LOCUS       NM_024392               2602 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 4
            (Hsd17b4), mRNA.
ACCESSION   NM_024392 XM_001056789
VERSION     NM_024392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2602)
  AUTHORS   Pan,L.C., Xiao,H.Y., Yin,W.J. and Lin,Z.
  TITLE     Correlation between HSD17B4 expression in rat liver cancer tissues
            and inflammation or proliferation
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (11), 3386-3393 (2018)
   PUBMED   29917219
  REMARK    GeneRIF: HSD17B4 is over-expressed in rat liver cancer tissues. Its
            expression was positively correlated with TNF-alpha, IL-6 and PCNA
            levels.
REFERENCE   2  (bases 1 to 2602)
  AUTHORS   Bjelic,M.M., Stojkov,N.J., Radovic,S.M., Baburski,A.Z.,
            Janjic,M.M., Kostic,T.S. and Andric,S.A.
  TITLE     Prolonged in vivo administration of testosterone-enanthate, the
            widely used and abused anabolic androgenic steroid, disturbs
            prolactin and cAMP signaling in Leydig cells of adult rats
  JOURNAL   J Steroid Biochem Mol Biol 149, 58-69 (2015)
   PUBMED   25603467
REFERENCE   3  (bases 1 to 2602)
  AUTHORS   Sokanovic,S.J., Janjic,M.M., Stojkov,N.J., Baburski,A.Z.,
            Bjelic,M.M., Andric,S.A. and Kostic,T.S.
  TITLE     Age related changes of cAMP and MAPK signaling in Leydig cells of
            Wistar rats
  JOURNAL   Exp Gerontol 58, 19-29 (2014)
   PUBMED   25019473
REFERENCE   4  (bases 1 to 2602)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   5  (bases 1 to 2602)
  AUTHORS   Kashiwayama,Y., Tomohiro,T., Narita,K., Suzumura,M., Glumoff,T.,
            Hiltunen,J.K., Van Veldhoven,P.P., Hatanaka,Y. and Imanaka,T.
  TITLE     Identification of a substrate-binding site in a peroxisomal
            beta-oxidation enzyme by photoaffinity labeling with a novel
            palmitoyl derivative
  JOURNAL   J Biol Chem 285 (34), 26315-26325 (2010)
   PUBMED   20566640
REFERENCE   6  (bases 1 to 2602)
  AUTHORS   Kurosawa,T., Sato,M., Yoshimura,T., Jiang,L.L., Hashimoto,T. and
            Tohma,M.
  TITLE     Stereospecific formation of (24R,25R)-3 alpha,7 alpha,12
            alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid catalyzed with a
            peroxisomal bifunctional D-3-hydroxyacyl-CoA
            dehydratase/D-3-hydroxyacyl-CoA dehydrogenase
  JOURNAL   Biol Pharm Bull 20 (3), 295-297 (1997)
   PUBMED   9084892
REFERENCE   7  (bases 1 to 2602)
  AUTHORS   Corton,J.C., Bocos,C., Moreno,E.S., Merritt,A., Marsman,D.S.,
            Sausen,P.J., Cattley,R.C. and Gustafsson,J.A.
  TITLE     Rat 17 beta-hydroxysteroid dehydrogenase type IV is a novel
            peroxisome proliferator-inducible gene
  JOURNAL   Mol Pharmacol 50 (5), 1157-1166 (1996)
   PUBMED   8913347
REFERENCE   8  (bases 1 to 2602)
  AUTHORS   Dieuaide-Noubhani,M., Novikov,D., Baumgart,E., Vanhooren,J.C.,
            Fransen,M., Goethals,M., Vandekerckhove,J., Van Veldhoven,P.P. and
            Mannaerts,G.P.
  TITLE     Further characterization of the peroxisomal 3-hydroxyacyl-CoA
            dehydrogenases from rat liver. Relationship between the different
            dehydrogenases and evidence that fatty acids and the C27 bile acids
            di- and tri-hydroxycoprostanic acids are metabolized by separate
            multifunctional proteins
  JOURNAL   Eur J Biochem 240 (3), 660-666 (1996)
   PUBMED   8856068
  REMARK    Erratum:[Eur J Biochem 1997 Jan 15;243(1-2):537]
REFERENCE   9  (bases 1 to 2602)
  AUTHORS   Jiang,L.L., Miyazawa,S. and Hashimoto,T.
