LOCUS       NM_001135612            4641 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus HPS5, biogenesis of lysosomal organelles complex
            2 subunit 2 (Hps5), mRNA.
ACCESSION   NM_001135612
VERSION     NM_001135612.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4641)
  AUTHORS   Huizing,M., Hess,R., Dorward,H., Claassen,D.A., Helip-Wooley,A.,
            Kleta,R., Kaiser-Kupfer,M.I., White,J.G. and Gahl,W.A.
  TITLE     Cellular, molecular and clinical characterization of patients with
            Hermansky-Pudlak syndrome type 5
  JOURNAL   Traffic 5 (9), 711-722 (2004)
   PUBMED   15296495
REFERENCE   2  (bases 1 to 4641)
  AUTHORS   Di Pietro,S.M., Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Characterization of BLOC-2, a complex containing the
            Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6
  JOURNAL   Traffic 5 (4), 276-283 (2004)
   PUBMED   15030569
REFERENCE   3  (bases 1 to 4641)
  AUTHORS   Zhang,Q., Zhao,B., Li,W., Oiso,N., Novak,E.K., Rusiniak,M.E.,
            Gautam,R., Chintala,S., O'Brien,E.P., Zhang,Y., Roe,B.A.,
            Elliott,R.W., Eicher,E.M., Liang,P., Kratz,C., Legius,E.,
            Spritz,R.A., O'Sullivan,T.N., Copeland,N.G., Jenkins,N.A. and
            Swank,R.T.
  TITLE     Ru2 and Ru encode mouse orthologs of the genes mutated in human
            Hermansky-Pudlak syndrome types 5 and 6
  JOURNAL   Nat Genet 33 (2), 145-153 (2003)
   PUBMED   12548288
REFERENCE   4  (bases 1 to 4641)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   5  (bases 1 to 4641)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000001.1  106457038-106457220 c
            184-339             JAXUCZ010000001.1  106452704-106452859 c
            340-450             JAXUCZ010000001.1  106449055-106449165 c
            451-515             JAXUCZ010000001.1  106448904-106448968 c
            516-708             JAXUCZ010000001.1  106448129-106448321 c
            709-842             JAXUCZ010000001.1  106446603-106446736 c
            843-1055            JAXUCZ010000001.1  106443330-106443542 c
            1056-1127           JAXUCZ010000001.1  106442872-106442943 c
            1128-1216           JAXUCZ010000001.1  106438631-106438719 c
            1217-1395           JAXUCZ010000001.1  106437743-106437921 c
            1396-1554           JAXUCZ010000001.1  106436757-106436915 c
            1555-1741           JAXUCZ010000001.1  106435418-106435604 c
            1742-1865           JAXUCZ010000001.1  106434650-106434773 c
            1866-2015           JAXUCZ010000001.1  106432758-106432907 c
            2016-2087           JAXUCZ010000001.1  106432171-106432242 c
            2088-2662           JAXUCZ010000001.1  106431309-106431883 c
            2663-2783           JAXUCZ010000001.1  106427076-106427196 c
            2784-2939           JAXUCZ010000001.1  106426725-106426880 c
            2940-3059           JAXUCZ010000001.1  106425831-106425950 c
            3060-3173           JAXUCZ010000001.1  106424917-106425030 c
            3174-3280           JAXUCZ010000001.1  106422309-106422415 c
            3281-3551           JAXUCZ010000001.1  106420395-106420665 c
            3552-4641           JAXUCZ010000001.1  106417902-106418991 c
