LOCUS       NM_001108340             783 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus HscB mitochondrial iron-sulfur cluster
            co-chaperone (Hscb), mRNA.
ACCESSION   NM_001108340 XM_001080654 XM_341099
VERSION     NM_001108340.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 783)
  AUTHORS   Maio N and Rouault TA.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   2  (bases 1 to 783)
  AUTHORS   Maio N, Singh A, Uhrigshardt H, Saxena N, Tong WH and Rouault TA.
  TITLE     Cochaperone binding to LYR motifs confers specificity of iron
            sulfur cluster delivery
  JOURNAL   Cell Metab 19 (3), 445-457 (2014)
   PUBMED   24606901
REFERENCE   3  (bases 1 to 783)
  AUTHORS   Uhrigshardt H, Singh A, Kovtunovych G, Ghosh M and Rouault TA.
  TITLE     Characterization of the human HSC20, an unusual DnaJ type III
            protein, involved in iron-sulfur cluster biogenesis
  JOURNAL   Hum Mol Genet 19 (19), 3816-3834 (2010)
   PUBMED   20668094
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341099.3, XM_001080654.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM065613.1, CB612787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..783
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /note="HscB mitochondrial iron-sulfur cluster
                     co-chaperone"
                     /db_xref="GeneID:360826"
                     /db_xref="RGD:1311005"
     exon            1..261
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..733
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /note="iron-sulfur cluster co-chaperone protein HscB,
                     mitochondrial; HscB iron-sulfur cluster co-chaperone
                     homolog"
                     /codon_start=1
                     /product="iron-sulfur cluster co-chaperone protein HscB
                     precursor"
                     /protein_id="NP_001101810.1"
                     /db_xref="GeneID:360826"
                     /db_xref="RGD:1311005"
                     /translation="MWSCRARSLLCVWEVRLARFLGRSLLSSNAASGKSIEPQCWNCG
                     RAMGAGRGDEFFCAHCRALQPPDPTRDYFSLMNCNQSFRVDIRKLQQRYQQLQRLVHP
                     DFFSQKSQTEKRFSEKHSTLVNDAYKTLQAPVSRGLYLLKLQGIEIPEGTDYRTDSQF
                     LVEIMEINEKLADAKSEAAMEEVEATVRAKQKEFTDNINRAFEQGDFEKAKELLTKMR
                     YFSNIEEKIKLSKNPL"
     exon            262..358
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /inference="alignment:Splign:2.1.0"
     exon            359..448
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /inference="alignment:Splign:2.1.0"
     exon            449..593
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /inference="alignment:Splign:2.1.0"
     exon            594..641
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /inference="alignment:Splign:2.1.0"
     exon            642..783
                     /gene="Hscb"
                     /gene_synonym="RGD1311005"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taacccgggc cagcaggcgg ccttacgaat gtggagctgc agggctcggt ccctgctgtg
       61 cgtgtgggag gtgcgactgg ctaggttcct tggtaggagc ctgctgagca gcaatgccgc
      121 ctcgggaaag agcatcgagc cgcaatgctg gaactgcggc cgcgcgatgg gagccgggcg
      181 tggggatgag tttttctgcg cacactgccg cgcgctgcag cctcctgacc ccactcggga
      241 ctacttcagc ctcatgaact gcaaccaatc cttcagggtt gacatccgga aacttcaaca
      301 aaggtaccag caactacagc gccttgtcca cccagatttc ttcagccaaa agtctcagac
      361 tgagaaacgg ttctcggaga agcattcgac cctggtgaat gatgcctaca agactcttca
      421 ggcccccgtg agcagaggac tatatcttct aaagctccaa ggaatagaaa ttcctgaagg
      481 gacagattat agaacagaca gtcagttcct tgtggaaatc atggaaatca atgaaaaact
      541 cgcagacgcc aaaagtgagg cagccatgga agaggtagaa gccactgtca gagctaaaca
      601 gaaagaattt acggacaata taaacagagc ttttgaacaa ggtgattttg aaaaagccaa
      661 ggaacttctt acaaaaatga gatacttttc aaacatagaa gaaaagatca agttaagcaa
      721 gaaccctctc tagttgctaa cttaaagttt taaaaataaa ctttgtattt cttttccggc
      781 ttc
//
