LOCUS       NM_001415809            4321 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus heparanase 2 (inactive) (Hpse2), mRNA.
ACCESSION   NM_001415809 XM_008760445
VERSION     NM_001415809.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4321)
  AUTHORS   Guo,C., Kaneko,S., Sun,Y., Huang,Y., Vlodavsky,I., Li,X., Li,Z.R.
            and Li,X.
  TITLE     A mouse model of urofacial syndrome with dysfunctional urination
  JOURNAL   Hum Mol Genet 24 (7), 1991-1999 (2015)
   PUBMED   25510506
REFERENCE   2  (bases 1 to 4321)
  AUTHORS   Levy-Adam,F., Feld,S., Cohen-Kaplan,V., Shteingauz,A., Gross,M.,
            Arvatz,G., Naroditsky,I., Ilan,N., Doweck,I. and Vlodavsky,I.
  TITLE     Heparanase 2 interacts with heparan sulfate with high affinity and
            inhibits heparanase activity
  JOURNAL   J Biol Chem 285 (36), 28010-28019 (2010)
   PUBMED   20576607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 30, 2022 this sequence version replaced XM_008760445.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.7300.1,
                                           SRR26643297.5422.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000001.1  252194876-252195213 c
            339-496             JAXUCZ010000001.1  252191555-252191712 c
            497-658             JAXUCZ010000001.1  252111346-252111507 c
            659-832             JAXUCZ010000001.1  251785883-251786056 c
            833-1004            JAXUCZ010000001.1  251773511-251773682 c
            1005-1052           JAXUCZ010000001.1  251746903-251746950 c
            1053-1146           JAXUCZ010000001.1  251687086-251687179 c
            1147-1253           JAXUCZ010000001.1  251667436-251667542 c
            1254-1368           JAXUCZ010000001.1  251663031-251663145 c
            1369-1514           JAXUCZ010000001.1  251558427-251558572 c
            1515-1661           JAXUCZ010000001.1  251552034-251552180 c
            1662-4321           JAXUCZ010000001.1  251532149-251534808 c
FEATURES             Location/Qualifiers
     source          1..4321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4321
                     /gene="Hpse2"
                     /note="heparanase 2 (inactive)"
                     /db_xref="GeneID:368128"
                     /db_xref="RGD:1307959"
     exon            1..338
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1827
                     /gene="Hpse2"
                     /note="heparanase-2; inactive heparanase-2"
                     /codon_start=1
                     /product="inactive heparanase-2 precursor"
                     /protein_id="NP_001402738.1"
                     /db_xref="GeneID:368128"
                     /db_xref="RGD:1307959"
                     /translation="MRVLCAFPEAMSSSSSRPPSCLALVALFLALLLPLSLSFHAGNR
                     RPLPVDRATGLKEKTLILLDVSTKNPVRTVSENFLSLHLDPSIIHDGWLDFLSSKRLV
                     TLARGLSPAFLRFGGKRTDFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDK
                     QKGCKIAQHPDIMLELQREKAAQMHLVLLKEQYSNTYSNLILTARSLDKLYNFADCSG
                     LHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNEPNNYRSIHGRAVNG
                     SQLGKDYIQLRSLLQPIRIYSRAGLYGPSIGRPRKNVIALLDGFLKVAGSTVDAVTWQ