FEATURES             Location/Qualifiers
     source          1..4641
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..4641
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /note="HPS5, biogenesis of lysosomal organelles complex 2
                     subunit 2"
                     /db_xref="GeneID:308598"
                     /db_xref="RGD:1311916"
     exon            1..183
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            184..339
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..3612
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /note="Hermansky-Pudlak syndrome 5"
                     /codon_start=1
                     /product="BLOC-2 complex member HPS5"
                     /protein_id="NP_001129084.1"
                     /db_xref="GeneID:308598"
                     /db_xref="RGD:1311916"
                     /translation="MTSVPVIPEAYSHVLAEFESLDPLLTALRLDSSRLKCSSIAVSR
                     KWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIACCSHDDDYVAVATSQGLVVVW
                     ELNQERRGKPERIHVSSEHKGRKVTALCWDTAVLRVFVGDHVGKVSAIKLNTLKQAKA
                     AAAFVMFPVQTIITVDSCVVQLDYLDGRLLVSSLTRTFLCDTEREKFWKIGNKEREGE
                     FGACFFPGRCAGSQQPLIYCARPGSRIWEVSFDGEVLSTHQFKKLLSMPPLPVITASS
                     EPQYDHAVGSSQSLSFPKLLHFSEHCVLTWTEKGIYIFIPQNVQVLLWSEVKDIQDVA
                     VYKNELFCLHFNGKISHLSLLSVERCVERLLRRGLWDLAARTCCLFQNSIITSRGRKT
                     LSTDKLEHLKSQLDLTACSELISQLEEVIFKFEPLDSACSSRRSSISSHESFSILDSG
                     IYRIISSRRGSQSDEDSCSLHSQTFSEDERLKEFASHQEEEQPEQGCCANRNGDSVSH
                     SPMMSEIDKGEAFLPFNIPLPFRSPSPLLSLQAVKDSVSSFVRKTTEKIGTLHASPEL
                     KETSEPRDADQVHEEEVSAVTCPLEEDTEEKEIHQPPEEDRLQGLRAATAEAVTKLLD
                     PLVLFEPKLLRAVLHEWLSQLEKTFAMKGFAAISNTSSLPEKSNLDTHLLGESEKRVL
                     CEESGEERRVTLGTEEPGGQTTCDSVSSLSEPSADSFQVCPPYAIANSLQKDLVELTT
                     LCLELNVLTSAVESDSRHMDCALQQLSPETLACRFLKKYFFLLDLKRAKESVKLSHYS
                     PCVWDTFVEGLKEMASSTPAYMEMGERDLPTGLQLLDGSVPSHSPLLIAFAARLYDRF
                     GEPALRALIKFYPSISPSDIAQLCRRHPAQFLAYLDSLVKSRPEDQWPSFLEFLLQPE
                     SLRLEWLLLAVSHDAPPSTSTVDDEGHPRPHSHLLSWGYSQLILLLIKLPADFATKEK
                     MTDICRSYGFWPGYLTLCLELERRREAFTNIVYLNDVSLMEGDNGWIPETLEEWKLLL
                     HLLQNKNTRPAPQESLNGSLSDGPTPINVENVALLLAKAMGPDRAWSLLQECGLALEL
                     SEKFTRTCDILRIAERRQRALIQGMLEKCDRFLWSQQA"
     exon            340..450
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            451..515
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            516..708
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            709..842
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1055
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1127
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1216
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1395
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1554
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1741
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1865
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2015
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2087