  TITLE     Purification and properties of rat D-3-hydroxyacyl-CoA dehydratase:
            D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase
            bifunctional protein
  JOURNAL   J Biochem 120 (3), 633-641 (1996)
   PUBMED   8902630
REFERENCE   10 (bases 1 to 2602)
  AUTHORS   Adamski,J., Normand,T., Leenders,F., Monte,D., Begue,A.,
            Stehelin,D., Jungblut,P.W. and de Launoit,Y.
  TITLE     Molecular cloning of a novel widely expressed human 80 kDa 17
            beta-hydroxysteroid dehydrogenase IV
  JOURNAL   Biochem J 311 (Pt 2) (Pt 2), 437-443 (1995)
   PUBMED   7487879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U37486.1, BC072472.1 and BM391394.1.
            
            On Dec 11, 2007 this sequence version replaced NM_024392.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37486.1, X94978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               U37486.1           1-275
            276-2039            BC072472.1         266-2029
            2040-2508           BC072472.1         2078-2546
            2509-2602           BM391394.1         1-94                c
FEATURES             Location/Qualifiers
     source          1..2602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2602
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /note="hydroxysteroid (17-beta) dehydrogenase 4"
                     /db_xref="GeneID:79244"
                     /db_xref="RGD:621806"
     exon            1..107
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2257
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /EC_number="4.2.1.107"
                     /EC_number="4.2.1.119"
                     /EC_number="1.1.1.n12"
                     /note="DBP; MFE-2; 17-beta-HSD 4; D-bifunctional protein;
                     17-beta-hydroxysteroid dehydrogenase 4; multifunctional
                     protein 2; peroxisomal multifunctional enzyme type II"
                     /codon_start=1
                     /product="peroxisomal multifunctional enzyme type 2"
                     /protein_id="NP_077368.2"
                     /db_xref="GeneID:79244"
                     /db_xref="RGD:621806"
                     /translation="MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGD
                     FKGVGKGSSAADKVVEEIRRRGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGI
                     LRDRSFSRISDEDWDIIQRVHLRGSFQVTRAAWDHMKKQNYGRIIMTASASGIYGNFG
                     QANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNAGSRMTETVMPEDLVEALKPEYV
                     APLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWVKI
                     CDFSNASKPKSIQESTGGIIEVLHKIDSEGISQNHTGQVASADASGFAGVVGHKLPSF
                     SSSYTELQCIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSLMSGGLAE
                     VPGLSINFAKVLHGEQYLELYKPLPRSGELKCEAVIADILDKGSGIVIVMDVYSYSGK
                     ELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPSRPPDAVLRDTTSLNQAALYRLSG
                     DSNPLHIDPSFASIAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPV
                     YPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLVPTSGVSAQTPSEGGALQSA
                     LVFGEIGRRLKDVGREVVKKVNAVFEWHITKNGNVAAKWTIDLKNGSGEVYQGPAKGS
                     ADTTITISDEDFMEVVLGKLNPQNAFFSGRLKARGNIMLSQKLQMILKDYAKL"
     exon            108..161
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            162..269
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..329
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..351
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..398
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..483
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..671
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..763
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..788
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..917
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1018
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1255
