LOCUS       NM_057130               5255 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus harakiri, BCL2 interacting protein (Hrk), mRNA.
ACCESSION   NM_057130
VERSION     NM_057130.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5255)
  AUTHORS   Wang,H., Lin,X., Li,J., Zeng,G. and Xu,T.
  TITLE     Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis
            of Cardiomyocyte by Targeting miR-942-5p/DP5
  JOURNAL   Drug Des Devel Ther 15, 481-492 (2021)
   PUBMED   33603338
  REMARK    GeneRIF: Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced
            Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5255)
  AUTHORS   Duval,N., Sumner,W.A., Andrianakos,A.G., Gray,J.J., Bouchard,R.J.,
            Wilkins,H.M. and Linseman,D.A.
  TITLE     The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and
            BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant
            SOD1 Mouse Spinal Cord
  JOURNAL   Front Cell Neurosci 12, 15 (2018)
   PUBMED   29440992
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5255)
  AUTHORS   Du,H., Wolf,J., Schafer,B., Moldoveanu,T., Chipuk,J.E. and
            Kuwana,T.
  TITLE     BH3 domains other than Bim and Bid can directly activate Bax/Bak
  JOURNAL   J Biol Chem 286 (1), 491-501 (2011)
   PUBMED   21041309
REFERENCE   4  (bases 1 to 5255)
  AUTHORS   Gurzov,E.N., Ortis,F., Cunha,D.A., Gosset,G., Li,M., Cardozo,A.K.
            and Eizirik,D.L.
  TITLE     Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk
            activation: a novel mechanism for pancreatic beta-cell apoptosis
  JOURNAL   Cell Death Differ 16 (11), 1539-1550 (2009)
   PUBMED   19629134
  REMARK    GeneRIF: The inactivation of hrk protein protects -cells from
            IL-1beta+IFN-gamma and chemical Endoplasmic Reticulum
            stress-mediated cell death.
REFERENCE   5  (bases 1 to 5255)
  AUTHORS   Lomonosova,E. and Chinnadurai,G.
  TITLE     BH3-only proteins in apoptosis and beyond: an overview
  JOURNAL   Oncogene 27 Suppl 1 (Suppl 1), S2-S19 (2008)
   PUBMED   19641503
  REMARK    Review article
REFERENCE   6  (bases 1 to 5255)
  AUTHORS   Sunayama,J., Ando,Y., Itoh,N., Tomiyama,A., Sakurada,K.,
            Sugiyama,A., Kang,D., Tashiro,F., Gotoh,Y., Kuchino,Y. and
            Kitanaka,C.
  TITLE     Physical and functional interaction between BH3-only protein Hrk
            and mitochondrial pore-forming protein p32
  JOURNAL   Cell Death Differ 11 (7), 771-781 (2004)
   PUBMED   15031724
REFERENCE   7  (bases 1 to 5255)
  AUTHORS   Polster,B.M., Robertson,C.L., Bucci,C.J., Suzuki,M. and Fiskum,G.
  TITLE     Postnatal brain development and neural cell differentiation
            modulate mitochondrial Bax and BH3 peptide-induced cytochrome c
            release
  JOURNAL   Cell Death Differ 10 (3), 365-370 (2003)
   PUBMED   12700636
  REMARK    GeneRIF: BH3 peptide has a role in releasing cytochrome c in rat
            brain mitochondria
REFERENCE   8  (bases 1 to 5255)
  AUTHORS   Harris,C.A. and Johnson,E.M. Jr.
  TITLE     BH3-only Bcl-2 family members are coordinately regulated by the JNK
            pathway and require Bax to induce apoptosis in neurons
  JOURNAL   J Biol Chem 276 (41), 37754-37760 (2001)
   PUBMED   11495903
REFERENCE   9  (bases 1 to 5255)
  AUTHORS   Imaizumi,K., Morihara,T., Mori,Y., Katayama,T., Tsuda,M.,
            Furuyama,T., Wanaka,A., Takeda,M. and Tohyama,M.
