LOCUS       NM_181369               2486 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus histidine rich calcium binding protein (Hrc),
            mRNA.
ACCESSION   NM_181369
VERSION     NM_181369.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Singh,V.P., Rubinstein,J., Arvanitis,D.A., Ren,X., Gao,X.,
            Haghighi,K., Gilbert,M., Iyer,V.R., Kim,D.H., Cho,C., Jones,K.,
            Lorenz,J.N., Armstrong,C.F., Wang,H.S., Gyorke,S. and Kranias,E.G.
  TITLE     Abnormal calcium cycling and cardiac arrhythmias associated with
            the human Ser96Ala genetic variant of histidine-rich
            calcium-binding protein
  JOURNAL   J Am Heart Assoc 2 (5), e000460 (2013)
   PUBMED   24125847
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Park,C.S., Cha,H., Kwon,E.J., Jeong,D., Hajjar,R.J., Kranias,E.G.,
            Cho,C., Park,W.J. and Kim,D.H.
  TITLE     AAV-mediated knock-down of HRC exacerbates transverse aorta
            constriction-induced heart failure
  JOURNAL   PLoS One 7 (8), e43282 (2012)
   PUBMED   22952658
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Arvanitis,D.A., Sanoudou,D., Kolokathis,F., Vafiadaki,E.,
            Papalouka,V., Kontrogianni-Konstantopoulos,A., Theodorakis,G.N.,
            Paraskevaidis,I.A., Adamopoulos,S., Dorn,G.W. 2nd, Kremastinos,D.T.
            and Kranias,E.G.
  TITLE     The Ser96Ala variant in histidine-rich calcium-binding protein is
            associated with life-threatening ventricular arrhythmias in
            idiopathic dilated cardiomyopathy
  JOURNAL   Eur Heart J 29 (20), 2514-2525 (2008)
   PUBMED   18617481
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Arvanitis,D.A., Vafiadaki,E., Fan,G.C., Mitton,B.A., Gregory,K.N.,
            Del Monte,F., Kontrogianni-Konstantopoulos,A., Sanoudou,D. and
            Kranias,E.G.
  TITLE     Histidine-rich Ca-binding protein interacts with sarcoplasmic
            reticulum Ca-ATPase
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (3), H1581-H1589 (2007)
   PUBMED   17526652
REFERENCE   5  (bases 1 to 2486)
  AUTHORS   Gregory,K.N., Ginsburg,K.S., Bodi,I., Hahn,H., Marreez,Y.M.,
            Song,Q., Padmanabhan,P.A., Mitton,B.A., Waggoner,J.R., Del
            Monte,F., Park,W.J., Dorn,G.W. 2nd, Bers,D.M. and Kranias,E.G.
  TITLE     Histidine-rich Ca binding protein: a regulator of sarcoplasmic
            reticulum calcium sequestration and cardiac function
  JOURNAL   J Mol Cell Cardiol 40 (5), 653-665 (2006)
   PUBMED   16600288
REFERENCE   6  (bases 1 to 2486)
  AUTHORS   Hong,S., Kim,T.W., Choi,I., Woo,J.M., Oh,J., Park,W.J., Kim,D.H.
            and Cho,C.
  TITLE     Complementary DNA cloning, genomic characterization and expression
            analysis of a mammalian gene encoding histidine-rich calcium
            binding protein
  JOURNAL   Biochim Biophys Acta 1727 (3), 188-196 (2005)
   PUBMED   15777620
  REMARK    GeneRIF: Structure and expression of the mammalian HRC gene,
            together with the comparative expression data of the related
            sarcoplasmic reticulum genes.
REFERENCE   7  (bases 1 to 2486)
  AUTHORS   Kim,E., Shin,D.W., Hong,C.S., Jeong,D., Kim,D.H. and Park,W.J.
