LOCUS       NM_181432               2636 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus HPS6, biogenesis of lysosomal organelles complex
            2 subunit 3 (Hps6), mRNA.
ACCESSION   NM_181432
VERSION     NM_181432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Li,K., Yang,L., Zhang,C., Niu,Y., Li,W. and Liu,J.J.
  TITLE     HPS6 interacts with dynactin p150Glued to mediate retrograde
            trafficking and maturation of lysosomes
  JOURNAL   J Cell Sci 127 (Pt 21), 4574-4588 (2014)
   PUBMED   25189619
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Bultema,J.J., Ambrosio,A.L., Burek,C.L. and Di Pietro,S.M.
  TITLE     BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and
            Rab32 proteins to mediate protein trafficking to lysosome-related
            organelles
  JOURNAL   J Biol Chem 287 (23), 19550-19563 (2012)
   PUBMED   22511774
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Huizing,M., Pederson,B., Hess,R.A., Griffin,A., Helip-Wooley,A.,
            Westbroek,W., Dorward,H., O'Brien,K.J., Golas,G., Tsilou,E.,
            White,J.G. and Gahl,W.A.
  TITLE     Clinical and cellular characterisation of Hermansky-Pudlak syndrome
            type 6
  JOURNAL   J Med Genet 46 (12), 803-810 (2009)
   PUBMED   19843503
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Di Pietro,S.M., Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Characterization of BLOC-2, a complex containing the
            Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6
  JOURNAL   Traffic 5 (4), 276-283 (2004)
   PUBMED   15030569
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Zhang,Q., Zhao,B., Li,W., Oiso,N., Novak,E.K., Rusiniak,M.E.,
            Gautam,R., Chintala,S., O'Brien,E.P., Zhang,Y., Roe,B.A.,
            Elliott,R.W., Eicher,E.M., Liang,P., Kratz,C., Legius,E.,
            Spritz,R.A., O'Sullivan,T.N., Copeland,N.G., Jenkins,N.A. and
            Swank,R.T.
  TITLE     Ru2 and Ru encode mouse orthologs of the genes mutated in human
            Hermansky-Pudlak syndrome types 5 and 6
  JOURNAL   Nat Genet 33 (2), 145-153 (2003)
   PUBMED   12548288
REFERENCE   7  (bases 1 to 2636)
  AUTHORS   Mayerhofer,A., Russell,L.D., Grothe,C., Rudolf,M. and Gratzl,M.
  TITLE     Presence and localization of a 30-kDa basic fibroblast growth
            factor-like protein in rodent testes
  JOURNAL   Endocrinology 129 (2), 921-924 (1991)
   PUBMED   1855483
REFERENCE   8  (bases 1 to 2636)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   9  (bases 1 to 2636)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
REFERENCE   10 (bases 1 to 2636)
  AUTHORS   Markert,C.L. and Silvers,W.K.
  TITLE     The Effects of Genotype and Cell Environment on Melanoblast
            Differentiation in the House Mouse
  JOURNAL   Genetics 41 (3), 429-450 (1956)
   PUBMED   17247639
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086975.1.
            
            On Dec 26, 2004 this sequence version replaced NM_181432.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC086975.1, SRR8487227.207505.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2636
                     /gene="Hps6"
                     /gene_synonym="Hsp6"
                     /note="HPS6, biogenesis of lysosomal organelles complex 2
                     subunit 3"
                     /db_xref="GeneID:309446"
                     /db_xref="RGD:631341"
     exon            1..2610
                     /gene="Hps6"
                     /gene_synonym="Hsp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2498
                     /gene="Hps6"
                     /gene_synonym="Hsp6"
                     /note="ruby-eye-like protein; hermansky-Pudlak syndrome 6
                     protein homolog; ruby-eye protein homolog"
                     /codon_start=1
                     /product="BLOC-2 complex member HPS6"
                     /protein_id="NP_852097.1"
                     /db_xref="GeneID:309446"
                     /db_xref="RGD:631341"
                     /translation="MKRAGTLRLLSDLSNFTGAARLRELLAGDPAILVRCSPDGRHLL
                     LLRPPGSPAPQLLVAVRGPGLPLERAWSEGDPSPLDVFFVPWLARPALILVWESGLTE
                     VWGVGMEPGWKLLQSTELCPDGGARVMAVAATRGRLVWCEERQPGVEDQPGQLSMAFN
