LOCUS       NM_017265               1697 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus hydroxy-delta-5-steroid dehydrogenase, 3 beta-
            and steroid delta-isomerase 2 (Hsd3b2), mRNA.
ACCESSION   NM_017265 XM_342302
VERSION     NM_017265.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Kimoto,T., Ishii,H., Higo,S., Hojo,Y. and Kawato,S.
  TITLE     Semicomprehensive analysis of the postnatal age-related changes in
            the mRNA expression of sex steroidogenic enzymes and sex steroid
            receptors in the male rat hippocampus
  JOURNAL   Endocrinology 151 (12), 5795-5806 (2010)
   PUBMED   21047951
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Elumalai,P., Krishnamoorthy,G., Selvakumar,K., Arunkumar,R.,
            Venkataraman,P. and Arunakaran,J.
  TITLE     Studies on the protective role of lycopene against polychlorinated
            biphenyls (Aroclor 1254)-induced changes in StAR protein and
            cytochrome P450 scc enzyme expression on Leydig cells of adult rats
  JOURNAL   Reprod Toxicol 27 (1), 41-45 (2009)
   PUBMED   19071209
  REMARK    GeneRIF: Lycopene protects against PCB-induced changes in Leydig
            cellular StAR protein, cytochrome P450 scc expression and activity
            of 3beta-HSD.
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Nampoothiri,L.P. and Gupta,S.
  TITLE     Biochemical effects of gestational coexposure to lead and cadmium
            on reproductive performance, placenta, and ovary
  JOURNAL   J Biochem Mol Toxicol 22 (5), 337-344 (2008)
   PUBMED   18972398
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   O'Shaughnessy,P.J., Morris,I.D. and Baker,P.J.
  TITLE     Leydig cell re-generation and expression of cell signaling
            molecules in the germ cell-free testis
  JOURNAL   Reproduction 135 (6), 851-858 (2008)
   PUBMED   18502897
REFERENCE   5  (bases 1 to 1697)
  AUTHORS   Szoltys,M., Slomczynska,M., Galas,J., Duda,M. and Sakiewicz,A.
  TITLE     Expression of androgen receptor and 3beta-hydroxysteroid
            dehydrogenase in corpora lutea during pregnancy in the rat
  JOURNAL   Reprod Fertil Dev 19 (2), 356-365 (2007)
   PUBMED   17257522
  REMARK    GeneRIF: The present studies showed differences in AR and 3beta-HSD
            distribution within various generations of corpora lutea (CL) and
            within particular regions of the same young CL.
REFERENCE   6  (bases 1 to 1697)
  AUTHORS   Simard,J., Couet,J., Durocher,F., Labrie,Y., Sanchez,R., Breton,N.,
            Turgeon,C. and Labrie,F.
  TITLE     Structure and tissue-specific expression of a novel member of the
            rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase
            (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in
            the skin
  JOURNAL   J Biol Chem 268 (26), 19659-19668 (1993)
   PUBMED   7690038
REFERENCE   7  (bases 1 to 1697)
  AUTHORS   Rheaume,E., Lachance,Y., Zhao,H.F., Breton,N., Dumont,M., de
            Launoit,Y., Trudel,C., Luu-The,V., Simard,J. and Labrie,F.
  TITLE     Structure and expression of a new complementary DNA encoding the
            almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta
            4-isomerase in human adrenals and gonads
  JOURNAL   Mol Endocrinol 5 (8), 1147-1157 (1991)
   PUBMED   1944309
REFERENCE   8  (bases 1 to 1697)
  AUTHORS   Naville,D., Keeney,D.S., Jenkin,G., Murry,B.A., Head,J.R. and
            Mason,J.I.
  TITLE     Regulation of expression of male-specific rat liver microsomal 3
            beta-hydroxysteroid dehydrogenase
  JOURNAL   Mol Endocrinol 5 (8), 1090-1100 (1991)
   PUBMED   1944305
REFERENCE   9  (bases 1 to 1697)
  AUTHORS   Zhao,H.F., Labrie,C., Simard,J., de Launoit,Y., Trudel,C.,
            Martel,C., Rheaume,E., Dupont,E., Luu-The,V., Pelletier,G. et al.
  TITLE     Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4 isomerase cDNAs and differential tissue-specific
            expression of the corresponding mRNAs in steroidogenic and
            peripheral tissues
  JOURNAL   J Biol Chem 266 (1), 583-593 (1991)
   PUBMED   1985917
REFERENCE   10 (bases 1 to 1697)
  AUTHORS   Lachance,Y., Luu-The,V., Labrie,C., Simard,J., Dumont,M., de
            Launoit,Y., Guerin,S., Leblanc,G. and Labrie,F.
  TITLE     Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4-isomerase gene and its expression in mammalian cells
  JOURNAL   J Biol Chem 265 (33), 20469-20475 (1990)
   PUBMED   2243100
  REMARK    Erratum:[J Biol Chem. 1992 Feb 15;267(5):3551.. PMID: 1737804]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089937.1.
