LOCUS       NM_001098241            1392 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HRas proto-oncogene, GTPase (Hras), transcript
            variant 2, mRNA.
ACCESSION   NM_001098241 XM_001061671 XM_001062236
VERSION     NM_001098241.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1392)
  AUTHORS   Matsuda,T., Jeong,J.I., Ikeda,S., Yamamoto,T., Gao,S., Babu,G.J.,
            Zhai,P. and Del Re,D.P.
  TITLE     H-Ras Isoform Mediates Protection Against Pressure Overload-Induced
            Cardiac Dysfunction in Part Through Activation of AKT
  JOURNAL   Circ Heart Fail 10 (2) (2017)
   PUBMED   28193718
  REMARK    GeneRIF: H-ras isoform mediates protection against pressure
            overload-induced cardiac dysfunction in part through activation of
            AKT/PI3K signaling pathway.
REFERENCE   2  (bases 1 to 1392)
  AUTHORS   Vitiello,M., Valentino,T., De Menna,M., Crescenzi,E., Francesca,P.,
            Rea,D., Arra,C., Fusco,A., De Vita,G., Cerchia,L. and Fedele,M.
  TITLE     PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in
            rat thyroid cells
  JOURNAL   Sci Rep 6, 25268 (2016)
   PUBMED   27125250
  REMARK    GeneRIF: Together, these results suggest a novel mechanism
            regulating PATZ1 expression based on the upregulation of miR-29b
            expression induced by Ras oncogene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1392)
  AUTHORS   Najumudeen,A.K., Posada,I.M., Lectez,B., Zhou,Y., Landor,S.K.,
            Fallarero,A., Vuorela,P., Hancock,J. and Abankwa,D.
  TITLE     Phenotypic Screening Identifies Protein Synthesis Inhibitors as
            H-Ras-Nanocluster-Increasing Tumor Growth Inducers
  JOURNAL   Biochemistry 54 (49), 7212-7221 (2015)
   PUBMED   26568031
  REMARK    GeneRIF: Phenotypic Screening Identifies Protein Synthesis
            Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
REFERENCE   4  (bases 1 to 1392)
  AUTHORS   Gripp,K.W., Sol-Church,K., Smpokou,P., Graham,G.E., Stevenson,D.A.,
            Hanson,H., Viskochil,D.H., Baker,L.C., Russo,B., Gardner,N.,
            Stabley,D.L., Kolbe,V. and Rosenberger,G.
  TITLE     An attenuated phenotype of Costello syndrome in three unrelated
            individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates
            with uncommon functional consequences
  JOURNAL   Am J Med Genet A 167A (9), 2085-2097 (2015)
   PUBMED   25914166
REFERENCE   5  (bases 1 to 1392)
  AUTHORS   Gordeev,S.A., Bykova,T.V., Zubova,S.G., Aksenov,N.D. and
            Pospelova,T.V.
  TITLE     [Antiapoptotic gene bcl-2 prevents cellular senescence program
            reactivation induced by histone deacetylase inhibitor sodium
            butyrate in E1A and cHa-ras transformed rat fibroblasts]
  JOURNAL   Tsitologiia 57 (2), 135-143 (2015)
   PUBMED   26035971
  REMARK    GeneRIF: It has been found that NaBut reduces proliferation rate of
            ERasBcl (E1A, cHa-ras and bcl-2 ) cells significantly weaker than
            of ERas transformed cells
REFERENCE   6  (bases 1 to 1392)
  AUTHORS   Chakraborty,A.K., Cichutek,K. and Duesberg,P.H.
  TITLE     Transforming function of proto-ras genes depends on heterologous
            promoters and is enhanced by specific point mutations
  JOURNAL   Proc Natl Acad Sci U S A 88 (6), 2217-2221 (1991)
   PUBMED   2006160
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 May 1;88(9):4059]
REFERENCE   7  (bases 1 to 1392)
  AUTHORS   Nelson,M.A., Sanchez,I.M., Bull,R.J. and Sylvester,S.R.
  TITLE     Increased expression of c-myc and c-Ha-ras in dichloroacetate and
            trichloroacetate-induced liver tumors in B6C3F1 mice
  JOURNAL   Toxicology 64 (1), 47-57 (1990)
   PUBMED   2219132
REFERENCE   8  (bases 1 to 1392)
  AUTHORS   Bhave,M.R., Wilson,M.J. and Poirier,L.A.
  TITLE     c-H-ras and c-K-ras gene hypomethylation in the livers and
            hepatomas of rats fed methyl-deficient, amino acid-defined diets
  JOURNAL   Carcinogenesis 9 (3), 343-348 (1988)
   PUBMED   3345576
REFERENCE   9  (bases 1 to 1392)
  AUTHORS   Ruta,M., Wolford,R., Dhar,R., Defeo-Jones,D., Ellis,R.W. and
            Scolnick,E.M.