                     HCVCVKTLDTSGEAGTKLGCTHILLHHCPSFGLIASRKELFLVPTSTTWPGVAHVLLI
                     WSPSKGKVIVAAPSLGLSHSKSLNPKQGDTWDFRTLLRGLPGFLSPREPLAVHTWAPS
                     SQGLLLLDLKGKVSLVQCHGGTRTVGLLQEAPVGLQGSAALGTFHGTLACVLGSTLEL
                     LDMSSGRLLERKVLSTDRVHLLEPPAPGVKNEEDLETRGALRLLSALGLFCVCWEAPQ
                     GLEVPSDKDLVFEEACGYYQRRSLRGTQLTPEELRHNSMFRAPQALASILQGHLPPSA
                     LLTTLRAELRDYRSIEQLKAQLVAGDDEETGWTELAEHEVARLLRTHLTGDQLAQFNT
                     IFQALPTAAWSATLQALQLQPDRSGRLRSQAPPDVWKKVLRAPTAGKEHPNGILPPFE
                     LLCQCLGQLEPQWLPPFVELAQQQGGPGWGAEGPSLPLYRRALSVLGEEGKRPEALEL
                     ELLLGSGRPKAVLQAVRQLIKKEQWERALEAGLTLDSSSPLLRSEIFNLLLAEFAQHR
                     RLDTHLPLLCRLCPPEVAPDELLLLLRTHLPDDAGATPFPEPGAEPGAEPPLTVGLVR
                     ALLEQTGAQGRSSGPVQSTFEDILWDSGTPPPTPPRGPMTTLQASDHPGQEAWGPSGQ
                     GLGAADVGVHS"
ORIGIN      
        1 cggagtagca gccaggcctc gccccaccgg gcgatcaggc cttggcaagc tcctacgcca
       61 gaggcgtcat gaagcgtgca ggaactctgc gcctgctttc ggatctgagc aacttcactg
      121 gcgcggcccg gctccgcgag ttgttggcag gggacccagc tatcctagtc cgctgcagcc
      181 ctgatggccg tcacctgcta ctgttaagac ctcccggatc gcccgccccc caacttctag
      241 tggctgtgcg tgggccgggc ctgcctctgg agcgtgcctg gtcggagggc gacccctcgc
      301 cgctggacgt ctttttcgtt ccatggctgg cgcgacccgc gctgatattg gtatgggaga
      361 gtggcctaac agaggtgtgg ggcgtgggga tggagcctgg atggaagcta cttcagagca
      421 ctgagttgtg tccggatggt ggagcccgcg tgatggctgt ggcagcaacc cgaggccgcc
      481 tagtttggtg cgaggagcgt cagcctggcg ttgaggacca accagggcag ctttcaatgg
      541 ccttcaacca ctgtgtgtgc gtcaagaccc tggacaccag cggggaggct ggcaccaaac
      601 taggctgcac ccacatcctg ctgcatcact gcccctcttt tggactgata gcctcccgca
      661 aggaactctt cctggtgcct acttccacca cttggcctgg tgtggcccat gttctgctca
      721 tctggagccc aagcaagggg aaggtaatag ttgctgcccc atctctcggt ctttctcaca
      781 gtaaaagcct gaatcccaaa caaggggata cttgggactt tcggaccctg ctgcgaggcc
      841 ttcctggatt cctgtccccc agggagccgc tggctgtaca cacttgggcc ccatcttccc
      901 agggcttgtt gttgcttgac ttgaaaggta aggtgagcct agtgcagtgc catggtggta
      961 ctcgaactgt gggactcctg caggaggcac ctgtaggtct acaagggtct gcagccctgg
     1021 gaacatttca tggcacctta gcctgtgtct tgggctccac cttggaactg ctggacatga
     1081 gcagtgggcg gctgttggaa aggaaggtac taagtacaga cagagtacac ctcctggagc
     1141 ctccagcccc tggcgtgaag aatgaggaag acctagagac ccgaggagct ctccgtttgc
     1201 tttcagcctt gggtctcttt tgtgtgtgtt gggaagctcc ccaaggcctt gaggtgccct
     1261 cggacaagga tctggtgttt gaggaggcct gtgggtacta ccagcgtcgg agtcttcgag
     1321 gcacccagct taccccggaa gagctgagac acaacagcat gtttcgggca cctcaggcct
     1381 tggcctccat tctccagggc cacctgcccc catctgcact attgaccacc ctgagggctg
     1441 aacttcgaga ttatcggagt atagaacagc tcaaggccca gctggtggct ggggatgatg
     1501 aagagacggg ctggacggag ttagcagagc acgaggtggc acgcctgctg agaacccact
     1561 tgacaggaga ccagctggcc caattcaaca ccattttcca agcccttcct acagcagctt
     1621 ggagtgccac cctccaagcc ctacaactgc agccggatag gagtggcagg ctgaggtccc
     1681 aagcgccccc ggatgtatgg aagaaagtcc tgagggctcc aacggctgga aaggaacatc
     1741 ccaatggaat cctgcctccc tttgaactcc tgtgtcagtg cctaggccag ctagagcctc
     1801 agtggcttcc cccgtttgtg gaactggcac agcaacaggg tggtccaggc tggggcgccg
     1861 aaggtcccag tctgcccctt tatcgccgag ccctgtccgt gctgggtgag gaagggaaga
     1921 gacctgaggc tctagaactc gagctgcttc tgggcagcgg gcgacccaaa gccgtgctac
     1981 aagctgtgag gcagctaata aagaaagaac agtgggaacg ggctctggag gccggcctga
     2041 ccctggactc ctccagcccc ctgcttcgaa gcgagatctt caacctgctg ctggcagagt
     2101 ttgcccagca ccgccgcctt gatacacacc tccctctcct ctgtcgcctg tgcccaccag
     2161 aagtggctcc agatgagctc ctgcttctac tgaggacaca tctcccagac gatgcgggag
     2221 ccaccccttt ccctgagcct ggggctgagc ctggggctga gccccctctc acagtgggct
     2281 tggtcagagc cctgctagaa cagactgggg ctcagggaag gtcctctggc ccagttcaaa
     2341 gcacctttga ggacatccta tgggattcag gcactccacc ccctacccca cctcgcggac
     2401 ctatgactac tctccaggca tcagaccacc cagggcagga agcctgggga ccatctggac
     2461 aggggcttgg tgcagctgac gtgggagttc attcgtagag cacggagatg cgaagagtac
     2521 ccggggttgg agagtacgaa ggtggaactt gtgtgtgcaa tactgtctgt tgtgggacaa
     2581 attttaaaat acatgcaaat agcaaatata aaaaaaaaaa aaaaaaaaaa aaaaaa
//