                     HCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGIVTTSAGGTNN
                     LSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDYWLSLLYKR
                     LIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFIINLHRSR
                     KKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRPLRAG
                     RTLVIPPVTMGFYVVKNVNALACRYR"
     exon            339..496
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..658
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..832
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1004
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1052
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1146
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1253
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1368
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1514
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1661
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..4321
                     /gene="Hpse2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaccatc gagatccagt agggagagaa gtttaaatca gagggataat gagggtgctc
       61 tgtgctttcc ctgaagccat gtcctccagc agctcccgcc ccccctcgtg cctagccctg
      121 gtggctctct tcttggctct gcttctccct ctctcccttt ccttccacgc tggaaacagg
      181 agacctttgc ctgtagacag agctacaggg ttgaaggaaa agaccctgat tctacttgat
      241 gtgagcacca agaacccagt caggacagtc agtgagaact tcctctctct gcatctggat
      301 ccgtccatca ttcatgatgg ctggctcgat ttcttaagct ccaagcgtct ggtgaccctg
      361 gcccggggac tctcgcccgc ctttctgcgc ttcgggggca aaaggacgga tttcctgcag
      421 ttccagaacc tgagaaatcc ggcgaaaagc cgcgggggcc cgggcccgga ttactatctc
      481 aaaaactatg aggatgacat tgtccggagt gatgttgccc tggacaaaca gaaaggctgt
      541 aagattgccc agcaccctga tatcatgctg gagctccaga gagagaaggc ggcgcagatg
      601 catctggttc ttctgaagga gcaatactcc aatacttaca gtaatctcat attaacagcc
      661 aggtctctag acaaacttta taactttgct gattgctctg gactccacct gatatttgct
      721 ctaaatgcac tgcgtcgtaa tcccaataac tcctggaaca gttctagtgc cctgagcctg
      781 ttgaagtaca gtgccagcaa aaagtacaac atttcttggg aactgggtaa tgaacccaat
      841 aactatcgga gcatccacgg ccgggcagta aatggcagtc agttgggaaa ggattacatc
      901 cagctgagga gcctgctgca acccatccgg atttactcca gagccggctt gtacggcccc
      961 agtattggac ggcccaggaa gaacgtcatt gccctcctgg atggattcct gaaggtggca
     1021 ggaagcacag tagatgcggt tacctggcaa cattgctaca ttgatggccg ggtggtcaag
     1081 gtgatggact tcctgaaaac tcgcctgtta gatacactct ctgaccagat taggaaaatt
     1141 cagaaagtgg tcaacacata cactccagga aagaagattt ggctggaagg catagtgacc
     1201 acctcagctg gaggcacaaa caatctgtca gattcctacg ctgcaggatt cttatggcta
     1261 aacactttag gaatgctggc caatcagggc attgatgtcg tgatacgaca ttcatttttc
     1321 gaccacggat acaaccatct ggtggaccag aactttaacc cattaccaga ctattggctt
     1381 tctcttcttt acaagcgtct gattggcccc aaagtcctgg cagtgcatgt agctgggctc
     1441 cagcggaagc ctcggccagg aagagtcatc cgagacaaac taaggatcta tgctcactgt
     1501 acaaaccacc acaaccacaa ctatgtccgt ggctctatca cacttttcat catcaaccta
     1561 catcgatcaa gaaagaaaat caaactggct gggactctca gggacaagct cgtgcaccag
     1621 tatctgctgc agccctatgg gcaggaaggc ctaaagtcca agtcagtgca gctcaatggc
     1681 cagcccttag tgatggtgga cgacgggacc cttccagaac tgaagccccg ccccctgcgg