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1307
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1379
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1483
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1549
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1619
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1726
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1813
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1900
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2039
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2167
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2584
                     /gene="Hsd17b4"
                     /gene_synonym="MFP-2; MPF-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcagtacc ccggccactg ccagtgtgtg cgtggtgcag gatagactca tggcttcgcc
       61 tctgaggttc gacgggcgtg tggtcctggt caccggcgcc gggggagggt tgggcagagc
      121 ttatgccctg gcttttgcag aaagaggagc attagttgtt gtgaatgact taggagggga
      181 cttcaaaggc gttgggaaag gctcttctgc cgcagacaag gtcgtggaag aaataagaag
      241 gagaggcggg aaagcggtgg ccaattacga ttcagtcgaa gcaggcgaga agcttgtgaa
      301 gacagcactg gacacattcg gcagaataga tgttgtggtg aacaatgctg ggatcctgag
      361 ggaccgttcc ttctctagga taagtgatga agactgggat ataattcaaa gagttcattt
      421 gcggggctcc ttccaagtga cccgggcagc atgggatcat atgaagaagc agaattatgg
      481 aagaatcatt atgacggcct cagcttctgg aatatacggc aactttggcc aggcaaatta
      541 tagtgctgca aagctgggcc ttctgggtct cgccaatact ctcgtgattg aaggcaggaa
      601 gaacaacatt cattgtaaca ccattgcccc aaacgctggg tcacggatga cagagacggt
      661 gatgccagaa gacctcgttg aagccctgaa gccagagtat gtggcaccgc tggtcctttg
      721 gctttgccat gagagctgtg aggaaaatgg tggcttgttt gaggttggag caggatggat
      781 tggaaaattg cgctgggaga ggaccctggg agccattgtc aggaagcgga atcagcccat
      841 gactcccgag gcagtgaggg acaactgggt gaagatctgt gacttcagca atgccagcaa
      901 gccgaagagc attcaagagt ccacaggtgg tataatcgaa gttttacata aaatagattc
      961 agaaggaatc tcacaaaatc acaccggtca agtggcatct gcagatgcat caggatttgc
     1021 tggcgtcgtt ggccacaaac ttccttcatt ttcttcttca tatacggaac tgcagtgcat
     1081 tatgtatgcc ctcggagtag gagcttcagt caaaaatcca aaggacttga agtttgttta
     1141 tgaagggagt gctgacttct cctgtttgcc tacatttgga gtcattgtcg ctcagaagtc
     1201 cttgatgagt ggaggcttag cagaggttcc tgggctgtca atcaactttg caaaggttct
     1261 tcatggggag cagtacttgg agttgtataa gccacttccc cgatcagggg aattaaaatg
     1321 tgaagcagtt attgctgaca tcctggataa aggctctggc atagtgattg ttatggacgt
     1381 ctattcttat tctggcaagg aacttatatg ctataatcag ttctctgtct tcgttgttgg
     1441 ctctggaggc tttggtggaa aacggacatc agaaaaactc aaagcagctg tagccgtacc
     1501 aagtcggcct ccagatgctg tactgagaga taccacttca ctgaatcagg ccgctctgta
     1561 ccgcctcagt ggagactcga atcctttaca cattgacccg agctttgcga gcattgccgg
     1621 ttttgagaaa cccatattac acggattatg tacttttggg ttttctgcaa ggcatgtttt
     1681 acagcagttt gcggataatg atgtgtcaag attcaaggcc attaaggttc gttttgccaa
     1741 accagtgtat ccaggacaaa ctctacaaac tgagatgtgg aaggaaggaa acagaattca
     1801 ttttcaaacc aaggtccaag agactggaga cattgtcatt tccaatgcat atgtggatct
     1861 tgttcctaca tctggagttt ccgctcagac accttctgag ggtggagcac tgcagagtgc
     1921 tcttgtattt ggggaaatag gtcgacgcct caaggatgtt ggacgtgagg tggtaaagaa
     1981 agtaaatgct gtatttgaat ggcatatcac gaaaaatggg aatgttgcag ccaagtggac
     2041 cattgacctg aagaacggct ctggagaggt ttaccaaggc cctgccaaag gctctgctga
     2101 cacgaccatc acaatttctg atgaggattt catggaagtg gtcctgggca agcttaaccc
     2161 acagaatgcc ttcttcagtg gcagactgaa ggcccgagga aacatcatgc tgagccagaa
     2221 gctacagatg attctgaaag actatgccaa gctctgaagg acccactgcg tgctttaata
     2281 aaaccagaat cattacgttc tgtctacgca gtcatgctcc agccttcttt gaaacgatcc
     2341 acggtaatgt gcagcagaaa ttgcttaaca ttttcagatt cagataactt tcagattttc
     2401 attttctact aatttttcac atattatttt tacaaggaac tgtaatctag ctagcaaata
     2461 attgttctgt tcatagatct gtatcttaat aaaaaaaaaa tcaaccaatc tggtttctct
     2521 agactttgta atagtgttag cactgaatgg agaattgaat gaataaaagc cactttacct
     2581 cgtcaaaaaa aaaaaaaaaa aa
//
