LOCUS       NM_017081               1863 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2),
            mRNA.
ACCESSION   NM_017081
VERSION     NM_017081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Wang,G., Huang,Y., Hu,T., Zhang,B., Tang,Z., Yao,R., Huang,Y.,
            Fan,X. and Ni,X.
  TITLE     Contribution of placental 11beta-HSD2 to the pathogenesis of
            preeclampsia
  JOURNAL   FASEB J 34 (11), 15379-15399 (2020)
   PUBMED   32978833
  REMARK    GeneRIF: Contribution of placental 11beta-HSD2 to the pathogenesis
            of preeclampsia.
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Lavall,D., Schuster,P., Jacobs,N., Kazakov,A., Bohm,M. and Laufs,U.
  TITLE     Rac1 GTPase regulates 11beta hydroxysteroid dehydrogenase type 2
            and fibrotic remodeling
  JOURNAL   J Biol Chem 292 (18), 7542-7553 (2017)
   PUBMED   28320863
  REMARK    GeneRIF: Rac1 GTPase regulates 11beta-HSD2 expression,
            mineralocorticoid receptor activation, and mineralocorticoid
            receptor-mediated pro-fibrotic signaling.
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Lan,N., Chiu,M.P., Ellis,L. and Weinberg,J.
  TITLE     Prenatal alcohol exposure and prenatal stress differentially alter
            glucocorticoid signaling in the placenta and fetal brain
  JOURNAL   Neuroscience 342, 167-179 (2017)
   PUBMED   26342748
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Haque,M., Wilson,R., Sharma,K., Mills,N.J. and Teruyama,R.
  TITLE     Localisation of 11beta-Hydroxysteroid Dehydrogenase Type 2 in
            Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory
            Neurones of the Rat Supraoptic and Paraventricular Nuclei
  JOURNAL   J Neuroendocrinol 27 (11), 835-849 (2015)
   PUBMED   26403275
  REMARK    GeneRIF: Specific 11beta-HSD2 immunoreactivity was found in the
            cytoplasm of the Magnocellular Neurosecretory Cells in both the
            Supraoptic and Paraventricular nuclei.
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Li,L., Wu,X., Guan,H., Mao,B., Wang,H., Yuan,X., Chu,Y., Sun,J. and
            Ge,R.S.
  TITLE     Zearalenone Inhibits Rat and Human 11beta-Hydroxysteroid
            Dehydrogenase Type 2
  JOURNAL   Biomed Res Int 2015, 283530 (2015)
   PUBMED   26798634
  REMARK    GeneRIF: zearalenone is a selective inhibitor of HSD11B2, implying
            that this agent may cause excessive glucocorticoid action in local
            tissues such as kidney and placentas.
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Sheppard,K.E. and Autelitano,D.J.
  TITLE     11Beta-hydroxysteroid dehydrogenase 1 transforms
            11-dehydrocorticosterone into transcriptionally active
            glucocorticoid in neonatal rat heart
  JOURNAL   Endocrinology 143 (1), 198-204 (2002)
   PUBMED   11751610
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Liu,Y.J., Nakagawa,Y., Toya,K., Wang,Y., Saegusa,H., Nakanishi,T.
            and Ohzeki,T.
  TITLE     Effects of spironolactone on systolic blood pressure in
            experimental diabetic rats
  JOURNAL   Kidney Int 57 (5), 2064-2071 (2000)
   PUBMED   10792625
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Li,A., Tedde,R., Krozowski,Z.S., Pala,A., Li,K.X., Shackleton,C.H.,
            Mantero,F., Palermo,M. and Stewart,P.M.
  TITLE     Molecular basis for hypertension in the 'type II variant' of
            apparent mineralocorticoid excess
  JOURNAL   Am J Hum Genet 63 (2), 370-379 (1998)
   PUBMED   9683587
REFERENCE   9  (bases 1 to 1863)
  AUTHORS   Liu,Y.J., Nakagawa,Y. and Ohzeki,T.
  TITLE     Gene expression of 11beta-hydroxysteroid dehydrogenase type 1 and
            type 2 in the kidneys of insulin-dependent diabetic rats
  JOURNAL   Hypertension 31 (3), 885-889 (1998)
   PUBMED   9495277
REFERENCE   10 (bases 1 to 1863)
  AUTHORS   Zhou,M.Y., Gomez-Sanchez,E.P., Cox,D.L., Cosby,D. and
            Gomez-Sanchez,C.E.
