LOCUS       NM_031682                923 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 10
            (Hsd17b10), mRNA.
ACCESSION   NM_031682
VERSION     NM_031682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Reinhard,L., Sridhara,S. and Hallberg,B.M.
  TITLE     The MRPP1/MRPP2 complex is a tRNA-maturation platform in human
            mitochondria
  JOURNAL   Nucleic Acids Res 45 (21), 12469-12480 (2017)
   PUBMED   29040705
REFERENCE   2  (bases 1 to 923)
  AUTHORS   Oerum,S., Roovers,M., Leichsenring,M., Acquaviva-Bourdain,C.,
            Beermann,F., Gemperle-Britschgi,C., Fouilhoux,A.,
            Korwitz-Reichelt,A., Bailey,H.J., Droogmans,L., Oppermann,U.,
            Sass,J.O. and Yue,W.W.
  TITLE     Novel patient missense mutations in the HSD17B10 gene affect
            dehydrogenase and mitochondrial tRNA modification functions of the
            encoded protein
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (12), 3294-3302 (2017)
   PUBMED   28888424
REFERENCE   3  (bases 1 to 923)
  AUTHORS   Vilardo,E. and Rossmanith,W.
  TITLE     Molecular insights into HSD10 disease: impact of SDR5C1 mutations
            on the human mitochondrial RNase P complex
  JOURNAL   Nucleic Acids Res 43 (10), 5112-5119 (2015)
   PUBMED   25925575
  REMARK    Erratum:[Nucleic Acids Res. 2015 Jul 27;43(13):6649. doi:
            10.1093/nar/gkv658.. PMID: 26092698]
REFERENCE   4  (bases 1 to 923)
  AUTHORS   Carlson,E.A., Marquez,R.T., Du,F., Wang,Y., Xu,L. and Yan,S.S.
  TITLE     Overexpression of 17beta-hydroxysteroid dehydrogenase type 10
            increases pheochromocytoma cell growth and resistance to cell death
  JOURNAL   BMC Cancer 15, 166 (2015)
   PUBMED   25879199
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 923)
  AUTHORS   Bogenhagen,D.F., Martin,D.W. and Koller,A.
  TITLE     Initial steps in RNA processing and ribosome assembly occur at
            mitochondrial DNA nucleoids
  JOURNAL   Cell Metab 19 (4), 618-629 (2014)
   PUBMED   24703694
REFERENCE   6  (bases 1 to 923)
  AUTHORS   He,X.Y., Merz,G., Chu,C.H., Lin,D., Yang,Y.Z., Mehta,P., Schulz,H.
            and Yang,S.Y.
  TITLE     Molecular cloning, modeling, and localization of rat type 10
            17beta-hydroxysteroid dehydrogenase
  JOURNAL   Mol Cell Endocrinol 171 (1-2), 89-98 (2001)
   PUBMED   11165016
REFERENCE   7  (bases 1 to 923)
  AUTHORS   Powell,A.J., Read,J.A., Banfield,M.J., Gunn-Moore,F., Yan,S.D.,
            Lustbader,J., Stern,A.R., Stern,D.M. and Brady,R.L.
  TITLE     Recognition of structurally diverse substrates by type II
            3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding
            alcohol dehydrogenase (ABAD)
  JOURNAL   J Mol Biol 303 (2), 311-327 (2000)
   PUBMED   11023795
REFERENCE   8  (bases 1 to 923)
  AUTHORS   He,X.Y., Merz,G., Mehta,P., Schulz,H. and Yang,S.Y.
  TITLE     Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is
            a single-domain multifunctional enzyme. Characterization of a novel
            17beta-hydroxysteroid dehydrogenase
  JOURNAL   J Biol Chem 274 (21), 15014-15019 (1999)
   PUBMED   10329704
REFERENCE   9  (bases 1 to 923)
  AUTHORS   Hansis,C., Jahner,D., Spiess,A.N., Boettcher,K. and Ivell,R.
  TITLE     The gene for the Alzheimer-associated beta-amyloid-binding protein
            (ERAB) is differentially expressed in the testicular Leydig cells
            of the azoospermic by w/w(v) mouse
  JOURNAL   Eur J Biochem 258 (1), 53-60 (1998)
   PUBMED   9851691
REFERENCE   10 (bases 1 to 923)
  AUTHORS   Yan,S.D., Fu,J., Soto,C., Chen,X., Zhu,H., Al-Mohanna,F.,
            Collison,K., Zhu,A., Stern,E., Saido,T., Tohyama,M., Ogawa,S.,
            Roher,A. and Stern,D.
