LOCUS       NM_001191111            1368 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 14
            (Hsd17b14), mRNA.
ACCESSION   NM_001191111 XM_001076540
VERSION     NM_001191111.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Witecka,A., Kazak,V., Kwiatkowski,S., Kiersztan,A., Jagielski,A.K.,
            Kozminski,W., Augustyniak,R. and Drozak,J.
  TITLE     Hydroxysteroid 17-beta dehydrogenase 14 (HSD17B14) is an L-fucose
            dehydrogenase, the initial enzyme of the L-fucose degradation
            pathway
  JOURNAL   J Biol Chem 300 (8), 107501 (2024)
   PUBMED   38944119
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1368)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1368)
  AUTHORS   Lukacik,P., Keller,B., Bunkoczi,G., Kavanagh,K.L., Lee,W.H.,
            Adamski,J. and Oppermann,U.
  TITLE     Structural and biochemical characterization of human orphan DHRS10
            reveals a novel cytosolic enzyme with steroid dehydrogenase
            activity
  JOURNAL   Biochem J 402 (3), 419-427 (2007)
   PUBMED   17067289
  REMARK    Erratum:[Biochem J. 2007 May 1;403(3):615. Kavanagh, Kathryn
            [Kavanagh, Kathryn L]; Hwa, Lee Wen [corrected to Lee, Wen Hwa]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 19, 2022 this sequence version replaced NM_001191111.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.2279.1,
                                           SRR26643294.2421.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000001.1  105165695-105165848
            155-193             JAXUCZ010000001.1  105166645-105166683
            194-276             JAXUCZ010000001.1  105166801-105166883
            277-343             JAXUCZ010000001.1  105167812-105167878
            344-435             JAXUCZ010000001.1  105169269-105169360
            436-540             JAXUCZ010000001.1  105172608-105172712
            541-608             JAXUCZ010000001.1  105174433-105174500
            609-705             JAXUCZ010000001.1  105174596-105174692
            706-1368            JAXUCZ010000001.1  105175383-105176045
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1368
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /note="hydroxysteroid (17-beta) dehydrogenase 14"
                     /db_xref="GeneID:691018"
                     /db_xref="RGD:1588673"
     exon            1..154
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..879
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /EC_number="1.1.1.62"
                     /note="dehydrogenase/reductase (SDR family) member 10"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase 14"
                     /protein_id="NP_001178040.1"
                     /db_xref="GeneID:691018"
                     /db_xref="RGD:1588673"
                     /translation="MAAVGRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEA
                     GGRAVEQELLGTVFIPGDVTQEGDLQTLISETVSRFGHLDCVVNNAGYHPPAQLPEET
                     SAQGFRQLLEENLLGAYTLIKLALPHLRKSKGNIINISSLVGAIGQSQALTYVATKGA
                     VTAMTKALALDESRYGVRVNCISPGNIWTPLWQELAAATSDPRATILEGTLAQPLGRM
                     GQPAEVGAAAVFLASEATFCTGLELFMTGGAELGYGRKASSSTLVEVPILPP"
     exon            155..193
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     exon            194..276
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     exon            277..343
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     exon            344..435
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     exon            436..540
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     exon            541..608
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     exon            609..705
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1368
                     /gene="Hsd17b14"
                     /gene_synonym="Dhrs10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctctgg actttaaagg tgggaagagg cccagagggt gtgggacacg agcgagatag
       61 ctgggaatgg ctgcagtagg ccgatattct gggaaggtgg tggtggtgac tgggggcagt
      121 cggggcatcg gggctgcgat cgtgagagcc ttcgtggaca gtggggctca agtggttttc
      181 tgtgacaagg atgaggctgg gggccgggct gtggagcagg aactcttggg cactgtcttc
      241 atccccggtg acgtgactca ggaaggagat ttacagactc tgatttctga gactgtctct
      301 cgatttggtc acctggattg tgtggtgaat aatgccggct accacccacc tgcacagttg
      361 ccagaggaga cctctgccca gggcttccgc cagctgctgg aggagaacct cctgggggca
      421 tacaccttga tcaagcttgc cctcccccac cttcggaaga gtaaaggaaa tatcatcaac
      481 atctccagcc tggtcggggc catcggccag tcccaggcac taacctatgt ggccaccaag
      541 ggggcagtga ctgccatgac caaagctttg gccttggatg agagtcgata tggtgtccgt
      601 gtcaactgca tctccccagg aaacatctgg actccactgt ggcaagagct tgcggctgca
      661 acttcagacc ccagggccac cattctagaa ggcaccttgg cccagcccct gggccgcatg
      721 ggccagccag ccgaggtggg ggccgcagcc gtgtttctgg cctctgaagc caccttctgc
      781 acagggcttg agctttttat gactgggggt gcagaactgg gctatggacg caaggctagt
      841 agcagcactc tcgtggaagt ccccattctc ccaccataat tcacactaac atgtcctact
      901 catccgtctt ccttccttcc tttctttttc tgcagtactg gagattaaac ctaggacctc
      961 ttgtgttcta ggctggggct ttaccactga gtcacacccc agtgccacac tggaggattc
     1021 tgggcaaggg ctttaccact taactctcag gttccaaaga aagtcaggat aaactagtcg
     1081 ctggcagccc agccctctca gtacctgctg ctttcctcac tcacttgccc ctgtcctccc
     1141 ctctctaccc caaggactta gtgtcccttc ccccagcttc tggttcctat aaaaacctgc
     1201 cactttgtcc atgtccattc ctggtccttg gctcctctct tggtcccact tgccctctct
     1261 ctctcctctt ctttcacttt cttcccccca accccctctc tgctctcatg gactcttcca
     1321 gacgcctctg tgctctccct tattgcaaca ataaaacctc ccagccat
//
