LOCUS       NM_001007719            1640 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus hydroxy-delta-5-steroid dehydrogenase, 3 beta-
            and steroid delta-isomerase 1 (Hsd3b1), mRNA.
ACCESSION   NM_001007719 XM_346637
VERSION     NM_001007719.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Brzoskwinia,M., Pardyak,L., Kaminska,A., Tworzydlo,W., Hejmej,A.,
            Marek,S., Bilinski,S.M. and Bilinska,B.
  TITLE     Flutamide treatment reveals a relationship between steroidogenic
            activity of Leydig cells and ultrastructure of their mitochondria
  JOURNAL   Sci Rep 11 (1), 13772 (2021)
   PUBMED   34215832
  REMARK    GeneRIF: Flutamide treatment reveals a relationship between
            steroidogenic activity of Leydig cells and ultrastructure of their
            mitochondria.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Lee,J.H., Lee,M., Ahn,C., Kang,H.Y., Tran,D.N. and Jeung,E.B.
  TITLE     Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene
            Diepoxide-Induced Ovarian Failure Model
  JOURNAL   Int J Environ Res Public Health 14 (2), 161 (2017)
   PUBMED   28208728
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Bilbao,M.G., Di Yorio,M.P. and Faletti,A.G.
  TITLE     Different levels of leptin regulate different target enzymes
            involved in progesterone synthesis
  JOURNAL   Fertil Steril 99 (5), 1460-1466 (2013)
   PUBMED   23332974
  REMARK    GeneRIF: Leptin, which inhibits the ovulatory process, caused a
            significant reduction in the ovarian expression of P450scc without
            changes in StAR or 3betaHSD.
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Kostic,T.S., Stojkov,N.J., Bjelic,M.M., Mihajlovic,A.I.,
            Janjic,M.M. and Andric,S.A.
  TITLE     Pharmacological doses of testosterone upregulated androgen receptor
            and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase
            and impaired leydig cells steroidogenesis in adult rats
  JOURNAL   Toxicol Sci 121 (2), 397-407 (2011)
   PUBMED   21427060
  REMARK    GeneRIF: The upregulation of AR and 3betaHSD in
            testosterone-impaired Leydig cells steroidogenesis could be the
            possible mechanism that maintains and prevents loss of
            steroidogenic function.
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Keeney,D.S. and Mason,J.I.
  TITLE     Regulation of expression of 3beta-hydroxysteroid dehydrogenase is
            mediated by cAMP in rat Leydig cells and H540 rat Leydig tumor
            cells
  JOURNAL   J Steroid Biochem Mol Biol 43 (8), 915-922 (1992)
   PUBMED   22217836
  REMARK    GeneRIF: Data suggest that cAMP mediates transcriptional regulation
            of Hsd3b1 in Leydig cells (i.e., both normal Leydig cells and
            Leydig tumor cells); luteinizing hormone may be required to
            maintain expression of testicular Hsd3b1.
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Keeney,D.S. and Mason,J.I.
  TITLE     Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta
            5----4-isomerase: regulation by luteinizing hormone and forskolin
            in Leydig cells of adult rats
  JOURNAL   Endocrinology 130 (4), 2007-2015 (1992)
   PUBMED   1312436
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   de Launoit,Y., Zhao,H.F., Belanger,A., Labrie,F. and Simard,J.
  TITLE     Expression of liver-specific member of the 3 beta-hydroxysteroid
            dehydrogenase family, an isoform possessing an almost exclusive
            3-ketosteroid reductase activity
  JOURNAL   J Biol Chem 267 (7), 4513-4517 (1992)
   PUBMED   1537836
REFERENCE   8  (bases 1 to 1640)
  AUTHORS   de Launoit,Y., Simard,J., Durocher,F. and Labrie,F.
  TITLE     Androgenic 17 beta-hydroxysteroid dehydrogenase activity of
            expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4 isomerase
  JOURNAL   Endocrinology 130 (1), 553-555 (1992)
   PUBMED   1309351
REFERENCE   9  (bases 1 to 1640)
  AUTHORS   Dupont,E., Rheaume,E., Simard,J., Luu-The,V., Labrie,F. and
            Pelletier,G.
  TITLE     Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4
            isomerase in the rat adrenal as revealed by immunocytochemistry and
            in situ hybridization
  JOURNAL   Endocrinology 129 (5), 2687-2692 (1991)
   PUBMED   1935797
REFERENCE   10 (bases 1 to 1640)
  AUTHORS   Naville,D., Keeney,D.S., Jenkin,G., Murry,B.A., Head,J.R. and
            Mason,J.I.
  TITLE     Regulation of expression of male-specific rat liver microsomal 3
            beta-hydroxysteroid dehydrogenase
  JOURNAL   Mol Endocrinol 5 (8), 1090-1100 (1991)
   PUBMED   1944305
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086578.1.