  TITLE     Nucleotide sequence of the two rat cellular rasH genes
  JOURNAL   Mol Cell Biol 6 (5), 1706-1710 (1986)
   PUBMED   3023901
REFERENCE   10 (bases 1 to 1392)
  AUTHORS   Yaswen,P., Goyette,M., Shank,P.R. and Fausto,N.
  TITLE     Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types
            during hepatocarcinogenesis
  JOURNAL   Mol Cell Biol 5 (4), 780-786 (1985)
   PUBMED   2581126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099130.1 and BC086608.1.
            
            On or before Jul 25, 2008 this sequence version replaced
            XM_001062236.1, XM_001061671.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086608.1, BC099130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1152              BC099130.1         23-1174
            1153-1392           BC086608.1         1149-1388
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1392
                     /gene="Hras"
                     /gene_synonym="c-H-ras; HRAS1"
                     /note="HRas proto-oncogene, GTPase"
                     /db_xref="GeneID:293621"
                     /db_xref="RGD:2827"
     exon            1..125
                     /gene="Hras"
                     /gene_synonym="c-H-ras; HRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..277
                     /gene="Hras"
                     /gene_synonym="c-H-ras; HRAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..736
                     /gene="Hras"
                     /gene_synonym="c-H-ras; HRAS1"
                     /EC_number="3.6.5.2"
                     /note="Harvey rat sarcoma viral (v-Ha-ras) oncogene
                     homolog; transforming protein p21; Harvey ras1 protein;
                     p21ras; H-Ras-1; Harvey rat sarcoma virus oncogene"
                     /codon_start=1
                     /product="GTPase HRas"
                     /protein_id="NP_001091711.1"
                     /db_xref="GeneID:293621"
                     /db_xref="RGD:2827"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKR
                     VKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV
                     REIRQHKLRKLNPPDESGPGCMSCKCVLS"
     exon            278..456
                     /gene="Hras"
                     /gene_synonym="c-H-ras; HRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..616
                     /gene="Hras"
                     /gene_synonym="c-H-ras; HRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1372
                     /gene="Hras"
                     /gene_synonym="c-H-ras; HRAS1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccggcgcc cgcagcccga gccgcacccg ccgcggacgg agcccatgcg cgggcccagt
       61 cggcgcccgt ccgcgccccc gccctgcccc ggccccggcc ccgggggcag tcgcgccagc
      121 aagcggtggg gcaggagctc ctggtttggc agcccctgta gaagcgatga cagaatacaa
      181 gcttgtggtg gtgggcgctg gaggcgtggg aaagagtgcc ctgaccatcc agctgatcca
      241 gaaccatttt gtggacgagt atgatcccac tatagaggac tcctaccgga aacaggtagt
      301 cattgatggg gagacgtgtt tactggacat cttagacaca gcaggtcaag aagagtatag
      361 tgccatgcgg gaccagtaca tgcgcacagg ggagggcttc ctctgtgtat ttgccatcaa
      421 caacaccaag tcctttgaag acatccatca gtacagggag cagatcaagc gggtgaaaga
      481 ttcagatgat gtgccaatgg tgctggtggg caacaagtgt gacctggccg ctcgcactgt
      541 tgagtctcgg caggcccagg accttgctcg cagctatggc atcccctaca ttgaaacatc
      601 agccaagacc cggcagggtg tggaggatgc cttctacaca ctagtacgtg agattcggca
      661 gcataaactg cggaaactga acccgcctga tgagagtggc cctggctgca tgagctgcaa
      721 gtgtgtgctg tcctgacacc aggtgaggca gggaccagca agacatctgg ggcagtgacc
      781 tcagctagcc agatgaactt catatccact ttgatgtccc tgctccccca attctgccaa
      841 tccccctgcc tgcagtcagt catgtccttt gtgcccgtcc cggcacaggc tcaggacgag
      901 gaggtgccgg atgcagggag gaggtgctgt cggaaggaag gaaagaggag ggaaggaagg
      961 aaacgatgct ggagccagtc cagtccaggg atggtggaca gatgtgacca agaccttcgc
     1021 atggacaatt tgaacagact gtcatgaact atccctgttg ccactggcac ccaagtcctc
     1081 cgcccctctc agctcccttg ggcgcctatg agggcacatg ttgaatcaca gtaaattatt
     1141 tgatggtctt gacttgtctc tggctggaag taggaggtgt agtgcctgtg gcctcacaga
     1201 agatactggg gacctgggat ctatcatctg ccttgttcct gtttctagaa gaggctgggg
     1261 aggctggcct gggacctggg actgtgcagc ccttctcttc tgcctgcctc aactgtcttg
     1321 tgtttcctgc agaaagttat aaataacaca agaatagtca ggtgatatga aaaaaaaaaa
     1381 aaaaaaaaaa aa
//
