LOCUS       NM_024391               1267 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 2
            (Hsd17b2), mRNA.
ACCESSION   NM_024391
VERSION     NM_024391.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Gao,H., Yallampalli,U. and Yallampalli,C.
  TITLE     Gestational protein restriction reduces expression of Hsd17b2 in
            rat placental labyrinth
  JOURNAL   Biol Reprod 87 (3), 68 (2012)
   PUBMED   22837477
  REMARK    GeneRIF: Gestational protein restriction reduces expression of
            Hsd17b2 in rat placental labyrinth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Banu,S.K., Samuel,J.B., Arosh,J.A., Burghardt,R.C. and
            Aruldhas,M.M.
  TITLE     Lactational exposure to hexavalent chromium delays puberty by
            impairing ovarian development, steroidogenesis and pituitary
            hormone synthesis in developing Wistar rats
  JOURNAL   Toxicol Appl Pharmacol 232 (2), 180-189 (2008)
   PUBMED   18602937
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Rantakari,P., Strauss,L., Kiviranta,R., Lagerbohm,H., Paviala,J.,
            Holopainen,I., Vainio,S., Pakarinen,P. and Poutanen,M.
  TITLE     Placenta defects and embryonic lethality resulting from disruption
            of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene
  JOURNAL   Mol Endocrinol 22 (3), 665-675 (2008)
   PUBMED   18048640
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Su,E.J., Cheng,Y.H., Chatterton,R.T., Lin,Z.H., Yin,P.,
            Reierstad,S., Innes,J. and Bulun,S.E.
  TITLE     Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human
            placental endothelial cells
  JOURNAL   Biol Reprod 77 (3), 517-525 (2007)
   PUBMED   17538076
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Jazbutyte,V., Hu,K., Kruchten,P., Bey,E., Maier,S.K.,
            Fritzemeier,K.H., Prelle,K., Hegele-Hartung,C., Hartmann,R.W.,
            Neyses,L., Ertl,G. and Pelzer,T.
  TITLE     Aging reduces the efficacy of estrogen substitution to attenuate
            cardiac hypertrophy in female spontaneously hypertensive rats
  JOURNAL   Hypertension 48 (4), 579-586 (2006)
   PUBMED   16940216
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Payne,A.H. and Hales,D.B.
  TITLE     Overview of steroidogenic enzymes in the pathway from cholesterol
            to active steroid hormones
  JOURNAL   Endocr Rev 25 (6), 947-970 (2004)
   PUBMED   15583024
  REMARK    Review article
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   van der Eerden,B.C., Lowik,C.W., Wit,J.M. and Karperien,M.
  TITLE     Expression of estrogen receptors and enzymes involved in sex
            steroid metabolism in the rat tibia during sexual maturation
  JOURNAL   J Endocrinol 180 (3), 457-467 (2004)
   PUBMED   15012600
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Akinola,L.A., Poutanen,M. and Vihko,R.
  TITLE     Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and
            characterization of tissue distribution and catalytic activity of
            rat type 1 and type 2 enzymes
  JOURNAL   Endocrinology 137 (5), 1572-1579 (1996)
   PUBMED   8612487
REFERENCE   9  (bases 1 to 1267)
  AUTHORS   Wu,L., Einstein,M., Geissler,W.M., Chan,H.K., Elliston,K.O. and
            Andersson,S.
