LOCUS       NM_024364               5617 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HR, lysine demethylase and nuclear receptor
            corepressor (Hr), mRNA.
ACCESSION   NM_024364 XM_006252284 XM_346476
VERSION     NM_024364.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5617)
  AUTHORS   Kuramoto,T., Kuwamura,M., Tagami,F., Mashimo,T., Nose,M. and
            Serikawa,T.
  TITLE     Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair
            loss and exhibit focal glomerulosclerosis
  JOURNAL   Exp Anim 60 (1), 57-63 (2011)
   PUBMED   21325752
REFERENCE   2  (bases 1 to 5617)
  AUTHORS   Hsieh,J.C., Slater,S.A., Whitfield,G.K., Dawson,J.L., Hsieh,G.,
            Sheedy,C., Haussler,C.A. and Haussler,M.R.
  TITLE     Analysis of hairless corepressor mutants to characterize molecular
            cooperation with the vitamin D receptor in promoting the mammalian
            hair cycle
  JOURNAL   J Cell Biochem 110 (3), 671-686 (2010)
   PUBMED   20512927
  REMARK    GeneRIF: Hr and VDR interact via multiple protein-protein
            interfaces, catalyzing histone demethylation to effect chromatin
            remodeling and repress the transcription of VDR target genes that
            control the hair cycle.
REFERENCE   3  (bases 1 to 5617)
  AUTHORS   Wen,Y., Liu,Y., Xu,Y., Zhao,Y., Hua,R., Wang,K., Sun,M., Li,Y.,
            Yang,S., Zhang,X.J., Kruse,R., Cichon,S., Betz,R.C., Nothen,M.M.,
            van Steensel,M.A., van Geel,M., Steijlen,P.M., Hohl,D., Huber,M.,
            Dunnill,G.S., Kennedy,C., Messenger,A., Munro,C.S., Terrinoni,A.,
            Hovnanian,A., Bodemer,C., de Prost,Y., Paller,A.S., Irvine,A.D.,
            Sinclair,R., Green,J., Shang,D., Liu,Q., Luo,Y., Jiang,L.,
            Chen,H.D., Lo,W.H., McLean,W.H., He,C.D. and Zhang,X.
  TITLE     Loss-of-function mutations of an inhibitory upstream ORF in the
            human hairless transcript cause Marie Unna hereditary hypotrichosis
  JOURNAL   Nat Genet 41 (2), 228-233 (2009)
   PUBMED   19122663
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
REFERENCE   4  (bases 1 to 5617)
  AUTHORS   Hsieh,J.C., Sisk,J.M., Jurutka,P.W., Haussler,C.A., Slater,S.A.,
            Haussler,M.R. and Thompson,C.C.
  TITLE     Physical and functional interaction between the vitamin D receptor
            and hairless corepressor, two proteins required for hair cycling
  JOURNAL   J Biol Chem 278 (40), 38665-38674 (2003)
   PUBMED   12847098
REFERENCE   5  (bases 1 to 5617)
  AUTHORS   Fernandez,A., Silio,L., Noguera,J.L., Sanchez,A. and Ovilo,C.
  TITLE     Linkage mapping of the porcine hairless gene (HR) to chromosome 14
  JOURNAL   Anim Genet 34 (4), 317-318 (2003)
   PUBMED   12873232
REFERENCE   6  (bases 1 to 5617)
  AUTHORS   Potter,G.B., Zarach,J.M., Sisk,J.M. and Thompson,C.C.
  TITLE     The thyroid hormone-regulated corepressor hairless associates with
            histone deacetylases in neonatal rat brain
  JOURNAL   Mol Endocrinol 16 (11), 2547-2560 (2002)
   PUBMED   12403844
REFERENCE   7  (bases 1 to 5617)
  AUTHORS   Zlotogorski,A., Ahmad,W. and Christiano,A.M.
  TITLE     Congenital atrichia in five Arab Palestinian families resulting
            from a deletion mutation in the human hairless gene
  JOURNAL   Hum Genet 103 (4), 400-404 (1998)
   PUBMED   9856480
REFERENCE   8  (bases 1 to 5617)
  AUTHORS   Cichon,S., Anker,M., Vogt,I.R., Rohleder,H., Putzstuck,M.,
            Hillmer,A., Farooq,S.A., Al-Dhafri,K.S., Ahmad,M., Haque,S.,
            Rietschel,M., Propping,P., Kruse,R. and Nothen,M.M.
