LOCUS       NM_017018               2827 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Rattus norvegicus histamine receptor H 1 (Hrh1), mRNA.
ACCESSION   NM_017018
VERSION     NM_017018.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Daniali,R., Zeraati,F., Mohammadi,M. and Haddadi,R.
  TITLE     The role of histamine H1 receptor in the anterior cingulate cortex
            on nociception level following acute restraint stress in male rats
  JOURNAL   Pharmacol Res Perspect 12 (2), e1188 (2024)
   PUBMED   38483045
  REMARK    GeneRIF: The role of histamine H1 receptor in the anterior
            cingulate cortex on nociception level following acute restraint
            stress in male rats.
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   De la Merced-Garcia,D.S., Sanchez-Barrera,A., Hernandez-Yonca,J.,
            Mancilla,I., Garcia-Lopez,G., Diaz,N.F., Terrazas,L.I. and
            Molina-Hernandez,A.
  TITLE     Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell
            Number and Increased Neurogenesis in the Dorsal Telencephalon of
            Embryos of Diabetic Rats through Histamine H1 Receptors
  JOURNAL   Cells 12 (3), 510 (2023)
   PUBMED   36766852
  REMARK    GeneRIF: Increased Nuclear FOXP2 Is Related to Reduced Neural Stem
            Cell Number and Increased Neurogenesis in the Dorsal Telencephalon
            of Embryos of Diabetic Rats through Histamine H1 Receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Tan,S.L., Barri,M., Atakpa-Adaji,P., Taylor,C.W., St John Smith,E.
            and Murrell-Lagnado,R.D.
  TITLE     P2X4 Receptors Mediate Ca2+ Release from Lysosomes in Response to
            Stimulation of P2X7 and H1 Histamine Receptors
  JOURNAL   Int J Mol Sci 22 (19), 10492 (2021)
   PUBMED   34638832
  REMARK    GeneRIF: P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in
            Response to Stimulation of P2X7 and H1 Histamine Receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Zhuang,Q.X., Xu,H.T., Lu,X.J., Li,B., Yung,W.H., Wang,J.J. and
            Zhu,J.N.
  TITLE     Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing
            Neurons via Postsynaptic H1 and H2 Receptors
  JOURNAL   Mol Neurobiol 55 (10), 8059-8070 (2018)
   PUBMED   29498008
  REMARK    GeneRIF: the histaminergic afferent inputs in the striatum may
            modulate both dopamine D1 and D2 receptor-expressing medium spiny
            projection neurons by activation of postsynaptic histamine H1 and
            H2 receptors.
REFERENCE   5  (bases 1 to 2827)
  AUTHORS   Yu,C., Li,L., Xia,Q. and Tang,Y.
  TITLE     Expression and localization of histamine H1, H2, and H3 receptors
            in rat olfactory epithelium
  JOURNAL   Int J Pediatr Otorhinolaryngol 101, 102-106 (2017)
   PUBMED   28964277
  REMARK    GeneRIF: findings indicate that histamine H1, H2, and H3 receptors
            are present in rat olfactory epithelium and may play a
            physiological role in olfactory transmission.
REFERENCE   6  (bases 1 to 2827)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 2827)
  AUTHORS   Azuma,H., Sawada,S., Takeuchi,S., Higashiyama,K., Kakigi,A. and
            Takeda,T.
  TITLE     Expression of mRNA encoding the H1, H2, and H3 histamine receptors
            in the rat cochlea
  JOURNAL   Neuroreport 14 (3), 423-425 (2003)
   PUBMED   12634496
  REMARK    GeneRIF: H1, H2, and H3 histamine receptor mRNA detected in
            modiolus but not in lateral and medial portions of the cochlea.
            First evidence of H1, H2, and H3 histamine receptor mRNA in rat
            cochlea.
REFERENCE   8  (bases 1 to 2827)
  AUTHORS   Borda,E., Stranieri,G. and Sterin-Borda,L.