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2662
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2783
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2939
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3059
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3173
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3280
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3551
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..4641
                     /gene="Hps5"
                     /gene_synonym="Aa2-028; Ab1-018"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagtttgcg gttctatgat cctggcttgg aaaatctgct tcctggactt ctccagagcg
       61 acagctgcgg tttacagtta gggcggttta aaagttagtt gtgattgaca ggagcttctt
      121 gtggtaaggg acttgttctg ctctttcttc atctccagca gaacctccag ggcctaaaac
      181 acgagagaaa tcctgtgcct attacagaac aatcttcctc tttctggcta aatgacttct
      241 gtgcccgtga taccagaagc ctacagccat gttcttgcag agtttgagtc cttggacccg
      301 ttactcacag ccctgcggct ggactccagt cgtctgaagt gttccagcat agctgtgtct
      361 cggaaatggc tggccttagg cagcacagga ggaggactca atctcattca gaaagatggc
      421 tggaagcaaa ggctgtttct ctcccaccgg gaaggggcaa tctctcagat tgcctgctgc
      481 tctcatgatg atgattatgt tgccgtggct accagtcaag gtcttgtagt tgtttgggaa
      541 ttaaatcaag agcgtcgtgg gaaaccagag cgaatccatg tgtcctcaga acacaaaggc
      601 cgaaaagtta ccgccctttg ttgggacaca gctgtcctga gagtctttgt aggtgaccac
      661 gtgggcaaag tttctgccat caaactcaat actttgaaac aagcaaaggc agctgcggcc
      721 tttgtgatgt ttcctgtcca gacaataata acagtcgact cctgtgtcgt ccagttagat
      781 tatttggatg gaagattact tgtgtcttca ctgactcgaa ccttcttgtg cgacactgag
      841 agggaaaagt tttggaagat tggaaataag gaaagagaag gagagtttgg ggcgtgtttc
      901 ttccctggaa ggtgtgctgg gagccagcag cctctgatct actgtgcccg cccaggctcc
      961 aggatatggg aagtgagctt tgatggggaa gtgctcagta cacaccagtt caagaagctc
     1021 ctctcaatgc cgccccttcc tgtcatcact gcaagctcgg agcctcagta tgatcacgca
     1081 gttgggtcct cccagtcttt atcgttcccc aaactcttgc attttagtga acactgtgtg
     1141 ctgacttgga cagaaaaggg aatttatatt ttcattcctc agaatgttca agttcttctt
     1201 tggagtgaag tcaaggatat tcaggatgta gctgtctaca agaatgaatt gttctgtttg
     1261 cactttaatg ggaaaatctc acatctttcc ctgttgtctg tggaacgctg tgtagaacgc
     1321 ctgttaagga gaggcctgtg ggacctggct gctcgcacat gctgtctctt ccaaaactct
     1381 attattacca gcagaggaag aaaaacactg tctacagata aattggagca tttgaaatct
     1441 cagctggacc ttacagcctg cagtgaacta atttctcagc tggaagaagt gatcttcaag
     1501 tttgagcctt tggattcagc ttgcagcagc agaagaagct ccatttcgtc acatgaaagt
     1561 tttagcatct tggactctgg tatttatcgt atcatcagta gtagaagagg cagtcagtcc
     1621 gacgaagatt cttgctccct tcacagccag accttctcag aagacgagag acttaaagaa
     1681 tttgcatcac accaggaaga ggagcagcca gagcagggct gttgtgcaaa cagaaatgga
     1741 gacagtgttt cccacagtcc aatgatgtct gagatagata agggggaagc gtttctgccc
     1801 ttcaacattc cactgccatt tcgttctcct tctcccctcc tgtctcttca ggctgttaag
     1861 gacagtgttt ctagctttgt gcgtaagact actgagaaga ttggcaccct tcatgcaagc
     1921 ccagagctga aagagacatc ggaacccagg gatgctgacc aagttcatga agaggaagtg
     1981 agtgccgtca cctgccctct ggaggaggac actgaggaga aagaaatcca tcaacctcct
     2041 gaagaagaca ggcttcaggg actcagagca gcgacagcag aagcagtgac caagttactg
