LOCUS       NM_053506               2792 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histamine receptor H3 (Hrh3), transcript variant
            1, mRNA.
ACCESSION   NM_053506
VERSION     NM_053506.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2792)
  AUTHORS   Vazquez-Vazquez,H., Gonzalez-Sandoval,C., Vega,A.V.,
            Arias-Montano,J.A. and Barral,J.
  TITLE     Histamine H3 Receptor Activation Modulates Glutamate Release in the
            Corticostriatal Synapse by Acting at CaV2.1 (P/Q-Type) Calcium
            Channels and GIRK (KIR3) Potassium Channels
  JOURNAL   Cell Mol Neurobiol 42 (3), 817-828 (2022)
   PUBMED   33068216
  REMARK    GeneRIF: Histamine H3 Receptor Activation Modulates Glutamate
            Release in the Corticostriatal Synapse by Acting at CaV2.1
            (P/Q-Type) Calcium Channels and GIRK (KIR3) Potassium Channels.
REFERENCE   2  (bases 1 to 2792)
  AUTHORS   Coslovich,T., Della Mora,A., D'Angelo,G., Ortolani,F. and
            Taccola,G.
  TITLE     Histamine H3 Receptors Expressed in Ventral Horns Modulate Spinal
            Motor Output
  JOURNAL   Cell Mol Neurobiol 41 (1), 185-190 (2021)
   PUBMED   32211996
  REMARK    GeneRIF: Histamine H3 Receptors Expressed in Ventral Horns Modulate
            Spinal Motor Output.
REFERENCE   3  (bases 1 to 2792)
  AUTHORS   Yu,C., Li,L., Xia,Q. and Tang,Y.
  TITLE     Expression and localization of histamine H1, H2, and H3 receptors
            in rat olfactory epithelium
  JOURNAL   Int J Pediatr Otorhinolaryngol 101, 102-106 (2017)
   PUBMED   28964277
  REMARK    GeneRIF: indicate that histamine H1, H2, and H3 receptors are
            present in rat olfactory epithelium and may play a physiological
            role in olfactory transmission.
REFERENCE   4  (bases 1 to 2792)
  AUTHORS   Gbahou,F., Rouleau,A. and Arrang,J.M.
  TITLE     The histamine autoreceptor is a short isoform of the H receptor
  JOURNAL   Br J Pharmacol 166 (6), 1860-1871 (2012)
   PUBMED   22356432
  REMARK    GeneRIF: Finsings show that short, but not long, isoforms fulfill
            the function of autoreceptor and thereby confirm the hypothesis
            that H3 receptor isoforms have distinct functional roles in the
            brain
REFERENCE   5  (bases 1 to 2792)
  AUTHORS   Bakker,R.A., Lozada,A.F., van Marle,A., Shenton,F.C., Drutel,G.,
            Karlstedt,K., Hoffmann,M., Lintunen,M., Yamamoto,Y., van Rijn,R.M.,
            Chazot,P.L., Panula,P. and Leurs,R.
  TITLE     Discovery of naturally occurring splice variants of the rat
            histamine H3 receptor that act as dominant-negative isoforms
  JOURNAL   Mol Pharmacol 69 (4), 1194-1206 (2006)
   PUBMED   16415177
REFERENCE   6  (bases 1 to 2792)
  AUTHORS   Morisset,S., Sasse,A., Gbahou,F., Heron,A., Ligneau,X.,
            Tardivel-Lacombe,J., Schwartz,J.C. and Arrang,J.M.
  TITLE     The rat H3 receptor: gene organization and multiple isoforms
  JOURNAL   Biochem Biophys Res Commun 280 (1), 75-80 (2001)
   PUBMED   11162480
REFERENCE   7  (bases 1 to 2792)
  AUTHORS   Drutel,G., Peitsaro,N., Karlstedt,K., Wieland,K., Smit,M.J.,
            Timmerman,H., Panula,P. and Leurs,R.
  TITLE     Identification of rat H3 receptor isoforms with different brain
            expression and signaling properties
  JOURNAL   Mol Pharmacol 59 (1), 1-8 (2001)
   PUBMED   11125017
REFERENCE   8  (bases 1 to 2792)
  AUTHORS   Lovenberg,T.W., Roland,B.L., Wilson,S.J., Jiang,X., Pyati,J.,
            Huvar,A., Jackson,M.R. and Erlander,M.G.
