LOCUS       NM_032066               1844 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 12
            (Hsd17b12), mRNA.
ACCESSION   NM_032066 XM_006234599
VERSION     NM_032066.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Moon,Y.A. and Horton,J.D.
  TITLE     Identification of two mammalian reductases involved in the
            two-carbon fatty acyl elongation cascade
  JOURNAL   J Biol Chem 278 (9), 7335-7343 (2003)
   PUBMED   12482854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 1, 2020 this sequence version replaced
            XM_006234599.3, NM_032066.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213557.1, BC061543.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000003.1  100568706-100568898 c
            194-240             JAXUCZ010000003.1  100528936-100528982 c
            241-316             JAXUCZ010000003.1  100526372-100526447 c
            317-424             JAXUCZ010000003.1  100496325-100496432 c
            425-489             JAXUCZ010000003.1  100479549-100479613 c
            490-534             JAXUCZ010000003.1  100478723-100478767 c
            535-569             JAXUCZ010000003.1  100464196-100464230 c
            570-651             JAXUCZ010000003.1  100457277-100457358 c
            652-717             JAXUCZ010000003.1  100455807-100455872 c
            718-867             JAXUCZ010000003.1  100446641-100446790 c
            868-1844            JAXUCZ010000003.1  100445393-100446369 c
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..1844
                     /gene="Hsd17b12"
                     /note="hydroxysteroid (17-beta) dehydrogenase 12"
                     /db_xref="GeneID:84013"
                     /db_xref="RGD:708367"
     exon            1..193
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..972
                     /gene="Hsd17b12"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.330"
                     /note="estradiol 17-beta-dehydrogenase 12; KAR;
                     17-beta-HSD 12; 3-ketoacyl-CoA reductase;
                     17-beta-hydroxysteroid dehydrogenase 12; smooth
                     muscle-specific 17 beta-hydroxysteroid dehydrogenase type
                     3"
                     /codon_start=1
                     /product="very-long-chain 3-oxoacyl-CoA reductase"
                     /protein_id="NP_114455.2"
                     /db_xref="GeneID:84013"
                     /db_xref="RGD:708367"
                     /translation="MERALPAAGFLYWVGASTIAYLTLRASYSLFRAFQVWCVGNQAF
                     VGPRLGEWAVVTGGTDGIGKSYAEELAKRGMKIVLISRSQDKLKEVSNNIKEKFNVET
                     RTIAVDFSLDDIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLEIPDLDNTIKKLINI
                     NVLSICKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTVYSATKAFVDFFSQCLHE
                     EYKSKGIFVQSVLPFFVATKLAKIRKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHA
                     IMGSINSILPRWIYFKTIMGFNKSLRNRYLKKTKKN"
     exon            194..240
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            241..316
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            317..424
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            425..489
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            490..534
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            535..569
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            570..651
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            652..717
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            718..867
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1844
                     /gene="Hsd17b12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcaccgta gtagtgaggc ctagtggcga gctatggagc gcgctctccc ggcggccggc
       61 ttcctatact gggtgggcgc gagcaccatt gcttacctga ccctgcgagc ctcgtactcg
      121 ctcttcaggg ccttccaggt gtggtgcgtg ggcaaccagg cctttgtcgg cccgcggctc
      181 ggagaatggg cagttgttac aggtggcact gatggaattg gaaaatcata tgcagaagag
      241 ttagcaaagc gtggaatgaa gattgtcttg ataagcagat cccaggataa actgaaggaa
      301 gtttccaaca acatcaaaga aaaattcaac gttgaaacaa ggaccattgc tgtcgacttt
      361 tcattggatg atatttatga taaaattaag acaggcctgt ctggtcttga aattggcgtt
      421 ttagtgaaca acgtgggcat gtcatacgag tatccagaat actttttgga aattcctgac
      481 ttggacaaca ccatcaagaa actgataaat attaatgtgc tttccatttg caaggtgaca
      541 cgcttggtgc tgcctggcat ggtagagaga tctaaagggg tgattctcaa catctcctct
      601 gccagtggca tgctcccggt tccactgttg acagtctact ctgcaaccaa ggcctttgta
      661 gatttcttct ctcagtgcct ccatgaggag tataagagca agggcatctt tgtgcagagt
      721 gtcctgccat tctttgtagc tacaaaactg gcaaaaatac ggaagccgac tttggataag
      781 ccctctgcag agacatttgt gaagtctgca attaaaacag taggtctgca gacccgaacc
      841 actggatatg tgatccacgc catcatgggc tcaataaact caatcttgcc ccgttggatt
      901 tattttaaaa caatcatggg tttcaacaag tctttgcgga atcgctatct gaagaaaacc
      961 aagaagaact aagtactgct gggtcatcga gctccttggc cagacgcttg acctgtgctt
     1021 gcatactggg cccctgcctg tccccagagt ctctactgtc atctcagtaa ttactaacat
     1081 ggcatagctg gcggaaagca aattcctttt agaggttcct aacatatatt ctggatacaa
     1141 ccaggagtaa tttgaagttt aatataaatg ttcttggcaa atgtatgtag accactttga
     1201 cagaaaggaa cagatcccag aatgacagac gtagacccat ccggcccaga atgccaatga
     1261 ttacctaata tttggtctgg aacctactat aaagtgtaat agctagctac ttttttattt
     1321 ttaacattaa agggaatggg gcttagttga ttttttttta tgggcagata caatgcagtt
     1381 tacattgatt tctgtaaggt tttctaaagg tatgttccag cttatgtgtt tctatggaac
     1441 tggtcttctt aaaagtagct aagaaagaca taaagagaat tgaaacacgg agttctttct
     1501 aacacagaag tccacaaaat gttattcttg gaacacacat tatgtccgct ctgttccatg
     1561 tatgtaaata ctgaatgcta tatagtgtga ctgaaatgta aaggtaagtg ggccaaagtg
     1621 tacatcaaga ccagcaacat cctgtggtac tgtgggatcc agaagagcag cctgcatgga
     1681 tatccagtgt tggtcatgtc tgtactgcac ccatactatt tgcctaggat gacagactcc
     1741 ttctgtggta gtgaggggtc atggaaacat gttcttttta agttggtgtc tcatttgaat
     1801 tcatatatcc acttttaata aaagatgatg taaccgtgtt gttg
//