  TITLE     The cell death-promoting gene DP5, which interacts with the BCL2
            family, is induced during neuronal apoptosis following exposure to
            amyloid beta protein
  JOURNAL   J Biol Chem 274 (12), 7975-7981 (1999)
   PUBMED   10075695
REFERENCE   10 (bases 1 to 5255)
  AUTHORS   Imaizumi,K., Tsuda,M., Imai,Y., Wanaka,A., Takagi,T. and Tohyama,M.
  TITLE     Molecular cloning of a novel polypeptide, DP5, induced during
            programmed neuronal death
  JOURNAL   J Biol Chem 272 (30), 18842-18848 (1997)
   PUBMED   9228060
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_057130.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83697.1, SRR22582424.1336298.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               JAXUCZ010000012.1  44070191-44070561   c
            372-5255            JAXUCZ010000012.1  44048402-44053285   c
FEATURES             Location/Qualifiers
     source          1..5255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..5255
                     /gene="Hrk"
                     /gene_synonym="Bid3; Dp5"
                     /note="harakiri, BCL2 interacting protein"
                     /db_xref="GeneID:117271"
                     /db_xref="RGD:70549"
     exon            1..371
                     /gene="Hrk"
                     /gene_synonym="Bid3; Dp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..304
                     /gene="Hrk"
                     /gene_synonym="Bid3; Dp5"
                     /note="neuronal death protein DP5; BH3-interacting
                     domain-containing protein 3; harakiri, BCL2 interacting
                     protein (contains only BH3 domain); BH3 interacting (with
                     BCL2 family) domain, apoptosis agonist; BH3 interacting
                     domain 3"
                     /codon_start=1
                     /product="activator of apoptosis harakiri"
                     /protein_id="NP_476471.1"
                     /db_xref="GeneID:117271"
                     /db_xref="RGD:70549"
                     /translation="MCPCPRHRGRGPPAVCGCGDARPGLRWAAAQVTALRLQALGDEL
                     HRRAMRRRARPRDPLPALLPALRARWPWLCAAAQVAALAAWLLGRRSA"
     exon            372..5255
                     /gene="Hrk"
                     /gene_synonym="Bid3; Dp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccagggag gctcctccgc acgccatgtg cccgtgtccc cggcatcgcg gccgcgggcc
       61 cccggccgtg tgcggttgcg gcgacgctcg ccccgggctg cgctgggcgg cggcgcaggt
      121 gaccgcgctg cggctgcagg cgctgggcga cgagctgcac cgacgcgcca tgaggcgtcg
      181 cgcgcggccc cgggacccgc tgcccgcgct gctgcccgcg ctccgcgccc gctggccctg
      241 gctgtgcgcg gccgcgcagg tggcggcgct ggcggcctgg ctgctcggca ggcggagcgc
      301 gtaggcggcg cgcgcggggc cttcttggtg ggggggaccg gagccgagac ccagcccgga
      361 cggagcaaca ggttggcgaa accctgtgtc cttggaggaa gctggttcct gttttcctga
      421 gggagtagcc cggagtgcgg aaggaagcca agagtgtaca gagttgatgg tgggaacgcg
      481 ggcagaggaa gcccctcggg aagtccagct gcagagatag ccacctcagt gctatttaca
