagctggg ggagagctcc
     1681 tacttctctg agggagatga ctacacggat gatcccacca tctctcttct gacgggcact
     1741 gaaccccaca aagccaagga ccccactgtc tcctagaggt ttcagttgtc aggctggctt
     1801 gggcctggcc cccagcctat tcctaggaca cggctggtcc tggggagaca agacagttgg
     1861 gtagtccagg gaatcctagg tcaagccagc acaaccccag tggagcacag atgggacttg
     1921 ggcttgggca gtaccttgga tcaagaggaa gatcctgaag gctgcatacc tgctgccttc
     1981 accccagccc caggtctgct ctctgggtca gagcttcaca gccacacttg gactgaccct
     2041 gcaggttgtt cataaaattg tattttggat ttttacatga gagtcccctt taacccttca
     2101 caaataaata tatatataca tacatatata tatatatata catgcacacg gagatgggca
     2161 gatgataaac aggttctact gtggcctcct gtgtgtttcc tcctgccctg agggatctgg
     2221 aaggtgggga tgtaggcagg gagttcagaa cttactacat gtctccttgg aaaaatacag
     2281 atacctgtga taccccctag accaaccttg atctacagaa ctagtatttg ctcacagctt
     2341 tttctttagg ggaccaatct ggcccatgct gttgtcagca agagtgttct gcatggccat
     2401 gctggacacg ttggc
//