  TITLE     Increased Ca2+ storage capacity in the sarcoplasmic reticulum by
            overexpression of HRC (histidine-rich Ca2+ binding protein)
  JOURNAL   Biochem Biophys Res Commun 300 (1), 192-196 (2003)
   PUBMED   12480542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 7, 2020 this sequence version replaced NM_181369.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224148.1, AY277279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2156              JAXUCZ010000001.1  104949750-104951905
            2157-2227           JAXUCZ010000001.1  104951985-104952055
            2228-2296           JAXUCZ010000001.1  104952426-104952494
            2297-2351           JAXUCZ010000001.1  104952692-104952746
            2352-2388           JAXUCZ010000001.1  104953152-104953188
            2389-2486           JAXUCZ010000001.1  104953378-104953475
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2486
                     /gene="Hrc"
                     /note="histidine rich calcium binding protein"
                     /db_xref="GeneID:292905"
                     /db_xref="RGD:727864"
     exon            1..2156
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2425
                     /gene="Hrc"
                     /note="sarcoplasmic reticulum histidine-rich
                     calcium-binding protein"
                     /codon_start=1
                     /product="sarcoplasmic reticulum histidine-rich
                     calcium-binding protein precursor"
                     /protein_id="NP_852034.2"
                     /db_xref="GeneID:292905"
                     /db_xref="RGD:727864"
                     /translation="MGFQEPWLYSCLLWATVAILLVPPVVTQELRGTGLGLGNWNNNA
                     GIPGSSEDLSTEYGHHIHSHGAYQGEKDRHHREEDEDFSREYGHQVQDHRYPGHEVGE
                     ENVSEEVFRGHVRQLHGHHKPNSEDLGDSAESHFPRQQSHNREEEDGVVSGEDHRHIP
                     RHDHHGNEEEDDDGEEEERVGVMENSDDKHQAHGHHSHSKERDGLHHAHSHRHQGHHD
                     EDDDDEDGVSTEGEHQAHRYQDHDEEDDDDSDEESHAHRLQGQEDENDDEDGDSSENG
                     HQTQDHQGHKEQDDDDDEEEEEEEEEEEEEEEEEEEEEEDDDDDSTEHRHRHQTQGHR
                     KGKDEDESDEDDHVTRHGRRGHEDEDDDDDDDDDDDDDNDGGSTENVHQAHRHRGHEH
                     EDDGDDSEEDYHHVPSHGHQSHQNEEEEDEAVSTEHWHQSPRHAHHDLGRENQEEATV
                     KYSRHVASHRPQGHSAEEDSLEDSTNEVPGHHHHRVSRDGDEDISTEFGHKAPRHRLQ
                     DQDEWTRQGHGKSVQEDIGHQPLQPTGPGSGESRKEDDHSSQEGDEDLKQRQEAHSEE
                     EEEEEEGHGLPMSLEDEEEEEKDKKESKGDRAAVSAPLSHHRKHDDDDDGDGDDDDDD
                     NDDDDEILEENLLPFTIIPNPLAGREVAREGSSEEESREVTGQQDAQEYENYQPGSLC
                     GYCSFCNRCSECESCHCDEENMGEHCDQCQHCQFCYLCPLVCDTLCTPGSYVDYFSSS
                     VYQAVADMLETQEP"
     exon            2157..2227
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2296
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2351
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2388
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2486
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggtcat ccaagaccta aggaagatag agaagcagag tggaagccgt accacaaaaa
