LOCUS       NM_017235               1704 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 7
            (Hsd17b7), transcript variant 1, mRNA.
ACCESSION   NM_017235
VERSION     NM_017235.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1704)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1704)
  AUTHORS   Matsuoka,H., Uchino,Y., Choshi,M., Nakamura,T. and Michihara,A.
  TITLE     Stroke-prone spontaneously hypertensive rats have reduced
            hydroxysteroid 17-beta dehydrogenase 7 levels for low cholesterol
            biosynthesis
  JOURNAL   Clin Exp Pharmacol Physiol 47 (2), 255-262 (2020)
   PUBMED   31587341
  REMARK    GeneRIF: Stroke-prone spontaneously hypertensive rats have reduced
            hydroxysteroid 17-beta dehydrogenase 7 levels for low cholesterol
            biosynthesis.
REFERENCE   3  (bases 1 to 1704)
  AUTHORS   Pascual-Mathey,L.I., Rojas-Duran,F., Aranda-Abreu,G.E., Manzo,J.,
            Herrera-Covarrubias,D., Munoz-Zavaleta,D.A., Garcia,L.I. and
            Hernandez,M.E.
  TITLE     Effect of hyperprolactinemia on PRL-receptor expression and
            activation of Stat and Mapk cell signaling in the prostate of
            long-term sexually-active rats
  JOURNAL   Physiol Behav 157, 170-177 (2016)
   PUBMED   26873413
  REMARK    GeneRIF: This study showed that Effect of hyperprolactinemia on
            PRL-receptor expression in the prostate of long-term
            sexually-active rats.
REFERENCE   4  (bases 1 to 1704)
  AUTHORS   Salilew-Wondim,D., Wang,Q., Tesfaye,D., Schellander,K., Hoelker,M.,
            Hossain,M.M. and Tsang,B.K.
  TITLE     Polycystic ovarian syndrome is accompanied by repression of gene
            signatures associated with biosynthesis and metabolism of steroids,
            cholesterol and lipids
  JOURNAL   J Ovarian Res 8, 24 (2015)
   PUBMED   25887459
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1704)
  AUTHORS   Stottmann,R.W., Moran,J.L., Turbe-Doan,A., Driver,E., Kelley,M. and
            Beier,D.R.
  TITLE     Focusing forward genetics: a tripartite ENU screen for
            neurodevelopmental mutations in the mouse
  JOURNAL   Genetics 188 (3), 615-624 (2011)
   PUBMED   21515572
REFERENCE   6  (bases 1 to 1704)
  AUTHORS   Marijanovic,Z., Laubner,D., Moller,G., Gege,C., Husen,B.,
            Adamski,J. and Breitling,R.
  TITLE     Closing the gap: identification of human 3-ketosteroid reductase,
            the last unknown enzyme of mammalian cholesterol biosynthesis
  JOURNAL   Mol Endocrinol 17 (9), 1715-1725 (2003)
   PUBMED   12829805
REFERENCE   7  (bases 1 to 1704)
  AUTHORS   Nokelainen,P., Peltoketo,H., Vihko,R. and Vihko,P.
  TITLE     Expression cloning of a novel estrogenic mouse 17
            beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase
            (m17HSD7), previously described as a prolactin receptor-associated
            protein (PRAP) in rat
  JOURNAL   Mol Endocrinol 12 (7), 1048-1059 (1998)
   PUBMED   9658408
REFERENCE   8  (bases 1 to 1704)
  AUTHORS   Duan,W.R., Parmer,T.G., Albarracin,C.T., Zhong,L. and Gibori,G.
  TITLE     PRAP, a prolactin receptor associated protein: its gene expression
            and regulation in the corpus luteum
  JOURNAL   Endocrinology 138 (8), 3216-3221 (1997)
   PUBMED   9231770
REFERENCE   9  (bases 1 to 1704)
  AUTHORS   Duan,W.R., Linzer,D.I. and Gibori,G.
  TITLE     Cloning and characterization of an ovarian-specific protein that
            associates with the short form of the prolactin receptor
  JOURNAL   J Biol Chem 271 (26), 15602-15607 (1996)
   PUBMED   8663045
REFERENCE   10 (bases 1 to 1704)
  AUTHORS   McLean,M.P., Nelson,S., Parmer,T., Khan,I., Steinschneider,A.,
            Puryear,T. and Gibori,G.
  TITLE     Identification and characterization of an abundant phosphoprotein
            specific to the large luteal cell
  JOURNAL   Endocrinology 126 (4), 1796-1805 (1990)
   PUBMED   2318142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1, FM073997.1 and FN803430.1.
