LOCUS       NM_017080               1585 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Rattus norvegicus hydroxysteroid 11-beta dehydrogenase 1 (Hsd11b1),
            transcript variant 1, mRNA.
ACCESSION   NM_017080
VERSION     NM_017080.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1585)
  AUTHORS   Victorio,J.A., Barssotti,L., Aprahamian,T., Costa,R.G.,
            Mousovich-Neto,F., Oliveira,H.C.F., Mori,M., Rossoni,L.V. and
            Davel,A.P.
  TITLE     beta-Adrenergic Stimulation-Induced PVAT Dysfunction in Male Sex: A
            Role for 11beta-Hydroxysteroid Dehydrogenase-1
  JOURNAL   Endocrinology 165 (6) (2024)
   PUBMED   38712392
  REMARK    GeneRIF: beta-Adrenergic Stimulation-Induced PVAT Dysfunction in
            Male Sex: A Role for 11beta-Hydroxysteroid Dehydrogenase-1.
REFERENCE   2  (bases 1 to 1585)
  AUTHORS   Brossaud,J., Bosch-Bouju,C., Marissal-Arvy,N.,
            Campas-Lebecque,M.N., Helbling,J.C., Webster,S.P., Walker,B.R.,
            Fioramonti,X., Ferreira,G., Barat,P., Corcuff,J.B. and Moisan,M.P.
  TITLE     Memory deficits in a juvenile rat model of type 1 diabetes are due
            to excess 11beta-HSD1 activity, which is upregulated by high
            glucose concentrations rather than insulin deficiency
  JOURNAL   Diabetologia 66 (9), 1735-1747 (2023)
   PUBMED   37300580
  REMARK    GeneRIF: Memory deficits in a juvenile rat model of type 1 diabetes
            are due to excess 11beta-HSD1 activity, which is upregulated by
            high glucose concentrations rather than insulin deficiency.
REFERENCE   3  (bases 1 to 1585)
  AUTHORS   Tseilikman,V., Lapshin,M., Klebanov,I., Chrousos,G., Vasilieva,M.,
            Pashkov,A., Fedotova,J., Tseilikman,D., Shatilov,V., Manukhina,E.,
            Tseilikman,O., Sarapultsev,A. and Downey,H.F.
  TITLE     The Link between Activities of Hepatic 11beta-Hydroxysteroid
            Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following
            Repeated Predator Stress: Focus on Heightened Anxiety
  JOURNAL   Int J Mol Sci 23 (9), 4881 (2022)
   PUBMED   35563271
  REMARK    GeneRIF: The Link between Activities of Hepatic
            11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in
            the Brain Following Repeated Predator Stress: Focus on Heightened
            Anxiety.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1585)
  AUTHORS   Li,X., Hu,S., Zhu,Q., Yao,G., Yao,J., Li,J., Wang,Y., Ding,Y.,
            Qi,J., Xu,R., Zhao,H., Zhu,Z., Du,Y., Sun,K. and Sun,Y.
  TITLE     Addressing the role of 11beta-hydroxysteroid dehydrogenase type 1
            in the development of polycystic ovary syndrome and the putative
            therapeutic effects of its selective inhibition in a preclinical
            model
  JOURNAL   Metabolism 119, 154749 (2021)
   PUBMED   33722534
  REMARK    GeneRIF: Addressing the role of 11beta-hydroxysteroid dehydrogenase
            type 1 in the development of polycystic ovary syndrome and the
            putative therapeutic effects of its selective inhibition in a
            preclinical model.
REFERENCE   5  (bases 1 to 1585)
  AUTHORS   Mori,R.C., Santos-Bezerra,D.P., Pelaes,T.S., Admoni,S.N.,
            Perez,R.V., Monteiro,M.B., Machado,C.G., Queiroz,M.S., Machado,U.F.
            and Correa-Giannella,M.L.
  TITLE     Variants in HSD11B1 gene modulate susceptibility to diabetes kidney
            disease and to insulin resistance in type 1 diabetes
  JOURNAL   Diabetes Metab Res Rev 37 (1), e3352 (2021)
   PUBMED   32453474
REFERENCE   6  (bases 1 to 1585)
  AUTHORS   Obeid,J. and White,P.C.
  TITLE     Tyr-179 and Lys-183 are essential for enzymatic activity of 11
            beta-hydroxysteroid dehydrogenase
  JOURNAL   Biochem Biophys Res Commun 188 (1), 222-227 (1992)
   PUBMED   1417845
REFERENCE   7  (bases 1 to 1585)
  AUTHORS   Moisan,M.P., Edwards,C.R. and Seckl,J.R.
  TITLE     Differential promoter usage by the rat 11 beta-hydroxysteroid
            dehydrogenase gene
  JOURNAL   Mol Endocrinol 6 (7), 1082-1087 (1992)
   PUBMED   1508221
REFERENCE   8  (bases 1 to 1585)
  AUTHORS   Krozowski,Z., Obeyesekere,V., Smith,R. and Mercer,W.
  TITLE     Tissue-specific expression of an 11 beta-hydroxysteroid
            dehydrogenase with a truncated N-terminal domain. A potential
            mechanism for differential intracellular localization within
            mineralocorticoid target cells
  JOURNAL   J Biol Chem 267 (4), 2569-2574 (1992)
   PUBMED   1733955
REFERENCE   9  (bases 1 to 1585)
  AUTHORS   Agarwal,A.K., Monder,C., Eckstein,B. and White,P.C.