     2101 gaccccctgg ttttgtttga acccaagttg ctaagagcgg ttttacacga gtggctttca
     2161 cagttagaaa aaacatttgc catgaaaggc tttgctgcca tttccaacac cagcagtcta
     2221 cccgagaaat cgaacctgga tacgcacctc ctcggtgagt cagaaaaaag agtattatgt
     2281 gaagagagtg gagaagaaag aagggtcacc ttaggcactg aagaacctgg cggtcagaca
     2341 acctgtgact ctgtaagcag cctgagtgag ccctcggccg acagttttca agtctgtcct
     2401 ccttacgcca tagcaaacag ccttcagaag gacctggtgg aattgacaac gttgtgcttg
     2461 gaactgaacg tgttgacctc tgcggtggaa agcgatagta gacacatgga ctgtgctttg
     2521 cagcagctct ctccagagac cctggcttgt cgtttcctga agaagtactt ttttctcctg
     2581 gacttgaaaa gggcaaagga gagtgtcaag cttagtcact acagcccctg tgtttgggac
     2641 acttttgttg aaggactaaa agaaatggca agttctactc ctgcctacat ggagatggga
     2701 gaaagagacc tgcccaccgg gttacagttg ctggatggct ccgtcccttc ccatagtccc
     2761 ctgctgattg cctttgccgc ccggctgtat gacagatttg gggagcctgc ccttcgagcc
     2821 ttgatcaagt tttacccgtc catctcacct tccgacattg cgcagctttg ccgtcgtcat
     2881 ccggctcagt ttttggccta tctggacagt ctggtgaagt ccaggcccga ggaccagtgg
     2941 ccatccttcc ttgagttcct tctacaacca gaatctttaa gacttgaatg gctgcttttg
     3001 gcagtgtccc atgatgctcc accaagcaca agtacagtgg atgatgaagg acatcccagg
     3061 ccccattcac acctgctttc ttggggttat agccagctga ttcttcttct gattaaactt
     3121 cctgcagact ttgcaaccaa agagaaaatg actgacatct gtaggtctta tggtttctgg
     3181 cctggatatc ttaccctctg tctggagctg gagaggagga gggaggcctt caccaacatt
     3241 gtgtatctga atgatgtcag cctgatggaa ggggacaatg ggtggatccc tgagaccttg
     3301 gaggaatgga agcttctcct acatctacta cagaacaaga acacaaggcc agctcctcag
     3361 gagtcactaa atgggagcct cagtgatggg cctaccccca tcaatgtgga gaatgtggca
     3421 ctcctgttag ctaaggccat gggcccagat agggcctggt cactgctaca ggagtgcggt
     3481 ctggcccttg agttgtcaga aaagtttacc agaacctgtg acatcctgag gattgctgag
     3541 agaaggcaga gagcgctgat acaaggcatg cttgagaagt gcgaccggtt cctctggtca
     3601 cagcaggcct agtgggagat gtactctgac caagtggaat cctgctctag aaccttcaga
     3661 gggctttggc acagaaggaa agaggacatc ccaagccacg ccatgaccgg aaggaccgtg
     3721 ccatgctgct gcagctgctg atgcctcacc accgccttgg ccctcggttt ctgtggctct
     3781 gtgacgtcag aatctctcaa ggaaagccag ctttcagaag cagcgggttg tctggaagca
     3841 gcatggggtg ctccctgctg tgtggaattt actgtgtaca gtgaatcagg gaattggttt
     3901 ctactgaggc agatctgtgg gtgccgcagc tttgttacag aagacagata atgttctaat
     3961 ctgcagttta gtaccttttc ctttccgttt gtctgaggtg actacagatt actgagtgag
     4021 gacccggaac aatgacaccg ttcctgtcgg catatgtaat aaatactaaa gatacaaacc
     4081 agagttttaa gtaagattac catatctgag ttgagctcag tttaaagtat ttttccagta
     4141 tttatttgat atcttctaat ctaaacctat ctatactgac taatccctgg aaacatatga
     4201 ttcgtaattt ttaaagagcg ggtgatcaaa acactcatgc cctctcttct attttttatt
     4261 gagtcatgca cttttttcct tccttccttc cttccttcct tctttccttc cttccttcct
     4321 tccttccttc cttccttcct ggtggaaaca gggtcttgat ctgtagccct cgctagcctg
     4381 gagggcgcag gtttgcaagg ctgtctcagg ctgtctcgac tttacagatc tccagcctcc
     4441 aggatgttaa gattaagggt gtgtgccatc acacacattt ttaacattta tttttaaaaa
     4501 gccatagtaa gagaaagcca tgtactaata taaattatag caaatgattg tattagtcaa
     4561 gccatgtaac tagattgcat ttctgaggct ttctgtagcc tcttgcattg gtaataaaca
     4621 atgaagtttc tttaagcaga a
//
