LOCUS       NM_173305               1537 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 6
            (Hsd17b6), mRNA.
ACCESSION   NM_173305 XM_001081802
VERSION     NM_173305.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1537)
  AUTHORS   Biswas,M.G. and Russell,D.W.
  TITLE     Expression cloning and characterization of oxidative 17beta- and
            3alpha-hydroxysteroid dehydrogenases from rat and human prostate
  JOURNAL   J Biol Chem 272 (25), 15959-15966 (1997)
   PUBMED   9188497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jun 4, 2021 this sequence version replaced NM_173305.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088104.1, SRR26643286.21210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JAXUCZ010000007.1  850704-850950       c
            248-574             JAXUCZ010000007.1  840785-841111       c
            575-833             JAXUCZ010000007.1  838079-838337       c
            834-997             JAXUCZ010000007.1  834686-834849       c
            998-1537            JAXUCZ010000007.1  831407-831946       c
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1537
                     /gene="Hsd17b6"
                     /gene_synonym="Hsd17b9"
                     /note="hydroxysteroid (17-beta) dehydrogenase 6"
                     /db_xref="GeneID:286964"
                     /db_xref="RGD:708343"
     exon            1..247
                     /gene="Hsd17b6"
                     /gene_synonym="Hsd17b9"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1215
                     /gene="Hsd17b6"
                     /gene_synonym="Hsd17b9"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.239"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="17-beta-HSD6; 3-alpha->beta-HSE;
                     3-alpha->beta-hydroxysteroid epimerase; oxidative 3-alpha
                     hydroxysteroid dehydrogenase; 17-beta-HSD 6;
                     hydroxysteroid (17-beta) dehydrogenase 9; oxidative 17
                     beta hydroxysteroid dehydrogenase type 6; hydroxysteroid
                     17-beta dehydrogenase 6-like"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase type 6"
                     /protein_id="NP_775427.2"
                     /db_xref="GeneID:286964"
                     /db_xref="RGD:708343"
                     /translation="MITAPGHSLIMWFYLVTLVGLYYLLRWYRERQVVSHLHDKYVFI
                     TGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELKSKTSDRLETVILDVTNTDSISA
                     ATQWVKEHVGDKGLWGLVNNAGVFQAFAYIEWCRPEDCMSIFQVNLIGLAQVTLSMLF
                     LVKKARGRIVNVSSVLGRVALFGGFYSCSKYGVEAFSDVLRREIRDFGVKVSIIEPGS
                     FKTRMTDAELIIEKTKKTWEATPEHIRESYGQQFFDDFCNTTRRELKKCSTNLSLVTD
                     CMEHALTSKYPRTRYSAGWDARLFFIPLSYLPTSLVDCLLAISRRKPAQAV"
     exon            248..574
                     /gene="Hsd17b6"
                     /gene_synonym="Hsd17b9"
                     /inference="alignment:Splign:2.1.0"
     exon            575..833
                     /gene="Hsd17b6"
                     /gene_synonym="Hsd17b9"
                     /inference="alignment:Splign:2.1.0"
     exon            834..997
                     /gene="Hsd17b6"
                     /gene_synonym="Hsd17b9"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1537
                     /gene="Hsd17b6"
                     /gene_synonym="Hsd17b9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagaaagaa caaacagggc agaagaaagg tgatttcctc tttcctaaac ctggaacact
       61 ttaattctgt ccacaagggc agagtggtga actcccagca atctaggact caacctttag
      121 cctttagcct cactctgagg gttatggtga tcaattttcc tggatctgaa gacttggaca
      181 tggactgaga cctcagttac agacagcctg ttgtgagact tctcagcctc tatgattact
      241 gctcctggac attccctcat aatgtggttt tacctggtga ctcttgtggg cctttactac
      301 cttctgcgtt ggtatcgtga aaggcaggtg gtgagccatc tacatgacaa gtatgtcttc
      361 atcacgggtt gtgactctgg ctttgggaac ctgctggcca gacagctgga caggagaggc
      421 atgagggtgc tggctgcatg tctgactgag aagggagcag aggagctgaa gagcaagaca
      481 tctgacaggc tggagacagt gatccttgac gttaccaaca cagacagtat ttcagcagcc
      541 actcagtggg tgaaggagca tgttggagac aaaggactct ggggtttggt taataatgca
      601 ggtgtgtttc aagcatttgc ctacattgag tggtgccgac cggaggactg catgtctatc
      661 tttcaagtga acctcattgg tttggcacag gtgactctga gcatgctttt cctggtaaag
      721 aaggctcggg gcaggatcgt caacgtctcc agtgttttgg gaagagttgc attgtttgga
      781 ggattctaca gttgctccaa gtatggagtc gaggcatttt cggacgtgct aagacgtgag
      841 attcgagatt tcggggtgaa agtcagcata attgaacctg gaagcttcaa aacgagaatg
      901 actgacgcag agctaatcat tgagaaaacc aagaaaacct gggaggcaac ccctgagcac
      961 atcagggagt cctacggaca gcagtttttt gatgactttt gcaacaccac cagacgagaa
     1021 ctgaagaagt gcagcacgaa cctgagcctg gtcacagact gcatggagca cgctctgacc
     1081 tctaagtatc ctcgcacccg atactcagct ggctgggatg ccagactttt cttcatccct
     1141 ctgtcttatt tgcctacatc actggtagac tgcctactgg ccatatctag gcgcaagcca
     1201 gctcaggcag tctgaaggat cctgggtcgg cggctctggg aatgaagaaa caactcagtt
     1261 attcccagct caagctgtgt gcgctgacat actttcttgc ctaaaccacg taagggctgt
     1321 cttttcctct ctctacaccc acaggcacct ggcctcgctc tataaccctg gctggcagca
     1381 aactcataga aaacgtctgt ctctctctta atcaaggcgt ttgcattcca ggcgtacaaa
     1441 acttagtact aacttagcca ctttttcctg gggatatttc catattgtgt tattctttct
     1501 tgtcctatta aaaagtgtcc catagaagaa caattta
//
