LOCUS       NM_133428               1713 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histidine-rich glycoprotein (Hrg), mRNA.
ACCESSION   NM_133428 XM_346419
VERSION     NM_133428.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Mattii,L., Bianchi,F., Falleni,A., Frascarelli,S., Masini,M.,
            Ali,G., Chiellini,G. and Sabbatini,A.R.M.
  TITLE     Ultrastructural Localization of Histidine-rich Glycoprotein in
            Skeletal Muscle Fibers: Colocalization With AMP Deaminase
  JOURNAL   J Histochem Cytochem 68 (2), 139-148 (2020)
   PUBMED   31880188
  REMARK    GeneRIF: Ultrastructural Localization of Histidine-rich
            Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP
            Deaminase.
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   White,C., Yuan,X., Schmidt,P.J., Bresciani,E., Samuel,T.K.,
            Campagna,D., Hall,C., Bishop,K., Calicchio,M.L., Lapierre,A.,
            Ward,D.M., Liu,P., Fleming,M.D. and Hamza,I.
  TITLE     HRG1 is essential for heme transport from the phagolysosome of
            macrophages during erythrophagocytosis
  JOURNAL   Cell Metab 17 (2), 261-270 (2013)
   PUBMED   23395172
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Claesson-Welsh,L.
  TITLE     Blood vessels as targets in tumor therapy
  JOURNAL   Ups J Med Sci 117 (2), 178-186 (2012)
   PUBMED   22348394
  REMARK    Review article
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Hulett,M.D. and Parish,C.R.
  TITLE     Murine histidine-rich glycoprotein: cloning, characterization and
            cellular origin
  JOURNAL   Immunol Cell Biol 78 (3), 280-287 (2000)
   PUBMED   10849117
REFERENCE   7  (bases 1 to 1713)
  AUTHORS   Gorgani,N.N., Parish,C.R. and Altin,J.G.
  TITLE     Differential binding of histidine-rich glycoprotein (HRG) to human
            IgG subclasses and IgG molecules containing kappa and lambda light
            chains
  JOURNAL   J Biol Chem 274 (42), 29633-29640 (1999)
   PUBMED   10514432
REFERENCE   8  (bases 1 to 1713)
  AUTHORS   Shigekiyo,T., Yoshida,H., Matsumoto,K., Azuma,H., Wakabayashi,S.,
            Saito,S., Fujikawa,K. and Koide,T.
  TITLE     HRG Tokushima: molecular and cellular characterization of
            histidine-rich glycoprotein (HRG) deficiency
  JOURNAL   Blood 91 (1), 128-133 (1998)
   PUBMED   9414276
REFERENCE   9  (bases 1 to 1713)
  AUTHORS   Lijnen,H.R., Van Hoef,B. and Collen,D.
  TITLE     Histidine-rich glycoprotein modulates the anticoagulant activity of
            heparin in human plasma
  JOURNAL   Thromb Haemost 51 (2), 266-268 (1984)
   PUBMED   6740558
REFERENCE   10 (bases 1 to 1713)
  AUTHORS   Morgan,W.T.
  TITLE     Human serum histidine-rich glycoprotein. I. Interactions with heme,
            metal ions and organic ligands
  JOURNAL   Biochim Biophys Acta 535 (2), 319-333 (1978)
   PUBMED   678554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ210661.1 and AB055895.1.