  TITLE     Cloning, genomic organization, alternative transcripts and
            mutational analysis of the gene responsible for autosomal recessive
            universal congenital alopecia
  JOURNAL   Hum Mol Genet 7 (11), 1671-1679 (1998)
   PUBMED   9736769
  REMARK    Erratum:[Hum Mol Genet 1998 Nov;7(12):1987-8]
REFERENCE   9  (bases 1 to 5617)
  AUTHORS   Thompson,C.C. and Bottcher,M.C.
  TITLE     The product of a thyroid hormone-responsive gene interacts with
            thyroid hormone receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8527-8532 (1997)
   PUBMED   9238010
REFERENCE   10 (bases 1 to 5617)
  AUTHORS   Thompson,C.C.
  TITLE     Thyroid hormone-responsive genes in developing cerebellum include a
            novel synaptotagmin and a hairless homolog
  JOURNAL   J Neurosci 16 (24), 7832-7840 (1996)
   PUBMED   8987811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473951.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006252284.1, NM_024364.2.
            
            Summary: This gene encodes a protein that is involved in hair
            growth. This protein functions as a transcriptional corepressor of
            multiple nuclear receptors, including thyroid hormone receptor, the
            retinoic acid receptor-related orphan receptors and the vitamin D
            receptors, and it interacts with histone deacetylases. The
            translation of this protein is modulated by a regulatory open
            reading frame (ORF) that exists upstream of the primary ORF.
            Mutations in this upstream ORF cause Marie Unna hereditary
            hypotrichosis (MUHH), an autosomal dominant form of genetic hair
            loss in human. [provided by RefSeq, Oct 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: KR109217.1, U71293.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            regulatory uORF        :: PMID: 19122663
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..5617
                     /gene="Hr"
                     /note="HR, lysine demethylase and nuclear receptor
                     corepressor"
                     /db_xref="GeneID:60563"
                     /db_xref="RGD:620634"
     exon            1..113
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            114..216
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            217..812
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      561..665
                     /regulatory_class="uORF"
                     /gene="Hr"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19122663]"
                     /note="this uORF is known as U2HR and is predicted to
                     encode a 34 aa peptide (PMID:19122663)"
     exon            813..1463
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     CDS             852..4397
                     /gene="Hr"
                     /EC_number="1.14.11.65"
                     /note="gene_id=rCG36905.0 transcript_id=rCT36902.0
                     protein_id=rCP32180.0 isoform=CRA_a; protein hairless;
                     hairless homolog; hairless protein; hair growth
                     associated; [histone H3]-dimethyl-L-lysine(9) demethylase
                     hairless"
                     /codon_start=1
                     /product="lysine-specific demethylase hairless"
