LOCUS       NM_053391               1647 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus heparan sulfate-glucosamine 3-sulfotransferase 1
            (Hs3st1), mRNA.
ACCESSION   NM_053391
VERSION     NM_053391.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Takeda,K., Hashimoto,K., Uchikawa,R., Tegoshi,T., Yamada,M. and
            Arizono,N.
  TITLE     Direct effects of IL-4/IL-13 and the nematode Nippostrongylus
            brasiliensis on intestinal epithelial cells in vitro
  JOURNAL   Parasite Immunol 32 (6), 420-429 (2010)
   PUBMED   20500673
  REMARK    GeneRIF: These results suggested that HS3ST1 gene expression is
            strictly regulated by IL-4/IL-13.
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Li,Z.Y., Hirayoshi,K. and Suzuki,Y.
  TITLE     Expression of N-deacetylase/sulfotransferase and
            3-O-sulfotransferase in rat alveolar type II cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 279 (2), L292-L301 (2000)
   PUBMED   10926552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 5, 2020 this sequence version replaced NM_053391.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK601016.1, CV078944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000014.1  75398973-75399156
            185-1647            JAXUCZ010000014.1  75427239-75428701
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1647
                     /gene="Hs3st1"
                     /gene_synonym="3OST-I"
                     /note="heparan sulfate-glucosamine 3-sulfotransferase 1"
                     /db_xref="GeneID:84406"
                     /db_xref="RGD:71084"
     exon            1..184
                     /gene="Hs3st1"
                     /gene_synonym="3OST-I"
                     /inference="alignment:Splign:2.1.0"
     exon            185..1647
                     /gene="Hs3st1"
                     /gene_synonym="3OST-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1229
                     /gene="Hs3st1"
                     /gene_synonym="3OST-I"
                     /EC_number="2.8.2.23"
                     /note="heparan sulfate glucosamine 3-O-sulfotransferase I;
                     heparan sulfate 3-O-sulfotransferase 1; heparan sulfate
                     D-glucosaminyl 3-O-sulfotransferase 1; heparan sulfate
                     (glucosamine) 3-O-sulfotransferase 1"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     1 precursor"
                     /protein_id="NP_445843.2"
                     /db_xref="GeneID:84406"
                     /db_xref="RGD:71084"
                     /translation="MTLLLLLGTVLLVAQPQLVPSHPAAPGPGLKQQELLRKVIILPE
                     DTGEGAATNGSTQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYS
                     QGLGWYLTQMPFSSPHQLTVEKTPAYFTSPKVPERIHSMNPTIRLLLILRDPSERVLS
                     DYTQVLYNHLQKHKPYPPIEDLLMRDGRLNVDYKALNRSLYHAHMLNWLRFFPLGHIH
                     IVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGKDRCLHESKG
                     RAHPQVDPKLLDKLHEYFHEPNKKFFKLVGRTFDWH"
ORIGIN      
        1 cctggagctg cggccaccgc aggctctctc tcggtgagtg cctgtgtccc ttcacggctc
       61 gcccgtcccg gggtgcctgg gaatttgctc caaggggcgc aggtgcttgg cggcggtgct
      121 gcccatggcc gggtcggaga gaggattgag agcgccggac cggctggacg ggtacgcgac
      181 tcagtaattg gaaattggag acactcatgt tccagtaatc aagagggatc cttgctgccg
      241 cttcatgatc caggggcgtg tggcccagtg aagttcctga gctgtacagc atgaccttgc
      301 tgctgctcct gggcacggtg ctgctggtgg cccagcccca gctcgtgcct tcccacccgg
      361 ctgctcctgg cccgggactc aaacagcagg agcttctgag gaaggtgatt attctcccgg
      421 aggacactgg agaaggtgca gccaccaatg gttccactca gcagctgcca cagactatca
      481 tcattggagt acgcaagggt ggtacccgag ccctgctgga gatgctcagc ctgcatcctg
      541 atgttgcggc agctgaaaac gaggtccatt tctttgactg ggaggaacat tatagccaag
      601 gcctgggctg gtacctcacc cagatgccct tctcctcccc acaccagctc acggtagaga
      661 agacacctgc ctacttcact tcgcccaaag tgcctgagag aatccacagc atgaacccta
      721 ctatccgcct gctgctcatc ctgagggacc catccgaacg tgtgctatcc gactacaccc
      781 aggtgttgta caaccacctt cagaagcaca aaccttaccc acccattgag gacctcctaa
      841 tgcgggacgg acggctcaac gtggactaca aggctctcaa ccgcagcctg taccatgcac
      901 acatgctgaa ctggctgcgt tttttcccac tgggccacat ccacatcgtg gatggcgacc
      961 gtctcatcag agaccctttc cctgagatcc agaaagtcga aaggttcctc aagctgtctc
     1021 cacagatcaa cgcctcgaac ttctacttta acaaaaccaa gggcttctac tgcctgcggg
     1081 acagtggcaa ggaccgctgc ttacatgagt ccaaaggccg ggcgcaccct caagtagatc
     1141 ccaaactact tgataaactg cacgaatatt ttcatgagcc aaataagaaa tttttcaagc
     1201 tcgtgggcag aacattcgac tggcactaat ttgccgtctg ttaggcacgg gacttttcct
     1261 gttgtaactt ctggtgtaca tctgaagtgg ggggaggaac aaattttaaa aaagcattta
     1321 agctataatt tatttgtaaa acccacaaat gacttctgta cagtattaga ttcacagttg
     1381 ccatatatag tagttatatt tttctacttg ttaaatggag ggcgttttgt attgtttttc
     1441 atggttgtta acattgtgta tgtctctata atatgaagga acttaactat tgcactgaaa
     1501 aaaataagag attttttttt ctggagacgt cttttttttt tttaatataa ttaacctgcc
     1561 tccaattcaa aatagctctt tgtttgcaac cctccttgtc aaatctataa tctttttctg
     1621 cttaaaaaaa tttattggta ttatgga
//
