LOCUS       NM_001107148            2830 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus HPS4, biogenesis of lysosomal organelles complex
            3 subunit 2 (Hps4), mRNA.
ACCESSION   NM_001107148 XM_001078272 XM_222245
VERSION     NM_001107148.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Marubashi,S., Shimada,H., Fukuda,M. and Ohbayashi,N.
  TITLE     RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and
            Regulates Melanogenic Enzyme Trafficking in Melanocytes
  JOURNAL   J Biol Chem 291 (3), 1427-1440 (2016)
   PUBMED   26620560
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Saito,A., Kuratomi,G., Ito,C., Matsuoka,H., Suzuki,T., Ozeki,Y.,
            Watanabe,T., Fujii,K., Shimoda,K., Fukushima,Y., Inukai,T.,
            Ohmori,K. and Akiyama,K.
  TITLE     An association study of the Hermansky-Pudlak syndrome type 4 gene
            in schizophrenic patients
  JOURNAL   Psychiatr Genet 23 (4), 163-173 (2013)
   PUBMED   23563589
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Gerondopoulos,A., Langemeyer,L., Liang,J.R., Linford,A. and
            Barr,F.A.
  TITLE     BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine
            nucleotide exchange factor
  JOURNAL   Curr Biol 22 (22), 2135-2139 (2012)
   PUBMED   23084991
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Kloer,D.P., Rojas,R., Ivan,V., Moriyama,K., van Vlijmen,T.,
            Murthy,N., Ghirlando,R., van der Sluijs,P., Hurley,J.H. and
            Bonifacino,J.S.
  TITLE     Assembly of the biogenesis of lysosome-related organelles complex-3
            (BLOC-3) and its interaction with Rab9
  JOURNAL   J Biol Chem 285 (10), 7794-7804 (2010)
   PUBMED   20048159
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Martina,J.A., Moriyama,K. and Bonifacino,J.S.
  TITLE     BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome
            gene products HPS1 and HPS4
  JOURNAL   J Biol Chem 278 (31), 29376-29384 (2003)
   PUBMED   12756248
REFERENCE   7  (bases 1 to 2830)
  AUTHORS   Anderson,P.D., Huizing,M., Claassen,D.A., White,J. and Gahl,W.A.
  TITLE     Hermansky-Pudlak syndrome type 4 (HPS-4): clinical and molecular
            characteristics
  JOURNAL   Hum Genet 113 (1), 10-17 (2003)
   PUBMED   12664304
REFERENCE   8  (bases 1 to 2830)
  AUTHORS   Chiang,P.W., Oiso,N., Gautam,R., Suzuki,T., Swank,R.T. and
            Spritz,R.A.
  TITLE     The Hermansky-Pudlak syndrome 1 (HPS1) and HPS4 proteins are
            components of two complexes, BLOC-3 and BLOC-4, involved in the
            biogenesis of lysosome-related organelles
  JOURNAL   J Biol Chem 278 (22), 20332-20337 (2003)
   PUBMED   12663659
REFERENCE   9  (bases 1 to 2830)
  AUTHORS   Suzuki,T., Li,W., Zhang,Q., Karim,A., Novak,E.K., Sviderskaya,E.V.,
            Hill,S.P., Bennett,D.C., Levin,A.V., Nieuwenhuis,H.K., Fong,C.T.,
            Castellan,C., Miterski,B., Swank,R.T. and Spritz,R.A.
  TITLE     Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human
            homolog of the mouse light-ear gene
  JOURNAL   Nat Genet 30 (3), 321-324 (2002)
   PUBMED   11836498
REFERENCE   10 (bases 1 to 2830)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1 and BC168901.1.