            
            On Feb 15, 2005 this sequence version replaced NM_001007719.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086578.1, M38178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN16093044
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1640
                     /gene="Hsd3b1"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 1"
                     /db_xref="GeneID:360348"
                     /db_xref="RGD:1308676"
     exon            1..90
                     /gene="Hsd3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..297
                     /gene="Hsd3b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1274
                     /gene="Hsd3b1"
                     /EC_number="1.1.1.145"
                     /EC_number="5.3.3.1"
                     /EC_number="1.1.1.270"
                     /EC_number="1.1.1.210"
                     /note="3 beta-hydroxysteroid dehydrogenase 1; 3-beta-HSD
                     I; 3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type I; hydroxysteroid dehydrogenase-1,
                     delta<5>-3-beta; 3betaHSD; steroid Delta-isomerase;
                     delta-5-3-ketosteroid isomerase; dihydrotestosterone
                     oxidoreductase; 3-beta-hydroxysteroid 3-dehydrogenase;
                     3-beta-hydroxy-5-ene steroid dehydrogenase;
                     3-beta-hydroxy-Delta(5)-steroid dehydrogenase"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type 1"
                     /protein_id="NP_001007720.3"
                     /db_xref="GeneID:360348"
                     /db_xref="RGD:1308676"
                     /translation="MPGWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETK
                     EEFSKLQTKAKVTMLEGDILDAQYLRRACQGISVVIHTAAVIDVSHVLPRQTILDVNL
                     KGTQNILEACVEASVPAFIYCSTVDVAGPNSYKKIILNGHEEEHHESTWSDAYPYSKR
                     MAEKAVLAANGSILKNGGTLHTCALRPMYIYGERSPFLSVMILAALKNKGILNVTGKF
                     SIANPVYVGNVAWAHILAARGLRDPKKSQNVQGQFYYISDDTPHQSYDDLNCTLSKEW
                     GLRLDSSWSLPLPLLYWLAFLLETVSFLLRPFYNYRPPFNCHLVTLSNSKFTFSYKKA
                     QRDLGYVPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ"
     exon            298..462
                     /gene="Hsd3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1614
                     /gene="Hsd3b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaccagg gaataaaact ctagtcctga tctgagggct gaggagagcc gcatccagac
       61 tttctcatct gattttgaac aatttagcag ccctcctcag gatcaccata catcaccact
      121 gctccgcctg tgatctgttt cctgggttga ccatgcctgg atggagctgc ctggtgacag
      181 gagcaggagg gtttgtgggc cagaggatca tccggatgtt ggtgcaggag aaagaactgc
      241 aggaggtcag ggctctggac aaagtcttca gaccagaaac caaggaggaa ttctctaagc
      301 tgcagacaaa ggccaaggtg acaatgttag aaggagatat tctggatgcc cagtacctga
      361 ggagagcgtg ccagggcatc tctgttgtca tccacaccgc tgctgtcatt gatgtctcac
      421 atgtcctacc caggcagacc atcctagatg tcaatctgaa aggtacccag aacatattgg
      481 aggcctgcgt cgaagccagt gtgccagcct tcatctactg cagcacagtt gacgttgcag
      541 ggcccaactc ctacaagaag atcatcctga atggccatga ggaagagcat catgaaagca
      601 catggtcaga tgcataccca tacagcaaaa ggatggccga gaaggcagtg ctggcagcca
      661 atgggagcat cctgaaaaat ggtggcacac tgcatacttg tgccttaagg cccatgtaca
      721 tttatgggga gagaagtcca ttcctttctg tcatgatact tgcggccctc aaaaataagg
      781 gtattctgaa tgttactggc aaattctcca tagccaatcc agtgtatgta ggcaatgtgg
      841 cctgggcaca tattctggct gccaggggcc ttcgagaccc caagaagtca caaaatgtcc
      901 aaggacagtt ctactacatc tcagatgaca cccctcacca aagctatgat gatttaaatt
      961 gcaccctgag caaggaatgg ggcctccgcc ttgattccag ctggagcctt cctctgcccc
     1021 tgctctactg gcttgccttc ctgctggaaa ctgtgagctt cctgctgcgt ccattttaca
     1081 actataggcc accctttaac tgccacttgg tcacactgtc aaatagcaag ttcactttct
     1141 cctacaagaa agctcagaga gatctgggct atgtgccact tgtcagctgg gaggaagcca
     1201 agcagaaaac ctcggagtgg atcgggacac tagtggagca gcacagggag acactggaca
     1261 caaagtctca gtgacagaaa gggggcaagg atgtggttct gggtgttacc aggtcctcca
     1321 gctaggacag aggcacaatc caggtcctga tgccctcttt tgacacagac tctaactcta
     1381 tgtctttatg acttcactgg aagccttgct agtccacaag ctttcttccc taatcccctg
     1441 tccagagaca cacaggtagt tgtgcctcag ctgctgtgac caaaggcttc agcaatgaca
     1501 atttcctgtc acttagagct gagtattact tttctgttcc tcttcaagtc ctaaatcaca
     1561 tcctgctttg gttatatctc attgatttat aaagcaataa atattgtaat gcctaaaaaa
     1621 aaaaaaaaaa aaaaaaaaaa
//