            
            On Sep 4, 2012 this sequence version replaced NM_017235.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44803.1, SRR26643288.49894.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 JAXUCZ010000013.1  84722748-84722754   c
            8-703               FM073997.1         1-696
            704-1030            FN803430.1         317-643
            1031-1704           JAXUCZ010000013.1  84706002-84706675   c
FEATURES             Location/Qualifiers
     source          1..1704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1704
                     /gene="Hsd17b7"
                     /note="hydroxysteroid (17-beta) dehydrogenase 7"
                     /db_xref="GeneID:29540"
                     /db_xref="RGD:2837"
     exon            1..104
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1074
                     /gene="Hsd17b7"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.270"
                     /EC_number="1.1.1.210"
                     /note="3-keto-steroid reductase; prolactin
                     receptor-associated protein; PRAP; 17-beta-HSD 7; PRL
                     receptor-associated protein; estradiol
                     17-beta-dehydrogenase 7; 17-beta-hydroxysteroid
                     dehydrogenase 7; hydroxysteroid dehydrogenase 17 beta,
                     type 7; dihydrotestosterone oxidoreductase"
                     /codon_start=1
                     /product="3-keto-steroid reductase/17-beta-hydroxysteroid
                     dehydrogenase 7"
                     /protein_id="NP_058931.1"
                     /db_xref="GeneID:29540"
                     /db_xref="RGD:2837"
                     /translation="MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKAGAV
                     RDALLASHPSAEVSIVQMDVSNLQSVVRGAEEVKRRFQRLDYLYLNAGIMPNPQLNLK
                     AFFCGIFSRNVIHMFSTAEGLLTQNDKITADGFQEVFETNLFGHFILIRELEPLLCHS
                     DNPSQLIWTSSRNAKKSNFSLEDIQHAKGQEPYSSSKYATDLLNVALNRNFNQKGLYS
                     SVTCPGVVMTNLTYGILPPFVWTLLLPVIWLLRFFAHAFTVTPYNGAEALVWLFHQKP
                     ESLNPLTKYLSGTTGLGTNYVKGQKMDVDEDTAEKFYKTLLELEKQVRITIQKSDHHS
                     "
     exon            105..308
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     exon            309..401
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     exon            402..516
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     exon            517..711
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     exon            712..816
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     exon            817..873
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     exon            874..972
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1704
                     /gene="Hsd17b7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatcgtggtt ctggctgaga gctgctgaga accgtggacg gggtggaact ccgctgcaag
       61 gcgtgaatga tgcggaaggt ggttttgatt accggggcga gcagtggcat tgggctggcc
      121 ctttgcggtc ggctgttggc agaagacgat gaccttcacc tgtgtttggc gtgtaggaac
      181 ctgagcaaag caggagctgt ccgtgatgcc ctgctggcct ctcacccctc cgccgaggtc
      241 agcattgtgc agatggatgt cagcaacttg cagtcggtgg tccggggagc agaggaagtc
      301 aagcgaaggt ttcaaagatt agactactta tacctgaacg ccggaatcat gcctaacccc
      361 cagctaaacc tcaaagcgtt tttctgtggt atcttttcaa gaaatgtgat tcatatgttc
      421 tccacagcgg aaggactttt gacccagaat gacaagatta ctgctgatgg gttccaggag
      481 gtgtttgaaa ccaatctctt tggccacttt atcctgattc gggaactgga accacttctc
      541 tgccacagtg acaacccctc tcagctcatc tggacgtctt ctcgaaatgc aaagaagtct
      601 aacttcagtc ttgaggacat ccagcacgcc aaaggccagg aaccttacag ctcttccaaa
      661 tacgctactg acctcctgaa tgtagctttg aacaggaatt tcaatcagaa gggtctgtat
      721 tccagtgtga cgtgtccagg ggtcgtaatg accaatctga cgtatgggat tctgcccccc
      781 tttgtttgga cgttgcttct cccggtgata tggctccttc gcttttttgc acatgcgttc
      841 actgtgacac cgtacaatgg tgcagaggca ttggtgtggc ttttccacca aaaaccggag
      901 tctctcaacc ctctgaccaa atacttgagc ggcaccacag gattagggac taattatgtc
      961 aagggccaaa agatggacgt agatgaagac actgcagaaa agttctacaa gaccttactg
     1021 gagctagaaa agcaagtcag gatcaccatt cagaaatcag atcaccacag ctgacagcga
     1081 cgttccccag agcatccagt ccgcgtacgc cctggtgcgc gcagctttct atcatactgg
     1141 gtgatacatg tttgtagtaa accataagcc atgatgatct ctcctcctac tttttagaat
     1201 ggtctccaag actgcgtggg tgcacttgtg agaaaggcgt cgcaaagcag aggggccagc
     1261 tgaataccct ccagagtagt gtcctgtcag aattgctaga ggcttcccgc agagcatcct
     1321 cggatagcat tctgccaccc ggagcccagt agtttagact tgcgtgatgg ggacacagta
     1381 cagcctgaat cttcttttag tcccagcgag gagaggcaat gctactgact aggacttcta
     1441 cttcctttgc ttttctccat gatccctttt tttttttttt aactctcttt acattcttca
     1501 tatgctgctt cggataatct catacgttgt ctgagcacgt ggccccacgt gaccgcccac
     1561 gcagtcattt tcaggaacaa agtatgtttg tgtttgggcc acaagcatgg tttctgatct
     1621 ttaataacat ccacagatgt attcattatg aacagcttat cgtcacgatc atagttcact
     1681 ggaattaaac ttgtagcaaa catc
//
