LOCUS       NM_022605               3177 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus heparanase (Hpse), mRNA.
ACCESSION   NM_022605
VERSION     NM_022605.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3177)
  AUTHORS   Whitehead,M.J., McGonigal,R., Willison,H.J. and Barnett,S.C.
  TITLE     Heparanase attenuates axon degeneration following sciatic nerve
            transection
  JOURNAL   Sci Rep 8 (1), 5219 (2018)
   PUBMED   29581478
  REMARK    GeneRIF: We identified Hpse as a previously unexplored candidate,
            being up-regulated following injury. We confirmed these results and
            demonstrated inhibition of Hpse led to an acceleration of axonal
            degeneration, accompanied by an increase in b-catenin
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3177)
  AUTHORS   Changyaleket,B., Chong,Z.Z., Dull,R.O., Nanegrungsunk,D. and Xu,H.
  TITLE     Heparanase promotes neuroinflammatory response during subarachnoid
            hemorrhage in rats
  JOURNAL   J Neuroinflammation 14 (1), 137 (2017)
   PUBMED   28720149
  REMARK    GeneRIF: Heparanase plays an important role in mediating the
            neuroinflammatory response after subarachnoid hemorrhage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3177)
  AUTHORS   Wang,F., Jia,J., Lal,N., Zhang,D., Chiu,A.P., Wan,A., Vlodavsky,I.,
            Hussein,B. and Rodrigues,B.
  TITLE     High glucose facilitated endothelial heparanase transfer to the
            cardiomyocyte modifies its cell death signature
  JOURNAL   Cardiovasc Res 112 (3), 656-668 (2016)
   PUBMED   27979811
  REMARK    GeneRIF: Endothelial cell-to-cardiomyocyte transfer of heparanase
            to modulates the cardiomyocyte cell death signature. This mechanism
            was observed in the acutely diabetic heart, and its interruption
            following chronic diabetes may contribute towards the development
            of diabetic cardiomyopathy.
REFERENCE   4  (bases 1 to 3177)
  AUTHORS   Ishiguro-Oonuma,T., Suemoto,M., Okada,M., Yoshioka,K., Hara,Y.,
            Hashizume,K. and Kizaki,K.
  TITLE     Aberrant gene expression of heparanase in ventricular hypertrophy
            induced by monocrotaline in rats
  JOURNAL   J Vet Med Sci 78 (3), 499-503 (2016)
   PUBMED   26638897
  REMARK    GeneRIF: the expression of the gene for heparanase was increased in
            the right and left ventricles after treatment with monocrotaline
REFERENCE   5  (bases 1 to 3177)
  AUTHORS   Wang,Y., Chiu,A.P., Neumaier,K., Wang,F., Zhang,D., Hussein,B.,
            Lal,N., Wan,A., Liu,G., Vlodavsky,I. and Rodrigues,B.
  TITLE     Endothelial cell heparanase taken up by cardiomyocytes regulates
            lipoprotein lipase transfer to the coronary lumen after diabetes
  JOURNAL   Diabetes 63 (8), 2643-2655 (2014)
   PUBMED   24608441
  REMARK    GeneRIF: Inhibiting heparanase function could offer a new strategy
            for managing cardiomyopathy observed after diabetes.
REFERENCE   6  (bases 1 to 3177)
  AUTHORS   Goldshmidt,O., Zcharia,E., Cohen,M., Aingorn,H., Cohen,I.,
            Nadav,L., Katz,B.Z., Geiger,B. and Vlodavsky,I.
  TITLE     Heparanase mediates cell adhesion independent of its enzymatic
            activity
  JOURNAL   FASEB J 17 (9), 1015-1025 (2003)
   PUBMED   12773484
REFERENCE   7  (bases 1 to 3177)
  AUTHORS   Okada,Y., Yamada,S., Toyoshima,M., Dong,J., Nakajima,M. and
            Sugahara,K.
  TITLE     Structural recognition by recombinant human heparanase that plays
            critical roles in tumor metastasis. Hierarchical sulfate groups
            with different effects and the essential target disulfated
            trisaccharide sequence
  JOURNAL   J Biol Chem 277 (45), 42488-42495 (2002)
   PUBMED   12213822
REFERENCE   8  (bases 1 to 3177)
  AUTHORS   Podyma-Inoue,K.A., Yokote,H., Sakaguchi,K., Ikuta,M. and
            Yanagishita,M.
