LOCUS       NM_001398675            1849 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus hydroxy-delta-5-steroid dehydrogenase, 3 beta-
            and steroid delta-isomerase 7 (Hsd3b7), transcript variant 1, mRNA.
ACCESSION   NM_001398675 XM_006230212
VERSION     NM_001398675.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Yi,T., Wang,X., Kelly,L.M., An,J., Xu,Y., Sailer,A.W.,
            Gustafsson,J.A., Russell,D.W. and Cyster,J.G.
  TITLE     Oxysterol gradient generation by lymphoid stromal cells guides
            activated B cell movement during humoral responses
  JOURNAL   Immunity 37 (3), 535-548 (2012)
   PUBMED   22999953
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Maeda,Y., Nagatomo,H., Kuroki,N., Nagatomo,J., Uchiyama,F.,
            Shimozono,K., Kohno,Y. and Chijiiwa,K.
  TITLE     Bile acid biosynthesis during liver regeneration: enzyme activities
            of cholesterol 7alpha-hydroxylase and
            3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats
  JOURNAL   Ann Clin Lab Sci 35 (3), 323-328 (2005)
   PUBMED   16081591
  REMARK    GeneRIF: results suggest that the mechanisms of regulation of these
            bile acid metabolizing enzymes are significantly different during
            liver regeneration
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Cheng,J.B., Jacquemin,E., Gerhardt,M., Nazer,H., Cresteil,D.,
            Heubi,J.E., Setchell,K.D. and Russell,D.W.
  TITLE     Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid
            oxidoreductase deficiency in 16 patients with loss of bile acid
            synthesis and liver disease
  JOURNAL   J Clin Endocrinol Metab 88 (4), 1833-1841 (2003)
   PUBMED   12679481
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Schwarz,M., Wright,A.C., Davis,D.L., Nazer,H., Bjorkhem,I. and
            Russell,D.W.
  TITLE     The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid
            oxidoreductase is mutated in progressive intrahepatic cholestasis
  JOURNAL   J Clin Invest 106 (9), 1175-1184 (2000)
   PUBMED   11067870
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Hayashi,Y., Kiyono,T., Fujita,M. and Ishibashi,M.
  TITLE     Isolation of a novel cDNA whose corresponding mRNA is accumulated
            in growth-arrested confluent but not in growing sub-confluent rat
            3Y1 cells
  JOURNAL   Biochim Biophys Acta 1352 (2), 145-150 (1997)
   PUBMED   9199244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 21, 2021 this sequence version replaced XM_006230212.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.4538.1,
                                           SRR26643298.5466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000001.1  191842688-191842744
            58-229              JAXUCZ010000001.1  191843093-191843264
            230-385             JAXUCZ010000001.1  191843474-191843629
            386-494             JAXUCZ010000001.1  191843844-191843952
            495-594             JAXUCZ010000001.1  191844026-191844125
            595-757             JAXUCZ010000001.1  191844243-191844405
            758-1849            JAXUCZ010000001.1  191844828-191845919
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1849
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 7"
                     /db_xref="GeneID:246211"
                     /db_xref="RGD:628727"
     exon            1..57
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /inference="alignment:Splign:2.1.0"
     exon            58..229
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1173
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /EC_number="1.1.1.181"
                     /note="isoform 1 is encoded by transcript variant 1; 3
