LOCUS       NM_001413011            4889 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histamine receptor H 2 (Hrh2), mRNA.
ACCESSION   NM_001413011
VERSION     NM_001413011.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4889)
  AUTHORS   Zhuang,Q.X., Xu,H.T., Lu,X.J., Li,B., Yung,W.H., Wang,J.J. and
            Zhu,J.N.
  TITLE     Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing
            Neurons via Postsynaptic H1 and H2 Receptors
  JOURNAL   Mol Neurobiol 55 (10), 8059-8070 (2018)
   PUBMED   29498008
  REMARK    GeneRIF: the histaminergic afferent inputs in the striatum may
            modulate both dopamine D1 and D2 receptor-expressing medium spiny
            projection neurons by activation of postsynaptic histamine H1 and
            H2 receptors.
REFERENCE   2  (bases 1 to 4889)
  AUTHORS   Yu,C., Li,L., Xia,Q. and Tang,Y.
  TITLE     Expression and localization of histamine H1, H2, and H3 receptors
            in rat olfactory epithelium
  JOURNAL   Int J Pediatr Otorhinolaryngol 101, 102-106 (2017)
   PUBMED   28964277
  REMARK    GeneRIF: findings indicate that histamine H1, H2, and H3 receptors
            are present in rat olfactory epithelium and may play a
            physiological role in olfactory transmission.
REFERENCE   3  (bases 1 to 4889)
  AUTHORS   Kurtz,K.H., Moor,A.N., Souza-Smith,F.M. and Breslin,J.W.
  TITLE     Involvement of H1 and H2 receptors and soluble guanylate cyclase in
            histamine-induced relaxation of rat mesenteric collecting
            lymphatics
  JOURNAL   Microcirculation 21 (7), 593-605 (2014)
   PUBMED   24702851
  REMARK    GeneRIF: Isolated rat mesenteric collecting lymphatics were treated
            with 1- to 100-muM histamine. Pharmacologic blockade of either H1
            or H2 histamine receptors significantly inhibited the response to
            histamine.
REFERENCE   4  (bases 1 to 4889)
  AUTHORS   Zeng,Z., Shen,L., Li,X., Luo,T., Wei,X., Zhang,J., Cao,S.,
            Huang,X., Fukushima,Y., Bin,J., Kitakaze,M., Xu,D. and Liao,Y.
  TITLE     Disruption of histamine H2 receptor slows heart failure progression
            through reducing myocardial apoptosis and fibrosis
  JOURNAL   Clin Sci (Lond) 127 (7), 435-448 (2014)
   PUBMED   24655024
REFERENCE   5  (bases 1 to 4889)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (bases 1 to 4889)
  AUTHORS   Simonin,F., Karcher,P., Boeuf,J.J., Matifas,A. and Kieffer,B.L.
  TITLE     Identification of a novel family of G protein-coupled receptor
            associated sorting proteins
  JOURNAL   J Neurochem 89 (3), 766-775 (2004)
   PUBMED   15086532
REFERENCE   7  (bases 1 to 4889)
  AUTHORS   Azuma,H., Sawada,S., Takeuchi,S., Higashiyama,K., Kakigi,A. and
            Takeda,T.
  TITLE     Expression of mRNA encoding the H1, H2, and H3 histamine receptors
            in the rat cochlea
  JOURNAL   Neuroreport 14 (3), 423-425 (2003)
   PUBMED   12634496
  REMARK    GeneRIF: H1, H2, and H3 histamine receptor mRNA detected in
            modiolus but not in lateral and medial portions of the cochlea.
            First evidence of H1, H2, and H3 histamine receptor mRNA in rat
            cochlea.
REFERENCE   8  (bases 1 to 4889)
  AUTHORS   Kobayashi,T., Tonai,S., Ishihara,Y., Koga,R., Okabe,S. and
            Watanabe,T.
  TITLE     Abnormal functional and morphological regulation of the gastric
            mucosa in histamine H2 receptor-deficient mice
  JOURNAL   J Clin Invest 105 (12), 1741-1749 (2000)
   PUBMED   10862789
REFERENCE   9  (bases 1 to 4889)
  AUTHORS   Traiffort,E., Ruat,M., Arrang,J.M., Leurs,R., Piomelli,D. and
            Schwartz,J.C.
  TITLE     Expression of a cloned rat histamine H2 receptor mediating
            inhibition of arachidonate release and activation of cAMP
            accumulation
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2649-2653 (1992)
   PUBMED   1313563
REFERENCE   10 (bases 1 to 4889)
  AUTHORS   Ruat,M., Traiffort,E., Arrang,J.M., Leurs,R. and Schwartz,J.C.