                     /protein_id="NP_077340.3"
                     /db_xref="GeneID:60563"
                     /db_xref="RGD:620634"
                     /translation="MESMPSFLKDTPAWEKTAPVNGIVGQEPGTSPQDGLHHGALCLG
                     EPVPFWRGVLSAPDSWLPPGFLQGPKDTLSVVEGEGSRNGERKANWLGSKEGLRWKEA
                     MLAHPLAFCGPACPPRYGPLIPEHSSGHPKSDPVAFRPLHCPFLLETKILERAPFWVP
                     TCLPPYLMSSLPPERSYDWPLAPSPWVYSGSQPKVPSAFSLGSKGFYHKDPNILRPAK
                     EPLAASESGMLGLAPGGHLQQACDAEGPSLHQRDGETGAGRQQNLCPVFLGYPDTVPR
                     TPWPSCPPGLVHTLGNVWAGPGSNSFGYQLGPPVTPRCPSPGPPTPPGGCCSSHLPAR
                     EGDPGPCRKCQDSPEGSSSGPGESSEERNKAGSRASPPSHHTKLKKTWLTRHSEQFEC
                     PGGCPGKGESPATGLRALKRAGSPEVQGARGPAPKRPSHTFPGTGRQGARAWQETPET
                     STGSKAEAQQQEEQRGPRDGRIRLRESRLEDTSCQHHLAGVTQCPSCVQAAGEVEILT
                     SHSQKSHRLPLEEKPLEEDSCATSEEGGGSSPEASINKGLAKHLLSGLGDRLCRLLRK
                     EREALAWAQREGQGPAMTEDSPGIPHCCSRCHHGLFNTHWRCSHCSHRLCVACGRIAG
                     AGKNREKTGSREQRTDDCAQEAGHAACSLILTQFVSSQALAELSTVMHQVWAKFDIRG
                     HCFCQVDARVWAPGDGGQQKEPTEKTPPAPQLSCNGDSNRTKDIKEETPDSTESPAED
                     RAGRSPLPCPSLCELLASTAVKLCLGHERIHMAFAPVTPALPSDDRITNILDSIIAQV
                     VERKIQEKALGPGLRAGSGLRKGLSLPLSPVRTRLSPPGALLWLQEPRPKHGFRLFQE
                     HWRQGQPVLVSGIQKTLRLSLWGMEALGTLGGQVQTLTALGPPQPTSLDSTAFWKGFS
                     HPEARPKLDEGSVLLLHRPLGDKDESRVENLASSLPLPEYCAHQGKLNLASYLPLGLT
                     LHPLEPQLWAAYGVNSHRGHLGTKNLCVEVSDLISILVHAEAQLPPWYRAQKDFLSGL
                     DGEGLWSPGSQTSTVWHVFRAQDAQRIRRFLQMVCPAGAGTLEPGAPGSCYLDSGLRR
                     RLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTISVTQHFLSPETSALSAQLCH
                     QGASLPPDHRMLYAQMDRAVFQAVKVAVGTLQEAK"
     exon            1464..2247
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2398
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2583
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2748
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2838
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2954
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3036
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3200
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3437
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3603
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3673
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3804
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3924
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4040
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4205
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4334
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..5617
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5592..5597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hr"
     polyA_site      5616
                     /gene="Hr"
ORIGIN      
        1 gcccggatta gtggcagctt ggcctgactc tccggggctc cttcccccgc cctgcctgct
       61 gcccacccct gggcaggggg ctactctgcc tgaggggcac tgtgcttgcc caggggaaga
      121 cagccacaag cccctaggac tctggatggc ccaagtttcc actctggaca tttctaggcc
      181 tcaagccata ggattctccc acaagcctct gctaagggtg ctggaggagg aaaccggcgg
      241 agcagcttcc ccactctcag ttgcgcgtct ggcgatggcg atcagaggtc ctgctgcgct