  TITLE     Expression cloning and characterization of human 17
            beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme
            possessing 20 alpha-hydroxysteroid dehydrogenase activity
  JOURNAL   J Biol Chem 268 (17), 12964-12969 (1993)
   PUBMED   8099587
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_024391.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X91234.1, BC088134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000019.1  62662320-62662625
            307-519             JAXUCZ010000019.1  62704987-62705199
            520-705             JAXUCZ010000019.1  62714738-62714923
            706-843             JAXUCZ010000019.1  62724766-62724903
            844-1267            JAXUCZ010000019.1  62733521-62733944
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1267
                     /gene="Hsd17b2"
                     /note="hydroxysteroid (17-beta) dehydrogenase 2"
                     /db_xref="GeneID:79243"
                     /db_xref="RGD:621803"
     exon            1..306
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1184
                     /gene="Hsd17b2"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.239"
                     /note="17-beta-HSD 2; testosterone 17-beta-dehydrogenase;
                     17-beta-hydroxysteroid dehydrogenase 2;
                     17-beta-hydroxysteroid dehydrogenase type 2"
                     /codon_start=1
                     /product="estradiol 17-beta-dehydrogenase 2"
                     /protein_id="NP_077367.2"
                     /db_xref="GeneID:79243"
                     /db_xref="RGD:621803"
                     /translation="MNPFSSESAWLCLTATAVLGGMLLCKAWSSGQLRSQVVCLAGLW
                     GGACLLSLSLLCSLFLLSVSCFFLLYVSSSDQDLLPVDQKAVLVTGADSGFGHALAKH
                     LDKLGFTVFAGVLDKEGPGAEELRKNCSERLSVLQMDVTKPEQIKDVHSEVAEKIQDK
                     GLWAVVNNAGVLHFPIDGELIPMTVYRKCMAVNFFGAVEVTKVFLPLLRKSKGRLVNV
                     SSMGAMIPFQMMAAYASTKAAISMFSAVIRQELAKWGVKVVTIHPGGFQTNIVGSQDS
                     WDKMEKEILDHFSKEIQENYGQEYVHTQKLALPVMREMSNPDITPVLRDIQHAICAKN
                     HSSFYCSGRMTYLWICFAAYSPISLLDYILKNYFTPKLMPRALRTAS"
     exon            307..519
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..705
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..843
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1267
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctcactg gcccagagca agtgaagacc agtggagaat gaacccgttt tcctctgagt
       61 cagcatggct ctgcttgact gccactgcgg tgctgggggg catgcttctc tgcaaagcct
      121 ggagttcagg gcagctaagg agccaggtgg tgtgtctggc tggcctctgg ggaggtgcct
      181 gcctgctcag cctgtccctc ctctgcagct tgttcctctt atcggtgtcc tgcttcttcc
      241 ttctgtatgt gagttcatct gaccaagact tgttacctgt ggatcaaaag gctgtgctgg
      301 tgacaggtgc cgattccggt ttcggtcatg ctttggccaa gcacctggac aagctgggtt
      361 tcacagtgtt tgctggagtg ctggataaag agggcccagg agcggaggaa ttgaggaaaa
      421 actgctctga gcgcctttcg gtgctccaga tggatgtcac caagccagag cagataaaag
      481 atgttcacag cgaagtcgca gagaagatac aagacaaagg actgtgggct gtggtcaaca
      541 atgctggggt cttgcacttt ccgatcgacg gggaactcat tcccatgacc gtgtacagaa
      601 aatgcatggc agtgaacttc ttcggagccg tcgaggtcac caaggtgttt ctgcctctac
      661 ttagaaagtc caaggggagg ctggttaacg tcagcagcat gggagccatg attccatttc
      721 agatgatggc cgcctacgcc tccacgaagg cagctataag catgttctca gccgtcatca
      781 ggcaagagct tgccaaatgg ggagtcaaag tcgtgaccat ccatcctgga ggcttccaaa
      841 caaacatcgt aggctcacag gacagttggg ataaaatgga gaaggagatc ctggaccact
      901 tttccaaaga gattcaggag aactatggac aggaatatgt ccatacgcag aagctcgccc
      961 tcccggtcat gagagagatg tccaacccgg atatcacccc tgtgctgcgg gacatccagc
     1021 acgccatttg tgccaagaac cactcttcct tttattgctc agggagaatg acttacctgt
     1081 ggatctgctt cgcggcctac tccccgatca gcttattgga ctatattttg aaaaactatt
     1141 ttactccaaa actcatgcca agagctttaa ggacagcaag ttagaagaac aaggcccggg
     1201 tagggtggga aatgccacat gcttaggatg aaagggaaac ctcttattaa actaactttc
     1261 tacctca
//