  TITLE     Cloning and functional expression of the human histamine H3
            receptor
  JOURNAL   Mol Pharmacol 55 (6), 1101-1107 (1999)
   PUBMED   10347254
REFERENCE   9  (bases 1 to 2792)
  AUTHORS   Godlewski,G., Malinowska,B., Buczko,W. and Schlicker,E.
  TITLE     Inhibitory H3 receptors on sympathetic nerves of the pithed rat:
            activation by endogenous histamine and operation in spontaneously
            hypertensive rats
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 355 (2), 261-266 (1997)
   PUBMED   9050021
REFERENCE   10 (bases 1 to 2792)
  AUTHORS   Fujimoto,K., Mizuguchi,H., Fukui,H. and Wada,H.
  TITLE     Presynaptic localization of histamine H3-receptors in rat brain
  JOURNAL   Biochem Biophys Res Commun 177 (3), 907-912 (1991)
   PUBMED   1647769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB015646.1, CB735595.1 and
            BC087707.1.
            
            On Jul 19, 2012 this sequence version replaced NM_053506.1.
            
            Summary: This gene encodes a histamine H3 receptor that belongs to
            the superfamily of G-protein coupled receptors. This protein
            functions as a presynaptic autoreceptor on histamine neurons in the
            brain, and a presynaptic heteroreceptor in nonhistamine-containing
            neurons in both the central and peripheral nervous systems. It is
            deemed a great target for the development of therapeutics for
            numerous disorders, including obesity, epilepsy, and such cognitive
            diseases as attention deficit hyperactivity disorder and
            Alzheimer's disease. Several alternatively spliced transcript
            variants encoding different isoforms, with different brain
            expression patterns and signaling properties, have been described
            for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform H3A (also known as H3L or H3(445)),
            which contains 7 transmembrane domains.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB015646.1, AY009370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1968              AB015646.1         1-1968
            1969-2257           CB735595.1         175-463
            2258-2792           BC087707.1         1420-1954
FEATURES             Location/Qualifiers
     source          1..2792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..2792
                     /gene="Hrh3"
                     /note="histamine receptor H3"
                     /db_xref="GeneID:85268"
                     /db_xref="RGD:620630"
     exon            1..587
                     /gene="Hrh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1675
                     /gene="Hrh3"
                     /note="isoform H3A is encoded by transcript variant 1;
                     histamine H3 receptor; HH3R; H3R"
                     /codon_start=1
                     /product="histamine H3 receptor isoform H3A"
                     /protein_id="NP_445958.1"
                     /db_xref="GeneID:85268"
                     /db_xref="RGD:620630"
                     /translation="MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALL
                     IVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTF
                     GRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVW
                     VLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFN
                     LSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYG
                     VGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLE
                     KRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDY
                     WYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK"
     exon            588..754
                     /gene="Hrh3"