       61 agagacaatc tgaaagtcaa agccaaaaaa ggcacaagga cccatcagag gcagctgaag
      121 ccagcctggt tagacgctca gctgctaaac gaacgtcccc atgggcttcc aggagccatg
      181 gttgtacagt tgtctccttt gggccacagt ggccatcctg ctggtccctc cagtggtgac
      241 ccaggagctg agagggactg ggctgggcct cggcaactgg aacaacaacg caggtatccc
      301 tgggtcctca gaggacctat caactgagta tggtcaccac atccacagcc acggggccta
      361 tcaaggtgag aaggacagac accacagaga agaagatgaa gacttctcca gggaatatgg
      421 ccaccaagtc caagaccaca ggtaccctgg ccatgaagtt ggggaggaga atgtctcaga
      481 agaggtcttc agagggcatg ttagacagct ccatgggcac cacaaaccta acagtgaaga
      541 tttaggggac tcagcagaga gccacttccc cagacagcag agccacaacc gtgaagaaga
      601 ggacggcgtt gtctccggtg aggatcaccg tcacatcccc aggcatgacc accatggcaa
      661 cgaagaggag gatgatgatg gagaggagga ggagagggtg ggagtgatgg agaactctga
      721 tgataagcac caggcccacg gccaccacag ccactcaaaa gaaagagatg gactccatca
      781 tgcccacagc cacaggcacc aagggcacca tgatgaagat gatgatgatg aagatggtgt
      841 ctccactgag ggtgaacacc aagctcacag atatcaagac catgatgagg aagacgatga
      901 tgactcagat gaagagagtc atgcccacag acttcaaggc caagaagatg aaaatgatga
      961 tgaagatggt gactccagtg aaaatggaca ccagacccag gaccaccaag gccataaaga
     1021 acaagatgat gatgacgatg aagaagaaga agaagaagaa gaagaagaag aagaagaaga
     1081 agaagaagaa gaagaagaag aagaagacga tgacgacgac tccactgagc acaggcacag
     1141 gcaccagacc caaggccaca ggaagggaaa agatgaggat gagtcagatg aagatgatca
     1201 tgtcacccgg catggccgcc gaggccatga agatgaagat gatgacgatg acgatgacga
     1261 tgacgatgat gacgacaatg atggtggctc tactgagaat gtgcaccaag cccacagaca
     1321 cagaggccat gagcacgaag acgatgggga tgactcagaa gaagactacc atcatgtccc
     1381 cagccatggt caccaaagcc atcaaaatga ggaagaggaa gatgaggctg tctccactga
     1441 acactggcac cagtctccta gacatgctca ccatgatctt ggacgtgaga atcaagaaga
     1501 ggcaacagtc aagtacagcc gccatgttgc aagccatcga ccccaaggcc acagtgcgga
     1561 ggaggactct ctagaagact ctaccaatga agtccctgga catcaccacc acagagtctc
     1621 cagggatggc gacgaagaca tttctactga gtttggccac aaggccccca gacacaggct
     1681 acaagatcaa gatgaatgga ccaggcaggg tcacggaaaa tctgtccagg aagacattgg
     1741 tcatcagccc ctgcagccca caggtcctgg ttctggagaa tcaaggaagg aagatgacca
     1801 cagctctcaa gagggagatg aggacttaaa gcagagacaa gaagcccaca gtgaggagga
     1861 ggaggaggaa gaggagggcc atggcctccc catgagcctg gaagatgaag aggaggaaga
     1921 aaaagataag aaagagagca agggagacag ggctgcagtt tcggctccac tgagtcatca
     1981 caggaagcat gatgatgatg atgacggcga cggtgatgat gatgatgacg acaatgacga
     2041 cgatgatgag atcctggagg aaaacctgct acctttcacc attatcccaa acccactggc
     2101 tgggagggag gtggccagag aaggttccag tgaggaggag agccgcgagg tcacaggtca
     2161 gcaggatgcc caggagtatg agaactacca gccagggtcc ctgtgtggct actgttcttt
     2221 ctgcaaccga tgtagtgaat gtgaaagctg ccactgtgat gaggagaaca tgggggaaca
     2281 ctgtgaccag tgtcagcact gccaattctg ctacctctgc ccgctggtct gtgacacact
     2341 ctgcactcca ggaagctacg ttgactattt ctcctcctct gtgtatcaag ctgtggctga
     2401 catgctggag acgcaagagc cctgatctgg ccacctggca agagccgcat ttatttctct
     2461 gaataaatgt gctcctagaa acatca
//