  TITLE     Cloning and tissue expression of a rat histamine H2-receptor gene
  JOURNAL   Biochem Biophys Res Commun 179 (3), 1470-1478 (1991)
   PUBMED   1930188
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000017.1  10412640-10412724   c
            86-1603             JAXUCZ010000017.1  10389524-10391041   c
            1604-4889           JAXUCZ010000017.1  10371083-10374368   c
FEATURES             Location/Qualifiers
     source          1..4889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..4889
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /note="histamine receptor H 2"
                     /db_xref="GeneID:25461"
                     /db_xref="RGD:2831"
     exon            1..85
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     exon            86..1603
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..1739
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /note="gastric receptor I"
                     /codon_start=1
                     /product="histamine H2 receptor"
                     /protein_id="NP_001399940.1"
                     /db_xref="GeneID:25461"
                     /db_xref="RGD:2831"
                     /translation="MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVS
                     LNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFKWSFGHVFCNIYTSLDVMLC
                     TASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNS
                     RNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHI
                     SSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLG
                     YANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQ
                     EEKPLKLQVWSGTELTHPQGNPIRKTTLSCTTRSNGLPSCCKSLWRLRFLRQHLQGTS
                     EEQSGEPLSE"
     exon            1604..4889
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccttgccc cagccagtgc gagcgcgcgg tcctaagcga cccggtgcag ccagtggcgc
       61 acagcagcag cagcagcagc accagcttct atgacccccc agagagggta gctaatagtt
      121 ttctacctta agtcatcgat gggagcaggt accagccatg gagaaggaca tgacagccta
      181 tgtgtgtgaa cccttgcata taaaacctaa gccacttcaa gacatatcca gcagtgcctc
      241 agactccatg aggaacctag aaggtagata tgtattacag acctgggaga agtctggctt
      301 ggaagaccag ctaaggactg gggtgtgagc ttttaaggcc ctgtcttact ttcgtcttat
      361 ccatgtcctg cacttcacaa ggaacagctt gatctattgt tagaacagca ttgggtcagt
      421 cactaagcct tccccaactt gcctttagct tggttggaag cccaattgtc agagctggaa
      481 gagaagtggc caagaccaag aggtgaatgt agaagccaca gggccccaga atggagccca
      541 atggcacagt tcattcctgc tgcttggact ctatggcatt gaaagtcacc atcagtgtgg
      601 tccttaccac gctcatcctc atcaccattg ctggcaatgt ggtcgtctgc ctggctgtca
      661 gcttgaaccg tcggctccgc agtctgacca attgcttcat tgtgtccctg gcagccactg
      721 acctgcttct tggactcctg gtgctgccct tctctgccat ttaccagctg tccttcaagt
      781 ggagttttgg ccacgtcttc tgcaacatct acaccagctt ggatgtgatg ctctgcacgg
      841 cctccatcct caacctcttc atgatcagct tggaccgcta ctgcgctgtc acggacccac
      901 tgcggtaccc tgtgctggtc accccagttc gagttgccat ctctttggtc tttatttggg
      961 ttatttctat caccctatcc ttcctctcta ttcacctagg atggaacagc agaaatggga
     1021 ccagaggggg caatgacacc ttcaagtgca aagtccaggt caatgaggtg tacggactgg
     1081 tggatgggct ggtcaccttc tacctgcctc ttctcatcat gtgtgtcact tactacagaa
     1141 tctttaagat tgccagggag caggccaaac ggatcaacca catcagctcc tggaaggcag
     1201 ccaccatcag agagcacaaa gccaccgtga cactggcggc cgtcatggga gcgttcatca
     1261 tctgctggtt tccttacttc actgcattcg tttaccgtgg gctgagaggg gatgatgcca
     1321 tcaatgaggc ggtcgagggc attgtcctat ggttgggcta tgccaattca gccctgaacc
     1381 ccatcctgta cgctgctctc aacagagact tccgcacggc gtaccaacag ctcttccact
     1441 gcaagttcgc aagccacaac tctcacaaaa cttccctgag gttgaacaac tctctgctgc
     1501 ccaggagcca gagccgagaa ggtagatggc aggaggagaa gcccttgaag ctccaagtgt
     1561 ggagtgggac agaactcaca cacccccagg gaaacccaat caggaaaaca acactgtctt
     1621 gcaccacacg ctccaatggc ctcccaagct gctgcaagag cctgtggagg cttcgtttcc
     1681 tcaggcaaca cctacaagga acctcagagg agcaatcggg ggagccactg tctgagtaga
