LOCUS       NM_053318               1484 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus hemopexin (Hpx), mRNA.
ACCESSION   NM_053318
VERSION     NM_053318.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1484)
  AUTHORS   Detsika,M.G. and Lianos,E.A.
  TITLE     Hemopexin Modulates Expression of Complement Regulatory Proteins in
            Rat Glomeruli
  JOURNAL   Curr Issues Mol Biol 43 (2), 1081-1089 (2021)
   PUBMED   34563046
  REMARK    GeneRIF: Hemopexin Modulates Expression of Complement Regulatory
            Proteins in Rat Glomeruli.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1484)
  AUTHORS   Liu,Y., Tan,C., Li,W., Liu,X., Wang,X., Gui,Y., Qin,L., Deng,F.,
            Hu,C. and Chen,L.
  TITLE     Adenoviral transfer of hemopexin gene attenuates oxidative stress
            and apoptosis in cultured primary cortical neuron cell exposed to
            blood clot
  JOURNAL   Neuroreport 31 (15), 1065-1071 (2020)
   PUBMED   32804709
  REMARK    GeneRIF: Adenoviral transfer of hemopexin gene attenuates oxidative
            stress and apoptosis in cultured primary cortical neuron cell
            exposed to blood clot.
REFERENCE   3  (bases 1 to 1484)
  AUTHORS   Hahl,P., Hunt,R., Bjes,E.S., Skaff,A., Keightley,A. and Smith,A.
  TITLE     Identification of oxidative modifications of hemopexin and their
            predicted physiological relevance
  JOURNAL   J Biol Chem 292 (33), 13658-13671 (2017)
   PUBMED   28596380
  REMARK    GeneRIF: Data suggest that apo-hemopexin isolated from plasma
            exchibits low endogenous levels of tyrosine nitration in the
            peptide YYCFQGNQFLR in the heme-binding site of human hemopexin,
            which was similarly nitrated in rabbit and rat hemopexins; heme
            binding by hemopexin declined as tyrosine nitration proceeded in
            vitro.
REFERENCE   4  (bases 1 to 1484)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   5  (bases 1 to 1484)
  AUTHORS   Takagi,T., Naito,Y., Okada,H., Takaoka,M., Oya-Ito,T., Yamada,S.,
            Hirai,Y., Mizushima,K., Yoshida,N., Kamada,K., Katada,K.,
            Uchiyama,K., Ishikawa,T., Handa,O., Yagi,N., Konishi,H., Kokura,S.,
            Ichikawa,H. and Yoshikawa,T.
  TITLE     Hemopexin is upregulated in rat intestinal mucosa injured by
            indomethacin
  JOURNAL   J Gastroenterol Hepatol 27 Suppl 3, 70-75 (2012)
   PUBMED   22486875
  REMARK    GeneRIF: Hemopexin was identified as upregulated protein in the
            small intestine exposed to indomethacin.
REFERENCE   6  (bases 1 to 1484)
  AUTHORS   Tolosano,E., Hirsch,E., Patrucco,E., Camaschella,C., Navone,R.,
            Silengo,L. and Altruda,F.
  TITLE     Defective recovery and severe renal damage after acute hemolysis in
            hemopexin-deficient mice
  JOURNAL   Blood 94 (11), 3906-3914 (1999)
   PUBMED   10572107
REFERENCE   7  (bases 1 to 1484)
  AUTHORS   Nagae,Y. and Muller-Eberhard,U.
  TITLE     Identification of an interleukin-6 responsive element and
            characterization of the proximal promoter region of the rat
            hemopexin gene
  JOURNAL   Biochem Biophys Res Commun 185 (1), 420-429 (1992)
   PUBMED   1599480
REFERENCE   8  (bases 1 to 1484)
  AUTHORS   Swerts,J.P., Soula,C., Sagot,Y., Guinaudy,M.J., Guillemot,J.C.,
            Ferrara,P., Duprat,A.M. and Cochard,P.
  TITLE     Hemopexin is synthesized in peripheral nerves but not in central
            nervous system and accumulates after axotomy
  JOURNAL   J Biol Chem 267 (15), 10596-10600 (1992)
   PUBMED   1587840
REFERENCE   9  (bases 1 to 1484)
  AUTHORS   Nikkila,H., Gitlin,J.D. and Muller-Eberhard,U.
  TITLE     Rat hemopexin. Molecular cloning, primary structural
            characterization, and analysis of gene expression
  JOURNAL   Biochemistry 30 (3), 823-829 (1991)
   PUBMED   1988069
REFERENCE   10 (bases 1 to 1484)
  AUTHORS   Wellner,D., Cheng,K.C. and Muller-Eberhard,U.