            
            On Aug 2, 2012 this sequence version replaced NM_133428.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210661.1, FQ111739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                FQ210661.1         1-11
            12-1713             AB055895.1         12-1713
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1713
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /note="histidine-rich glycoprotein"
                     /db_xref="GeneID:171016"
                     /db_xref="RGD:619808"
     exon            1..234
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1629
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /note="histidine-rich glycoprotein 1;
                     histidine-proline-rich glycoprotein"
                     /codon_start=1
                     /product="histidine-rich glycoprotein precursor"
                     /protein_id="NP_596919.1"
                     /db_xref="GeneID:171016"
                     /db_xref="RGD:619808"
                     /translation="MKVLTTALLLVTLQCSHALSPTNCDASKPLAEKVLDLINKGRRS
                     GYTFQLLRVSDAHLDRVETATIYYLVLDVVESDCWVLSTKAQDECLPAMRTSEVVIGQ
                     CKVIATRYSNESQDLSVNGYNCTMRSVSSAYINTKDSPVLVDSFEDSEPYRKLARKAL
                     DKYKAENGDFASFRVERAERVIRMRGGERTSYFIEFSVRNCSTQHFPRHPPVFGLCRV
                     VLTYSTEASDLETPEYTDLICEVFNTEDLKNRSDMKPHRGHEHPHCDKHLCKLSGPRD
                     HHHTHKTHEIGCPPPPEGKDNSDRPPLQEGALPQMLPGHSGPSGTNRSHRPPHNHSCN
                     EHPCHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGHH
                     PHGDHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGHGPPHGHSRKRGPGKGLFPF
                     HQRQIGYVYRLPPLNVGEVLTPPEANFPIFSLPNCNRPPQPEIRPFPQTASKSCPGKF
                     EGKFPQVSNFFEHTPPK"
     exon            235..345
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..436
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..603
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..684
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..786
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1701
                     /gene="Hrg"
                     /gene_synonym="HPRG; HRG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtagcat tctccactat ggtggaccac agccgaggat ggttttgcac catgaaggtg
       61 ctcaccacgg cattgcttct agtcaccctg cagtgttccc atgccctgag tcccaccaac
      121 tgtgatgcct ccaagccttt ggctgagaaa gttctagact tgatcaataa agggcggagg
      181 agtggctata cttttcagct gctgcgggtc tctgatgccc acttggacag agtggaaact
      241 gccaccatct actacttagt tttagatgtg gtagaatctg actgttgggt cctctccaca
      301 aaagcccagg atgagtgtct tccagccatg aggacatctg aggttgtgat tggacagtgt
      361 aaggtaatag ccacaagata ctccaatgag tctcaagatc ttagcgtgaa tggctataac
      421 tgcaccatga gatccgtctc ttcggcatat atcaacacca aagacagtcc tgtactagtg
      481 gactcatttg aggattccga gccctacaga aagctagccc gtaaagccct cgacaagtac
      541 aaagcggaga atggtgactt tgcctcattc agagtggaaa gggctgaaag ggttataaga
      601 atgagaggag gggaaagaac cagctacttc atagaattct cggtgaggaa ctgttccaca
      661 caacacttcc ccagacaccc tccggtcttt ggattgtgca gagtagtttt gacctacagt
      721 acagaagcct ctgacttgga aaccccagaa tacactgacc tgatctgtga agtcttcaac
      781 actgaggatc ttaaaaacag gagtgacatg aaaccccatc ggggccatga gcatcctcat
      841 tgtgacaaac atctgtgtaa gctcagtgga cccagggacc atcatcatac ccataagaca
      901 catgaaattg gatgcccacc accaccagaa ggaaaagata actcagacag accacccctt
      961 caagaaggag cccttccaca aatgctccct ggccattctg gtccttctgg taccaacagg
     1021 agccatagac cccctcataa tcacagttgt aatgagcatc cgtgccatgg acagcatccc
     1081 catggacacc accctcatgg tcagcatccc catggacacc accctcatgg tcagcatccc
     1141 catggacacc accctcatgg tcagcatccc catggacacc accctcatgg tcagcatccc
     1201 catggacacc acccccatgg tcaccatcct catggtgacc atccccatgg acaccacccc
     1261 catggacatg atttccttga ctatggacct tgtgacccac cctccaatag ccaagaactc
     1321 aagggtcagt atcatcgggg acatggtcca ccacacggac actcaaggaa aagagggcca
     1381 ggtaaaggac tctttccttt ccaccaacga caaatcggat atgtctaccg actccctcca
     1441 ctgaatgtag gtgaagttct cactcctcct gaagccaatt tccccatctt ctctttgcca
     1501 aattgcaaca gacccccaca accagagatt cggcccttcc ctcagacagc ctcaaagtcc
     1561 tgtccaggga aatttgaggg taagtttcca caagtttcca acttttttga acatacgcct
     1621 ccaaaataaa acctgatttc ttggtagggg aaagagtaca atattctgaa taaataaaat
     1681 atgaccagtt agaaatgaaa aaaaaaaaaa aaa
//
