LOCUS       NM_001042619            1629 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus hydroxy-delta-5-steroid dehydrogenase, 3 beta-
            and steroid delta-isomerase 3 (Hsd3b3), mRNA.
ACCESSION   NM_001042619 XM_001061878 XM_001061941
VERSION     NM_001042619.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Zurvarra,F.M., Salvetti,N.R., Mason,J.I., Velazquez,M.M.,
            Alfaro,N.S. and Ortega,H.H.
  TITLE     Disruption in the expression and immunolocalisation of steroid
            receptors and steroidogenic enzymes in letrozole-induced polycystic
            ovaries in rat
  JOURNAL   Reprod Fertil Dev 21 (7), 827-839 (2009)
   PUBMED   19698287
  REMARK    GeneRIF: Letrozole-induced polycystic ovaries showed increased
            3beta-HSD expression.
REFERENCE   2  (bases 1 to 1629)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   3  (bases 1 to 1629)
  AUTHORS   Naville,D., Keeney,D.S., Jenkin,G., Murry,B.A., Head,J.R. and
            Mason,J.I.
  TITLE     Regulation of expression of male-specific rat liver microsomal 3
            beta-hydroxysteroid dehydrogenase
  JOURNAL   Mol Endocrinol 5 (8), 1090-1100 (1991)
   PUBMED   1944305
REFERENCE   4  (bases 1 to 1629)
  AUTHORS   Zhao,H.F., Labrie,C., Simard,J., de Launoit,Y., Trudel,C.,
            Martel,C., Rheaume,E., Dupont,E., Luu-The,V., Pelletier,G. et al.
  TITLE     Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4 isomerase cDNAs and differential tissue-specific
            expression of the corresponding mRNAs in steroidogenic and
            peripheral tissues
  JOURNAL   J Biol Chem 266 (1), 583-593 (1991)
   PUBMED   1985917
REFERENCE   5  (bases 1 to 1629)
  AUTHORS   Lachance,Y., Luu-The,V., Labrie,C., Simard,J., Dumont,M., de
            Launoit,Y., Guerin,S., Leblanc,G. and Labrie,F.
  TITLE     Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4-isomerase gene and its expression in mammalian cells
  JOURNAL   J Biol Chem 265 (33), 20469-20475 (1990)
   PUBMED   2243100
  REMARK    Erratum:[J Biol Chem. 1992 Feb 15;267(5):3551.. PMID: 1737804]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M38179.1.
            
            On or before Jul 30, 2006 this sequence version replaced
            XM_001061941.1, XM_001061878.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M38179.1, EX488740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1629
                     /gene="Hsd3b3"
                     /gene_synonym="Hsd3b"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 3"
                     /db_xref="GeneID:682974"
                     /db_xref="RGD:1592771"
     exon            1..90
                     /gene="Hsd3b3"
                     /gene_synonym="Hsd3b"
                     /inference="alignment:Splign:2.1.0"
     exon            91..297
                     /gene="Hsd3b3"
                     /gene_synonym="Hsd3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1274
                     /gene="Hsd3b3"
                     /gene_synonym="Hsd3b"
                     /EC_number="1.1.1.145"
                     /EC_number="5.3.3.1"
                     /note="3-beta-HSD II; 3 beta-hydroxysteroid
                     dehydrogenase/Delta 5-->4-isomerase type II; 3
                     beta-hydroxysteroid dehydrogenase/delta-5-delta-4