  TITLE     N-terminal amino acid sequences of the hemopexins from chicken, rat
            and rabbit
  JOURNAL   Biochem Biophys Res Commun 155 (2), 622-625 (1988)
   PUBMED   3421961
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M62642.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210231.1, FQ211176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1484
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /note="hemopexin"
                     /db_xref="GeneID:58917"
                     /db_xref="RGD:62040"
     exon            1..105
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1405
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /EC_number="3.2.1.35"
                     /codon_start=1
                     /product="hemopexin precursor"
                     /protein_id="NP_445770.1"
                     /db_xref="GeneID:58917"
                     /db_xref="RGD:62040"
                     /translation="MARTVVALNILVLLGLCWSLAVANPLPAAHETVAKGENGTKPDS
                     DVIEHCSDAWSFDATTMDHNGTMLFFKGEFVWRGHSGIRELISERWKNPVTSVDAAFR
                     GPDSVFLIKEDKVWVYPPEKKENGYPKLFQEESPGIPYPPDAAVECHRGECQSEGVLF
                     FQGNRKWFWDFATRTQKERSWPAVGNCTAALRWLERYYCFQGNKFLRFNPVTGEVPPR
                     YPLDARDYFISCPGRGHGKLRNGTAHGNSTHPMHSRCNADPGLSALLSDHRGATYAFS
                     GSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSWDEKVYLIQGTQVYVFLTKGGNN
                     LVSGYPKRLEKELGSPPGISLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQATWA
                     ELSWPHEKVDGALCLEKSLGPYSCSSNGPNLFFIHGPNLYCYSSIDKLNAAKSLPQPQ
                     KVNSILGCSQ"
     exon            106..164
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            165..236
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            237..355
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            356..509
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            510..722
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            723..851
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            852..982
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1145
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1484
                     /gene="Hpx"
                     /gene_synonym="Hpxn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtggtct ttgcagctcg ccatggctag gacagtagta gcactaaata tcctggtatt
       61 gctgggcctg tgctggtccc tggctgttgc caaccctctt cctgctgccc atgagactgt
      121 tgctaaaggt gaaaatggga ccaagccaga ctcagatgta atcgaacact gctcagatgc
      181 ctggagcttt gacgctacca ccatggatca caatgggacc atgctgttct ttaaagggga
      241 gtttgtgtgg aggggtcact cagggatccg ggagttaatc tcagagaggt ggaagaatcc
      301 cgtcacctca gtggatgctg cattccgtgg tcctgacagt gtcttcctga tcaaggaaga
      361 caaagtctgg gtgtatcctc ctgaaaagaa agagaacggg tatccaaagt tgttccaaga
      421 agagtctcct ggaatcccat acccaccaga cgcagctgtg gaatgccacc gtggagaatg
      481 ccagagtgaa ggtgtcctct tcttccaagg taaccgcaag tggttctggg actttgccac
      541 aagaacccaa aaggaacgtt cctggcctgc tgttgggaat tgcactgcgg ccttgaggtg
      601 gcttgaacgc tactactgct tccagggtaa caagttcctg agatttaacc ccgtcacagg
      661 agaggtgcct cccagatacc ctctggatgc ccgtgactac ttcatatcct gccctggcag
      721 aggccatggt aaactaagaa atggaactgc tcatgggaat agcacccatc ctatgcattc
      781 gcgttgtaac gcagatcctg gcctgtctgc actgctgtct gaccatcgag gtgccaccta
      841 tgccttcagt ggctcccact actggcgtct ggactccagc cgtgatgggt ggcatagctg
      901 gcccattgct catcactggc cccagggtcc ttcagcagta gatgctgcct tttcctggga
      961 tgagaaagtc tatctgatcc agggcactca agtatatgtc ttcctgacga aggggggcaa
     1021 taacctagta agtggttatc caaagcggct ggagaaggaa cttgggagcc ctcccgggat
     1081 cagccttgat accatagatg cagccttttc ctgccctggt tcttccaagc tctacgtcac
     1141 atcaggacgg cggctttggt ggctggacct gaagtcagga gcccaggcga catgggcaga
     1201 gctttcctgg ccccatgaga aagttgatgg tgccctgtgt ttggaaaagt cccttggtcc
     1261 ctactcatgc tcttccaatg gtcccaactt gttctttatc catgggccca atttatactg
     1321 ctatagcagt atagacaaac tgaatgcagc caagagtctg cctcagcccc agaaagtgaa
     1381 cagcatcctt ggctgcagtc aataaaaagc cctgatggga attagcccag cccaccccac
     1441 ctctccattt ccattctaat aaaaccagat ggtttcttca catg
//