                     /inference="alignment:Splign:2.1.0"
     exon            755..2772
                     /gene="Hrh3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hrh3"
     polyA_site      2772
                     /gene="Hrh3"
ORIGIN      
        1 cgggcagatc gcggggcgca ctcggttgcg cgctgagcta ggggtgcacc gacgcaccgc
       61 gggcggctgg agctcggctt tgctctcgct gcagcagccg cgccgcccgc cccactccgc
      121 tcagattccg acaccagccc cctctggatc gccctcctgg actctagccc gggctcttgc
      181 tccgaccccg cggaccatgc tccgggcgcc ccccggaaaa ccgggctggg cgaagagccg
      241 gcaaagatta ggctcacgag cgggggcccc acccggccac ccagctctcc gcccgtgccc
      301 tgcccggtgt ccccgagccg tgtgagcctg ctgggccatg gagcgcgcgc cgcccgacgg
      361 gctgatgaac gcgtcgggca ctctggccgg agaggcggcg gctgcaggcg gggcgcgcgg
      421 cttctcggct gcctggaccg ctgtcctggc tgcgctcatg gcgctgctca tcgtggccac
      481 agtactgggc aacgcgctgg tcatgctcgc cttcgtggcg gattcgagcc tccgcaccca
      541 gaacaacttc tttctgctca acctcgccat ctccgacttc ctcgtgggtg ccttctgcat
      601 cccattgtac gtaccctatg tgctgaccgg ccgttggacc ttcggccggg gcctctgcaa
      661 gctgtggctg gtggtagact acctactgtg tgcctcctcg gtcttcaaca tcgtactcat
      721 cagctatgac cgattcctgt cagtcactcg agctgtctcc tacagggccc agcaggggga
      781 cacgagacgg gccgttcgga agatggcact ggtgtgggtg ctggccttcc tgctgtatgg
      841 gcctgccatc ctgagttggg agtacctgtc tggtggcagt tccatccccg agggccactg
      901 ctatgctgag ttcttctaca actggtactt tctcatcacg gcctccaccc tcgagttctt
      961 cacgcccttc ctcagcgtta ccttcttcaa cctcagcatc tacctgaaca tccagaggcg
     1021 cacccgcctt cggcttgatg ggggccgtga ggctggccca gaacccccac cagatgccca
     1081 gccctcgcca cctccagctc cccccagctg ctggggctgc tggccaaaag ggcatggcga
     1141 ggccatgccg ttgcacaggt atggggtggg tgaggcaggc cctggtgttg aggctgggga
     1201 ggctgccctc gggggtggca gtggtggagg tgctgctgcc tcgcccacct ccagctctgg
     1261 cagctcctca aggggcactg agaggccacg ctcactcaaa aggggctcca agccatcagc
     1321 atcttcagca tccctggaga agcgcatgaa gatggtgtcc cagagcatca cccagcgctt
     1381 ccggctgtcg cgggacaaga aggtggccaa gtcgctggcc atcatcgtga gcatctttgg
     1441 gctctgctgg gcgccgtaca cgctcctaat gatcatccga gctgcttgcc atggccgctg
     1501 catccccgat tactggtacg agacgtcctt ctggcttctg tgggccaact cggccgtcaa
     1561 ccccgtcctc tacccactgt gccactacag cttccgcaga gccttcacca agctcctctg
     1621 cccccagaag ctcaaggtcc agccccacgg ctccctggag cagtgctgga agtgagcagc
     1681 tgccccaccc ttctgaggcc aggcccttgt acttgtttga gtgggcagcc ggagcgtggg
     1741 cggggccctg gtccatgctc cgctccaaat gccatggcgg cctcttagat catcaacccc
     1801 gcagtggggt agcatggcag gtgggccaag agccctagtt ggtggagcta gagtgtgctg
     1861 gttagctctg ccgccacatt ctccttcacc acacagaaga gacaatccag gagtcccagg
     1921 catgccttcc acctacacac acacacacac acacacacac acacacacac acacacacca
     1981 cagtgcagtg ccagtgatgt ccccttttgc atatttagtg gttggtgtcc tccctaatgc
     2041 aaacctcggt gtgtgctccc ggctccggcc ctggcaatgc gtgcgtgcgc cctgcatgtg
     2101 ctcacacccg ccacacaccc gcccgccaca cacttgcaac acctcctctc tcccagaaga
     2161 gctggggacg atgccctttg ctgccactgt ctcttgctta atcccagagc ctggctcctt
     2221 atcccccact ctcccttcaa ctctgcccca caaagtgtcg agcgcctcgg gaaacttgaa
     2281 gcttctctgc tccttccact ctggatgttt tcaggaagat ggaggagaag aaaacacgtc
     2341 tgtgaacttg atgttccttg gatgtttaat caagagagac aaaattgccg aggagctcgg
     2401 ggctggattg gcaggtgtgg gctcccacgc cctcctccct cagtgctgca gcttccggct
     2461 gagccgcgcc agctgcttct gcctgccccg cccccaggct tgggacgatg gccctgccct
     2521 gcttgccccg tctgtacaat cagaatttgg gggtgggtgg ttatggggta gagcggctct
     2581 tcactgtgcc ctaaaggtcc tgaggctcac aggacagtca gcaggagagc aggcaggccc
     2641 gcgacacctg ggaggaatgc tttgcctcgt cctgtgtact cacctcaggc ttctgcatgc
     2701 tctgctgccc ttgtgccctg gtgtgctgcc tctgccaatg tgaaaacaca ataaagtgta
     2761 tttttttacg gaaaaaaaaa aaaaaaaaaa aa
//