                     isomerase type II; 3 beta-hydroxysteroid
                     dehydrogenase/delta-5-delta-4 isomerase type 3"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type 2"
                     /protein_id="NP_001036084.1"
                     /db_xref="GeneID:682974"
                     /db_xref="RGD:1592771"
                     /translation="MPGWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETK
                     EEFSKLQTKAKVTMLEGDILDAQYLRRACQGISVVIHTASVMDFSRVLPRQTILDVNL
                     KGTQNLLEAGIHASVPAFIYCSTVDVAGPNSYKKTILNGREEEHHESTWSNPYPYSKK
                     MAEKAVLAANGSILKNGGTLHTCALRPMYIYGERGQFLSRIIIMALKNKGVLNVTGKF
                     SIVNPVYVGNVAWAHILAARGLRDPKKSQNIQGQFYYISDDTPHQSYDDLNCTLSKEW
                     GLRLDSSWSLPLPLLYWLAFLLETVSFLLRPFYNYRPPFNCHLVTLSNSKFTFSYKKA
                     QRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ"
     exon            298..462
                     /gene="Hsd3b3"
                     /gene_synonym="Hsd3b"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1629
                     /gene="Hsd3b3"
                     /gene_synonym="Hsd3b"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1629
                     /gene="Hsd3b3"
                     /gene_synonym="Hsd3b"
ORIGIN      
        1 gaagaccagg gaataaaact ctagtcctga tctgagggct gaggagagcc gcatccagac
       61 tttctcatct gattttgaac aatttagcag ccctcctcag gatcaccata catcaccact
      121 gctccgcctg tgatctgttt cctgggtgga ccatgcctgg atggagctgc ctggtgacag
      181 gagcaggagg gtttgtgggc cagaggatca tccggatgtt ggtgcaggag aaagaactgc
      241 aggaggtcag ggctctggac aaagtcttca gaccagaaac caaggaggaa ttctctaagc
      301 tgcagacaaa ggccaaggtg acaatgttag aaggagatat tctggatgcc cagtacctga
      361 ggagagcgtg ccagggcatc tctgttgtca tccacacggc ttctgtcatg gatttctcac
      421 gtgtcctacc caggcagacc atcctagatg tcaatctgaa aggtacccag aacctattgg
      481 aggccggtat ccacgctagt gtgccagcct tcatctactg cagcacagtt gacgttgcag
      541 ggcccaactc ctacaagaag accatcctga atggccgtga ggaagagcat catgaaagca
      601 catggtcaaa tccataccca tacagcaaaa agatggccga gaaggcagtg ctggcagcca
      661 atgggagcat cctgaaaaat ggtggcacac tgcatacttg tgccttaagg cccatgtaca
      721 tttatgggga gagaggtcaa ttcctttcta gaataataat tatggccctc aaaaataagg
      781 gtgttctgaa cgttactggc aaattctcca tagtcaatcc agtgtatgta ggcaatgtgg
      841 cctgggcaca tattctggct gccaggggcc ttcgagaccc caagaagtca caaaatatcc
      901 aaggacagtt ctactatatc tcagatgaca cccctcacca aagctatgat gatttaaatt
      961 gcaccctgag caaggaatgg ggcctccgcc ttgattccag ctggagcctt cctctgcccc
     1021 tgctctactg gcttgccttc ctgctggaaa ctgtgagctt cctgctgcgt ccattttaca
     1081 actataggcc accctttaac tgccacttgg tcacactgtc aaatagcaag ttcactttct
     1141 cctacaagaa agctcagaga gatctgggct atgagccact tgtcagctgg gaggaagcca
     1201 agcagaaaac ctcggagtgg atcgggacac tagtggagca gcacagggag acactggaca
     1261 caaagtctca gtgacagaaa gggggcaagg atgtggttct gggtgttacc aggtcctcca
     1321 gctaggacag aggcacaatc caggtcctga tgccctcttt tgacacagac tctaactcta
     1381 tgtctttatg acttcactgg aagccttgct agtccacaag ctttcttccc taatcccctg
     1441 tccagagaca cacaggtagt tatgcctcag ctgctgtgac caaaggcttc agcaatgaca
     1501 atttcctgtc acttagagct gagtattact tttctgttcc ccttcaagtc ctaaatcaca
     1561 ccctgctttg gttaaaactc actgctttat aaagcaagag agaaacagca ataaatactg
     1621 taatgcctt
//