      301 ctccgctgcg ctctccctcc attagccgcg ctacgcggtg ctgcgccctc gctggtgcct
      361 cgctcctggc tcacaggatc ggccccccac ttccaggcac gacccccttc cccggcccct
      421 cggcctttcc ccccactcag ccatctccga cccggggcgc gcgttccccc cggcccggct
      481 tcttctctcc ctccggggac acccgctccc tagccccggt tcgaccctcc ccaaagcgca
      541 gcacggagtc tcggcgtccc atggcgcaac ctacagcctc ggcccagaag ctggtgcggc
      601 ccatccgcgc cgtgtgccgc atcctgcaaa tcccggagtc cgacccctcc aacctgcggc
      661 cctagagcgc ccccgacgcc cggggggaaa gagagcgcga gcgcgctgag cagaaagcgg
      721 gagaacgccc cgaagccggc ccatggggag cgagtgccca gcaccggctt gcacgaccgc
      781 cgcccacacc gcgcccggcc tgtgaagccc aggacccccc cctgggagag ccccatgagg
      841 gtaggagagt gatggagagt atgcccagct tcctgaagga caccccagcc tgggagaaga
      901 ctgcccctgt gaacggcatt gtgggacagg agcctggtac ctccccgcag gatggcttgc
      961 accatggggc actgtgccta ggagaacctg ttcccttttg gaggggtgtt ctgagcgccc
     1021 cagactcctg gctccctcct ggcttcctcc aaggccccaa ggacacactc tcagtggtgg
     1081 agggtgaggg ttctcggaat ggggagagga aagccaactg gctgggtagc aaggagggac
     1141 tacgctggaa ggaagcgatg ctggcccatc cactggcctt ctgtgggcca gcatgcccac
     1201 ctcgctatgg ccccctgata cctgagcata gcagtggcca tcccaagagt gaccctgtgg
     1261 ccttccggcc cttgcactgc cctttcctgc tggagaccaa gattctagag cgagctccct
     1321 tctgggttcc tacctgcttg cctccctacc tgatgtccag cctgcctcca gagcgttcgt
     1381 atgactggcc tttggcccca agcccctggg tatactctgg gagccagcca aaagtgccct
     1441 ctgccttcag cttaggcagc aagggctttt accacaagga tccaaacatc ctcaggccag
     1501 caaaggagcc cttggcagcg tcagagtctg ggatgttggg cttagctcct ggagggcatc
     1561 tccagcaagc ctgcgatgca gaaggcccct cgcttcacca gagggatggg gagacaggag
     1621 ctggcaggca gcagaatctt tgcccagttt tcttggggta cccagacact gttcctcgaa
     1681 ccccctggcc ttcttgtccc ccaggcctgg ttcacactct cggtaacgtt tgggctgggc
     1741 caggaagtaa cagctttggg taccagctag gcccaccagt cacaccaagg tgcccatcac
     1801 ctgggcctcc cacccctcca gggggctgtt gctcatccca tctgcctgcc agagagggtg
     1861 atcctggccc ttgtaggaaa tgtcaggata gcccagaggg aagtagcagt gggccagggg
     1921 aatccagtga agaaagaaac aaggctggct ccagggcctc tcctccaagc catcacacca
     1981 agctgaaaaa gacctggctc acacgccact cggaacagtt cgagtgccca ggtggctgtc
     2041 ctgggaaggg agagagccca gccactgggc tccgggcact caagagggca ggcagtccag
     2101 aggtccaggg agcaaggggc ccggctccca aacgcccatc ccacactttc ccaggtactg
     2161 ggaggcaggg ggccagggct tggcaggaga caccagagac atccacagga agcaaggcag
     2221 aggcacagca acaagaggag caaagagggc cccgagatgg caggattcgg ctccgggaat
     2281 ccagacttga ggatacatcc tgccagcatc acttagcagg tgtcactcag tgcccaagct
     2341 gtgtccaggc agctggagag gtggagatac tgaccagcca ctcccagaaa tcacataggt
     2401 tacccctgga agagaagccg ttggaggagg attcctgtgc cacttctgag gaaggaggag
     2461 ggtctagccc agaagcttcc atcaacaagg gcctagccaa gcatctactg agtggtctgg
     2521 gtgaccgact ctgccgcctg ctgcggaagg agcgggaagc cctcgcctgg gcacagcgtg
     2581 aaggccaggg gccagccatg acagaggaca gcccaggcat tccacactgc tgcagccgtt
     2641 gccaccacgg actcttcaac acccactgga gatgttccca ctgtagccac cggctgtgtg
     2701 tagcctgtgg tcgcatagcc ggagctggga agaacaggga gaaaacaggc tctcgggagc
     2761 agcgcacaga tgactgtgcc caggaggctg ggcatgctgc ctgttccctg attctgaccc
     2821 agtttgtctc cagccaggcg ctggcagaac tgagcactgt gatgcaccaa gtctgggcca
     2881 agtttgacat tcgggggcac tgtttctgtc aagtcgatgc ccgtgtgtgg gcccccgggg
     2941 atgggggtca gcagaaggaa ccaacagaga aaactccccc agctccacaa ctttcctgca
