LOCUS       NM_001108210            3269 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus heparan sulfate 6-O-sulfotransferase 1 (Hs6st1),
            mRNA.
ACCESSION   NM_001108210 XM_001056379 XM_237060
VERSION     NM_001108210.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3269)
  AUTHORS   Tornberg J, Sykiotis GP, Keefe K, Plummer L, Hoang X, Hall JE,
            Quinton R, Seminara SB, Hughes V, Van Vliet G, Van Uum S, Crowley
            WF, Habuchi H, Kimata K, Pitteloud N and Bulow HE.
  TITLE     Heparan sulfate 6-O-sulfotransferase 1, a gene involved in
            extracellular sugar modifications, is mutated in patients with
            idiopathic hypogonadotrophic hypogonadism
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11524-11529 (2011)
   PUBMED   21700882
REFERENCE   2  (bases 1 to 3269)
  AUTHORS   Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL and Kimata K.
  TITLE     Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit
            defective heparan sulfate biosynthesis, abnormal placentation, and
            late embryonic lethality
  JOURNAL   J Biol Chem 282 (21), 15578-15588 (2007)
   PUBMED   17405882
REFERENCE   3  (bases 1 to 3269)
  AUTHORS   Habuchi H, Tanaka M, Habuchi O, Yoshida K, Suzuki H, Ban K and
            Kimata K.
  TITLE     The occurrence of three isoforms of heparan sulfate
            6-O-sulfotransferase having different specificities for hexuronic
            acid adjacent to the targeted N-sulfoglucosamine
  JOURNAL   J Biol Chem 275 (4), 2859-2868 (2000)
   PUBMED   10644753
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_237060.4, XM_001056379.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB707126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3269
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..3269
                     /gene="Hs6st1"
                     /note="heparan sulfate 6-O-sulfotransferase 1"
                     /db_xref="GeneID:316325"
                     /db_xref="RGD:1309218"
     exon            1..343
                     /gene="Hs6st1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1052
                     /gene="Hs6st1"
                     /EC_number="2.8.2.-"
                     /codon_start=1
                     /product="heparan-sulfate 6-O-sulfotransferase 1"
                     /protein_id="NP_001101680.1"
                     /db_xref="GeneID:316325"
                     /db_xref="RGD:1309218"
                     /translation="MKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCT
                     CYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDPAGLRSPRKFYYITLL
                     RDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCP
                     YNLANNRQVRMLADLSLVGCYNLSFIPESKRAQLLLESAKKNLRGMAFFGLTEFQRKT
                     QYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRHIEELNDLDMQLYDYAKDLFQQR
                     YQYKRQLERREQRLRNREERLLHRSKEALPREDTEEPGRVPTEDYMSHIIEKW"
     exon            344..3269
                     /gene="Hs6st1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacattacga gaaaaagtac tacttcccgg tgcgcgagct ggagcgctcg ctgcgcttcg
       61 acatgaaggg cgacgacgtg atagtcttcc tgcatatcca gaagaccggc ggcaccacct
      121 tcggccgcca cctagtgcag aacgtgcgcc tcgaggtgcc ctgcgactgt cgcccgggcc
      181 agaagaagtg cacctgctat cggcccaatc gccgcgagac ctggctcttc tctcgcttct
      241 ccaccggctg gagctgcggg ctgcacgctg actggaccga actcaccaac tgtgttcccg
      301 gtgtgctaga ccgccgcgac ccagcaggtc tgcgttcgcc cagaaagttc tactacatca
      361 ccctgctgcg agaccctgta tcccgctacc tgagtgaatg gcgacatgta cagcgtgggg
