LOCUS       NP_001385604             369 aa            linear   ROD 30-MAR-2024
DEFINITION  3 beta-hydroxysteroid dehydrogenase type 7 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001385604 XP_006230274
VERSION     NP_001385604.1
DBSOURCE    REFSEQ: accession NM_001398675.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 369)
  AUTHORS   Yi,T., Wang,X., Kelly,L.M., An,J., Xu,Y., Sailer,A.W.,
            Gustafsson,J.A., Russell,D.W. and Cyster,J.G.
  TITLE     Oxysterol gradient generation by lymphoid stromal cells guides
            activated B cell movement during humoral responses
  JOURNAL   Immunity 37 (3), 535-548 (2012)
   PUBMED   22999953
REFERENCE   2  (residues 1 to 369)
  AUTHORS   Maeda,Y., Nagatomo,H., Kuroki,N., Nagatomo,J., Uchiyama,F.,
            Shimozono,K., Kohno,Y. and Chijiiwa,K.
  TITLE     Bile acid biosynthesis during liver regeneration: enzyme activities
            of cholesterol 7alpha-hydroxylase and
            3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats
  JOURNAL   Ann Clin Lab Sci 35 (3), 323-328 (2005)
   PUBMED   16081591
  REMARK    GeneRIF: results suggest that the mechanisms of regulation of these
            bile acid metabolizing enzymes are significantly different during
            liver regeneration
REFERENCE   3  (residues 1 to 369)
  AUTHORS   Cheng,J.B., Jacquemin,E., Gerhardt,M., Nazer,H., Cresteil,D.,
            Heubi,J.E., Setchell,K.D. and Russell,D.W.
  TITLE     Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid
            oxidoreductase deficiency in 16 patients with loss of bile acid
            synthesis and liver disease
  JOURNAL   J Clin Endocrinol Metab 88 (4), 1833-1841 (2003)
   PUBMED   12679481
REFERENCE   4  (residues 1 to 369)
  AUTHORS   Schwarz,M., Wright,A.C., Davis,D.L., Nazer,H., Bjorkhem,I. and
            Russell,D.W.
  TITLE     The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid
            oxidoreductase is mutated in progressive intrahepatic cholestasis
  JOURNAL   J Clin Invest 106 (9), 1175-1184 (2000)
   PUBMED   11067870
REFERENCE   5  (residues 1 to 369)
  AUTHORS   Hayashi,Y., Kiyono,T., Fujita,M. and Ishibashi,M.
  TITLE     Isolation of a novel cDNA whose corresponding mRNA is accumulated
            in growth-arrested confluent but not in growing sub-confluent rat
            3Y1 cells
  JOURNAL   Biochim Biophys Acta 1352 (2), 145-150 (1997)
   PUBMED   9199244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 21, 2021 this sequence version replaced XP_006230274.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.4538.1,
                                           SRR26643298.5466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     Protein         1..369
                     /product="3 beta-hydroxysteroid dehydrogenase type 7
                     isoform 1"
                     /EC_number="1.1.1.181"
                     /note="3 beta-hydroxysteroid dehydrogenase type 7;
                     3-beta-HSD VII; c(27) 3-beta-HSD; confluent 3Y1
                     cell-associated 2; 3 beta-hydroxysteroid dehydrogenase
                     type VII; 3-beta-hydroxy-Delta(5)-C27 steroid
                     oxidoreductase; cholest-5-ene-3-beta,7-alpha-diol
                     3-beta-dehydrogenase"
                     /calculated_mol_wt=41032
     Region          11..361
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(16,18..19,21,43..45,86..88,127..129,159,163,
                     191..194)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187535"
     Site            order(105,129,159,163)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..369
                     /gene="Hsd3b7"
                     /gene_synonym="Cca2"
                     /coded_by="NM_001398675.1:64..1173"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:246211"
                     /db_xref="RGD:628727"
ORIGIN      
        1 madsaqvpal vylvtggcgf lgehivrmll eweprlrelr vfdlhlsswl eelktgpvqv
       61 taiqgdvtqa hevaaamags hvvihtaglv dvfgkaspet ihkvnvqgtq nvidacvqtg
      121 trllvytssm evvgpnvkgh pfyrgnedtp yeaihrhpyp cskalaeqlv leangrkvng
      181 glplvtcalr ptgiygeghq vmrdfyhqgl rfggrlfrai pasvehgrvy vgnvawmhil
      241 vareleqraa lmggqvyfcy dkspyksyed fnmeflspcg lrligthpll pywllvllaa
      301 lnallqwllr plvlytplln pytlavantt ftvstnkaqr hfgykplfsw eesrartihw
      361 vqamegsaw
//