  TITLE     Cloning and expression of rat cDNA encoding corticosteroid 11
            beta-dehydrogenase
  JOURNAL   J Biol Chem 264 (32), 18939-18943 (1989)
   PUBMED   2808402
REFERENCE   10 (bases 1 to 1585)
  AUTHORS   Monder,C., Shackleton,C.H., Bradlow,H.L., New,M.I., Stoner,E.,
            Iohan,F. and Lakshmi,V.
  TITLE     The syndrome of apparent mineralocorticoid excess: its association
            with 11 beta-dehydrogenase and 5 beta-reductase deficiency and some
            consequences for corticosteroid metabolism
  JOURNAL   J Clin Endocrinol Metab 63 (3), 550-557 (1986)
   PUBMED   3460996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK474613.1 and BC078865.1.
            
            On Oct 28, 2005 this sequence version replaced NM_017080.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078865.1, FQ219567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               CK474613.1         18-196
            180-1585            BC078865.1         1-1406
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..1585
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /note="hydroxysteroid 11-beta dehydrogenase 1"
                     /db_xref="GeneID:25116"
                     /db_xref="RGD:2834"
     exon            1..415
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1206
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /EC_number="1.1.1.146"
                     /EC_number="1.1.1.201"
                     /note="isoform 1 is encoded by transcript variant 1;
                     corticosteroid 11-beta-dehydrogenase isozyme 1; 11-DH;
                     11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1;
                     cortocosteroid 11-beta dehydrogenase; hydroxysteroid
                     dehydrogenase, 11 beta type 1; 11beta-HSD1;
                     11-beta-hydroxysteroid dehydrogenase, type 1; 7-oxosteroid
                     reductase"
                     /codon_start=1
                     /product="11-beta-hydroxysteroid dehydrogenase 1 isoform
                     1"
                     /protein_id="NP_058776.2"
                     /db_xref="GeneID:25116"
                     /db_xref="RGD:2834"
                     /translation="MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGR
                     EMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEA
                     GKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGS
                     IAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTET
                     ALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLS
                     LRSYNRDLFVSN"
     exon            416..546
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /inference="alignment:Splign:2.1.0"
     exon            547..658
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /inference="alignment:Splign:2.1.0"
     exon            659..844
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /inference="alignment:Splign:2.1.0"
     exon            845..988
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1533
                     /gene="Hsd11b1"
                     /gene_synonym="LRRGT00065"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaggatgt ctcggtagga gatgctcagg aacccagccc tgcacagtca tgagcctggc
       61 catctggaag ttgcctctta ctcaatgaaa tggagtaaac attgtccatt atgaaatcca
      121 tcacgcaggc tgccagggac gaatgggatc ccacccaaag ccaatcattg ctctgacagg
      181 gaagttggct agtgctgcct gagactactc cagcctcccc cgtccctgat gtcacaattc
      241 agaggctgct gcctgcctgg gaggttgtag aaagagctgc aggttttctt tgtgtgtcct
      301 acagagctcc ctgagccagg tccctgttgg acggcagtta tgaaaaaata cctcctcccc
      361 gtcctggtgc tctgcctggg ttactactat tctacaaatg aagagttcag accagaaatg
      421 ctccagggga agaaagtgat tgtcactggg gccagcaaag ggatcggaag agaaatggca
      481 tatcatctgt caaaaatggg agcccatgtg gtattgactg caaggtcgga ggaagggctc
      541 cagaaggtgg tgtctcgctg ccttgaactc ggagcagcct ctgctcacta tattgccggc
      601 actatggaag acatggcttt tgcagagcga tttgttgttg aggcaggaaa gctcttgggt
      661 ggactggaca tgctcattct caatcacatc acacagacca ctatgtctct cttccacgat
      721 gatatccact ctgtgcgaag aagcatggag gtcaacttcc tcagctatgt ggtcctgagc
      781 acagcagcct tgcccatgct gaaacagagc aatggcagca ttgccatcat ctcctccatg
      841 gctgggaaaa tgacccaacc tctgattgct tcctactctg caagcaagtt tgctctggat
      901 gggttctttt ccaccattag aaaagaacac ttgatgacca aggtcaacgt gtccatcact
      961 ctctgtgtcc tcggcttcat agacacagaa acagctttga aagaaacctc tgggataatc
     1021 ttgagtcaag ctgctcccaa ggaggaatgc gccctggaga tcatcaaagg cacagttctg
     1081 cgcaaagatg aggtatacta tgacaaatca tcttggactc cacttctgct tgggaatcca
     1141 ggaaggagga tcatggaatt tctttcatta cggtcatata acagggacct atttgtaagc
     1201 aactaggaac tcctgaggcc tggtgaaggg tcttggaaca gtcctgcctg atatttctgt
     1261 gagccctacc cacaaatttc tatgagcccc tttccagaga tacacaaatt ttggggtaca
     1321 cctcaccatg agaaattctt gcaacacttg cacagtaaaa atgtaattgt aataaatgtc
     1381 acaaaccact ttgtagcctg cagttgtgaa cttgattgta actatggatt taagcacaca
     1441 gttgtatcaa ttttacctca tacagaatga aacaatgatg cctaatgtaa cattaaataa
     1501 aataaaggta atatcaactc tataaattca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaa
//