  TITLE     Characterization of heparanase from a rat parathyroid cell line
  JOURNAL   J Biol Chem 277 (36), 32459-32465 (2002)
   PUBMED   12077130
  REMARK    GeneRIF: characterization of rat heparanase activity in a
            parathyroid cell line
REFERENCE   9  (bases 1 to 3177)
  AUTHORS   Bame,K.J., Venkatesan,I., Dehdashti,J., McFarlane,J. and
            Burfeind,R.
  TITLE     Characterization of a novel intracellular heparanase that has a
            FERM domain
  JOURNAL   Biochem J 364 (Pt 1), 265-274 (2002)
   PUBMED   11988100
  REMARK    GeneRIF: Characterization of a novel intracellular heparanase that
            has a FERM domain.
REFERENCE   10 (bases 1 to 3177)
  AUTHORS   Hulett,M.D., Freeman,C., Hamdorf,B.J., Baker,R.T., Harris,M.J. and
            Parish,C.R.
  TITLE     Cloning of mammalian heparanase, an important enzyme in tumor
            invasion and metastasis
  JOURNAL   Nat Med 5 (7), 803-809 (1999)
   PUBMED   10395326
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF184967.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF184967.1, AF359508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3177
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3177
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /note="heparanase"
                     /db_xref="GeneID:64537"
                     /db_xref="RGD:61969"
     exon            1..271
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1676
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /EC_number="3.2.1.166"
                     /note="endo-glucoronidase"
                     /codon_start=1
                     /product="heparanase precursor"
                     /protein_id="NP_072127.1"
                     /db_xref="GeneID:64537"
                     /db_xref="RGD:61969"
                     /translation="MLRPLLLLWLWGRLRALTQGTPAGTAPTKDVVDLEFYTKRLFQS
                     VSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPNKE
                     PTSEERSYWQSQDNNDICGSERVSADVLRKLQMEWPFQELLLLREQYQREFKNSTYSR
                     SSVDMLYSFAKCSRLDLIFGLNALLRTPDLRWNSSNAQLLLNYCSSKGYNISWELGNE
                     PNSFWKKAQISIDGLQLGEDFVELHKLLQKSAFQNAKLYGPDIGQPRGKTVKLLRSFL
                     KAGGEVIDSLTWHHYYLNGRVATKEDFLSSDVLDTFILSVQKILKVTKEMTPGKKVWL
                     GETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQLGIEVVMRQVFFGAGNYHLVDENFE
                     PLPDYWLSLLFKKLVGPKVLMSRVKGPDRSKLRVYLHCTNVYHPRYREGDLTLYVLNL
                     HNVTKHLKLPPPMFSRPVDKYLLKPFGSDGLLSKSVQLNGQTLKMVDEQTLPALTEKP
                     LPAGSSLSVPAFSYGFFVIRNAKIAACI"
     exon            272..417
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            418..543
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            544..717
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            718..886
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            887..934
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1028
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1135
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1250
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1369
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1516
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..3138
                     /gene="Hpse"
                     /gene_synonym="Hep; Hpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaccttga gccagcgcgc cggctgcccc agctctcacg gccgctggcg gtccagccag
       61 gtaggatgct gcggccgctg ctgctgctgt ggctctgggg gcggctccgt gccctgaccc
      121 aaggcactcc ggcggggacc gcgccgacca aggacgtggt ggacttggag ttttacacca
      181 agaggctatt ccaaagcgtg agtccctcgt tcctgtccat caccatcgac gccagcctgg