                     beta-hydroxysteroid dehydrogenase type 7; 3-beta-HSD VII;
                     c(27) 3-beta-HSD; confluent 3Y1 cell-associated 2; 3
                     beta-hydroxysteroid dehydrogenase type VII;
                     3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase;
                     cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase type 7
                     isoform 1"
                     /protein_id="NP_001385604.1"
                     /db_xref="GeneID:246211"
                     /db_xref="RGD:628727"
                     /translation="MADSAQVPALVYLVTGGCGFLGEHIVRMLLEWEPRLRELRVFDL
                     HLSSWLEELKTGPVQVTAIQGDVTQAHEVAAAMAGSHVVIHTAGLVDVFGKASPETIH
                     KVNVQGTQNVIDACVQTGTRLLVYTSSMEVVGPNVKGHPFYRGNEDTPYEAIHRHPYP
                     CSKALAEQLVLEANGRKVNGGLPLVTCALRPTGIYGEGHQVMRDFYHQGLRFGGRLFR
                     AIPASVEHGRVYVGNVAWMHILVARELEQRAALMGGQVYFCYDKSPYKSYEDFNMEFL
                     SPCGLRLIGTHPLLPYWLLVLLAALNALLQWLLRPLVLYTPLLNPYTLAVANTTFTVS
                     TNKAQRHFGYKPLFSWEESRARTIHWVQAMEGSAW"
     exon            230..385
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /inference="alignment:Splign:2.1.0"
     exon            386..494
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..594
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..757
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1849
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccaggac acaacatctc ccagtggcca gtttgggcgc cctgggactt cctacagctg
       61 gccatggcag actctgcaca ggtgccagca ctggtatacc tggtcacagg tggctgtggc
      121 ttcctggggg agcatattgt tcgaatgctg ctggagtggg agcccaggct ccgggagctg
      181 cgtgtctttg acctgcacct gagttcttgg ctggaggagc tgaaaacagg gcctgtgcag
      241 gtgactgcca tccaggggga tgtgactcag gcccacgagg tggcagcagc catggctgga
      301 tctcatgtgg tcatccatac agctgggctg gtagatgtgt ttgggaaggc cagtccagag
      361 accatccaca aagtcaatgt gcagggcaca cagaatgtga ttgacgcttg tgtgcagacc
      421 gggactcggc tcctggtcta cacgagtagc atggaagtgg tagggcctaa tgtcaagggc
      481 caccccttct acaggggcaa tgaagacacc ccatatgagg ccatccacag gcatccctac
      541 ccatgtagca aggccctcgc tgagcagttg gtcctcgagg ccaatggaag gaaggtcaat
      601 ggagggctac ccctggtgac atgtgccctt cgacccacgg gcatttatgg tgaaggtcat
      661 caggtcatga gagacttcta tcaccaggga ctgcgctttg gaggtcggct gtttcgggcc
      721 atcccagctt ccgtggagca tggtcgggtc tacgttggca atgtggcttg gatgcatata
      781 ctggtggccc gagagctgga gcagcgggca gcactcatgg gtggccaggt gtatttctgc
      841 tatgataagt caccttataa aagctacgag gacttcaaca tggagtttct gagtccctgt
      901 ggacttcggc tgataggcac ccacccactg ctgccctact ggctactggt gctgctggct
      961 gccctcaacg ctctgctgca gtggctgctt cggccgctgg tgctgtacac acccctgctg
     1021 aatccctaca ctctggctgt ggccaacacc acctttactg tcagcaccaa caaggcacag
     1081 cgccatttcg gctacaagcc cctcttctca tgggaagaga gcagggcccg caccattcac
     1141 tgggtgcagg ccatggaggg ttccgcctgg tgatggcagg gccaggaact ggagaccact
     1201 gtggcacact ccaggtcctg agcccccaaa agcctggacg gagagaaatg gctacctttt
     1261 gaagctgctg actctgctag acacatcagg actgtgctat ggaccctgcc acgtctgtgc
     1321 ctggttcata tcccagtctc caagttctag gacagagtct gggtgcaggc ctatctttgg
     1381 tgccaactcg ggcctgccag ctagttggca aaaactgatt cctgaatggt ctcactaccc
     1441 cttcctgttt ctagtttctc aagcagggag ggacagagac tccagaggtc tcttgctggc
     1501 ctgcttactc caggtaccat tttcagacct ggctcctgcc acatctggtt ctccattttc
     1561 ttttcttttt ttttttcttt ttcttttttt tttatttttt tcggagctgg ggaccgaacc
     1621 cagggccttg cgcttgctag gcaagcgctc taccactgag ctaaatcgtt ttcttaagtg
     1681 tatctctttt agacattttt cttttaattt gctttaaaga aaactgaagg aatgaatggt
     1741 tttccatgtc ttgccttctt aacaaattca gctatgatat tgttagcttc ctccctgagg
     1801 atgccaacct gtatctggcc acacctggat taaaatcctt tgccaagtc
//