     1741 cagaaaggac acatcacagg aaggaatggg ggcgttgccc tatgaggctg tctagatcct
     1801 gcccaggaca ccaagatact ggccttattt cttggatctc ttttctggag cccctgtaga
     1861 tcaagcccca ccaaaactac caaggacaaa cttcagcctg gaggctcaca gaacatacag
     1921 atcagcttcc ctgagagcag attccagaca ggtacttagg cttacttagg ctgaattccc
     1981 tgggttcaaa gctcacgttg gtgctggccc taggagtcat gagcagagag agcagggcag
     2041 agacgtttac acatgtgtgc atggacacac ttctatagaa aacatgcaca tctgctgagc
     2101 agggcaagga atgcgattat acagcactgg ccccactcac ttccttgtgg gggtctcgat
     2161 atgagcagaa aaaaagagaa gagaatggga gagaaggaag aggagaaaaa ttgccctccc
     2221 tgaacaccta actaagttct aggtactttg cctatacagg ctctcataat ttatatacat
     2281 acgcttcgga taaacatcac tgtccagact ttacagagtc agggtagtat ggaatgtacc
     2341 tcaggccact cagccagaaa atgtgcctga gatagaggta cgcagggaat actcggtgag
     2401 tgaaagggtg tgtgggaaga tggatggatg gatggttgga tatatagatg gatggacgat
     2461 ggatggatgg atgatgggtg ggtggacgga tgaatggatg agtatatatg gatggatgat
     2521 ggatgataga ttgatgaatg gatggatgga tgggtatata gatggatgat tgatggatgg
     2581 agggatgatg gatggaggat ggatggatgg aggatggatg gatgggtata tagatggatg
     2641 attgatggat ggatggagga tggatggatg atggatggat ggatggatga tagattgatg
     2701 aatggatgga tggatgggta tatagatgga tgattgatgg atgggtggag gatggatgga
     2761 ggatggatgg aggatggatg gatggatgga tggatgaatg aatggttgga tggatggaaa
     2821 tccaggctta tgtccatgtt ttctaaacga cattgacact tggaagagaa gccaagatag
     2881 ttccttaact cagctaaccc tcctctagca agacttagcc cttcaagaag ccctccatga
     2941 tgagctacag ccattgatgg tgcctgttat caacaggaag gggtgtacag tggacttgtg
     3001 gggcaaagtg tgtctattga gtcccaggca agaacaggta gaagttggga agatgcaaag
     3061 agtacaaatg tgtaggctga cctagtgcca ccctcacctg gctacataac caggacaatt
     3121 cctggccctt tgggcagctc ttttacccct ctgtatacat ggattaaact ccctctctgt
     3181 agttagagaa ctactgaaga ggtgaagtag gtgagcgctc cagagagaag aggctgcctg
     3241 ggcttctctc ccctagggct tctcaatggc attgcccttc cttgactcca acccctcctt
     3301 aatacctatg tttccttggg tttccaagac cctctcctgc ccccaaccct gtccaccttt
     3361 tatgtgactt cccagtcctt gccttccaca tgaccattgg atacaaccac tccctggagc
     3421 tcagtgatgg gacttctcac cttggctgtc cctttgggac cccatctaca tccacgactt
     3481 ttgtcacaaa acagaaggag attatttact gattcacaat tgtaggcaaa gcattagccc
     3541 ctgggtcact tccccctgca tatttcaaag gcaccttacc tttaacaacc ttgcctttaa
     3601 caaccttacc tttaacaacc ttacctttaa caaccttgcc tttaacatgt ccacacgtgc
     3661 actctccagc tcctccctca cctgcttctc ccttctcaag cacaggacac atcctgggct
     3721 tcaaaagcct tggtcatcct tggcccctcc tttgaccatg cttcttctca tgggagacaa
     3781 ctagagtctt agctacaaca cataaccgcc atccaattga tagtactcat cgtccctgtc
     3841 tcacatgacc ccgctgctat agtctccatc gggacagctg gaaaagctgc ctagatctct
     3901 ttcctacacc caccccaccc tctttctccc atcagctctc cacaaacagc ttcagtgggc
     3961 tgtgaaaacg cataccctac tgtgtcacat ccaggatgga accttcttta gagtgacccg
     4021 ctgacctagc cttgttagct tccgtgtccc tctagcctcc cacttcccca tccccttcct
     4081 tctcttaatt ccactcctgt ttgtcttagc attttattta gatctactat ttctagcaga
     4141 caaggcactc agagtgctat ttccatgacc tcaaatgctc ccttctcttc tggacaagtt
     4201 gacaccatga gacctcatct aaaataccat ttcctagagg ctttcttcct tatctgtctg
     4261 acccttccta cactaggtcg ttgccacacg ccacagggct ttctgtagaa gccattggct
     4321 tgtttataat atgatagtca gctgtggttt cttgaacacc atcttcctcc tctacgcatg
     4381 agttccttct gttgaccttt gcctggtggg tctctggaag agtattcaca catagtagaa
     4441 gttgccaggg gaacaggcaa agaatggtcc acagtaatat tttaagggct agcctgccaa
     4501 tgagcttcaa ggagtaattt ggactgatga ctcccagaga tgaccaccga gtctcttaat
     4561 caaattccct ctgaaagccc aagaaaccca cttagacgtc ttcttgggag tctatggcag
     4621 gtgagtctct taagtcacag ccaactacct agaggtacaa gatctctggt gcaaatggag
     4681 ctgcatgatg agagagacaa ccaatcaggg ctcaagacca cagtgcccag gggacaacct
     4741 gccccatcag aagattcctg caaatgtgaa gtttctggag cctttcttag cagcacagtt
     4801 ggggtgcacg aagcctgggg gaaggaccag ctgaggtgga acttcaagtc cattctgtgt
     4861 tcatgttcca ataaagttat caaagcaca
//