      241 ccaccgaccc tcggttcctc accttcctgg gctctccacg gcttcgagcc ctggctagag
      301 gcttatctcc tgcgtacttg agatttggcg gcaccaagac tgacttcctt atttttgatc
      361 ccaacaagga acccacctct gaagaaagaa gttactggca atctcaagac aacaatgata
      421 tttgcgggtc tgagcgggtc tctgctgacg tgttgaggaa actccagatg gagtggccct
      481 tccaggagct gctgctgctc cgagaacagt accaaagaga attcaagaac agcacctact
      541 cacgaagctc ggtggacatg ctctacagtt ttgctaagtg ctcgaggtta gacctgatct
      601 ttggtctaaa tgcgttacta agaaccccag acttgcggtg gaacagctcc aacgcccagc
      661 ttctcctcaa ctactgctct tccaagggtt ataacatctc ctgggaactg ggcaacgagc
      721 ccaacagttt ctggaagaaa gctcagattt ccatcgatgg gttgcagcta ggagaagact
      781 ttgtggagtt gcataaactt ctacaaaagt cagctttcca aaacgcaaaa ctctatggtc
      841 ctgacattgg tcagcctcga gggaagacag ttaagctgct gagaagcttc ctgaaggctg
      901 gtggagaagt gattgactct ctcacctggc atcactacta cttgaatgga cgagttgcga
      961 ccaaagaaga ttttctgagc tctgatgtcc tggacacttt tatcctatct gtgcaaaaaa
     1021 ttctgaaggt gactaaggag atgacacctg gcaagaaggt ctggttggga gagacgagct
     1081 ctgcctacgg cggcggagcg cccttgctgt ccaatacctt tgcagctggc tttatgtggc
     1141 tggataaatt gggcctgtca gcccagctgg ggatagaagt cgtgatgagg caggtgtttt
     1201 tcggagcagg caactaccac ttagtggacg aaaacttcga gcccttgccc gattactggc
     1261 tctctctcct gttcaagaaa ctggtaggtc ccaaggtgtt aatgtcaaga gtgaaaggcc
     1321 cagacagaag caaactccga gtgtacctcc actgcacgaa cgtctatcac ccaaggtatc
     1381 gggaaggaga tttaactctg tacgtcctga acctccataa tgtcaccaag cacttgaagc
     1441 tgccgcctcc gatgttcagc agaccggtgg ataagtacct gctgaagcct ttcggttctg
     1501 acggactgct ttccaaatcc gtccaactga acggtcaaac cctgaagatg gtcgatgagc
     1561 agaccctgcc agctctaaca gaaaaacctc tccccgcagg aagctcacta agcgtgcccg
     1621 ccttttccta tgggtttttt gtcataagaa atgccaaaat cgcagcttgt atatgaaaat
     1681 aaaaggcatt acagtacccc tgagacgaaa gcggtcaggg gtgtcattca taagaataaa
     1741 gcaaaacccc agcggtaggg agcggactcc ttagcaagct ccagagcctc gggagggcgg
     1801 ggcatgctcc agtgctggat ccagagcctc gggagggcgg ggcaagcttc aacgctggat
     1861 ccagagcctc gggagggcgg ggcacgcgct tcagtgttaa catccagtgc ggtgttctct
     1921 aagtagacca ctgcaggtgg tgacagttaa tggcaccatg tggcaaatga cgcttagcac
     1981 tttgcatgca ctattttgag ggttattaaa aatgaataca aatgcctcca atatgaccaa
     2041 gaggcaaata agtgaaggat atgtcctgat ttaaaaaaaa aaaaaaacaa caaactttgt
     2101 ttttatttta ttgttattat tttgttagga agattgtcaa atacgacctc cagtagcctc
     2161 tctgtagctc caatggggga aaggcccatt gccttaacgc cacactggct gtaagaagac
     2221 acctgctcac cctgagagga actaaaacag agaaacagcc cctgtgcctc tcttcgttct
     2281 tcttgagtct gtgaaaggac aggtggctgg gtggagtaat actaaacaaa agcaagagac
     2341 cgtcacagtt gagagggaag ggaaatgact gtaaaggaga tggttggttg ctagggagct
     2401 gtttccggga acacctgaca tgccatcatt ggggtttatg gtttctacac ctgtagttct
     2461 tgctttgctg ggaaagcttt ggcctgtgag taacagaaat ctttaatgag gacatttgta
     2521 accccacata agttgttgaa gtgaggtaga gcctgacagc tgggcacatc agcaggacac
     2581 gtcatcatca ggagtctacc ttctttctcc ctctctgtcc tgctgtctgt agtgctggct
     2641 cccttctggg cctggtcatg tgatggctgc aactggtcta cagatccatt gagatctggc
     2701 agtgagcaga ggaagagatg agtggtttct tcacagacct gaagagctct ttcttggagg
     2761 ctctcccagc aagcctttcc tcaagtctca agtcttactg gctaggaata ggtctgtggt
     2821 cattctcaat gcccataact gtcttcacac agtactcctt tggggaagag aggtttggtg
     2881 gagtccacag ccctagacat ttgctttcgg tctgtgcttt tgatcaagca acaaagtgta
     2941 attctccccc ccaccccggg attttaatat taaggatcgc aattctatat gtttgtgcct
     3001 gctatgaata ttatctcgag tgaatttagc atgccgatga agctagaacg taaagtttgt
     3061 atgcctagat attttcaatt tttatgcaag taggttttat attttcacat tcgaaataaa
     3121 ctaattttat agcctcgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