            
            On Jun 25, 2015 this sequence version replaced NM_001107148.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168901.1, SRR26643429.43671.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               JAXUCZ010000012.1  49953182-49953613   c
            433-2776            BC168901.1         1-2344
            2777-2830           JAXUCZ010000012.1  49924444-49924497   c
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2830
                     /gene="Hps4"
                     /note="HPS4, biogenesis of lysosomal organelles complex 3
                     subunit 2"
                     /db_xref="GeneID:304555"
                     /db_xref="RGD:1308070"
     exon            1..466
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..2411
                     /gene="Hps4"
                     /note="Hermansky-Pudlak syndrome 4 homolog"
                     /codon_start=1
                     /product="BLOC-3 complex member HPS4"
                     /protein_id="NP_001100618.2"
                     /db_xref="GeneID:304555"
                     /db_xref="RGD:1308070"
                     /translation="MANTTPPETKSAAWWNYFFLYDGSKVQGEGDPTRAGICYFYPSQ
                     TLLDQQELLCGQLAGVVRCLWDLSGTPPMLIRLRNLKFALRVDGDYLWALGCGVELSD
                     ASCRQFLDQLIGFFHFYMGPVSLAYKSHPQEELRLQWDTFITQVLRSTSESHRIFNAL
                     WNLDRTKVEPLLLLKAALILQTCQRSPHVLAGCILYEGLIVNSQLPPSLTAKVLLHHT
                     VAADQRPPGAGAATQETGPALPPAVQITPVFLSEEEVASLHEFPVEHDPRLEESSFQC
                     PPWDQSTPTGAEDAWTSATVLEPTPCGGGHSPRLEQERAGPTGLCTEACDRSSDLSGR
                     LQRELCLSQELDLSAMHLSEAQDAFPPVPASCDLQALCVSRDTPTLPEDTAICSCLDP
                     SPLERPPEGGSLEALADLPLTHGHTHVPGTEPLPSSRTMVLLPQHPEGVEPGVEPCGS
                     GAQDRLPALARSSHSADSQGPSPSADRTGFNPSPSGPHAGLMPMNLYTHSVNGLVLSL
                     LAKETLGSDTAAIEEVYHSSLASLNGLEVHLKETLPRDETSPTGSTYNFLHYDRIQSV
                     LSANLPLVAAPQNRRFLQAVNLMHSDFAQLPMLYEMTIRNASTAVYACSNPAQETYFQ
                     QLAPTARSSGFPNPQDCAFSLSGKAKQKLLKHGVNLL"
     exon            467..557
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            558..701
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            702..809
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..926
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1021
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1094
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1131
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1228
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1997
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2130
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2239
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2830
                     /gene="Hps4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgagtta ctggtgtgtg tgtgtgtgaa ctggaaactt tggacctttt gaaggaactc
       61 agaagctgcc tccgcccatc cagcatgctt ctccctgtgg tggagattcc tgaggggagt
      121 tggaacaggt cccagcgtag acagccatat ggatgctcct gaaagcagac cacagactgt
      181 tgagtcaatc tggtccgcct ccagcctgtt tcttcctgga cttctcagcg gtgcaagata
      241 cttttggaag tgaacctgcc cagaagggaa gttacatttt catattgatt aaagagtgaa