     3001 atggagattc caatcggacc aaggacatca aagaagagac cccagactcc acagagagcc
     3061 cagcagagga ccgtgctggc cggtcaccac ttccttgtcc ctctctttgt gagctgctag
     3121 cctctacagc tgtcaaactc tgcctggggc atgagcggat tcacatggcc tttgccccgg
     3181 tcaccccggc tctgcccagt gatgaccgca ttaccaacat cctggacagc attattgcgc
     3241 aggtagtaga acggaagatc caagagaaag ccctggggcc aggccttcga gcagggtcag
     3301 gcttacgaaa gggcctcagc ctgcccctgt caccagtgcg aacccggttg tctcctcctg
     3361 gagctctgct gtggctgcaa gagcccaggc ctaagcacgg ctttcgtctc ttccaggagc
     3421 actggcggca gggccagcct gtgttagtat caggcatcca gaagacattg agacttagcc
     3481 tgtggggaat ggaagccctt gggacacttg gtggccaggt gcagacactg actgcccttg
     3541 ggccgcccca acccaccagc ctggacagca cagcattctg gaagggattc tctcatcctg
     3601 aggcacgtcc aaagttagat gagggctctg tcctcctgct acaccgaccc ctgggggata
     3661 aggacgagag cagggtggag aaccttgcct ccagccttcc actcccagag tactgtgccc
     3721 accaagggaa actcaaccta gcgtcctacc tccccctggg tctcacactg catccactgg
     3781 agccccagct ctgggcagcc tatggtgtga actcgcaccg tggacacctg gggaccaaga
     3841 acctatgtgt ggaggtgtct gacctaatca gtatcctggt gcatgctgag gcacagctgc
     3901 ctccctggta ccgagcacag aaagattttc tctcaggcct ggatggggaa gggctctggt
     3961 ctccaggtag ccagaccagc actgtgtggc atgtgttccg agcccaggat gcccagcgta
     4021 tccgtcgctt tctccagatg gtgtgcccag ctggagcagg aaccttggag cctggtgccc
     4081 caggcagctg ctacttggat tcagggttgc gacgcaggtt aagggaggag tggggtgtga
     4141 gctgctggac actgctgcag gctcctggag aagcggtgct ggtgcctgct ggggcacccc
     4201 atcaggtaca gggcttggtg agcacaatca gtgtcactca gcactttctg tctcctgaga
     4261 cctcggccct ctctgctcag ctctgccacc agggagccag cctgccccct gaccatcgta
     4321 tgctttatgc ccagatggac cgggctgtgt tccaagcagt gaaggtggcg gtggggacat
     4381 tacaggaagc taaatagggg accctggtgc ctggaggggg cgggggtgga gcaggtaact
     4441 gagtgttcag tctgcatgat ttcagcgggg aatggtactg tggaacttag gtggtgtgat
     4501 ccgttctaca aatatctctt tgggtacaag cagggaaccc tgttccctca ccctggccct
     4561 ggctctaaag ggaacaactg tagtgcttac agccgctccc ctctccacgg tatcaggttc
     4621 accctagggg tccatgactc cttctaagcc ccactccagg ggataagtac ccttccttgg
     4681 ggaagcttgg gaattgtttt agtttaagca acacttcctc tggctgcttc accctgtgtt
     4741 ctccctggca tccccacgcc cacccctggc tgtgctacag ctcaccagca tccacacaaa
     4801 gttccgactg taggtgtgct ggaccgggag ccacagaatt cttcccttac tgtggagttg
     4861 gggaggagag gacctcagtt aatgggccat actggctgga gggaacacca tgggcagaac
     4921 cactgggtcc cccgcttctg cctctctcct tccctgtcac tgttaaaatt ggttgttcag
     4981 tgactgctgc cagcatagtt ggcctcactc tgctggccac gtgggctagg gggaaaaggc
     5041 aaacacagaa atctgatctg gagcagaagc cagtggacag ggtgagaagg gactggggga
     5101 cctggtgaca gagacctcac ataccactgc cagatctttg ggagcccccc tggagctttc
     5161 tggggactga agatgttcct gacttacaga gggaaggcag agttctaagg acagcactga
     5221 gatagcctcc ctgggtggca tcaacctgtg gagattacag aaccccctgc ctctgtccca
     5281 cctgtcctgt gcgttctgac ttggagagac atccaggata gccctggctc aacccaacta
     5341 ctcttggtgt ccaagccacc aggacagagc ttcactgcct caaacagctg acccctaccc
     5401 tcatggccct tctggtgcca acagctgacc cctaccctca tggcccttct agtgccagca
     5461 gctgacccca tccccacggc cctctggtac tgccttgtct cctacctctt ccttgtgtat
     5521 ctcaaccgca cacatgcgcc agctcttgtt atacttaaca gttcctgctg tggtttgggg
     5581 attttttttt aattaaataa aagtttttat tataaat
//