      421 ccacgtggaa gacctccttg cacatgtgtg acgggcgcac accgacccca gaggagctgc
      481 caccctgcta cgagggcaca gactggtcgg gctgcacatt gcaggagttc atggattgcc
      541 cctacaacct ggccaacaac cggcaggtgc gcatgctggc tgacctcagc ctggtgggct
      601 gctacaacct gtctttcatc cccgagagca agcgggccca gctgctgctg gagagcgcca
      661 agaagaacct gcgcggcatg gccttcttcg gcctcacgga gttccagcgc aagacgcagt
      721 acctatttga gcggacgttc aacctcaagt tcatccggcc cttcatgcag tacaacagca
      781 cgcgggcggg cggtgtggag gtggatgagg acactatccg gcacatcgag gagctcaacg
      841 acctggacat gcagctttat gactatgcca aggacctctt ccagcagcgt taccagtaca
      901 agagacagct ggagcgcagg gagcagcgcc tgcgcaatcg cgaagagcgc ctcctgcatc
      961 gctccaagga agcgctgcca cgggaggaca cggaagagcc aggccgagta cccaccgagg
     1021 actacatgag ccatatcatt gagaagtggt agtaatgtca ggggcagaga atgatgggca
     1081 agaattaaca gggaaagaag tggggccaac agttcttgct gtttggtgcc gcgggaaccg
     1141 tgctagtagg ctgccctaga ccttgatgga gcagggtagg acctctgggg cagatggcct
     1201 ccctgctgtc ctggcccctg tgtcacagtt aaaactgaca aagatttgaa aaagactggc
     1261 gaggggacgt gtctgcccag ctgagactcc cacacctact atgcacgcac cggcccccaa
     1321 tgaccagccc gctaggaaca tgttactagc tcctaatagc ttggttgaag ctccttggtc
     1381 tttggggacc ctaatacccc cagaaccttg gggagccttt tcttttgaga atacaagcat
     1441 atctctgagg cgtcctcaga cctggagtgc tccccaaccc ccacctatca aagctgcttt
     1501 caaggtcagg gtcagcccca gctatggccg agatgactca agtctggcac ctggctactg
     1561 cactccctgg gccatgatca gaatccacgg catatcctgg ctttggggga accaggttca
     1621 agcagggaag ggatggacac caagaatgcc cccccaccaa tccctatgct ttctgatgca
     1681 ctgcccctcc cccatcactg aaacatttat acaagggctt gtgtgccaat gttcctacca
     1741 taccagcaac tctttcaatc ccatgcataa aagcatcctt tggctgggat acagggccac
     1801 atcaacctga gttggtactg aatggccggg atggggattt tcccattctc agctaagatt
     1861 ggaagaaacc attctggatg tcctttctgg ggcctgtttg cataaccctc cccatcctgg
     1921 ctctccttac accttcctac ccttcacaaa gtctgaccca gctatttcca gcagccccgt
     1981 gaaccaacca gggaccgtat tagaagccat gttgcatatt atattaagtt cttttttttt
     2041 tttttttttt ttttttttgg cctagtgccc tatcccttac gttctttaag aggccctggc
     2101 aagcccttag tggaggtgcc atgacttttt cagagtccat atgcatgcag ccaagggttg
     2161 tgagctgtcc ctgagatagg acagggccca ctccctgcct ctgcctcact ctgcactcag
     2221 gctaagaagg ggagggtcac cacagacagg agtgggggcc attatgtagc acagcaatat
     2281 tctagatgtt ggcaggtgtc actgctgccc cagagcaatg gcttaatctt cacgtgtgtg
     2341 gtataggatc aggcactggg cacttgacct tggggtccat gggcaagatg agttctgatt
     2401 gtgcactgtc cggcccaatc tagggccacc tttatggtgg ttgatcactc tgaagatatg
     2461 ggtggcaaga tgagttagaa ggtcaaggtc actgagaaga attggcttag atggccaagt
     2521 ttagagtgaa tatattatct ttggggagcc tggggcattt tggggaaccc atggatctct
     2581 tacaggtcat gctggttgct gccacttctg tcaggaagcg ccccagctcc acgttacccc
     2641 tccccccttc acaaccttct gtgtacccga cctgaacata ggctctgtcc tatacatact
     2701 ggaataggtt ttaacgtatg ccccgtcatc ctgactcaca cagaagcacg ggtctctcct
     2761 caatctttgc tgcatttgaa aaaatattcc ctcccatctc aggccagcgc caggttgaag
     2821 cgtcctcagt ccctcaattg tccacccctg cctgaggctc aggctaccag ctttgggaca
     2881 cagcttcctg gtactcgcgg catctcagaa cagggtgctt ctccagctcc gaggactctg
     2941 cctacagggc tgttccccgg caagccgaga actcagtccc caggcaccct gcaaccctgc
     3001 agacaccccc tcctagaatg ggaagcaggg aacctgccca gctgacgcgt ctgaactgga
     3061 actgtctcac ttgaacccag gagctttaaa actttattta tttatagctt cttattaaaa
     3121 aatttaaaaa aaaaaagcgc tgagaaggaa tcgttttggt tattcatacg gaattgatca
     3181 tggaaaagca aaactggttg gttgtcttct aattgtcttc gcctagatgg agtctgaaca
     3241 ttagcggatg aataaaccct gaaaaggtc
//
