LOCUS       NM_001004209            1622 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 11
            (Hsd17b11), mRNA.
ACCESSION   NM_001004209 XM_213994
VERSION     NM_001004209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Thomes,P.G., Strupp,M.S., Donohue,T.M. Jr., Kubik,J.L., Sweeney,S.,
            Mahmud,R., Schott,M.B., Schulze,R.J., McNiven,M.A. and Casey,C.A.
  TITLE     Hydroxysteroid 17beta-dehydrogenase 11 accumulation on lipid
            droplets promotes ethanol-induced cellular steatosis
  JOURNAL   J Biol Chem 299 (4), 103071 (2023)
   PUBMED   36849008
  REMARK    GeneRIF: Hydroxysteroid 17beta-dehydrogenase 11 accumulation on
            lipid droplets promotes ethanol-induced cellular steatosis.
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   Keller,B., Meier,M. and Adamski,J.
  TITLE     Comparison of predicted and experimental subcellular localization
            of two putative rat steroid dehydrogenases from the short-chain
            dehydrogenase/reductase protein superfamily
  JOURNAL   Mol Cell Endocrinol 301 (1-2), 43-46 (2009)
   PUBMED   18775470
  REMARK    GeneRIF: The localization studies on rat short-chain
            dehydrogenases/reductases dhrs7b and dhrs8, are shown.
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   Chai,Z., Brereton,P., Suzuki,T., Sasano,H., Obeyesekere,V.,
            Escher,G., Saffery,R., Fuller,P., Enriquez,C. and Krozowski,Z.
  TITLE     17 beta-hydroxysteroid dehydrogenase type XI localizes to human
            steroidogenic cells
  JOURNAL   Endocrinology 144 (5), 2084-2091 (2003)
   PUBMED   12697717
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078929.1.
            
            On Sep 10, 2004 this sequence version replaced XM_213994.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078929.1, FQ219665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1622
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /note="hydroxysteroid (17-beta) dehydrogenase 11"
                     /db_xref="GeneID:289456"
                     /db_xref="RGD:1303235"
     exon            1..264
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..951
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /EC_number="1.1.1.62"
                     /note="estradiol 17-beta-dehydrogenase 11; 17bHSD11;
                     17betaHSD11; 17betaHSDXI; 17-beta-HSD 11; 17-beta-HSD XI;
                     17-beta-hydroxysteroid dehydrogenase 11;
                     dehydrogenase/reductase SDR family member 8;
                     17-beta-hydroxysteroid dehydrogenase XI"
                     /codon_start=1
                     /product="estradiol 17-beta-dehydrogenase 11 precursor"
                     /protein_id="NP_001004209.1"
                     /db_xref="GeneID:289456"
                     /db_xref="RGD:1303235"
                     /translation="MKYLLDLILLLPLLIVFCIESFIKRLIPKKKKSVAGEIVLITGA
                     GHGIGRLTAYEFAKLNTKLVLWDINKNGIEETAAKCRKLGAQVHPFVVDCSQREEIYS
                     AVRKVKEEVGDVSILVNNAGVVYTADLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMM
                     KNNHGHVVTVASAAGHTVVPFLLAYCSSKFAAVGFHRALTDELAALGCTGVRTSCLCP
                     NFINTGFIKNPSTNLGPTLEPEEVVEHLMHGILTNQKMIFVPGSIALLTVLERVFPER
                     FLDVLKRRINVKFDAVVGYKDK"
     exon            265..372
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /inference="alignment:Splign:2.1.0"
     exon            373..504
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /inference="alignment:Splign:2.1.0"
     exon            505..611
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /inference="alignment:Splign:2.1.0"
     exon            612..749
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /inference="alignment:Splign:2.1.0"
     exon            750..866
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1595
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggactcgag aggcagttta ggacccggaa caagaacgcc gggctacaga aaggatgaag
       61 taccttcttg acctgatcct gctgctgcct ctgcttattg tcttctgcat tgagtctttc
      121 atcaagcgtt tgattcccaa gaagaaaaaa tccgtcgctg gagagatcgt tctgatcacc
      181 ggagctggtc atgggattgg aagactgacc gcctacgaat ttgccaaact aaacaccaaa
      241 ctggttctgt gggatatcaa taagaatggc atcgaggaaa cagcggcgaa gtgcaggaag
      301 ctaggtgccc aggtccatcc ctttgtggtg gactgcagcc agcgggaaga gatttacagc
      361 gctgtgagaa aggtaaagga agaagttgga gatgttagca ttctggtaaa taatgccggc
      421 gttgtctaca ctgcagatct atttgctacg caggaccctc agattgaaaa gactttcgaa
      481 gtcaatgtgc ttgcacactt ttggaccacc aaggcatttc tcccagccat gatgaagaat
      541 aatcatggtc atgttgtcac cgtggcgtcg gcagcagggc acaccgtcgt tcccttcctg
      601 ctggcttact gttctagcaa gtttgctgct gttggcttcc acagagcctt gactgatgaa
      661 ctggctgcct tgggatgcac tggagtccga acatcctgcc tctgccctaa cttcataaat
      721 accggcttca tcaagaaccc gagcaccaat ttagggccca ccctggaacc tgaggaggtg
      781 gtagagcatc tcatgcacgg gatcctcact aaccagaaga tgatcttcgt cccgggctct
      841 atagcgcttt tgacagtatt ggaaagggtg tttcctgaga gattcctgga cgttctaaag
      901 cgcaggatca acgttaagtt cgatgctgtt gttggctaca aagataaatg acgcagaccg
      961 cctggttttc ctgaaagctg aatcactgga ttcaagttga tctcaccaaa tattaatcca
     1021 aattctgatg tttttaatgt tttctcttta tcttgtctct tcattgcctc cccttgaagc
     1081 tgtgaccatt tccatgaaag ccagtttcct gtcatggacc caaacagccc taaggaagtt
     1141 gctcctatga agaaggggca gggacgattg gcctcgtgat agcgatttcc ccagatactg
     1201 tagctcacca ccgggttatc agaacttgaa ctgtcacttt ttacttatgg tatctgtaac
     1261 tgtactttag tttgttcgat tcacactctc cgctccgtcc cgtataacgt tagaaacctt
     1321 aacctccccg ggtagaatga aggactgagt ctagtgtcat ttcacagcgg tgtcatgtgc
     1381 tctgaaacat tccgtcccat gtatcagcgc tgtttcctga gacgccggcc caaggtagct
     1441 tgaagtaaaa gtgtctgtga gatttcgggc tggggacaga tggacaggtg gacaggtgga
     1501 aataataaat ggaccaaaac tcatgctcag tgtctctatc tgctgcaaag agaccatggc
     1561 ttgacctcta aataaaagga aaatcattaa cttgaaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aa
//