      541 tagagctata tatatacaaa acaggagaaa aatacaaaat tccgtatctg tgcatgcctg
      601 cgggggacgt ggtccctttc ctttccacgc aaccttgcga tgtgaactct gagactttgt
      661 gatgtctagg gtggcagggg agagagatgc ttgctgctgc gcgtgcaggg aacttacgtg
      721 gacctgtggg atcggcctca gtgtggacca actgctcagc acagatgctg gtgtggagta
      781 gagggaactc agcggccgaa ggcaagatgg acaagacaga ggggacgtgg ggcccgtttt
      841 gttgggggca gcctgggatc cctccatttc ttgacatgtc ctagcctctc actgtccccg
      901 ttgagtcagc tctctagatc tcatggcggt catagccaga gaaacgggat gtcattttct
      961 ttccctacct acaagtgtgt ctggtgcttc tcttcacagt ttcttggtgc taagtgtatc
     1021 cttcttggta cagacagagt cttacagaca gaccgggaag gccaggggat gagacgtttc
     1081 tattttgctc tttggataga ctctcgttgc ttttttaaaa aagggccagg tgacaagatt
     1141 gccactggaa agtctctctc tggggggagg ggtggtgctc acagggctta agagcagccc
     1201 ctcccccagg gggcagggct acgaagggga ggggcgggcc ttatacagga gctgctttgg
     1261 aggtggcagt ccctcctctc cctgcagcag cactctggga gactgctgtg gactcctcca
     1321 atttcctaag gggattcagg gcttaggttt ttgtagattc aagagccaag aaatagctgc
     1381 gttctgacgg agcgtgattt ctaagcaggg gatgtggggg gaggggggcg gaccgtttaa
     1441 atgaaatgtc cgatttcccc tgctccccaa acacacggaa taagctactg ttttcagaag
     1501 tttctagaag ggctaatata aatataaata tatatacaca aatataacga agctgagcgc
     1561 tagactgaca tttggctgca gtggctcacg gcttcaggac tggtggcttt tttttttttt
     1621 ttttttaagg aacaggtatt actcctctgc atggatactg tatcacaccc cccccccccc
     1681 caggtctttg tagccgagat ggtgagggat gcttgcttgg gctcagtgag acagttactc
     1741 ttgtttttat tttatctttt tttttccttt ctaattttgg agacaaggcc tcaccctgga
     1801 gcccaggctg acctcagctc atgagcctcc ctgccctgta tctggtattt gggactctga
     1861 ctaccagggg agcgtcattt tctcctggct ggatttgcag gtgacttgcc tagtacctgg
     1921 gggatcaggg tttctgctag aaagcatcgg ttgttcaggt gcgcagggct tcaagggaac
     1981 cggtccctgg ccaacattgc tgagtgtgat cagtaaaatg caccctttcc cagtttgtag
     2041 tcaacaggct cctctctcca ttttaaatcc atgccttata tttctctgaa taacccactt
     2101 aaaaaaaaaa aaacaaaaaa acaaaaaaac acaaccggga actcaatgct gaagcctccc
     2161 ccttttatct gccagaaccg aagtcagcaa agaaaactaa ataaaaggag agagcctgtc
     2221 tggcagggga agcagcaggc agcaggccat gccctcgccc agccagaatt acacagaatg
     2281 atctggaaga caccctctgc ttgtgttgag tccctttccc agcaaggaaa caagtccttg
     2341 caagcatcac atttcaacat ggtgggactc tgtggtgtca gcctctttaa agacacacgg
     2401 tccagatcac agcggggggc gcgctgaccc tggagagacc cagcgcaaag ggtgaggagt
     2461 gagagaaaac ctctctttct gtgttttgct ttctgagcct ggctttgcct gttagctagt
     2521 gatagctccc tggaggattt gaactccaaa cacaggggtt agcctctctg gtcattttca
     2581 tttcaatgaa gctgtgttgc cgagagagcc gggcaccctg tgaccttcct aatggaactt
     2641 ctcagccaag tcctctgtaa atactctccc gtagtaatgg aaaccacgta tttgtcgaat
     2701 ctgggccttg gctcgcacgc tgttcatttg agtgtgcttc tcctgccccg ggtttgatgg
     2761 ggttgttttt taaatgcctg ttttttctat gagatctgac ttcttgatgg acatttgtat
     2821 tagaatattg aagcatgctg gctgtgtcac tgttgtctca ctgtctctgc cgtggtgtta