  TITLE     An intracellular protein that binds amyloid-beta peptide and
            mediates neurotoxicity in Alzheimer's disease
  JOURNAL   Nature 389 (6652), 689-695 (1997)
   PUBMED   9338779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 15, 2021 this sequence version replaced NM_031682.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158587.1, AF069770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000021.1  24568551-24568599
            50-214              JAXUCZ010000021.1  24568957-24569121
            215-379             JAXUCZ010000021.1  24569955-24570119
            380-508             JAXUCZ010000021.1  24570248-24570376
            509-617             JAXUCZ010000021.1  24570472-24570580
            618-923             JAXUCZ010000021.1  24570707-24571012
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..923
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /note="hydroxysteroid (17-beta) dehydrogenase 10"
                     /db_xref="GeneID:63864"
                     /db_xref="RGD:69231"
     exon            1..49
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..808
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /EC_number="1.1.1.35"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.178"
                     /EC_number="1.1.1.239"
                     /EC_number="1.1.1.53"
                     /EC_number="1.1.1.159"
                     /function="catalyzes fatty acid and steroid metabolism"
                     /note="hydroxyacyl-Coenzyme A dehydrogenase, type II; type
                     II HADH; mitochondrial RNase P protein 2; mitochondrial
                     ribonuclease P protein 2; 17-beta-hydroxysteroid
                     dehydrogenase 10; 3-hydroxyacyl-CoA dehydrogenase type II;
                     3-hydroxy-2-methylbutyryl-CoA dehydrogenase; endoplasmic
                     reticulum-associated amyloid beta-peptide-binding protein;
                     17-beta-HSD 10; short chain L-3-hydroxyacyl-CoA
                     dehydrogenase; amyloid beta-peptide binding protein;
                     17I(2)-hydroxysteroid dehydrogenase type 10; amyloid-beta
                     peptide binding alcohol dehydrogenase; 17-beta-estradiol
                     17-dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase;
                     2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3alpha(or
                     20beta)-hydroxysteroid dehydrogenase; short-chain type
                     dehydrogenase/reductase XH98G2; short chain
                     dehydrogenase/reductase family 5C member 1;
                     3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))"
                     /codon_start=1
                     /product="3-hydroxyacyl-CoA dehydrogenase type-2"
                     /protein_id="NP_113870.1"
                     /db_xref="GeneID:63864"
                     /db_xref="RGD:69231"
                     /translation="MAAACRSVKGLVAVITGGASGLGLSTAKRLVGQGATAVLLDVPN
                     SEGETEAKKLGGNCIFAPANVTSEKEVQAALTLAKEKFGRIDVAVNCAGIAVAIKTYH
                     EKKNQVHTLEDFQRVINVNLIGTFNVIRLVAGVMGQNEPDQGGQRGVIINTASVAAFE
                     GQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVVTIAPGLFATPLLTTLPDKVRNFLA
                     SQVPFPSRLGDPAEYAHLVQMVIENPFLNGEVIRLDGAIRMQP"
     exon            50..214
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /inference="alignment:Splign:2.1.0"
     exon            215..379
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /inference="alignment:Splign:2.1.0"
     exon            380..508
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /inference="alignment:Splign:2.1.0"
     exon            509..617
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /inference="alignment:Splign:2.1.0"
     exon            618..923
                     /gene="Hsd17b10"
                     /gene_synonym="ABAD; ERAB; Hadh2; HSD10; MHBD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtggcga ggctcgtgca agatggctgc ggcgtgtcgg agcgtgaagg gcctggtggc
       61 agtaataacc ggaggagcct cgggccttgg cctgtctaca gccaaaagac tggtgggaca
      121 aggagccaca gctgtacttc tggacgtccc taactcagag ggtgagaccg aagccaagaa
      181 gttaggagga aactgcatat ttgccccagc aaatgtgacc tctgagaagg aggtacaagc
      241 agctttgact ctagcaaaag aaaagtttgg ccgtatagat gtggctgtca actgtgcagg
      301 cattgcagtg gccattaaga cataccacga aaagaagaac caggtccaca ccttggagga
      361 cttccagcgg gttatcaatg tgaatctcat aggcactttc aatgtgatcc gcctggttgc
      421 tggtgtgatg ggccagaatg aaccagacca gggaggtcaa cgtggagtta tcattaacac
      481 tgccagtgtg gctgcttttg agggccaggt tggacaagct gcatactctg catccaaagg
      541 gggcatagtg ggcatgacac tgcccattgc tcgagatctg gctcctatag gcatccgtgt
      601 ggtaacaatt gctccaggtc tgtttgccac cccactgctt accactctgc cagacaaagt
      661 gcgcaacttc ttggccagcc aggtaccctt ccccagccga ctaggtgacc ccgcggaata
      721 tgctcatctg gtacagatgg taatcgagaa cccattcttg aatggagagg tcatccggct
      781 ggatggggcc attcgaatgc agccttaaaa ggccaaggca ggaaaaacac cggctccttt
      841 tcagtttgaa ggaaacctaa cagccacttt gtaactctgc tccattcacc ctctgtgcct
      901 aataaattct caaatctaca gga
//