            
            On Mar 27, 2005 this sequence version replaced NM_017265.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089937.1, FQ148380.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN16676810
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1697
                     /gene="Hsd3b2"
                     /gene_synonym="Hsd3b1; Hsd3b2l1; Hsd3b6"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 2"
                     /db_xref="GeneID:29632"
                     /db_xref="RGD:67377"
     exon            1..156
                     /gene="Hsd3b2"
                     /gene_synonym="Hsd3b1; Hsd3b2l1; Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
     exon            157..363
                     /gene="Hsd3b2"
                     /gene_synonym="Hsd3b1; Hsd3b2l1; Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1340
                     /gene="Hsd3b2"
                     /gene_synonym="Hsd3b1; Hsd3b2l1; Hsd3b6"
                     /EC_number="1.1.1.145"
                     /EC_number="5.3.3.1"
                     /note="3 beta-hydroxysteroid dehydrogenase 6; 3-beta-HSD
                     IV; 3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type IV; hydroxysteroid dehydrogenase-6
                     delta<5>-3-beta; Hydroxy-delta-5-steroid dehydrogenase 3
                     beta- and steroid delta-isomerase; hydroxy-delta-5-steroid
                     dehydrogenase, 3 beta- and steroid delta-isomerase 6"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type 4"
                     /protein_id="NP_058961.4"
                     /db_xref="GeneID:29632"
                     /db_xref="RGD:67377"
                     /translation="MPGWSCLVTGAGGFLGQRIVQLLVQEKDLKEVRVLDKVFRPETR
                     EEFFNLGTSIKVTVLEGDILDTQCLRRACQGISVVIHTAALIDVTGVNPRQTILDVNL
                     KGTQNLLEACVQASVPAFIYCSTVDVAGPNSYKKIILNGHEEEHHESTWSNPYPYSKK
                     MAEKAVLAANGSILKNGGTLHTCALRPMYIYGERSPFLSVMILAALKSKGILNVTGKF
                     SIANPVYVGNVAWAHILAARGLRDPKKSQNVQGQFYYISDDTPHQSYDDLNYTLSKEW
                     GLHLDSSWSLPLPLLYWLAFLLEIVSFFLHPVYNYRPSFNRHLVTLSNSKFTFSYKKA
                     QRDLGYKPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ"
     exon            364..528
                     /gene="Hsd3b2"
                     /gene_synonym="Hsd3b1; Hsd3b2l1; Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
     exon            529..1668
                     /gene="Hsd3b2"
                     /gene_synonym="Hsd3b1; Hsd3b2l1; Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtgctg ctgctgctgg atcctttgca gagaccagaa cccccctttc caagcttgta
       61 tcattgtgga ctagggacca gctaggttcc agaaatcttc cttccacgat tccagctcct
      121 ggttgggact actgatacac cacaccctgt ggctgagcat ctccagggtc accgtgcatt
      181 aaccccactc ccactgtgat ctgcttcctg tgttgaccat gcctgggtgg agctgcctgg
      241 tgactggagc aggagggttt ttgggccaga ggatcgtcca gttgttggtg caggagaaag
      301 atctgaagga ggtcagggtc ctggacaagg tcttcagacc agaaaccaga gaagaattct
      361 tcaacctagg gacaagcatc aaggtgacag tgttggaagg agacattctt gacacccagt
      421 gcctgaggag agcgtgccag ggcatctctg ttgtcatcca cactgccgcc ctcattgatg
      481 tcacaggtgt caatcccagg cagaccatcc tagatgtcaa tctgaaaggt acccagaatc
      541 tgttggaggc ctgtgtccaa gctagtgtgc cagccttcat ctactgcagc acagttgacg
      601 ttgcagggcc caactcctac aagaagatca tcctgaatgg ccatgaggaa gagcatcatg
      661 aaagcacatg gtcaaatcca tacccataca gcaaaaagat ggccgagaag gcagtgctgg
      721 cagccaatgg gagcatcctg aaaaatggtg gcacattgca tacttgtgcc ttaaggccca
      781 tgtacattta tggggagaga agtccattcc tttctgtcat gatacttgcg gccctcaaaa
      841 gtaagggtat tctgaatgtt actggcaaat tctccatagc caatccagtg tatgtaggca
      901 atgtggcctg ggcacatatt ctggctgcca ggggccttcg agaccccaag aagtcacaaa
      961 atgtccaagg acagttctac tacatctcag atgacacccc tcaccaaagc tatgatgatt
     1021 taaattatac cctgagcaag gaatggggcc tccaccttga ttccagttgg agccttcctc
     1081 tgcccctgct ctactggctt gccttcctgc tggaaattgt gagcttcttt ctgcatccag
     1141 tgtacaacta taggccatcc tttaaccgcc acttggtcac actgtcaaat agcaagttca
     1201 ctttctccta caagaaagct cagagagatc tgggctataa gccacttgtc agctgggagg
     1261 aagccaagca gaaaacctcg gagtggatcg ggacactagt ggagcagcac agggagacat
     1321 tggacacaaa gtctcagtaa tgggaagagg gcagggacat ggtcctgggt gtttactgga
     1381 tcctccagca aggacagaca tataagccag gtcatgctgc cttctttcaa cacagaatcc
     1441 agtttagtgc cttcaagtca tcagaagaag ccttgccagc cactgaccca gccatgagct
     1501 gtctttctga aatacctgcc cagagataca cagcttccta agcacctttt gtacctcaga
     1561 gctctctcca ttcttttctc tccccatcca aagcatgtct aaccttcaga aaagtctgct
     1621 tgctttgtga agcccaatag aaggaacaat aaatatttgt caacacttaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaa
//