     2881 cttggactgc atgagataat gggacagcct ttctgttatt ggtgttattg aaaaaaaaaa
     2941 aaacaaaaaa aacccaaccc aacttccaca gtgtgtgaag ctctggcaca atctccctct
     3001 ctttatcctg ctctccctgg ctgccaagga gcattgattt tgattcgctt ctatgtagag
     3061 tctgtgaaga gggagagagg ctttgaaata aattttaaaa agacctcata ctgggtttca
     3121 gcagacagca gtgggtatgt gtgtgtgtgt tcgtgcatgt gagtgtgtgt gcatccatcc
     3181 gactgggagg cctctgagat cattgctaag gagctggttg tgtgaggagc tgaggcgcca
     3241 cccgggtcta aaagctgctg gctgctctct gagggggagt cctgggagtc tgtgggactg
     3301 aagccttcta gagtaggtcc actcccttct ggaagcttct ctccctcact tcatccccca
     3361 caagcaagag ctctgcccac atttggggtt caatttccct ttgtctagat ggagtttgag
     3421 ccagagttct tttggagagc ccaggaagga ctgtgcccac tgtccacagt cctgggctgg
     3481 gaggccatgc ccccccattc cctgtccctc tccacacccc atttacagtt accctggaga
     3541 ctgcctcccc acttctgtga tagccttgtt ctgtttcctt tctaccttga tgggggatac
     3601 tgactgaagc ctagtgtcac aggataacga ggccttgaat ggcctgatga tactctttag
     3661 atctgagctc atgtcctgta tgccacctga ctgtactgtc atgtttctaa aattgacaaa
     3721 gtgtcattct tgctcactga gaactggggg agggggcaga tccacgcatg agctccccag
     3781 gtatctctgg gagaccctgg gtcactattg gggacgacgg cttgtttttg ttattactat
     3841 tattgttttc tgagacacgg agccaggctg gccttgaact ctctatacag cagaggatag
     3901 ccctgaactc ctcatcctcc tgcctccacc tcctgattac tggaatgggc cgattactgg
     3961 cttttgttgt ggactttttg gatgtccacc gtggactgtt agaacacaag tctctcccgg
     4021 gttcatgctg ttttcttttc tgagcctgaa gtcaacttgg ggagagcagg gggtcagaag
     4081 gtgctgggga ttcggggaga ggggccgcag cctatttcca caggagctgg tccgaagccc
     4141 caccaagagg gaaagcgtac atcacagtgt ctcttgaaag ctttagccaa aagtttatct
     4201 ttttgacatt ttaatgtatt cactcgatgc ttatttactg aacatctacc gtgtaccagc
     4261 tgaagacctc cacgtctgag caaagtgact tagttatggt acagcaacag tcctttttgg
     4321 agaccagatg ccgtgaaatg tccctttcca gtctggctca taatttagaa cagatctgcc
     4381 gggtcaccat tgtgacccca agccttgctg gcagattgct atatagtatt ttctgcatgc
     4441 cactctctgg gctgaatgca attaaaaatt ttgctacgtt gtctccttct ccactgagag
     4501 gattggtccc ttttgtacaa taatcaacac cccccacaca cacacacaca ggagcacggc
     4561 cactgaacac tgcaggaggc gcttcccaag gcttcccctg agagagcccc atcctattgg
     4621 ttagtaccac tgatcccatt ttacaggcga ggaagctgag ggcacccaaa tggcaaacta
     4681 agggttgcat ttgagttcgt gccccccccc cccacaagcc aatgtggtgc ctgctctggt
     4741 gtcacccatt taaaagcaag cattatgggt gaaggcaaga tattctaggt caaaggcaga
     4801 cattgctagt ctaagggcag ggacaaacct gtggcccagc agggagtgtc tactttagct
     4861 gaaaagaaag caagccttat ttggggacac ttgagagcag aaggttgtct ccagttttag
     4921 aaacctccag ggtaaggggt atctaatgtg caaacggact gtcccaacca ttctggaggc
     4981 cctggggagt ctcccacccc tctctcctct atctcctctc ccaaccctgg atccccaagg
     5041 tctttgcact ggaagagtca aggagccggt atggatggca gaggtggctg tgagggcatt
     5101 tggagactgg gggagaggca gtaacttggg gggacattct gtctgggtcc tgaccttgtt
     5161 gccttgtgct cttttgtaag gggtgggggg ctccctgcct ggatgctttg tacatatttg
     5221 ttacactttt attaaaaaat tgatcgtgca cctct
//