  TITLE     Cloning, expression, and tissue distribution of the rat
            nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid
            dehydrogenase
  JOURNAL   Endocrinology 136 (9), 3729-3734 (1995)
   PUBMED   7649078
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U22424.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017081.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U22424.1, BC087023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1863              U22424.1           2-1864
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1863
                     /gene="Hsd11b2"
                     /note="hydroxysteroid 11-beta dehydrogenase 2"
                     /db_xref="GeneID:25117"
                     /db_xref="RGD:2835"
     exon            1..390
                     /gene="Hsd11b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1328
                     /gene="Hsd11b2"
                     /EC_number="1.1.1.146"
                     /note="corticosteroid 11-beta-dehydrogenase isozyme 2;
                     11-DH2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid
                     dehydrogenase; Hydroxysteroid dehydrogenase, 11 beta type
                     2"
                     /codon_start=1
                     /product="11-beta-hydroxysteroid dehydrogenase type 2"
                     /protein_id="NP_058777.1"
                     /db_xref="GeneID:25117"
                     /db_xref="RGD:2835"
                     /translation="MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAAL
                     DWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKL
                     DAMGFTVLATVLDLNGPGALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTG
                     LWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVG
                     SPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLW
                     EKRKQLLLANLPRELLQAYGEDYIEHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQP
                     RSRYYTGRGLGLMYFIHHYLPGGLRRRFLQNFFISHLLPRALRPGQPGPVHDTTQDPN
                     PSPTVSAL"
     exon            391..603
                     /gene="Hsd11b2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..789
                     /gene="Hsd11b2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..927
                     /gene="Hsd11b2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1863
                     /gene="Hsd11b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagcgagt atccctccca ccccaggctg gtgttcctct gcactccgtg tcctggccca
       61 gagtccctct cggcgctccc caacccggcc cccgcccctc cctagaccgg ccgggccccg
      121 aagtcatgga gcgctggcct tggccgtcgg gcggcgcctg gctgctggtg gctgcccgcg
      181 cgctgctgca gctgctgcgc tcagacctgc gtctgggccg cccgttgttg gcggcgctgg
      241 ccctgctggc cgctctcgac tggctgtgcc agcgcctgct gcccccgccg gctgcactcg
      301 tggtgctggc tggtgctggc tggatcgcgt tgtcccgcct agcgcgccct cctcgcctgc
      361 cggtggccac tcgcgcggtg ctcatcaccg gttgtgacac tggttttggc aaggagacag
      421 ctaagaaact ggatgccatg ggcttcacgg tgctggccac tgtgttggat ttgaatggcc
      481 ctggtgctct agaactgcgt gcccgatgtt cccctcgcct gaagctgctg cagatggacc
      541 tgaccaagcc agaggatatc agccgtgttc tggaaattac caaggctcac acggccagca
      601 ctggcctgtg gggtctggtt aacaatgctg gcctcaacat ggtagtggcc gatgtggaac
      661 tgtctccagt ggtaactttc cgcgaatgta tggaggtgaa cttctttggt gcacttgagc
      721 tgaccaaggg cctcctgcca ctcctacgtc actcaagggg acgtattgtg accgttggca
      781 gcccagcagg agacatgcca tacccctgct tggcagccta tggaacctcc aaggcagcta
      841 ttgcactgct catggacaca ttcagctgtg aactgcttcc ctggggtatc aaggtcagca
      901 tcatccagcc tggctgcttc aagacagagg cagtgactaa tgtgaacctc tgggagaagc
      961 gcaagcaact gctgctggcc aacttgccta gagagctgct gcaggcctat ggtgaagact
     1021 acattgagca cttgcatggg caattcctga attcactcag aatggcattg cctgacctta
     1081 gccccgttgt agatgccatc attgatgcac tgctggcagc tcagccacgc agccgctact
     1141 acacgggccg tggcctgggg ctcatgtatt tcatccacca ctacctgcca ggaggcctgc
     1201 ggcgccgctt cctacagaac ttcttcatca gtcaccttct accccgagca ctgaggcctg
     1261 gccaacctgg ccctgttcat gacacaaccc aggacccaaa cccttccccc acagtatcag
     1321 ctctgtgaac cacaaactta ggtgtttcag caggagaggc ttcttgagcc cttggccctc
     1381 tcccctggcc attatagacc cctcaacctt tccctagagt ctctgttaag aaaagcccag
     1441 cctctactgc tgatgccgag tccaggcccg ggaggtggaa tttgctagtg atcctctgga
     1501 cctctcctct gcttcatgag accatgtata ccctaccagg cacgaccctt cagcttggag
     1561 agcccagatg gatggagagt ttagcgtgag atgtggctgc aacctttgag aggatgctac
     1621 agaccacttc tgtgctgact ttagaatgat tagacatgtg gggcctcctc agaattcttt
     1681 gggtacccac tgtctcagtg ctgcagtcca gagtaaatcc ctcttgactg gctcaagatt
     1741 taggttccca accactggct cccagccaca tggaagctgt atgctgtatt tgtctggttg
     1801 ttggcatttt aaaataaaga tacatttttt tatttctcct agaatgggag agatagtgtt
     1861 tgg
//
