LOCUS       NM_054007               1111 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 3
            (Hsd17b3), mRNA.
ACCESSION   NM_054007
VERSION     NM_054007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1111)
  AUTHORS   Hassan,M.A., El Bohy,K.M., El Sharkawy,N.I., Imam,T.S.,
            El-Metwally,A.E., Hamed Arisha,A., Mohammed,H.A. and
            Abd-Elhakim,Y.M.
  TITLE     Iprodione and chlorpyrifos induce testicular damage, oxidative
            stress, apoptosis and suppression of steroidogenic- and
            spermatogenic-related genes in immature male albino rats
  JOURNAL   Andrologia 53 (4), e13978 (2021)
   PUBMED   33586219
REFERENCE   2  (bases 1 to 1111)
  AUTHORS   Suleiman,J.B., Nna,V.U., Othman,Z.A., Zakaria,Z., Bakar,A.B.A. and
            Mohamed,M.
  TITLE     Orlistat attenuates obesity-induced decline in steroidogenesis and
            spermatogenesis by up-regulating steroidogenic genes
  JOURNAL   Andrology 8 (5), 1471-1485 (2020)
   PUBMED   32438512
REFERENCE   3  (bases 1 to 1111)
  AUTHORS   Engeli,R.T., Rhouma,B.B., Sager,C.P., Tsachaki,M., Birk,J.,
            Fakhfakh,F., Keskes,L., Belguith,N. and Odermatt,A.
  TITLE     Biochemical analyses and molecular modeling explain the functional
            loss of 17beta-hydroxysteroid dehydrogenase 3 mutant G133R in three
            Tunisian patients with 46, XY Disorders of Sex Development
  JOURNAL   J Steroid Biochem Mol Biol 155 (Pt A), 147-154 (2016)
   PUBMED   26545797
REFERENCE   4  (bases 1 to 1111)
  AUTHORS   Latif,S.A., Shen,M., Ge,R.S., Sottas,C.M., Hardy,M.P. and
            Morris,D.J.
  TITLE     Role of 11beta-OH-C(19) and C(21) steroids in the coupling of
            11beta-HSD1 and 17beta-HSD3 in regulation of testosterone
            biosynthesis in rat Leydig cells
  JOURNAL   Steroids 76 (7), 682-689 (2011)
   PUBMED   21440566
  REMARK    GeneRIF: 11beta-HSD1 is enzymatically coupled to 17beta-HSD3
REFERENCE   5  (bases 1 to 1111)
  AUTHORS   Kimoto,T., Ishii,H., Higo,S., Hojo,Y. and Kawato,S.
  TITLE     Semicomprehensive analysis of the postnatal age-related changes in
            the mRNA expression of sex steroidogenic enzymes and sex steroid
            receptors in the male rat hippocampus
  JOURNAL   Endocrinology 151 (12), 5795-5806 (2010)
   PUBMED   21047951
REFERENCE   6  (bases 1 to 1111)
  AUTHORS   Murugesan,P., Muthusamy,T., Balasubramanian,K. and Arunakaran,J.
  TITLE     Effects of vitamins C and E on steroidogenic enzymes mRNA
            expression in polychlorinated biphenyl (Aroclor 1254) exposed adult
            rat Leydig cells
  JOURNAL   Toxicology 232 (3), 170-182 (2007)
   PUBMED   17280759
REFERENCE   7  (bases 1 to 1111)
  AUTHORS   Swathy,S.S., Panicker,S. and Indira,M.
  TITLE     Effect of exogenous selenium on the testicular toxicity induced by
            ethanol in rats
  JOURNAL   Indian J Physiol Pharmacol 50 (3), 215-224 (2006)
   PUBMED   17193892
REFERENCE   8  (bases 1 to 1111)
  AUTHORS   Jana,K., Jana,S. and Samanta,P.K.
  TITLE     Effects of chronic exposure to sodium arsenite on
            hypothalamo-pituitary-testicular activities in adult rats: possible
            an estrogenic mode of action
  JOURNAL   Reprod Biol Endocrinol 4, 9 (2006)
   PUBMED   16483355
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1111)
  AUTHORS   Tsai-Morris,C.H., Khanum,A., Tang,P.Z. and Dufau,M.L.