  TITLE     H(1)-Receptor activation triggers the endogenous nitric oxide
            signalling system in the rat submandibular gland
  JOURNAL   Mediators Inflamm 11 (6), 337-343 (2002)
   PUBMED   12581497
  REMARK    GeneRIF: ThEA stimulation evoked amylase release via H1 receptor
            but was not followed by L-arginine/nitric oxide pathway activation.
REFERENCE   9  (bases 1 to 2827)
  AUTHORS   Yang,Q.Z. and Hatton,G.I.
  TITLE     Histamine H1-receptor modulation of inter-neuronal coupling among
            vasopressinergic neurons depends on nitric oxide synthase
            activation
  JOURNAL   Brain Res 955 (1-2), 115-122 (2002)
   PUBMED   12419527
  REMARK    GeneRIF: Activation of H1-receptors in vasopressinergic neurons
            results in downstream activation of NO synthase, which then
            mediates the H1-receptor effects.
REFERENCE   10 (bases 1 to 2827)
  AUTHORS   Fujimoto,K., Horio,Y., Sugama,K., Ito,S., Liu,Y.Q. and Fukui,H.
  TITLE     Genomic cloning of the rat histamine H1 receptor
  JOURNAL   Biochem Biophys Res Commun 190 (1), 294-301 (1993)
   PUBMED   7678492
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 21, 2021 this sequence version replaced NM_017018.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.19310.1,
                                           SRR26643298.24728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000004.1  149120511-149120573
            64-2827             JAXUCZ010000004.1  149201504-149204267
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2827
                     /gene="Hrh1"
                     /gene_synonym="Hisr"
                     /note="histamine receptor H 1"
                     /db_xref="GeneID:24448"
                     /db_xref="RGD:2830"
     exon            1..63
                     /gene="Hrh1"
                     /gene_synonym="Hisr"
                     /inference="alignment:Splign:2.1.0"
     exon            64..2827
                     /gene="Hrh1"
                     /gene_synonym="Hisr"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1559
                     /gene="Hrh1"
                     /gene_synonym="Hisr"
                     /note="H1R; HH1R"
                     /codon_start=1
                     /product="histamine H1 receptor"
                     /protein_id="NP_058714.2"
                     /db_xref="GeneID:24448"
                     /db_xref="RGD:2830"
                     /translation="MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGL
                     NLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLF
                     WLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVI
                     PILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVR
                     RHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKST
                     SEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSMAEGDVRGSKANDQALSQPKMDEQS
                     LNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKR
                     LRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPVHM
                     FTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS"
ORIGIN      
        1 gccgccgcca ccgcatcgag cagactggcc gccgccacca aactttcccc ggagctggct
       61 cggggaggga gccatcactg gaggctgccc ttgtgccaat gagctttgcc aatacctcct
      121 ctaccttcga agacaagatg tgtgagggga acaggacagc catggccagc cctcagctgc
