LOCUS       NM_181370               2280 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heparan sulfate-glucosamine 3-sulfotransferase 2
            (Hs3st2), mRNA.
ACCESSION   NM_181370
VERSION     NM_181370.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2280)
  AUTHORS   Su,Y., Fang,H. and Jiang,F.
  TITLE     Integrating DNA methylation and microRNA biomarkers in sputum for
            lung cancer detection
  JOURNAL   Clin Epigenetics 8, 109 (2016)
   PUBMED   27777637
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2280)
  AUTHORS   Kuberan,B., Lech,M., Borjigin,J. and Rosenberg,R.D.
  TITLE     Light-induced 3-O-sulfotransferase expression alters pineal heparan
            sulfate fine structure. A surprising link to circadian rhythm
  JOURNAL   J Biol Chem 279 (7), 5053-5054 (2004)
   PUBMED   14630922
  REMARK    GeneRIF: 3-O sulfation catalyzed by HS 3-O-sulfotransferase
            (3-OST2) is predominantly restricted to daytime pineal glands in
            rats
REFERENCE   3  (bases 1 to 2280)
  AUTHORS   Borjigin,J., Deng,J., Sun,X., De Jesus,M., Liu,T. and Wang,M.M.
  TITLE     Diurnal pineal 3-O-sulphotransferase 2 expression controlled by
            beta-adrenergic repression
  JOURNAL   J Biol Chem 278 (18), 16315-16319 (2003)
   PUBMED   12601002
REFERENCE   4  (bases 1 to 2280)
  AUTHORS   Miyamoto,K., Asada,K., Fukutomi,T., Okochi,E., Yagi,Y.,
            Hasegawa,T., Asahara,T., Sugimura,T. and Ushijima,T.
  TITLE     Methylation-associated silencing of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and
            pancreatic cancers
  JOURNAL   Oncogene 22 (2), 274-280 (2003)
   PUBMED   12527896
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_181370.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY240873.1, BC128721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-923               JAXUCZ010000001.1  185387463-185388385
            924-2280            JAXUCZ010000001.1  185507344-185508700
FEATURES             Location/Qualifiers
     source          1..2280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2280
                     /gene="Hs3st2"
                     /note="heparan sulfate-glucosamine 3-sulfotransferase 2"
                     /db_xref="GeneID:293451"
                     /db_xref="RGD:727787"
     exon            1..923
                     /gene="Hs3st2"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1542
                     /gene="Hs3st2"
                     /EC_number="2.8.2.29"
                     /note="heparan sulfate 3-O-sulfotransferase 2; heparan
                     sulfate D-glucosaminyl 3-O-sulfotransferase 2; heparan
                     sulfate (glucosamine) 3-O-sulfotransferase 2"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     2"
                     /protein_id="NP_852035.1"
                     /db_xref="GeneID:293451"
                     /db_xref="RGD:727787"
                     /translation="MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDGL
                     GQSRLLGAPRCLRGPSASGQKLLAKSRPCDPPGPTPSEPSAPSAPAAAAPAPRLSGSN
                     HSGSPKPGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDW
                     YRSLMPRTLETQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQT
                     LSKKPDIPTFEGLSFRNRSLGLVDVSWNAIRIGMYALHLESWLRYFPLAQIHFVSGER
                     LITDPAGEMGRIQDFLGIKRFITDKHFYFNKTKGFPCLKKPESTLLPRCLGKSKGRTH
                     VQIDPEVIDQLREFYRPYNIKFYETVGQDFRWE"
     exon            924..2280
                     /gene="Hs3st2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaacgcgg ccggcgccag cgccaccgtc cggtccgcgc atcctcccgc ccgcacagcc
       61 gcgcggccac tgagcgtccc ctgaaaggcg ctcggagcat ccggaatggg gcttcgggcg
      121 ctgggcgcgc tccgaacccg acacgcgtga gagtcggagt gccgggagcc tccccgctgt
      181 ccggagcccc catcgcctag caccgggaga tgatgggaat gcagccacct ggtccccaag
      241 gagccaccat acccgggacc cccgggcatg gtgctcaccc aagccagctg tccccgaaga
      301 ggatgatatc ccttacgcct agtccacacg gtggggacag cgccacgcga gccctctagg
      361 caatcgcaga gccacgcagc agctccgccg caggtgccac ctcggaaacc atgacccccg
      421 gcgcgggccc atggagctat ggcctatagg gtcctgggcc gcgcggggcc acctcagccg
      481 cggagagcgc gcaggctgct cttcgccttc acactgtcct tgtcctgcac ttacctgtgt
      541 tacagcttcc tgtgctgctg cgacggtctg ggccagagcc gcctgctcgg cgcgccgcgc
      601 tgcctccgcg gccccagcgc aagcggccag aaacttctgg cgaagtcccg cccgtgtgat
      661 cccccggggc cgacgcccag tgagcccagc gctcccagcg cgcccgccgc tgccgcgcca
      721 gcaccgcgcc tctccggatc caaccactct ggctccccga agccaggcac caaacggctg
      781 ccccaagccc tcattgtggg cgttaagaaa ggtggtaccc gagcagtgct ggagtttatc
      841 cgagtgcacc cggacgttcg agccctgggc accgagcccc acttcttcga caggaattac
      901 ggccgagggc tggactggta caggagcctg atgccgagga ccttggagac ccagatcaca
      961 ctggagaaga cgcctagcta cttcgtcact caagaagccc ctcggaggat cttcaacatg
     1021 tctcgagaca ccaagctgat agtggtggtg cggaacccgg tgacccgagc catctctgac
     1081 tacacgcaga cgctttccaa gaagccggac atccccacct tcgagggctt gtccttccgc
     1141 aaccgcagcc tgggcctggt ggatgtgtct tggaacgcca tccgcatcgg catgtacgca
     1201 ctgcacctgg agagctggct ccggtacttc ccgctggccc agatccactt cgtcagtggt
     1261 gagcggctca tcaccgaccc agctggtgag atggggcgca ttcaggactt cctgggcatc
     1321 aagagattca tcacagacaa gcacttctac ttcaacaaga ccaaaggatt cccttgcttg
     1381 aaaaaaccag agtcaaccct cctgcctcga tgcctgggca aatcaaaagg gagaactcat
     1441 gtacagatcg accctgaagt tatagaccag ctccgggaat tttatagacc ttataatatt
     1501 aaattttatg aaactgttgg gcaggacttc cggtgggagt gagtctccag ggtacaaggg
     1561 ctctattgtt gtctcttcca caaggtttgc tcccagaaaa tctgaccccc atctccagcc
     1621 cctcttccca tcttgaaccc tatgatagat catctcggaa ccagaaaact gagtaaagac
     1681 ccagaattgg tggttcctgt ttaatccagg ataattctgc ctgcttctgg catacccatc
     1741 cagttctaga atctgctccc atccacccat gagtggtctt ggggaattcc tgtaagaaga
     1801 gtggacctcc cagtgttggg gcatattctg agtggagatg gagctgttgt gtgaaaacag
     1861 cagtccatcc caacactgta cactcagtgg tgggcttcgt aattccaagt ggcatgtacc
     1921 ttccctccga gcttaatttt ccccagcagc cctgagcggt ggggtggggg aacgccttcc
     1981 gccctcctca gaacacagca gctcactaac agtgtgcaga gccccaaacc cctctttggc
     2041 cactccagga gatggactct gggatgatga aataagccag tgacttcaaa gcctgtggtg
     2101 tccactgtgc tcggaggacg atgtctttga aaagcactca gtgactctcc ccactccctg
     2161 tggacaaaaa gcacataatt ctgctgttac gggtactttc ttcacgcgag ctttcatgtt
     2221 cggcatgcac gggatcatgc ttgtccatgt gaaataaata tggctttctc gtgtccttca
//