  TITLE     The rat 17beta-hydroxysteroid dehydrogenase type III: molecular
            cloning and gonadotropin regulation
  JOURNAL   Endocrinology 140 (8), 3534-3542 (1999)
   PUBMED   10433209
REFERENCE   10 (bases 1 to 1111)
  AUTHORS   Geissler,W.M., Davis,D.L., Wu,L., Bradshaw,K.D., Patel,S.,
            Mendonca,B.B., Elliston,K.O., Wilson,J.D., Russell,D.W. and
            Andersson,S.
  TITLE     Male pseudohermaphroditism caused by mutations of testicular 17
            beta-hydroxysteroid dehydrogenase 3
  JOURNAL   Nat Genet 7 (1), 34-39 (1994)
   PUBMED   8075637
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF035156.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF035156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1111
                     /gene="Hsd17b3"
                     /note="hydroxysteroid (17-beta) dehydrogenase 3"
                     /db_xref="GeneID:117182"
                     /db_xref="RGD:621805"
     exon            1..163
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..942
                     /gene="Hsd17b3"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.64"
                     /note="testosterone 17-beta-dehydrogenase 3; 17-beta-HSD
                     3; testicular 17-beta-hydroxysteroid dehydrogenase;
                     17beta-HSD; estradiol 17 beta-dehydrogenase 3; estradiol
                     17-beta-dehydrogenase 2"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase type 3"
                     /protein_id="NP_446459.1"
                     /db_xref="GeneID:117182"
                     /db_xref="RGD:621805"
                     /translation="MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMG
                     QWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQAD
                     FTREDIYDHIEEQLKGLEIGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKM
                     TQLVLKHMESRRRGLILNISSGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGII
                     IQVLTPYSVSTPMTKYLNTSRVTKTADEFVKESLKYVTIGAETCGCLAHEILAIILNL
                     IPSRIFYSSTTQRFLLKQFSDYLKSNISNR"
     exon            164..210
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            211..286
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            287..394
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            395..462
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..498
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..533
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            534..615
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            616..681
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..831
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1111
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagacagcca cagaggaggt catggaacag ttcctccttt ccgtggggct gcttgtgtgc
       61 ctcgtttgcc tggtgaagtg tgtgaggttc tcccggtacc tttttctgag cttctgcaag
      121 gctttaccag ggtctttcct gagatcaatg ggacaatggg cagtgatcac cggagcaggc
      181 gatggcatcg ggaaagccta ttcatttgag ctggccagac atggactcaa tgttgtactt
      241 atcagccgga cactggaaaa gctacaggtc atctcagaag agattgagag gaccactgga
      301 agccgtgtga aggttgtaca agcagatttt accagagaag acatctatga ccatattgaa
      361 gaacaactta aaggcttaga aataggagtt ttagtcaaca atgttggaat gctccccaac
      421 ctgctcccaa gtcatttcct gagcacgtcc ggtgagagcc agagtgtcat ccactgcaac
      481 attacctccg tagtcaagat gacacagctt gttctcaaac acatggaatc aaggcggaga
      541 ggcctcatct tgaatatttc ttcgggagta ggggttcgtc cctggcctct gtatagcctg
      601 tactcagctt ccaaggcttt tgtgtgcaca ttttccaagg ctttgaatgt ggaatacaga
      661 gataaaggaa tcattatcca ggtgctgacc ccttattctg tttcaacccc aatgactaag
      721 tacctaaata ccagcagggt gaccaagacc gccgatgagt ttgttaaaga atccttgaaa
      781 tatgtcacga ttggagctga aacctgtggc tgccttgctc atgaaatctt ggcgataatt
      841 ctgaacctga ttccttccag aatcttctac agcagcacca cccaaagatt tctcctgaag
      901 cagttctcag attacctgaa gagcaacatc agcaacagat agtggggaaa gggagtgggg
      961 gtgggtagag ttagggttgg gtgggagtag ggtgagcgtg ggctggaggg agagttgagg
     1021 agatcgagag ctcttccttg gtggtagtcg tcggccagag ggcgacggtc ctttacctcc
     1081 cgaaagggag cctgtcacgc cccaggcagt g
//