      301 caagaggcag aaaccacctg gcttgaccac acctggcatt actgggctgg ggacaccagc
      361 tggggacaga gaagtgcttc tagcaggaat acgagatgaa gagggtgaag ccatctggag
      421 agtaaatggc caacaccact cccccagaga caaagtcagc agcgtggtgg aactactttt
      481 tcctgtacga tggttccaag gtacagggag aaggagaccc aaccagagcc ggcatctgct
      541 acttctatcc ctcccagacc ctgttagacc agcaggagct gctctgtggc cagcttgctg
      601 gagttgtgcg ctgcttgtgg gacctttccg gcaccccgcc tatgctcatc cgtctgcgga
      661 acctcaagtt tgccctcagg gtggatgggg actacctgtg ggctctgggt tgtggtgtgg
      721 agctctccga tgccagctgc aggcagtttc tggatcagct cattggattt tttcatttct
      781 acatggggcc tgtctccctg gcctacaaga gccatcctca ggaagagctg aggttgcagt
      841 gggatacctt catcacacaa gtcctcagga gcaccagcga gtcgcacagg atcttcaatg
      901 ccctgtggaa cctggaccgc accaaagtgg agcccctgct gctgctgaag gcagccctca
      961 tcttacagac ctgccagcgc tcaccccatg tgctagctgg ctgcatcctc tatgaaggac
     1021 tgattgtgaa ttcccagctg ccaccttccc tcactgccaa ggtcctgctt catcacactg
     1081 tagctgcaga ccagaggccg cctggagcag gagctgccac acaggaaaca ggaccagcat
     1141 taccccctgc cgtgcagatc acccctgttt tcctgagtga ggaggaggtg gccagcctcc
     1201 atgagttccc agtagagcat gaccctcgac tggaggaaag ttcatttcag tgccctccct
     1261 gggatcaaag cacccctact ggggcggaag atgcctggac atcagccacc gtcctggagc
     1321 ccacaccatg tggtggagga cactcaccta ggcttgagca ggagcgtgct gggcccacag
     1381 gactgtgcac cgaggcctgt gaccggagct ctgatctcag tggcaggctg cagagggaac
     1441 tgtgtctctc ccaagaactg gacttgtctg caatgcacct ttctgaggct caggacgcat
     1501 tcccgcctgt gcctgcctcg tgtgatctgc aggctctctg cgtcagccgg gacaccccca
     1561 cactacctga agacacagcc atttgcagct gcctggaccc ttcccctctt gagaggccac
     1621 ccgagggcgg aagcctggag gcgcttgcag accttcccct cacccatggc cacacccacg
     1681 ttcctggcac agaacctctc cccagcagca gaactatggt acttcttccc caacatcctg
     1741 agggtgtaga gcccggtgtg gagccctgtg ggagtggagc tcaggacaga ctcccagccc
     1801 tggcacgcag ttcccactcg gctgactctc agggccctag cccctctgca gacagaactg
     1861 gcttcaatcc atccccatct gggccccatg cagggctcat gcccatgaac ctctacactc
     1921 acagtgtgaa cggactagtg ctgtccttgc tggccaaaga gactcttggc agtgatactg
     1981 cagccattga ggaggtgtac cacagcagcc tggcatcact gaatgggctg gaagtccatc
     2041 tgaaggagac actgcccaga gatgagacta gccccacagg tagcacatac aacttcctgc
     2101 attatgaccg catccagagc gtactctcag ccaacctgcc cctggtggct gctccccaga
     2161 accgccggtt tctgcaggct gtcaacctca tgcactccga ctttgcccag ctgcctatgc
     2221 tgtatgagat gaccatcagg aatgcctcca cagctgtgta cgcctgcagc aaccctgccc
     2281 aggagaccta cttccagcag ctggcaccca ctgcccgcag ctctggtttc ccgaaccctc
     2341 aggattgtgc cttcagcctc tcgggcaaag ccaagcagaa gctgctgaag catggggtaa
     2401 acctgctgtg agctgggtgc agccggtctg ctgtcagggg gccgtgtccc cagtgctaac
     2461 ggtctgctgt cagggggcca tgtccccagt gctaacggtc tgctgtcacg gggccgtgtc
     2521 cccagtgcta acggttgagc aggaccttgc tcttcagtgg cagctgcatg aaactgagtg
     2581 ggctcaggct ctgtcatgtg cgagtgactg gagtacagtg cagagcaggc tgcaggctca
     2641 ggaaggcagc tgcaggagtc tcagctgact ttacttgcgg tacccatggt gctttgcaac
     2701 cttatggtgc tgagttccag gcttatgaag cagattccca aaggttcaaa aataaaatga
     2761 ccaaactgag ctctgagtaa ctgactagca tttatttctg tgacagagta aaggtcagtg
     2821 tggacgcgga
//