     1741 gccggccgga cattggtcat ccctccggtc accatgggct tttatgtggt caagaatgtc
     1801 aatgctttgg cttgccgtta tcgataagtc gccctgccct ctgttcctga gctactggtg
     1861 ggcctgctgg actgctctct actcttccac acctgtagcg cccttattcc tcagacaccc
     1921 tcttggccaa ccagcctcta cccccatgct gctgggggca acatagactc tccaaaggca
     1981 gacgaaacgt catagtgtgg gcttagtcta gtaggtggca tctactccta aggaaaatgt
     2041 agacctctgt ttctatgtaa agataaagac gtgtgtctgt ttacacacaa acagctgaca
     2101 gcaagcttcc agtgcagtgt ttccaaacca actgcctgcg gtcctgacca cacagcactg
     2161 tgactcactg caaaccccag gccctagcct atggctgcta ccctcagcag aggttggggg
     2221 gagcagggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2281 tgtgtgtgca aatctaatcc tcttctaact cctcctttgt ctgtttcctg ctgctgcctc
     2341 gggtttcctg acacctctct tcccataggg agctaatggg tgagtcagct ctggcctgct
     2401 gggtgagctg tttatataat ttcctggctg atgtatgaat gtgtgcatct gggtttctga
     2461 cagtggcatc catcactggc tagtcctctg ggaacgggtg cttcacaagt agaattacag
     2521 tcatactcta aagttagtaa ggttctattc ctctgtgaat ctagactccc tccagcttgg
     2581 aatgggagtc aggtaacaat attcattgag tggagagcaa tgcattagtc tccacaagaa
     2641 gaaatcatca ttcttcatgc tgccagaggg agagagttgt agtacaaaga aaaagctcat
     2701 ggaaacatca aacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     2761 ctgatccaac aaagcagttt aggccttgcc ctcaaactga aaggatttca aagactcaag
     2821 acagtaagaa ggctgtagtt gttcgattga ccgaaaaccg tgtagaagaa gaaggcggca
     2881 tgaatgaagt cactcacagc cgacccattc tgcctcttct cacataaccg agtcttagtg
     2941 cattcactag gaagaaagat taaaagtgac cattccgtcc tactcaggtg ggtgtgctta
     3001 agcatggtgc gaagttggct ctattaagga agaatgggga actggtctga aagcaaagca
     3061 gataaatggt tggtggaagg cttctgagtc gggcggacag gggagggact tagagtccac
     3121 ggctgggacc tttacttggc tacagggtat gggagtcttt agagacaagc tgcagtcaca
     3181 ctgactttct gtggacagga ctgacctcag gaaacaaaag catgtgaatg atgccacctt
     3241 caaggagaaa ggggaccctt gacactccta ggtgccagac aagtcagggc accattttgg
     3301 tgtgaacaga caggcctggg gaagcagcgg agacatgtct aagatgccca gagaaagggt
     3361 ttagtcccgt ttgcaaagtg agaggcaaga cgaaggttag acagcaaggt gccccaagac
     3421 tttcggcttt cagagctagg aacttggtag aggggagcca cccatctgat tctccctaga
     3481 aggaagacag tgggattgga tttcagtgtg ctcattttca gtataggaag agcatcacac
     3541 agtcggcaca ctagggcgtg caagaacaga agactgaagg caggctggac ccgtcaatgg
     3601 tcagctcaga aacatctgga aatggtggcc catgagcctg ctcacccagc gagacaccca
     3661 gggagcttcc cttcccaggc accttccatg taagctctag cacacacaga aagtactggc
     3721 actaggggtt ggaaggaaga gaggaaggaa ggaaggaggg aggaaggaag gaaggaagga
     3781 aggaaggaag gaaggaagga aggaaggaag gaaggaggga aggaacgaaa agaagagaaa
     3841 aacaggtgga ccaaagtcag gaagaatgtg ggaagggaaa agagacagac tttttccttg
     3901 aacatgtgta agaatctctt ctaagtcctt gtctgggggc agctgccggg cccctgatta
     3961 cagtgaggtg atcagaaccc ctgatgccag gccctgggct aatttgcttt acataataaa
     4021 gttactgtgg ttatcccaag tacttgtggg gtgtgggaag ggtccctagg ctgccagtgt
     4081 cacccagtga aatgcgtttg tttaggagtc atccagagcc tacctagtcc caagctcagt
     4141 ggcctttcct gtcacagact tgcccctcac ctggtggact gctcagtata gccaagactt
     4201 ccagagcccc acacaagcac attttctgta aatagggtta attcttcact aagcctccca
     4261 gaatgtaggt cattttttgc tgcctttgtc tttctctgtg aattaaatgc tgcacccaag
     4321 a
//