      181 tgcccctggt ggtggttctc agtagtatct ccctggtcac agtgggcctc aacctgctgg
      241 tgctgtacgc tgtgcacagt gaacgcaagc tacacaccgt gggcaaccta tacattgtca
      301 gcctgtctgt ggcagacctg attgtagggg cagtcgtcat gcccatgaac atcctctatc
      361 tcatcatgac taagtggtcc ttgggccgcc ccctctgcct cttttggctt tctatggatt
      421 atgtggccag cacagcatcc atctttagcg tcttcatcct gtgtattgat cgctaccgct
      481 ccgtccagca acccctccgg tacctgaggt accgaaccaa gacccgggct tccgctacca
      541 tcctgggggc ctggttcttc tccttcctgt gggttatacc catacttggc tggcatcact
      601 tcatgccccc agccccagag cttcgggaag acaagtgtga gacagacttc tacaatgtca
      661 cttggttcaa gatcatgact gctattatta acttctacct ccccactttg cttatgctgt
      721 ggttctatgt gaagatctac aaggctgtgc ggcgacactg tcagcaccgc cagctcacca
      781 acgggtccct cccttccttt tcagaactca agctgaggtc agacgatacc aaggaaggtg
      841 ccaagaaacc tgggagagag tctccctggg gggttctgaa aaggccatca agagacccca
      901 gtgtaggact ggatcagaag tcaacatctg aagaccccaa gatgacctct ccaactgtct
      961 tcagccaaga gggggaaagg gaaacacgtc cctgtttccg tctcgacatc atgcagaaac
     1021 agtctatggc tgagggagat gtcaggggct caaaggccaa tgatcaggcc ttgagccagc
     1081 ccaaaatgga tgagcagagc ctgaatactt gtcggcggat cagtgagaca tcagaggacc
     1141 agaccttggt ggatcaacag tccttctccc ggaccacaga ctcagacaca agcatagagc
     1201 cagggccggg cagagtcaaa tcgagaagcg ggtctaacag tggcctggat tacatcaaaa
     1261 tcacctggaa gaggctccgc tcacactcca gacagtatgt gtccgggctg cacttgaacc
     1321 gagagcggaa ggcagccaag cagttgggtt ttatcatggc ggccttcatt ctctgctgga
     1381 ttccctattt catcttcttc atggtcattg ccttctgcaa gagctgctgc agtgaacccg
     1441 tgcatatgtt caccatttgg ctgggctaca tcaactccac gctgaacccc ctcatctacc
     1501 ccctgtgcaa cgagaacttc aagaagacat tcaaaaagat tctgcacatt cgttcctaag
     1561 ggcataccaa aaggatgcca catagtggat agacaacgtc tgatgtccaa gagggaacca
     1621 gaggaagaaa gcatgggtgt cactagaccc ctgagcatta ggaagtggaa tctaaggtcc
     1681 tgggctgagc agtctggagg cattcccagg agctgtcaga aggaaagcag gcagcagagc
     1741 gattgtgctc tgggtagaat gcagagcatc tgaaggagac ccaggcagag catgcctggc
     1801 cctcagggac tgtgggagtc tcagatactc cgtggaagtc aaactctctg acttaagttt
     1861 cttggtaact gaagtgggaa tgtgtggcta tagttcttct ggagggttag cctggactca
     1921 gacttcccga acaaaagctg tgtgactgca gagacatgca caccgatgct gtccccttcc
     1981 aggggttacc tggagaggcc tggcagctgt ttcattgcag ccacacttct caaaatgcag
     2041 tccttccgag ccgagcctct cttacagcat tgtccagagc tatgtgcccc accatggaac
     2101 ttgccttacc cgtgtctcag agtttctagg aaattaggca gcttgtgagt ccatcatttt
     2161 caactcttag ttcttttggg cttttaaaat ggcggcagca acaacaacaa cacagtaaca
     2221 aaaactgtcc tcaaatgtca agaggaggag gaagagactt ttgaatggtt ctattttaag
     2281 caaaggaaag gcaagacagc cttatttctt taagactcca ccagggggct ctcactctag
     2341 gcccctggcg tgacaaagga aaagaggttc ctggaatcat ttgatactca cgtcagaaac
     2401 tcgggatgag aactttgtat ggcctcagtt catcacttct ccaaaaggga agaaatgtcc
     2461 cctgccatgt actcacagtg ttccccaaga gaagtgacag tgtcccgagt aacgggcatg
     2521 gagcacacct gtccacagag ggtgaccctc ggaagggaca aatgtgcttt tctctatgag
     2581 actgtgtggt ttctggtcac acatgctgaa cgaattctgt tgaaatcatg ggaacgtcca
     2641 gttttattta tgacagaatc gagttgtgat ttatatttta aaatgtaatg ttgaacatca
     2701 atgagtgttg caagtaggaa cccctgtaaa agctggcctt ttgtgtctgt gttcctgttt
     2761 gcatgacctg tccaaatgag atatttttgc ttacctaaaa cacgacaaca tttggaaggt
     2821 actgtta
//
